Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.0129 | 0.8167 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0937 | 0.1004 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0751 | 0.0708 |
Echinococcus granulosus | zinc finger protein | 0.004 | 0.1332 | 0.0847 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1669 | 0.1952 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0937 | 0.0366 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0937 | 0.0961 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1669 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.494 | 0.5294 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0032 | 0.0751 | 1 |
Leishmania major | pyruvate kinase | 0.0032 | 0.0751 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0031 | 0.0663 | 0.8772 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1497 | 0.1112 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0035 | 0.0937 | 0.0272 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0042 | 0.1497 | 0.1604 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0046 | 0.1796 | 0.1524 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.4543 | 0.41 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.236 | 0.174 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0663 | 0.8772 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0122 | 0.7607 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.4543 | 0.5848 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.0751 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.236 | 0.2529 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.426 | 0.3794 |
Leishmania major | pyruvate kinase | 0.0032 | 0.0751 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0032 | 0.0751 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3936 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0034 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0937 | 0.0366 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.236 | 0.2529 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1669 | 0.1341 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3936 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0032 | 0.0751 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1066 | 0.0341 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.0751 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0032 | 0.0751 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.3936 | 0.4362 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.0751 | 0.0117 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0937 | 0.0366 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.236 | 0.174 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0937 | 0.0366 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1669 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0751 | 0.0804 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.3936 | 0.5025 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0036 | 0.1033 | 0.1107 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1066 | 0.1142 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3936 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0046 | 0.1796 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.4271 | 0.4577 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1669 | 0.1788 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.0751 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1066 | 0.0537 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1669 | 0.0993 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0035 | 0.0937 | 0.0961 |
Onchocerca volvulus | 0.0082 | 0.4543 | 1 | |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.4543 | 0.5171 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4641 | 0.4974 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0122 | 0.7607 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.4543 | 0.5531 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.3936 | 0.4362 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1669 | 0.1339 |
Plasmodium falciparum | pyruvate kinase | 0.0032 | 0.0751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4543 | 0.4869 |
Schistosoma mansoni | zinc finger protein | 0.004 | 0.1332 | 0.0891 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0751 | 0.0804 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0937 | 0.0272 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0751 | 0.0804 |
Chlamydia trachomatis | pyruvate kinase | 0.0032 | 0.0751 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0034 | 0.0087 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.0751 | 0.0117 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0046 | 0.1796 | 0.2125 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.3936 | 0.4646 |
Echinococcus multilocularis | zinc finger protein | 0.004 | 0.1332 | 0.1496 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1669 | 0.1339 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1669 | 0.1952 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0032 | 0.0751 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0032 | 0.0751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.9331 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0751 | 0.0708 |
Brugia malayi | hypothetical protein | 0.0074 | 0.3936 | 0.3444 |
Mycobacterium ulcerans | pyruvate kinase | 0.0032 | 0.0751 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.0751 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.389 | 0.4578 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3936 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0034 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0751 | 0.0804 |
Brugia malayi | PHD-finger family protein | 0.0051 | 0.2166 | 0.153 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.389 | 0.4962 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0032 | 0.0751 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.