Detailed information for compound 630654

Basic information

Technical information
  • TDR Targets ID: 630654
  • Name: 4-[3-(4-chloro-2,6-dimethylphenoxy)propyl]mor pholine
  • MW: 283.794 | Formula: C15H22ClNO2
  • H donors: 0 H acceptors: 0 LogP: 3.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(Cl)cc(c1OCCCN1CCOCC1)C
  • InChi: 1S/C15H22ClNO2/c1-12-10-14(16)11-13(2)15(12)19-7-3-4-17-5-8-18-9-6-17/h10-11H,3-9H2,1-2H3
  • InChiKey: SJVOTRYLENDHJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[3-(4-chloro-2,6-dimethyl-phenoxy)propyl]morpholine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0031 0.0715 0.562
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0016 0.0259 0.2087
Schistosoma mansoni Smad4 0.0008 0.0033 0.008
Onchocerca volvulus 0.0031 0.0715 0.3033
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0016 0.0259 0.2087
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0199 0.1653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0143 0.0501
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0907 0.1387
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1374 0.4265
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0715 0.7733
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.0059 0.0144
Schistosoma mansoni cpg binding protein 0.0026 0.0571 0.1398
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0143 0.067
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0016 0.0259 0.0635
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0025 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Schistosoma mansoni hypothetical protein 0.0145 0.4086 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0715 0.1038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0907 1
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0715 0.7733
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.053 0.1644
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0013 0.0199 0.0548
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0013 0.0199 0.0548
Echinococcus multilocularis GPCR, family 2 0.0017 0.0298 0.0298
Giardia lamblia GTOR 0.0016 0.0259 0.1519
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0278 0.0278
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0907 0.7511
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.116 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0016 0.0259 0.2363
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Onchocerca volvulus 0.003 0.0696 0.292
Loa Loa (eye worm) hypothetical protein 0.0034 0.0816 0.2534
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0715 0.562
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0013 0.0199 0.0548
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.4086 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0013 0.0199 0.0487
Echinococcus granulosus serine protein kinase ATM 0.0021 0.0431 0.0431
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0259 0.0635
Schistosoma mansoni hypothetical protein 0.0017 0.0298 0.0728
Echinococcus granulosus smad 0.0008 0.0033 0.0033
Echinococcus granulosus Smad4 0.0008 0.0033 0.0033
Brugia malayi hypothetical protein 0.0041 0.1003 0.2455
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0431 0.4387
Loa Loa (eye worm) hypothetical protein 0.003 0.0696 0.216
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0275
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0013 0.0199 0.1351
Onchocerca volvulus 0.0071 0.1899 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.116 0.1847
Mycobacterium tuberculosis Conserved protein 0.0031 0.0715 0.1038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0715 0.2219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0278 0.1996
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0143 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0088 0.0975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0143 0.0996
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0033 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0907 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0199 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0059 0.0649
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0907 1
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0199 0.0487
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0197 0.5647 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0907 0.2106
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0907 1
Onchocerca volvulus 0.0071 0.1899 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0016 0.026 0.1149
Brugia malayi beta-lactamase family protein 0.0031 0.0715 0.1749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0431 0.4751
Schistosoma mansoni hypothetical protein 0.0017 0.0298 0.0728
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0715 0.788
Toxoplasma gondii FATC domain-containing protein 0.0021 0.0431 0.3131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0761 0.1121
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0907 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0013 0.0199 0.2194
Loa Loa (eye worm) hypothetical protein 0.0031 0.0715 0.2219
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0021 0.0431 0.1055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0431 0.1055
Schistosoma mansoni cpg binding protein 0.0025 0.053 0.1296
Schistosoma mansoni cpg binding protein 0.0026 0.0571 0.1398
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0033 0.0033
Loa Loa (eye worm) oxidoreductase 0.0013 0.0199 0.0618
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.3221 1
Onchocerca volvulus 0.0071 0.1899 1
Entamoeba histolytica hypothetical protein 0.0145 0.4086 1
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0071 0.1899 0.4648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0059 0.0649
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0016 0.0259 0.1141
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0199 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Onchocerca volvulus 0.0041 0.1003 0.473
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0013 0.0199 0.0199
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0816 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.116 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0907 0.0907
