Detailed information for compound 630671

Basic information

Technical information
  • TDR Targets ID: 630671
  • Name: 1-(3-chlorophenyl)-3-[4-[di(phenyl)methyl]pip erazin-1-yl]pyrrolidine-2,5-dione
  • MW: 459.967 | Formula: C27H26ClN3O2
  • H donors: 0 H acceptors: 2 LogP: 4.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)N1C(=O)CC(C1=O)N1CCN(CC1)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C27H26ClN3O2/c28-22-12-7-13-23(18-22)31-25(32)19-24(27(31)33)29-14-16-30(17-15-29)26(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,18,24,26H,14-17,19H2
  • InChiKey: STRJQOXQCHMZJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-chlorophenyl)-3-[4-[di(phenyl)methyl]-1-piperazinyl]pyrrolidine-2,5-dione
  • 1-(3-chlorophenyl)-3-[4-[di(phenyl)methyl]piperazin-1-yl]pyrrolidine-2,5-quinone
  • AG-205/10360006
  • A1137/0053168
  • 3-(4-Benzhydryl-piperazin-1-yl)-1-(3-chloro-phenyl)-pyrrolidine-2,5-dione
  • BAS 00485212

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0083 0.0781 0.0775
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0706 0.9972 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.025 0.0242
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.025 0.0286
Brugia malayi Latrophilin receptor protein 2 0.0047 0.025 0.0286
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.199 0.1989
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.088 0.0874
Loa Loa (eye worm) hypothetical protein 0.0047 0.025 0.0251
Schistosoma mansoni survival motor neuron protein 0.0048 0.0266 0.0258
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.025 0.0242
Trypanosoma cruzi Aminopeptidase M1, putative 0.0037 0.0109 0.0191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0221
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0781 0.0692
Toxoplasma gondii proteasome subunit beta type, putative 0.0083 0.0781 0.8744
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0345 0.4646 0.4654
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Echinococcus multilocularis jumonji domain containing protein 0.0121 0.1345 0.1341
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0109 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Echinococcus granulosus jumonji domain containing protein 0.0121 0.1345 0.1341
Plasmodium vivax proteasome subunit beta type-5, putative 0.0083 0.0781 0.8878
Entamoeba histolytica aminopeptidase, putative 0.0037 0.0109 0.0016
Echinococcus granulosus aminopeptidase N 0.0037 0.0109 0.01
Schistosoma mansoni alpha-glucosidase 0.0142 0.1651 0.1648
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0145 0.0137
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0205 0.0205
Echinococcus granulosus PHD finger protein rhinoceros 0.0087 0.0841 0.0835
Mycobacterium ulcerans proteasome PrcB 0.0083 0.0781 0.1825
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0287 0.3793 1
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Trypanosoma brucei aminopeptidase, putative 0.0037 0.0109 0.0191
Brugia malayi hypothetical protein 0.0064 0.0507 0.0581
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0065 0.0508 0.0507
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0096 0.0109
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0841 0.9507
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.088 0.0874
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.088 1
Echinococcus granulosus jumonji domain containing 1A 0.0044 0.0205 0.0196
Loa Loa (eye worm) hypothetical protein 0.0236 0.3041 0.3049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0229 0.0221
Schistosoma mansoni lipoxygenase 0.0081 0.0745 0.0739
Loa Loa (eye worm) hypothetical protein 0.0165 0.1994 0.2
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Brugia malayi Pre-SET motif family protein 0.0622 0.8733 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0345 0.4646 0.4654
Loa Loa (eye worm) hypothetical protein 0.0149 0.1751 0.1756
Echinococcus granulosus phd:f box containing protein 0.0044 0.0205 0.0196
Onchocerca volvulus 0.0064 0.0507 0.0403
Echinococcus multilocularis geminin 0.0506 0.7029 0.7046
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.004 0.0145 0.0727
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0514 0.0507
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0109 0.01
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0588 0.8231 1
Trichomonas vaginalis set domain proteins, putative 0.0707 1 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus multilocularis lysine specific demethylase 6a 0.0044 0.0205 0.0196
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0841 0.9507
Toxoplasma gondii proteasome subunit beta type 2, putative 0.004 0.0145 0.0636
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0109 0.0191
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0767 0.0761
Leishmania major proteasome beta 5 subunit, putative 0.0083 0.0781 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0229 0.0221
Echinococcus granulosus peregrin 0.0087 0.0841 0.0835
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0037 0.0109 0.1274
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0044 0.0205 0.1392
Loa Loa (eye worm) proteasome subunit beta type 2 0.004 0.0145 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0221
Echinococcus granulosus geminin 0.0506 0.7029 0.7046
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0287 0.3793 1
Brugia malayi Proteasome A-type and B-type family protein 0.0083 0.0781 0.0895
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0841 0.956
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0083 0.0781 0.0843
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.199 0.1989
Brugia malayi jmjC domain containing protein 0.0167 0.2015 0.2307
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.0781 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0109 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.025 0.0242
Echinococcus multilocularis aminopeptidase N 0.0037 0.0109 0.01
Brugia malayi Bromodomain containing protein 0.0087 0.0841 0.0963
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Schistosoma mansoni jumonji domain containing protein 0.0286 0.378 0.3785
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0087 0.0841 0.0835
Brugia malayi jmjC domain containing protein 0.0345 0.4646 0.5319
