Detailed information for compound 629377

Basic information

Technical information
  • TDR Targets ID: 629377
  • Name: 4-[(2,4-dioxo-1,3-thiazolidin-3-yl)methyl]ben zoic acid
  • MW: 251.258 | Formula: C11H9NO4S
  • H donors: 1 H acceptors: 4 LogP: 1.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccc(cc1)CN1C(=O)CSC1=O
  • InChi: 1S/C11H9NO4S/c13-9-6-17-11(16)12(9)5-7-1-3-8(4-2-7)10(14)15/h1-4H,5-6H2,(H,14,15)
  • InChiKey: MCOAUWGCLSIVNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(2,4-dioxothiazolidin-3-yl)methyl]benzoic acid
  • 4-[(2,4-dioxo-3-thiazolidinyl)methyl]benzoic acid
  • 4-[(2,4-diketothiazolidin-3-yl)methyl]benzoic acid
  • STK215592

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0049 0.1194 0.2094
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0378 0.0399
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0369 0.3343
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0369 0.3343
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0552 0.019
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0552 0.019
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0025 0.0552 0.019
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0025 0.0552 0.0529
Plasmodium vivax enoyl-acyl carrier protein reductase 0.037 1 1
Schistosoma mansoni ets 0.001 0.0145 0.0254
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0129 0.2945
Schistosoma mansoni dihydropteridine reductase 0.0025 0.0552 0.0969
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0369 0.6679
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0503 0.0303
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0129 0.0104
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.1054 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0701 0.6568
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0292 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Trichomonas vaginalis set domain proteins, putative 0.0237 0.6341 0.6264
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0369 0.3343
Leishmania major DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0145 0.0189
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Loa Loa (eye worm) oxidoreductase 0.0025 0.0552 0.0831
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0369 0.0166
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.1787 0.2776
Loa Loa (eye worm) hypothetical protein 0.0238 0.6375 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Schistosoma mansoni hypothetical protein 0.0169 0.4498 0.7892
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0145 0.0025
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0369 0.5
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.1787 0.2655
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0652 0.0837
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0378 0.0663
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0378 0.001
Echinococcus granulosus protein C ets 2 0.001 0.0145 0.0025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0552 0.0831
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0378 0.0399
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.037 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0025 0.0552 0.0552
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0552 0.5125
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0025 0.0552 0.0831
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0682 0.1197
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0378 0.3432
Brugia malayi Fli-1 protein 0.0213 0.5699 0.8936
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0378 0.001
Giardia lamblia DINP protein human, muc B family 0.0019 0.0378 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0369 0.0384
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.108 0.1522
Schistosoma mansoni gabp alpha 0.007 0.1787 0.3136
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0552 0.0529
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0378 0.0354
Leishmania major oxidoreductase-like protein 0.0025 0.0552 0.5125
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0682 0.0886
Loa Loa (eye worm) hypothetical protein 0.003 0.0682 0.1035
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0025 0.0552 0.0969
Mycobacterium ulcerans oxidoreductase 0.0025 0.0552 0.0529
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0145 0.0025
Trichomonas vaginalis hypothetical protein 0.037 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.5555 0.8709
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.108 0.1522
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0025 0.0552 0.0529
Brugia malayi hypothetical protein 0.0238 0.6375 1
Schistosoma mansoni ap endonuclease 0.0018 0.0369 0.0647
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.108 0.1894
Schistosoma mansoni survival motor neuron protein 0.0049 0.1194 0.2094
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0145 0.0025
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0025 0.0552 0.5125
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0219 0.1887
Schistosoma mansoni elf1 0.001 0.0145 0.0254
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0206 0.1762
Plasmodium vivax SET domain protein, putative 0.003 0.0682 0.0659
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0682 0.1197
Trypanosoma brucei oxidoreductase-like protein 0.0025 0.0552 0.5125
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0503 0.0599
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0145 0.0189
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0552 0.0529
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0369 0.974
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0378 0.0399
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0378 0.0354
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0552 0.0831
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0025 0.0025
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0129 0.0129
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1194 0.184
Echinococcus granulosus dna polymerase kappa 0.0019 0.0378 0.0399
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0552 0.0831
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0369 0.0345
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0129 0.0164
Brugia malayi Ets-domain containing protein 0.007 0.1787 0.2776
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0369 0.0647
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0145 0.0025
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0025 0.0552 0.019
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0129 0.0164
Brugia malayi Pre-SET motif family protein 0.0208 0.5555 0.8709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.108 0.1894
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0145 0.0189
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0145 0.0189
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0219 0.1887
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.037 1 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0025 0.0044
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0503 0.0753
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Schistosoma mansoni DNA helicase recq5 0.001 0.0129 0.0226
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0552 0.0529
Echinococcus granulosus dna polymerase eta 0.0043 0.1054 0.1481
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0369 0.0345
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0145 0.0189
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0025 0.0552 0.0552