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0013 0.0199 0.0101
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0907 1
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0143 0.067
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0715 0.1038
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0143 0.0996
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0816 0.6617
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Echinococcus multilocularis cpg binding protein 0.0026 0.0571 0.0571
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0907 1
Brugia malayi hypothetical protein 0.0145 0.4086 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0278 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0143 0.067
Toxoplasma gondii target of rapamycin (TOR), putative 0.0016 0.0259 0.1561
Plasmodium vivax acetyl-CoA synthetase, putative 0.0013 0.0199 0.0828
Echinococcus granulosus cpg binding protein 0.0026 0.0571 0.0571
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0715 0.788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0059 0.0649
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0259 0.1141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0025
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0143 0.0351
Brugia malayi MH1 domain containing protein 0.0008 0.0033 0.008
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0013 0.0199 0.0101
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0278 0.3061
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0.0278 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0907 0.222
Brugia malayi AMP-binding enzyme family protein 0.0046 0.116 0.2839
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.116 0.2735
Loa Loa (eye worm) hypothetical protein 0.0034 0.0816 0.2534
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0199 0.0487
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0907 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0816 0.2534
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0023 0.0055
Onchocerca volvulus 0.0071 0.1899 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0013 0.0199 0.0548
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.116 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0816 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0047 0.1183 1
Entamoeba histolytica hypothetical protein 0.0145 0.4086 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0563 0.5801
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0715 0.1749
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0199 0.0548
Loa Loa (eye worm) hypothetical protein 0.0031 0.0715 0.2219
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0009 0.0059 0.0059
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0016 0.0259 0.0498
Leishmania major acetyl-CoA synthetase, putative 0.0013 0.0199 0.0548
Loa Loa (eye worm) hypothetical protein 0.0041 0.1003 0.3115
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0143 0.0501
Brugia malayi AMP-binding enzyme family protein 0.0046 0.116 0.2839
Trypanosoma brucei unspecified product 0.0026 0.0563 0.5801
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0278 0.0679
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.1003 0.3115
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0715 0.1038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0445
Entamoeba histolytica hypothetical protein 0.0145 0.4086 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1003 0.3115
Onchocerca volvulus 0.0031 0.0715 0.3033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0715 0.2219
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0696 0.216
Mycobacterium tuberculosis Conserved protein 0.0031 0.0715 0.1038
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.0278 0.1759
Mycobacterium ulcerans hypothetical protein 0.0046 0.116 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0059 0.0649
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0033 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0816 0.1222
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.1003 0.2455
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0876 0.2143
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0715 0.0715
Onchocerca volvulus 0.0071 0.1899 1
Brugia malayi AMP-binding enzyme family protein 0.0046 0.116 0.2839
Loa Loa (eye worm) hypothetical protein 0.0034 0.0816 0.2534
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.116 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0278 0.1996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0071 0.1899 0.5897
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0071 0.1899 0.4648
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0907 0.1387
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0715 0.788
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0907 0.222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0059 0.0649
Loa Loa (eye worm) hypothetical protein 0.003 0.0696 0.216
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0907 0.0907
Leishmania major hypothetical protein, conserved 0.0031 0.0715 0.562
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0715 0.1749
Schistosoma mansoni ap endonuclease 0.0016 0.0278 0.0679
Trichomonas vaginalis antibiotic synthetase, putative 0.0013 0.0199 0.2194
Echinococcus multilocularis dna polymerase eta 0.0037 0.0907 0.0907
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0816 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0907 0.0907
Brugia malayi polk-prov protein 0.0012 0.0143 0.0351
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0715 0.1038
Schistosoma mansoni smad1 5 8 and 0.0008 0.0033 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0715 0.1038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.116 1
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0907 0.7511
Loa Loa (eye worm) hypothetical protein 0.0018 0.0343 0.1064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0298 0.0924
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0298 0.0728
Leishmania major acetyl-CoA synthetase, putative 0.0013 0.0199 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0088 0.0975
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0298 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0278 0.3061
