Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sentrin specific protease 7 | 0.0144 | 0.5402 | 0.7319 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.01 | 0.01 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0637 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.01 | 0.01 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1436 | 0.1946 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.4404 | 0.4404 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0289 | 0.0289 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0289 | 0.0582 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0026 | 0.0637 | 0.165 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0525 | 0.077 |
Trypanosoma brucei | Metacaspase-4 | 0.0026 | 0.0637 | 0.165 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.3351 | 0.4539 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1436 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2532 | 0.2532 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0637 | 0.165 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.6421 | 0.6385 |
Echinococcus multilocularis | expressed conserved protein | 0.0131 | 0.4895 | 0.6631 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0637 | 0.0542 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0525 | 0.0525 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.3685 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.01 | 0.01 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0026 | 0.0637 | 0.0637 |
Trypanosoma brucei | metacaspase MCA3 | 0.0026 | 0.0637 | 0.165 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Brugia malayi | Cell death protein 3 precursor | 0.0026 | 0.0637 | 0.0637 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0026 | 0.0637 | 0.165 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0097 | 0.3497 | 0.4737 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0013 | 0.01 | 0.0136 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.3893 | 0.3893 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0169 | 0.6421 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 1 | 1 |
Plasmodium falciparum | metacaspase 1 | 0.0026 | 0.0637 | 0.1496 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0144 | 0.5402 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.902 | 0.902 |
Leishmania major | metacaspase, putative | 0.0026 | 0.0637 | 0.165 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0525 | 0.1308 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1436 | 0.1946 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.6421 | 0.6385 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.6421 | 0.6385 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0525 | 0.0525 |
Echinococcus granulosus | caspase | 0.0097 | 0.3497 | 0.4737 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3351 | 0.4539 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0953 | 0.1292 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1436 | 0.1946 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0637 | 0.0542 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0013 | 0.01 | 0.0136 |
Echinococcus granulosus | geminin | 0.0193 | 0.7381 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0525 | 0.077 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0289 | 0.0528 |
Echinococcus multilocularis | caspase 2 | 0.0026 | 0.0637 | 0.0862 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0026 | 0.0637 | 0.0991 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0953 | 0.1292 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.4404 | 0.4404 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.01 | 0.01 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0525 | 0.077 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0525 | 0.077 |
Onchocerca volvulus | 0.0013 | 0.01 | 0.0156 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0953 | 0.0953 |
Trypanosoma brucei | metacaspase | 0.0026 | 0.0637 | 0.165 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.6421 | 0.6385 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.3893 | 0.3893 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0525 | 0.1308 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0101 | 0.3685 | 0.3621 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0026 | 0.0637 | 0.1496 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.4404 | 0.4404 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.7381 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0637 | 0.0542 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0026 | 0.0637 | 0.0862 |
Onchocerca volvulus | 0.0023 | 0.0525 | 0.0818 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0026 | 0.0637 | 0.1496 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0144 | 0.5402 | 0.7319 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3351 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0953 | 0.0953 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0953 | 0.1292 |
Plasmodium vivax | metacaspase 1, putative | 0.0026 | 0.0637 | 0.1496 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.3351 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.6789 | 0.6756 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.01 | 0.01 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0289 | 0.0528 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0525 | 0.0525 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0013 | 0.01 | 0.0136 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.3685 | 0.3621 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0013 | 0.01 | 0.0136 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0061 | 0.2047 | 0.5431 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0289 | 0.0289 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0637 | 0.0542 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0061 | 0.2047 | 0.5742 |
Loa Loa (eye worm) | Ulp1 protease | 0.0013 | 0.01 | 0.01 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0525 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0289 | 0.0289 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0031 | 0.0838 | 0.227 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0093 | 0.3351 | 0.3351 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.3685 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2532 | 0.3431 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0637 | 0.0542 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0101 | 0.3685 | 0.3621 |
Echinococcus multilocularis | caspase 3 | 0.0071 | 0.2453 | 0.3323 |
Plasmodium falciparum | metacaspase-like protein | 0.0026 | 0.0637 | 0.1496 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0953 | 0.1292 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1436 | 0.1946 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0953 | 0.1292 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.902 | 0.902 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 1 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0101 | 0.3685 | 1 |
Echinococcus multilocularis | caspase | 0.0097 | 0.3497 | 0.4737 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0026 | 0.0637 | 0.1496 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0525 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0525 | 0.0802 |
Echinococcus granulosus | expressed conserved protein | 0.0131 | 0.4895 | 0.6631 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0032 | 0.0896 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.9513 | 0.9513 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0525 | 0.077 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0013 | 0.01 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.01 | 0.01 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1436 | 0.1946 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0637 | 0.165 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0637 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0637 | 0.0637 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0013 | 0.01 | 0.01 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0026 | 0.0637 | 0.1496 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0953 | 0.1292 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0289 | 0.0289 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.2532 | 0.2532 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0637 | 0.0637 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0525 | 0.4245 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.3893 | 0.3893 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.003 | 0.0802 | 0.2159 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1436 | 0.1436 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0101 | 0.3685 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0525 | 0.0525 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0026 | 0.0637 | 0.0862 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3351 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0289 | 0.0289 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.3351 | 0.4539 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0953 | 0.1292 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0637 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0525 | 0.0525 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.6421 | 0.6385 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0258 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3351 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0525 | 0.4245 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0953 | 0.1292 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0097 | 0.3497 | 0.4737 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0525 | 0.077 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 1 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0093 | 0.3351 | 0.3351 |
Echinococcus multilocularis | caspase 8 | 0.0026 | 0.0637 | 0.0862 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.7381 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0026 | 0.0637 | 0.165 |
Loa Loa (eye worm) | Ulp1 protease | 0.0013 | 0.01 | 0.01 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0013 | 0.01 | 0.0136 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0525 | 0.077 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0097 | 0.3497 | 0.4737 |
Echinococcus granulosus | caspase 3 | 0.0071 | 0.2453 | 0.3323 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0525 | 0.077 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0953 | 0.1292 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0953 | 0.1292 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0289 | 0.059 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.6789 | 0.6756 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.6421 | 0.6385 |
Echinococcus granulosus | sentrin specific protease 7 | 0.0144 | 0.5402 | 0.7319 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0525 | 0.1308 |
Echinococcus granulosus | caspase 2 | 0.0026 | 0.0637 | 0.0862 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0097 | 0.3497 | 0.4737 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0525 | 0.0802 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3351 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0525 | 0.0802 |
Echinococcus multilocularis | geminin | 0.0193 | 0.7381 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0637 | 0.0542 |
Trypanosoma brucei | metacaspase 5, putative | 0.0026 | 0.0637 | 0.165 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.6421 | 0.6385 |
Echinococcus granulosus | caspase 8 | 0.0026 | 0.0637 | 0.0862 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0953 | 0.0953 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1436 | 0.1436 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0245 | 0.9513 | 0.9513 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0013 | 0.01 | 0.0136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1436 | 0.1946 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.3893 | 0.3893 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.3351 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.