Detailed information for compound 630660

Basic information

Technical information
  • TDR Targets ID: 630660
  • Name: N-(5-chloro-2-methoxyphenyl)-1-phenylmethanes ulfonamide
  • MW: 311.784 | Formula: C14H14ClNO3S
  • H donors: 1 H acceptors: 2 LogP: 2.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NS(=O)(=O)Cc1ccccc1)Cl
  • InChi: 1S/C14H14ClNO3S/c1-19-14-8-7-12(15)9-13(14)16-20(17,18)10-11-5-3-2-4-6-11/h2-9,16H,10H2,1H3
  • InChiKey: QHASTRVKLPQMCK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-chloro-2-methoxy-phenyl)-1-phenyl-methanesulfonamide
  • ZINC00304086
  • IVK/8081146
  • BAS 00628741
  • N-(5-Chloro-2-methoxy-phenyl)-C-phenyl-methanesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0627 0.0627
Loa Loa (eye worm) RNA binding protein 0.0125 0.668 0.8433
Brugia malayi TAR-binding protein 0.0125 0.668 0.8433
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0362 1
Entamoeba histolytica hypothetical protein 0.0036 0.1397 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0181 1 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.668 1
Echinococcus multilocularis lamin 0.0026 0.0835 0.1054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0362 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.4087 0.5159
Brugia malayi RNA binding protein 0.0125 0.668 0.8433
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0362 0.5776
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0627 0.0627
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0181 1 1
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0627 0.0627
Schistosoma mansoni tar DNA-binding protein 0.0125 0.668 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.4087 0.5159
Loa Loa (eye worm) TAR-binding protein 0.0125 0.668 0.8433
Schistosoma mansoni hypothetical protein 0.0036 0.1397 0.2092
Loa Loa (eye worm) hypothetical protein 0.0146 0.7921 1
Brugia malayi hypothetical protein 0.0036 0.1397 0.1764
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0362 0.2593
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0362 0.0362
Echinococcus granulosus intermediate filament protein 0.0026 0.0835 0.1054
Schistosoma mansoni tar DNA-binding protein 0.0125 0.668 1
Echinococcus granulosus lamin dm0 0.0026 0.0835 0.1054
Schistosoma mansoni tar DNA-binding protein 0.0125 0.668 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.011 0.0139
Schistosoma mansoni lamin 0.0026 0.0835 0.125
Brugia malayi intermediate filament protein 0.0026 0.0835 0.1054
Entamoeba histolytica hypothetical protein 0.0036 0.1397 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0362 0.5
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0627 0.0627
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.011 0.0139
Echinococcus granulosus muscleblind protein 0.0146 0.7921 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.668 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0806 0.1018
Entamoeba histolytica hypothetical protein 0.0036 0.1397 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0362 0.0362
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0027 0.0034
Schistosoma mansoni intermediate filament proteins 0.0026 0.0835 0.125
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0181 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0362 0.0457
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0181 1 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.0181 1 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.7921 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.4087 0.6118
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0027 0.0034
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0627 0.0627
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.1397 0.1764
Schistosoma mansoni ap endonuclease 0.0018 0.0362 0.0542
Echinococcus multilocularis lamin dm0 0.0026 0.0835 0.1054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0835 0.1054
Onchocerca volvulus 0.0026 0.0835 0.2043
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0627 0.0627
Onchocerca volvulus 0.0026 0.0835 0.2043
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0362 0.0457
Echinococcus multilocularis muscleblind protein 0.0146 0.7921 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.668 0.8433
Toxoplasma gondii exonuclease III APE 0.0018 0.0362 0.0362
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0362 0.0362
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0627 0.0627
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.4087 0.5159
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0026 0.0835 0.1054
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.1397 0.2092
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0181 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0627 0.449
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0627 0.0627
Echinococcus multilocularis tar DNA binding protein 0.0125 0.668 0.8433
Echinococcus multilocularis musashi 0.0026 0.0835 0.1054
Brugia malayi Muscleblind-like protein 0.0146 0.7921 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0835 0.1054
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0835 0.1054
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0627 1
Schistosoma mansoni lamin 0.0026 0.0835 0.125
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0627 0.0627
Onchocerca volvulus 0.0081 0.4087 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0627 0.0627
Echinococcus multilocularis muscleblind protein 1 0.0146 0.7921 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.1397 0.1764
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.4087 0.5159
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0627 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0362 0.0457
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.668 0.8433
Entamoeba histolytica hypothetical protein 0.0036 0.1397 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0362 0.0457
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0627 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0181 1 1
Echinococcus granulosus tar DNA binding protein 0.0125 0.668 0.8433
Trichomonas vaginalis hypothetical protein 0.0181 1 1
Echinococcus granulosus lamin 0.0026 0.0835 0.1054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0362 0.0362
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0362 0.5776
Schistosoma mansoni ap endonuclease 0.0018 0.0362 0.0542

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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