TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.779 | Formula: C15H11ClN2OS
H donors: 0 H acceptors: 1 LogP: 4.21 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(=O)N=c1sc2c(n1C)cccc2
InChi: 1S/C15H11ClN2OS/c1-18-12-4-2-3-5-13(12)20-15(18)17-14(19)10-6-8-11(16)9-7-10/h2-9H,1H3/b17-15-
InChiKey: AJMFTPXHITWYTH-ICFOKQHNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0396	0.0701
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0375	0.095
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0375	0.095
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0914	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0914	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0388	0.3773
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0375	0.095
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0388	0.0316
Schistosoma mansoni	cpg binding protein	0.0028	0.0261	0.0193
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0747	0.0677
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0096	0.0021
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0075	0.0059
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0914	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0375	0.0803
Brugia malayi	beta-lactamase family protein	0.0036	0.0375	0.0803
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0096	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0409	0.0729
Trichomonas vaginalis	esterase, putative	0.0036	0.0375	0.1963
Toxoplasma gondii	ABC1 family protein	0.0036	0.0375	0.3573
Schistosoma mansoni	cpg binding protein	0.0032	0.0313	0.0245
Echinococcus granulosus	zinc finger protein	0.0021	0.0157	0.0082
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0375	0.0653
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0388	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0105	0.0035
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0652	0.1397
Leishmania major	glycosyl hydrolase-like protein	0.0027	0.0243	0.205
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0375	0.095
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0027	0.0243	0.205
Brugia malayi	hypothetical protein	0.0126	0.1697	0.3639
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0388	0.3736
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0328	0.4662	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0073	0.0914	1
Schistosoma mansoni	hypothetical protein	0.0017	0.01	0.003
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0331	0.0813
Schistosoma mansoni	hypothetical protein	0.0017	0.01	0.003
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0914	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0506	0.0435
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0375	0.095
Schistosoma mansoni	hypothetical protein	0.0038	0.0396	0.0329
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0388	0.2167
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0073	0.0914	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0506	0.0439
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0388	0.0321
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0388	0.2167
Echinococcus granulosus	lysosomal alpha glucosidase	0.0328	0.4662	0.4622
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0073	0.0914	1
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.5776	0.5745
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0375	0.1963
Brugia malayi	TAR-binding protein	0.0206	0.2868	0.6152
Brugia malayi	beta-lactamase	0.0036	0.0375	0.0803
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0388	0.2167
Brugia malayi	PHD-finger family protein	0.0027	0.0235	0.0504
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.323	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0075	0.0005
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0375	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0506	0.1086
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0073	0.0914	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0669	0.7078
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0496	0.0918
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0328	0.4662	1
Schistosoma mansoni	hypothetical protein	0.0017	0.01	0.003
Echinococcus multilocularis	zinc finger protein	0.0021	0.0157	0.0082
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2868	0.2818
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2868	0.2818
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0027	0.0243	0.0521
Echinococcus granulosus	neutral alpha glucosidase AB	0.0073	0.0914	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0375	0.0653
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0073	0.0914	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.01	0.0025
Onchocerca volvulus		0.0036	0.0375	0.0551
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0914	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0506	0.094
Schistosoma mansoni	cpg binding protein	0.0032	0.0313	0.0245
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0375	1
Loa Loa (eye worm)	TAR-binding protein	0.0206	0.2868	0.6089
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.01	0.0055
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0375	0.0653
Echinococcus granulosus	tar DNA binding protein	0.0206	0.2868	0.2814
Schistosoma mansoni	hypothetical protein	0.0021	0.0148	0.0079
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0396	0.085
Brugia malayi	Inositol-1	0.0037	0.0388	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0885	0.1767
Echinococcus multilocularis	tar DNA binding protein	0.0206	0.2868	0.2814
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0328	0.4662	0.4622
Schistosoma mansoni	microtubule-associated protein tau	0.0691	1	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0747	0.0677
Schistosoma mansoni	zinc finger protein	0.0021	0.0157	0.0087
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0388	0.5
Leishmania major	alpha glucosidase II subunit, putative	0.0073	0.0914	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0261	0.056
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0375	0.095
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0375	0.0653
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0375	0.1963
Schistosoma mansoni	alpha glucosidase	0.0073	0.0914	0.085
Loa Loa (eye worm)	hypothetical protein	0.0017	0.01	0.0055
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0375	0.3611
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0375	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0375	0.3611