Schistosoma mansoni cellular tumor antigen P53 0.005 0.1293 0.3163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Loa Loa (eye worm) hypothetical protein 0.0046 0.116 0.3602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0761 0.1121
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0715 0.562
Echinococcus granulosus dna polymerase kappa 0.0037 0.0907 0.0907
Echinococcus multilocularis Smad4 0.0008 0.0033 0.0033
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0013 0.0199 0.0348
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0715 0.1749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0059 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0199 0.0101
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0259 0.0805
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0143 0.0996
Loa Loa (eye worm) hypothetical protein 0.0013 0.0199 0.0618
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0259 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0278 0.0862
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0143 0.067
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0259 0.0635
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0199 0.1653
Brugia malayi MH2 domain containing protein 0.0115 0.3221 0.7882
Onchocerca volvulus 0.0046 0.116 0.5653
Schistosoma mansoni hypothetical protein 0.0017 0.0298 0.0728
Loa Loa (eye worm) hypothetical protein 0.0036 0.0876 0.2719
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0199 0.0487
Leishmania major DNA polymerase kappa, putative 0.0037 0.0907 0.7511
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0199 0.1011
Loa Loa (eye worm) hypothetical protein 0.005 0.1293 0.4013
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0199 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Toxoplasma gondii propionate-CoA ligase 0.0013 0.0199 0.1011
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.1003 0.2455
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.1003 0.3115
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.116 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0016 0.0259 0.2087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0013 0.0199 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0907 0.222
Onchocerca volvulus 0.0071 0.1899 1
Mycobacterium leprae Probable lipase LipE 0.0031 0.0715 0.5366
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0199 0.1351
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0143 0.067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0761 0.1121
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0278 0.0543
Trypanosoma brucei unspecified product 0.0026 0.0563 0.5801
Treponema pallidum exodeoxyribonuclease (exoA) 0.0016 0.0278 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0907 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0013 0.0199 0.0199
Schistosoma mansoni smad1 5 8 and 0.0008 0.0033 0.008
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0907 0.222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0033 0.0101
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.116 0.2735
Brugia malayi Smad1 0.0008 0.0033 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0563 0.5801
Loa Loa (eye worm) hypothetical protein 0.0031 0.0715 0.2219
Loa Loa (eye worm) Smad1 0.0008 0.0033 0.0101
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0907 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0278 0.2579
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0907 1
Onchocerca volvulus 0.0071 0.1899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Brugia malayi beta-lactamase 0.0031 0.0715 0.1749
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0715 0.2219
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0343 0.3345
Loa Loa (eye worm) hypothetical protein 0.0046 0.116 0.3602
Mycobacterium ulcerans beta-lactamase 0.0031 0.0715 0.562
Echinococcus granulosus GPCR family 2 0.0017 0.0298 0.0298
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0013 0.0199 0.0101
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0199 0.1653
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0033 0.0033
Onchocerca volvulus 0.0025 0.053 0.1944
Echinococcus granulosus dna polymerase eta 0.0037 0.0907 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.116 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0715 0.2219
Brugia malayi LBP/BPI 0.003 0.0696 0.1702
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0143 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0013 0.0199 0.0101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1374 0.3361
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0259 0.2363
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.026 0.2374
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.116 1
Brugia malayi beta-lactamase family protein 0.0031 0.0715 0.1749
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0199 0.0487
Brugia malayi hypothetical protein 0.003 0.0696 0.1702
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0298 0.0298
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0715 0.788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Loa Loa (eye worm) hypothetical protein 0.0034 0.0816 0.2534
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0563 0.5801
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0199 0.0101
Brugia malayi CXXC zinc finger family protein 0.0025 0.053 0.1296
Schistosoma mansoni smad 0.0008 0.0033 0.008
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0013 0.0199 0.0828
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0071 0.1899 0.4648
Brugia malayi MH2 domain containing protein 0.0008 0.0033 0.008
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0013 0.0199 0.0101
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0907 0.2816
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0278 0.1321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0259 0.1141
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0016 0.0259 0.1141
Echinococcus multilocularis tumor protein p63 0.0344 1 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0715 0.8493
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0013 0.0199 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0298 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0025
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0013 0.0199 0.0101