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0552 0.0529
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0129 0.0164
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0145 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0369 0.0542
Echinococcus multilocularis geminin 0.0169 0.4498 0.6995
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0025 0.0552 0.0552
Echinococcus multilocularis protein C ets 2 0.001 0.0145 0.0025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Loa Loa (eye worm) hypothetical protein 0.006 0.1509 0.2337
Toxoplasma gondii exonuclease III APE 0.0018 0.0369 0.0369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.108 0.1894
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0025 0.0552 0.019
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0552 0.5125
Schistosoma mansoni hypothetical protein 0.001 0.0145 0.0254
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0206 0.1762
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0378 0.6845
Loa Loa (eye worm) fli-1 protein 0.0213 0.5699 0.8936
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0552 0.019
Schistosoma mansoni ets-related 0.0213 0.5699 1
Schistosoma mansoni ap endonuclease 0.0018 0.0369 0.0647
Echinococcus granulosus bloom syndrome protein 0.0023 0.0503 0.0599
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.1054 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0378 0.3432
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0682 0.0886
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0369 0.3343
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0426 0.0402
Trypanosoma brucei unspecified product 0.0013 0.0219 0.1887
Loa Loa (eye worm) hypothetical protein 0.001 0.0145 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0219 0.1887
Leishmania major DNA polymerase eta, putative 0.0043 0.1054 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0025 0.0552 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0378 0.0175
Brugia malayi Pre-SET motif family protein 0.003 0.0682 0.1035
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.037 1 1
Echinococcus multilocularis ets variant gene 4 0.001 0.0145 0.0025
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0206 0.1762
Echinococcus granulosus geminin 0.0169 0.4498 0.6995
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.037 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0701 0.0701
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0369 0.0542
Leishmania major pteridine reductase 1 0.0025 0.0552 0.5125
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.6375 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.108 0.1661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0682 0.1197
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Schistosoma mansoni hypothetical protein 0.001 0.0145 0.0254
Onchocerca volvulus 0.0237 0.6341 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0297 0.0272
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0552 0.0529
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Schistosoma mansoni hypothetical protein 0.0169 0.4498 0.7892
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0025 0.0552 0.0529
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0025 0.0552 0.0678
Schistosoma mansoni DNA helicase recq1 0.001 0.0129 0.0226
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0552 0.0529
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0145 0.0025
Loa Loa (eye worm) hypothetical protein 0.0043 0.1054 0.162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0206 0.3735
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0378 0.0663
Loa Loa (eye worm) hypothetical protein 0.001 0.0145 0.0189
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0145 0.0025
Schistosoma mansoni DNA polymerase eta 0.0043 0.1054 0.1849
Echinococcus granulosus GA binding protein alpha chain 0.007 0.1787 0.2655
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0117 0.3072 0.4799
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0369 0.0384
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0369 0.0345
Trypanosoma brucei unspecified product 0.0013 0.0219 0.1887
Echinococcus multilocularis dna polymerase eta 0.0043 0.1054 0.1481
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0552 0.019
Plasmodium falciparum enoyl-acyl carrier reductase 0.037 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0025 0.0552 0.5125
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0378 0.0556
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0378 0.3432
Brugia malayi Ets-domain containing protein 0.007 0.1787 0.2776
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.6375 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0145 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.1054 0.162
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.037 1 1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0145 0.0254
Loa Loa (eye worm) retinol dehydrogenase 12 0.0025 0.0552 0.0831
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0552 0.019
Loa Loa (eye worm) hypothetical protein 0.001 0.0129 0.0164
Schistosoma mansoni ets-related 0.001 0.0145 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.108 0.1522
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0682 0.0886
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0552 0.019
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0552 0.0529
Trypanosoma brucei pteridine reductase 1 0.0025 0.0552 0.5125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.108 0.1661
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0145 0.0025
Onchocerca volvulus 0.003 0.0682 0.0224
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0369 0.0166
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0025 0.0025
Leishmania major DNA polymerase eta, putative 0.0031 0.0701 0.6568
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0682 0.1197
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0378 0.0175
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0378 0.0556
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0552 0.0529
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0025 0.0552 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Onchocerca volvulus 0.0049 0.1194 0.1108
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0145 0.0025
Brugia malayi Ets-domain containing protein 0.001 0.0145 0.0189
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0503 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.108 0.1522
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0552 0.5125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0682 0.0682
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0025 0.0552 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0378 0.3432
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Brugia malayi transcription factor E74 isoform 0.001 0.0145 0.0189
Trypanosoma brucei unspecified product 0.0019 0.0378 0.3432
Loa Loa (eye worm) RecQ helicase 0.0023 0.0503 0.0753
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0025 0.0552 0.5125
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0145 0.0025
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0552 0.0529
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0552 0.5125
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0378 0.3432
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0145 0.0025
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0025 0.0552 0.0529

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.