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0375	0.1963
Echinococcus multilocularis	microtubule associated protein 2	0.0691	1	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0073	0.0914	1
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2868	0.2818
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0375	0.0302
Onchocerca volvulus	Huntingtin homolog	0.0126	0.1697	0.6088
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0027	0.0243	0.205
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0073	0.0914	0.1829
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.01	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0375	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0375	0.0653
Brugia malayi	RNA binding protein	0.0206	0.2868	0.6152
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0075	0.016
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0375	0.0653
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0105	0.003
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0375	0.095
Echinococcus granulosus	cpg binding protein	0.0032	0.0313	0.024
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0075	0.016
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0373	0.0301
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0375	0.1963
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0375	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0652	0.1257
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0506	0.0435
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0652	0.1257
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0506	0.0435
Loa Loa (eye worm)	inositol-1	0.0037	0.0388	0.0683
Onchocerca volvulus		0.019	0.2631	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.01	0.0025
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0375	0.095
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.01	0.0025
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0375	0.3611
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0073	0.0914	0.0845
Echinococcus multilocularis	GPCR, family 2	0.0017	0.01	0.0025
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0914	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.01	0.0025
Loa Loa (eye worm)	RNA binding protein	0.0206	0.2868	0.6089
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0105	0.0065
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0096	0.0026
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0148	0.016
Echinococcus granulosus	GPCR family 2	0.0017	0.01	0.0025
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0388	0.3773
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0375	0.1963
Schistosoma mansoni	bromodomain containing protein	0.0065	0.08	0.0735
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0506	0.0439
Schistosoma mansoni	hypothetical protein	0.0404	0.5776	0.5747
Onchocerca volvulus		0.0036	0.0375	0.0551
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0105	0.003
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.01	0.0214
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0506	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0243	0.0366
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0105	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0375	0.0653
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.5776	0.5745
Trypanosoma brucei	glucosidase, putative	0.0073	0.0914	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0206	0.2868	0.6089
Schistosoma mansoni	alpha-glucosidase	0.0282	0.3991	0.3949
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.02	0.0131
Brugia malayi	Bromodomain containing protein	0.0077	0.0972	0.2085
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0073	0.0914	1
Onchocerca volvulus		0.0036	0.0375	0.0551
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0075	0.0059
Brugia malayi	Bromodomain containing protein	0.0038	0.0408	0.0876
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0388	0.3773
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0652	0.1397
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0388	0.2167
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0375	0.0302
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0728	0.0663
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0375	0.095
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0375	0.0307
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0373	0.0301
Echinococcus multilocularis	cpg binding protein	0.0032	0.0313	0.024
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1697	0.3536
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0388	0.0321
Leishmania major	hypothetical protein, conserved	0.0036	0.0375	0.3611
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0388	0.3773
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0105	0.0065
Schistosoma mansoni	hypothetical protein	0.0017	0.01	0.003
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0261	0.0406
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.02	0.0126
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0075	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1697	0.3536
Brugia malayi	RNA recognition motif domain containing protein	0.0206	0.2868	0.6152
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0075	0.0059
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0027	0.0243	0.205
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2868	0.2818
Onchocerca volvulus	Huntingtin homolog	0.0126	0.1697	0.6088
Schistosoma mansoni	alpha-glucosidase	0.0282	0.3991	0.3949
Brugia malayi	beta-lactamase family protein	0.0036	0.0375	0.0803
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.02	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0444	0.0805
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0075	0.0059
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0096	0.0026
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2868	0.2818
Onchocerca volvulus		0.0028	0.0261	0.0077
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0914	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0073	0.0914	0.196
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0388	0.0316
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0328	0.4662	0.4622
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0506	0.0435
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0375	0.095
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0075	0.0059

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 629363