Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.038 | 0.1336 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.0381 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.1213 | 0.0871 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1213 | 0.1213 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.1213 | 0.9521 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.2842 | 0.2842 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1255 | 0.0068 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1255 | 0.1255 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.1213 | 0.0871 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.038 | 0.1336 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1213 | 0.4269 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.165 | 0.5808 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.1213 | 0.0871 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.038 | 0.038 |
Brugia malayi | beta-lactamase | 0.0037 | 0.1213 | 0.1213 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0182 | 0.7564 | 0.7564 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.1341 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0136 | 0.5531 | 0.5531 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0136 | 0.5531 | 0.5531 |
Brugia malayi | MH2 domain containing protein | 0.0136 | 0.5531 | 0.5531 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.2842 | 0.2842 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1213 | 0.1213 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.1341 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.0381 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.1213 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.129 | 0.129 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.038 | 0.1336 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2842 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.1341 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.038 | 0.1336 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1213 | 0.1213 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.038 | 0.038 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.038 | 0.038 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0381 | 0.1341 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.1213 | 0.0871 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.1341 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.0381 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.1341 |
Onchocerca volvulus | 0.0037 | 0.1213 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.165 | 0.5808 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2074 | 0.2074 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1213 | 0.4269 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.1213 | 0.9521 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.2842 | 0.2842 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1255 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.129 | 0.129 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.1213 | 0.0871 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2074 | 0.2074 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.2842 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1213 | 0.1213 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.1213 | 0.1213 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.2842 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0381 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2842 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.038 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.7564 | 0.7564 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1213 | 0.9521 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.165 | 0.5808 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1255 | 0.4416 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.1213 | 0.0871 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.165 | 0.5808 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.038 | 0.1336 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.1213 | 0.0871 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1255 | 0.4416 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1213 | 0.9521 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1213 | 0.1213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2842 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.2842 | 0.2842 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2842 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.165 | 0.5808 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0381 | 0.1341 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.1213 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1255 | 1 |
Onchocerca volvulus | 0.0037 | 0.1213 | 0.5 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.038 | 0.038 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0236 | 0.9929 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.1213 | 0.0871 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1255 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.038 | 0.1336 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1255 | 0.1255 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0177 | 0.7346 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.1213 | 0.9521 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1213 | 0.1213 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1255 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1255 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.038 | 0.1336 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2074 | 0.2074 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1255 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.1213 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1255 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1081 | 0.0733 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1255 | 0.4416 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.165 | 0.5808 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.165 | 0.165 |
Brugia malayi | RNA binding protein | 0.0074 | 0.2842 | 0.2842 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1213 | 0.1213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2842 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.1213 | 0.0871 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1255 | 0.4416 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.165 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1213 | 0.1213 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.165 | 0.5808 |
Onchocerca volvulus | 0.0037 | 0.1213 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.129 | 0.4539 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.1213 | 0.1213 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1255 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.2842 | 0.2842 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.038 | 0.1336 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.1213 | 0.1213 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.1213 | 0.4269 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1255 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.1213 | 0.0871 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2074 | 0.2074 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.038 | 0.1336 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.1213 | 0.4269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.