Detailed information for compound 630671

Basic information

Technical information
  • TDR Targets ID: 630671
  • Name: 1-(3-chlorophenyl)-3-[4-[di(phenyl)methyl]pip erazin-1-yl]pyrrolidine-2,5-dione
  • MW: 459.967 | Formula: C27H26ClN3O2
  • H donors: 0 H acceptors: 2 LogP: 4.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)N1C(=O)CC(C1=O)N1CCN(CC1)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C27H26ClN3O2/c28-22-12-7-13-23(18-22)31-25(32)19-24(27(31)33)29-14-16-30(17-15-29)26(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,18,24,26H,14-17,19H2
  • InChiKey: STRJQOXQCHMZJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-chlorophenyl)-3-[4-[di(phenyl)methyl]-1-piperazinyl]pyrrolidine-2,5-dione
  • 1-(3-chlorophenyl)-3-[4-[di(phenyl)methyl]piperazin-1-yl]pyrrolidine-2,5-quinone
  • AG-205/10360006
  • A1137/0053168
  • 3-(4-Benzhydryl-piperazin-1-yl)-1-(3-chloro-phenyl)-pyrrolidine-2,5-dione
  • BAS 00485212

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0044 0.0205 0.0205
Echinococcus granulosus geminin 0.0506 0.7029 0.7046
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0109 0.1218
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0065 0.0508 0.6028
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.3415 0.3425
Echinococcus multilocularis GPCR, family 2 0.0047 0.025 0.0242
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0109 0.0013
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0345 0.4646 0.4654
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0417 0.4097
Loa Loa (eye worm) hypothetical protein 0.0102 0.1057 0.1059
Echinococcus granulosus lysine specific demethylase 6a 0.0044 0.0205 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2224 0.2149
Leishmania major proteasome beta 2 subunit, putative 0.004 0.0145 0.0727
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.025 0.0251
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.088 0.0874
Leishmania major hypothetical protein, conserved 0.0044 0.0205 0.1592
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0109 0.0191
Brugia malayi hypothetical protein 0.0037 0.0109 0.0124
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0588 0.8231 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0037 0.0109 0.1274
Schistosoma mansoni hypothetical protein 0.0048 0.0266 0.0258
Schistosoma mansoni jumonji domain containing protein 0.0286 0.378 0.3785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0229 0.0221
Schistosoma mansoni phosphatidylserine receptor 0.0044 0.0205 0.0196
Onchocerca volvulus Huntingtin homolog 0.0246 0.3192 0.3117
Brugia malayi Latrophilin receptor protein 2 0.0047 0.025 0.0286
Toxoplasma gondii aminopeptidase N protein 0.0037 0.0109 0.0167
Brugia malayi proteasome subunit beta type 2 0.004 0.0145 0.0167
Echinococcus granulosus jumonji domain containing protein 0.0121 0.1345 0.1341
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Loa Loa (eye worm) hypothetical protein 0.0246 0.3192 0.3201
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.025 0.0242
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Schistosoma mansoni hypothetical protein 0.0506 0.7029 0.7046
Brugia malayi PHD-finger family protein 0.0087 0.0841 0.0963
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0229 0.023
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0083 0.0781 0.0843
Loa Loa (eye worm) hypothetical protein 0.0044 0.0205 0.0205
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0145 0.0137
Brugia malayi hypothetical protein 0.0324 0.4344 0.4975
Onchocerca volvulus 0.0048 0.0266 0.0159
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0109 0.0191
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0037 0.0109 0.01
Loa Loa (eye worm) hypothetical protein 0.0246 0.3192 0.3201
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus granulosus lysine specific demethylase 5A 0.0167 0.2015 0.2014
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.0781 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Trypanosoma brucei aminopeptidase, putative 0.0037 0.0109 0.0191
Trypanosoma brucei proteasome beta 6 subunit 0.0065 0.0508 0.6011
Loa Loa (eye worm) aminopeptidase N 0.0037 0.0109 0.0109
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0065 0.0508 0.6011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0044 0.0205 0.1592
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0145 0.005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Loa Loa (eye worm) hypothetical protein 0.0047 0.025 0.0251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.088 0.0874
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0508 0.6011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.199 0.2279
Brugia malayi hypothetical protein 0.0037 0.0109 0.0124
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0841 0.956
Brugia malayi Pre-SET motif family protein 0.009 0.088 0.1007
Loa Loa (eye worm) hypothetical protein 0.0149 0.1751 0.1756
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.025 0.0242
Echinococcus granulosus proteasome prosome macropain 0.0083 0.0781 0.0775
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.1258 0.1253
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0205 0.0205
Echinococcus multilocularis jumonji domain containing 1A 0.0044 0.0205 0.0196
Schistosoma mansoni alpha-glucosidase 0.0142 0.1651 0.1648
Loa Loa (eye worm) PHD-finger family protein 0.0087 0.0841 0.0843
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0109 0.0191
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0706 0.9972 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0044 0.0205 0.1392
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0155 0.0177
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0229 0.0263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1751 0.1756
Echinococcus multilocularis phd:f box containing protein 0.0044 0.0205 0.0196
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.0781 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0096 0.0096
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0065 0.0508 0.0501
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0109 0.0191
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0044 0.0205 0.1392
Echinococcus granulosus leukotriene A 4 hydrolase 0.0706 0.9972 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0287 0.3793 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Schistosoma mansoni hypothetical protein 0.0087 0.0841 0.0835