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0096 0.0087
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.0229 0.0221
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Brugia malayi hypothetical protein 0.0037 0.0109 0.0124
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0044 0.0205 0.1592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.199 0.2279
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.0229 0.0221
Plasmodium falciparum JmjC domain-containing protein, putative 0.0044 0.0205 0.2418
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0065 0.0508 0.0501
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0109 0.01
Schistosoma mansoni lipoxygenase 0.0115 0.1258 0.1253
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0044 0.0205 0.1592
Onchocerca volvulus Huntingtin homolog 0.0246 0.3192 0.3117
Plasmodium falciparum phd finger protein, putative 0.0087 0.0841 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0109 0.0191
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2224 0.2149
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0044 0.0205 0.1392
Echinococcus granulosus dnaJ subfamily B 0.0414 0.5668 0.568
Brugia malayi TATA binding protein associated factor 0.0037 0.0109 0.0124
Schistosoma mansoni hypothetical protein 0.0048 0.0266 0.0258
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0109 0.0124
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.088 0.0874
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0205 0.0205
Brugia malayi Cytochrome P450 family protein 0.0048 0.0259 0.0297
Echinococcus multilocularis jun protein 0.0082 0.0767 0.0761
Giardia lamblia Fructose-bisphosphate aldolase 0.0588 0.8231 1
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Onchocerca volvulus 0.009 0.088 0.078
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.004 0.0145 0.0061
Loa Loa (eye worm) proteasome subunit beta type 1 0.0065 0.0508 0.0509
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0109 0.0124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0417 0.4097
Brugia malayi proteasome subunit beta type 1 0.0065 0.0508 0.0581
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.3041 0.3043
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0622 0.8733 0.8758
Schistosoma mansoni hypothetical protein 0.0506 0.7029 0.7046
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0109 0.0124
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0205 0.0205
Echinococcus multilocularis PHD finger protein rhinoceros 0.0087 0.0841 0.0835
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.1258 0.1253
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0065 0.0508 0.0501
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.3415 0.3425
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Plasmodium vivax SET domain protein, putative 0.009 0.088 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0734 0.0736
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0037 0.0109 0.1274
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.025 0.0251
Schistosoma mansoni jumonji/arid domain-containing protein 0.0167 0.2015 0.2014
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0109 0.0191
Onchocerca volvulus 0.0048 0.0266 0.0159
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0109 0.1218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1751 0.2005
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0508 0.6011
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0109 0.01
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.3041 0.3043
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0109 0.0013
Brugia malayi hypothetical protein 0.0324 0.4344 0.4975
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0083 0.0781 0.0783
Onchocerca volvulus 0.0095 0.0964 0.0864
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0145 0.005
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0706 0.9972 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0044 0.0205 0.1592
Echinococcus granulosus lysine specific demethylase 5A 0.0167 0.2015 0.2014
Brugia malayi hypothetical protein 0.0246 0.3192 0.3655
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.088 0.0874
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.1258 0.1253
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0109 0.0191
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.199 0.1996
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0109 0.0109
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0065 0.0508 0.6028
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2088 0.2001
Schistosoma mansoni hypothetical protein 0.0087 0.0841 0.0835
Toxoplasma gondii aminopeptidase n, putative 0.0037 0.0109 0.0167
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0266 0.0305
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0096 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0083 0.0781 1
Giardia lamblia Proteasome subunit beta type 1 0.0065 0.0508 0.0448
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0109 0.1218
Schistosoma mansoni phd/f-box containing protein 0.0044 0.0205 0.0196
Loa Loa (eye worm) peptidase family M1 containing protein 0.0037 0.0109 0.0109
Echinococcus multilocularis JmjC domain containing protein 4 0.0044 0.0205 0.0196
Echinococcus multilocularis jumonji domain containing 1A 0.0044 0.0205 0.0196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Plasmodium vivax proteasome subunit beta type-1, putative 0.0065 0.0508 0.5763
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0588 0.8231 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0706 0.9972 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0287 0.3793 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0229 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0229 0.0221
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0259 0.026
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0037 0.0109 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.018 0.221 0.2216
Schistosoma mansoni protein phosphatase 2C 0.0044 0.0205 0.0196
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Schistosoma mansoni hypothetical protein 0.0102 0.1057 0.1051
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0065 0.0508 0.5256
Onchocerca volvulus Alhambra homolog 0.0087 0.0841 0.074