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.116 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0143 0.0996
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0016 0.0259 0.1141
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0907 0.7511
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.116 0.2735
Trichomonas vaginalis esterase, putative 0.0031 0.0715 0.788
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0259 0.2087
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0278 0.2311
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0298 0.0728
Schistosoma mansoni acetyl-CoA synthetase 0.0013 0.0199 0.0487
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.3221 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0199 0.0618
Schistosoma mansoni hypothetical protein 0.0017 0.0298 0.0728
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0199 0.0487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0761 0.1121
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0259 0.2363
Loa Loa (eye worm) hypothetical protein 0.0053 0.1374 0.4265
Loa Loa (eye worm) hypothetical protein 0.0037 0.0907 0.2816
Loa Loa (eye worm) hypothetical protein 0.0041 0.1003 0.3115
Toxoplasma gondii ABC1 family protein 0.0031 0.0715 0.5724
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0016 0.0259 0.0259
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0259 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Brugia malayi MH1 domain containing protein 0.0008 0.0033 0.008
Mycobacterium tuberculosis Conserved protein 0.0031 0.0715 0.1038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0278 0.2579
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0715 0.5366
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.1003 0.2455
Loa Loa (eye worm) hypothetical protein 0.0009 0.0059 0.0183
Giardia lamblia DINP protein human, muc B family 0.0037 0.0907 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0009 0.0059 0.0144
Mycobacterium ulcerans lipase LipD 0.0031 0.0715 0.562
Schistosoma mansoni ap endonuclease 0.0016 0.0278 0.0679
Schistosoma mansoni smad1 5 8 and 0.0008 0.0033 0.008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0298 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.116 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0013 0.0199 0.0548
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.116 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0016 0.0259 0.2363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0059 0.0649
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0016 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0041 0.1003 0.3115
Loa Loa (eye worm) hypothetical protein 0.003 0.0696 0.216
Entamoeba histolytica hypothetical protein 0.0145 0.4086 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548
Loa Loa (eye worm) beta-lactamase 0.0031 0.0715 0.2219
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0013 0.0199 0.0548
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0013 0.0199 0.0548
Loa Loa (eye worm) hypothetical protein 0.0041 0.1003 0.3115
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0696 0.7668
Brugia malayi hypothetical protein 0.0041 0.1003 0.2455
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0052 0.1348 0.3299
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0715 0.1038
Loa Loa (eye worm) hypothetical protein 0.0071 0.1899 0.5897
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0199 0.0101
Brugia malayi MH2 domain containing protein 0.0008 0.0033 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1374 0.3361
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0199 0.0101
Echinococcus multilocularis serine protein kinase ATM 0.0021 0.0431 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0143 0.067
Echinococcus multilocularis smad 0.0008 0.0033 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.4086 0.4086
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0907 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Onchocerca volvulus 0.0041 0.1003 0.473
Leishmania major DNA polymerase eta, putative 0.0037 0.0907 0.7511
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0259 0.0259
Toxoplasma gondii exonuclease III APE 0.0016 0.0278 0.1729
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548
Schistosoma mansoni DNA polymerase eta 0.0037 0.0907 0.222
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0143 0.067
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0715 0.1038
Loa Loa (eye worm) hypothetical protein 0.0046 0.116 0.3602
Onchocerca volvulus 0.0031 0.0715 0.3033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0259 0.0635
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0013 0.0199 0.1011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Onchocerca volvulus 0.0071 0.1899 1
Onchocerca volvulus 0.005 0.1293 0.6432
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0715 0.788
Trypanosoma brucei unspecified product 0.0037 0.0907 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.116 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0009 0.0059 0.0059
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0016 0.0259 0.0498
Schistosoma mansoni hypothetical protein 0.0036 0.0876 0.2143
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.116 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Entamoeba histolytica hypothetical protein 0.0021 0.0431 0.0924
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.4086 0.4086
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0021 0.0431 0.4184
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0715 0.0715
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0199 0.1653
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0278 0.1321
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0278 0.0278
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0033 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0259 0.2087
Trypanosoma cruzi target of rapamycin kinase 3 0.0016 0.0259 0.2363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0259 0.2858
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0715 0.7651
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0199 0.0548

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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