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Treponema pallidum fructose-bisphosphate aldolase 0.0588 0.8231 0.5
Echinococcus granulosus jun protein 0.0082 0.0767 0.0761
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Echinococcus multilocularis lysine specific demethylase 5A 0.0165 0.1991 0.1989
Echinococcus granulosus GPCR family 2 0.0047 0.025 0.0242
Plasmodium vivax JmjC domain containing protein 0.0044 0.0205 0.2312
Entamoeba histolytica aminopeptidase, putative 0.0037 0.0109 0.0016
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0044 0.0205 0.0196
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.199 0.1989
Echinococcus multilocularis PHD finger protein rhinoceros 0.0087 0.0841 0.0835
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.5668 0.568
Schistosoma mansoni lipoxygenase 0.0081 0.0745 0.0739
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.199 0.1989
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.0229 0.0221
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0706 0.9972 1
Schistosoma mansoni jumonji domain containing protein 0.0044 0.0205 0.0196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0167 0.2015 0.2014
Loa Loa (eye worm) peptidase family M1 containing protein 0.0037 0.0109 0.0109
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0259 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Brugia malayi hypothetical protein 0.0236 0.3041 0.3482
Loa Loa (eye worm) hypothetical protein 0.009 0.088 0.0882
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0109 0.0013
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0109 0.01
Loa Loa (eye worm) proteasome subunit beta type 2 0.004 0.0145 0.0146
Loa Loa (eye worm) jmjC domain-containing protein 0.0167 0.2015 0.2021
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0109 0.01
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.199 0.1996
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0087 0.0841 0.0835
Brugia malayi Pre-SET motif family protein 0.0622 0.8733 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0096 0.0109
Trypanosoma cruzi Aminopeptidase M1, putative 0.0037 0.0109 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.025 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0221
Schistosoma mansoni jun-related protein 0.0067 0.054 0.0533
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0109 0.0124
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0588 0.8231 1
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.088 0.0874
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0287 0.3793 1
Echinococcus granulosus jumonji domain containing 1A 0.0044 0.0205 0.0196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.088 0.0874
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0109 0.0191
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0767 0.0761
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0083 0.0781 1
Plasmodium falciparum phd finger protein, putative 0.0087 0.0841 1
Schistosoma mansoni protein phosphatase 2C 0.0044 0.0205 0.0196
Schistosoma mansoni hypothetical protein 0.0414 0.5668 0.568
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0229 0.0221
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.004 0.0145 0.0137
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0044 0.0205 0.1592
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.004 0.0145 0.0061
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Echinococcus granulosus dnaJ subfamily B 0.0414 0.5668 0.568
Brugia malayi bZIP transcription factor family protein 0.0082 0.0767 0.0879
Onchocerca volvulus 0.0064 0.0507 0.0403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Schistosoma mansoni alpha glucosidase 0.0037 0.0096 0.0087
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Loa Loa (eye worm) hypothetical protein 0.0087 0.0841 0.0843
Schistosoma mansoni jumonji/arid domain-containing protein 0.0167 0.2015 0.2014
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0508 0.0416
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Loa Loa (eye worm) proteasome subunit beta type 1 0.0065 0.0508 0.0509
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Plasmodium vivax proteasome subunit beta type-1, putative 0.0065 0.0508 0.5763
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0109 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Echinococcus granulosus phd:f box containing protein 0.0044 0.0205 0.0196
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0044 0.0205 0.1592
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0508 0.6011
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0083 0.0781 0.0775
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Schistosoma mansoni alpha-glucosidase 0.0142 0.1651 0.1648
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.0781 0.0692
Echinococcus multilocularis proteasome (prosome, macropain) 0.0083 0.0781 0.0775
Plasmodium falciparum JmjC domain-containing protein, putative 0.0044 0.0205 0.2418
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0131 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0229 0.0221
Echinococcus multilocularis lysine specific demethylase 6a 0.0044 0.0205 0.0196
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.004 0.0145 0.0727
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0065 0.0508 0.0501
Schistosoma mansoni lipoxygenase 0.0115 0.1258 0.1253
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0109 0.0109
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0205 0.0205
Echinococcus multilocularis geminin 0.0506 0.7029 0.7046
Echinococcus granulosus JmjC domain containing protein 4 0.0044 0.0205 0.0196
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.088 0.0874
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.3041 0.3043
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0065 0.0508 0.0501
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0083 0.0781 0.0786
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0096 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.088 0.0874
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3415 0.3351
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0109 0.01
Schistosoma mansoni hypothetical protein 0.0506 0.7029 0.7046
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Brugia malayi jmjC domain containing protein 0.0345 0.4646 0.5319
Schistosoma mansoni hypothetical protein 0.0067 0.054 0.0533