Brugia malayi proteasome subunit beta type 2 0.004 0.0145 0.0167
Echinococcus granulosus lysine specific demethylase 6a 0.0044 0.0205 0.0196
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.5668 0.568
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.3415 0.391
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0145 0.0137
Echinococcus multilocularis proteasome (prosome, macropain) 0.0083 0.0781 0.0775
Loa Loa (eye worm) PHD-finger family protein 0.0087 0.0841 0.0843
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0822 0.0816
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0145 0.005
Brugia malayi hypothetical protein 0.0236 0.3041 0.3482
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Echinococcus granulosus GPCR family 2 0.0047 0.025 0.0242
Trypanosoma brucei proteasome beta 6 subunit 0.0065 0.0508 0.6011
Leishmania major proteasome beta 2 subunit, putative 0.004 0.0145 0.0727
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Loa Loa (eye worm) hypothetical protein 0.0044 0.0205 0.0205
Plasmodium falciparum proteasome subunit beta type-5 0.0083 0.0781 0.9287
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0131 0.0122
Echinococcus granulosus jun protein 0.0082 0.0767 0.0761
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0508 0.0416
Brugia malayi PHD-finger family protein 0.0087 0.0841 0.0963
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Plasmodium vivax proteasome subunit beta type-2, putative 0.004 0.0145 0.1637
Loa Loa (eye worm) aminopeptidase N 0.0037 0.0109 0.0109
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0109 0.0191
Echinococcus granulosus proteasome prosome macropain subunit beta 0.004 0.0145 0.0137
Brugia malayi Pre-SET motif family protein 0.009 0.088 0.1007
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1057 0.121
Echinococcus multilocularis lysine specific demethylase 5A 0.0165 0.1991 0.1989
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0109 0.0191
Schistosoma mansoni alpha glucosidase 0.0037 0.0096 0.0087
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.199 0.1989
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Brugia malayi bZIP transcription factor family protein 0.0082 0.0767 0.0879
Loa Loa (eye worm) hypothetical protein 0.0044 0.0205 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Echinococcus multilocularis peregrin 0.0087 0.0841 0.0835
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0109 0.0191
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.0781 1
Schistosoma mansoni hypothetical protein 0.0506 0.7029 0.7046
Schistosoma mansoni phosphatidylserine receptor 0.0044 0.0205 0.0196
Trypanosoma cruzi 20S proteasome subunit 0.004 0.0145 0.0727
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0065 0.0508 0.6011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Schistosoma mansoni hypothetical protein 0.0414 0.5668 0.568
Plasmodium falciparum proteasome subunit beta type-2, putative 0.004 0.0145 0.1712
Schistosoma mansoni alpha-glucosidase 0.0142 0.1651 0.1648
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0096 0.0096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Trypanosoma brucei proteasome subunit beta type-2, putative 0.004 0.0145 0.0727
Plasmodium vivax JmjC domain containing protein 0.0044 0.0205 0.2312
Schistosoma mansoni jun-related protein 0.0067 0.054 0.0533
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0229 0.0263
Schistosoma mansoni jumonji/arid domain-containing protein 0.0167 0.2015 0.2014
Onchocerca volvulus Huntingtin homolog 0.0246 0.3192 0.3117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.088 0.0874
Schistosoma mansoni jumonji domain containing protein 0.0044 0.0205 0.0196
Echinococcus granulosus JmjC domain containing protein 4 0.0044 0.0205 0.0196
Echinococcus granulosus leukotriene A 4 hydrolase 0.0706 0.9972 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Echinococcus multilocularis GPCR, family 2 0.0047 0.025 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2224 0.2149
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0109 0.0191
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1751 0.2005
Echinococcus granulosus proteasome prosome macropain 0.0083 0.0781 0.0775
Loa Loa (eye worm) hypothetical protein 0.0102 0.1057 0.1059
Toxoplasma gondii aminopeptidase N, putative 0.0037 0.0109 0.0167
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Loa Loa (eye worm) hypothetical protein 0.0087 0.0841 0.0843
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0044 0.0205 0.0196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.088 0.0874
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0767 0.0761
Giardia lamblia PHD finger protein 15 0.0087 0.0841 0.086
Leishmania major hypothetical protein, conserved 0.0044 0.0205 0.1592
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0083 0.0781 0.0786
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0229 0.023
Toxoplasma gondii aminopeptidase N protein 0.0037 0.0109 0.0167
Schistosoma mansoni hypothetical protein 0.0067 0.054 0.0533
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0109 0.0191
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.025 0.0242
Echinococcus multilocularis phd:f box containing protein 0.0044 0.0205 0.0196
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0508 0.6011
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0065 0.0508 0.0501
Treponema pallidum fructose-bisphosphate aldolase 0.0588 0.8231 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.088 0.0874
Loa Loa (eye worm) hypothetical protein 0.0246 0.3192 0.3201
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0109 0.0013
Brugia malayi hypothetical protein 0.0037 0.0109 0.0124
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.004 0.0145 0.0137
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0037 0.0109 0.01
Loa Loa (eye worm) hypothetical protein 0.0246 0.3192 0.3201
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0155 0.0177
Loa Loa (eye worm) jmjC domain-containing protein 0.0167 0.2015 0.2021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1751 0.1756
Loa Loa (eye worm) hypothetical protein 0.009 0.088 0.0882

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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