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.8231 0.8214
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0287 0.3793 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0588 0.8231 1
Brugia malayi Bromodomain containing protein 0.0087 0.0841 0.0963
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0065 0.0508 0.5256
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0841 0.9507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0229 0.0221
Echinococcus granulosus proteasome prosome macropain subunit beta 0.004 0.0145 0.0137
Echinococcus multilocularis jumonji domain containing protein 0.0121 0.1345 0.1341
Onchocerca volvulus 0.0095 0.0964 0.0864
Schistosoma mansoni survival motor neuron protein 0.0048 0.0266 0.0258
Echinococcus granulosus PHD finger protein rhinoceros 0.0087 0.0841 0.0835
Mycobacterium ulcerans proteasome PrcB 0.0083 0.0781 0.1825
Brugia malayi hypothetical protein 0.0246 0.3192 0.3655
Brugia malayi jmjC domain containing protein 0.0044 0.0205 0.0234
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0109 0.0191
Onchocerca volvulus Alhambra homolog 0.0087 0.0841 0.074
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0065 0.0508 0.0507
Brugia malayi Cytochrome P450 family protein 0.0048 0.0259 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1751 0.2005
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0145 0.0137
Loa Loa (eye worm) jmjC domain-containing protein 0.018 0.221 0.2216
Toxoplasma gondii proteasome subunit beta type, putative 0.0083 0.0781 0.8744
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0109 0.1218
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0109 0.0191
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0096 0.0087
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0841 0.9507
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0109 0.0124
Echinococcus granulosus peregrin 0.0087 0.0841 0.0835
Trypanosoma brucei proteasome subunit beta type-2, putative 0.004 0.0145 0.0727
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0145 0.005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1751 0.2005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0266 0.0305
Plasmodium vivax proteasome subunit beta type-5, putative 0.0083 0.0781 0.8878
Plasmodium falciparum proteasome subunit beta type-5 0.0083 0.0781 0.9287
Plasmodium vivax SET domain protein, putative 0.009 0.088 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0083 0.0781 0.0783
Echinococcus multilocularis JmjC domain containing protein 4 0.0044 0.0205 0.0196
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0622 0.8733 0.8758
Plasmodium vivax proteasome subunit beta type-2, putative 0.004 0.0145 0.1637
Brugia malayi Proteasome A-type and B-type family protein 0.0083 0.0781 0.0895
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0109 0.0191
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1057 0.121
Echinococcus granulosus aminopeptidase N 0.0037 0.0109 0.01
Toxoplasma gondii proteasome subunit beta type 2, putative 0.004 0.0145 0.0636
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0109 0.0013
Toxoplasma gondii aminopeptidase N, putative 0.0037 0.0109 0.0167
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2088 0.2001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0822 0.0816
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0205 0.0205
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0514 0.0507
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Loa Loa (eye worm) hypothetical protein 0.008 0.0734 0.0736
Brugia malayi jmjC domain containing protein 0.0167 0.2015 0.2307
Giardia lamblia Proteasome subunit beta type 1 0.0065 0.0508 0.0448
Brugia malayi TATA binding protein associated factor 0.0037 0.0109 0.0124
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.0229 0.0221
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0037 0.0109 0.1274
Giardia lamblia PHD finger protein 15 0.0087 0.0841 0.086
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Brugia malayi hypothetical protein 0.0064 0.0507 0.0581
Loa Loa (eye worm) hypothetical protein 0.0236 0.3041 0.3049
Onchocerca volvulus Huntingtin homolog 0.0246 0.3192 0.3117
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus multilocularis peregrin 0.0087 0.0841 0.0835
Trichomonas vaginalis set domain proteins, putative 0.0707 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0109 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.025 0.0242
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.3415 0.391
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.199 0.1989
Schistosoma mansoni hypothetical protein 0.0047 0.025 0.0242
Toxoplasma gondii aminopeptidase n, putative 0.0037 0.0109 0.0167
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.088 0.0874
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.088 1
Brugia malayi proteasome subunit beta type 1 0.0065 0.0508 0.0581
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0767 0.0761
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2224 0.2149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.025 0.0286
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0706 0.9972 1
Echinococcus multilocularis jun protein 0.0082 0.0767 0.0761
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0109 0.0191
Onchocerca volvulus 0.009 0.088 0.078
Plasmodium falciparum proteasome subunit beta type-2, putative 0.004 0.0145 0.1712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0221
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0037 0.0109 0.01
Loa Loa (eye worm) hypothetical protein 0.0165 0.1994 0.2
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0345 0.4646 0.4654
Trypanosoma cruzi 20S proteasome subunit 0.004 0.0145 0.0727
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.3041 0.3043
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2088 0.2011
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0109 0.0191
Echinococcus multilocularis aminopeptidase N 0.0037 0.0109 0.01
Leishmania major proteasome beta 5 subunit, putative 0.0083 0.0781 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0221
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.1258 0.1253
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0109 0.0191
Schistosoma mansoni hypothetical protein 0.0102 0.1057 0.1051
Schistosoma mansoni phd/f-box containing protein 0.0044 0.0205 0.0196

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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