Detailed information for compound 630950

Basic information

Technical information
  • TDR Targets ID: 630950
  • Name: N-[(5-bromo-2,4-dimethoxyphenyl)methyl]cyclop entanamine
  • MW: 314.218 | Formula: C14H20BrNO2
  • H donors: 1 H acceptors: 0 LogP: 3.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c(cc1CNC1CCCC1)Br
  • InChi: 1S/C14H20BrNO2/c1-17-13-8-14(18-2)12(15)7-10(13)9-16-11-5-3-4-6-11/h7-8,11,16H,3-6,9H2,1-2H3
  • InChiKey: ITPVMJOKEFXCBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(5-bromo-2,4-dimethoxy-phenyl)methyl]cyclopentanamine
  • (5-bromo-2,4-dimethoxy-benzyl)-cyclopentyl-amine
  • STK145554
  • Oprea1_090270
  • AG-690/11822117
  • Oprea1_857123

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0499 0.6154 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0499 0.6154 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1017 0.1653
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1017 0.1017
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0117 0.131 0.1909
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0063 0.0102
Onchocerca volvulus Huntingtin homolog 0.0134 0.1527 0.8615
Brugia malayi Tubulin alpha-2 chain 0.0377 0.4611 0.7492
Toxoplasma gondii alpha tubulin TUBA1 0.0377 0.4611 0.7492
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0063 0.0102
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0063 0.0063
Leishmania major beta tubulin 0.0499 0.6154 1
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1696 0.1696
Schistosoma mansoni tubulin subunit beta 0.0499 0.6154 1
Schistosoma mansoni chromobox protein 0.0069 0.0695 0.1129
Plasmodium falciparum tubulin gamma chain 0.027 0.3252 0.5284
Echinococcus granulosus tubulin alpha chain 0.0377 0.4611 0.7492
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0018
Plasmodium vivax tubulin gamma chain, putative 0.027 0.3252 0.5284
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0399 0.0649
Brugia malayi jmjC domain containing protein 0.0053 0.0494 0.0803
Loa Loa (eye worm) tubulin alpha-3 chain 0.0224 0.2669 0.4337
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0404 0.0395
Trypanosoma cruzi beta tubulin, putative 0.0499 0.6154 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0063 0.0102
Schistosoma mansoni tubulin subunit alpha 0.0377 0.4611 0.7492
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0311 0.0239
Giardia lamblia Alpha-tubulin 0.0377 0.4611 0.7316
Echinococcus granulosus Tubulin alpha 1 chain 0.0377 0.4611 0.7492
Schistosoma mansoni chromobox protein 0.0069 0.0695 0.1129
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0063 0.0102
Echinococcus multilocularis Tubulin alpha 1 chain 0.0377 0.4611 0.4611
Trichomonas vaginalis tubulin beta chain, putative 0.0377 0.4611 0.7422
Echinococcus multilocularis GPCR, family 2 0.0016 0.0018 0.0018
Trypanosoma cruzi tubulin delta chain 0.0117 0.131 0.2129
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1762 0.2663
Brugia malayi Tubulin alpha chain 0.0377 0.4611 0.7492
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0404 0.0395
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Echinococcus granulosus tubulin alpha 3 chain 0.0377 0.4611 0.7492
Brugia malayi ecdysteroid receptor 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1762 0.2663
Trypanosoma brucei beta tubulin 0.0499 0.6154 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0018 0.003
Echinococcus granulosus tubulin gamma 1 chain 0.027 0.3252 0.5284
Echinococcus multilocularis beta tubulin 0.0499 0.6154 0.6154
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0018 0.003
Plasmodium falciparum alpha tubulin 1 0.0377 0.4611 0.7492
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.0494 0.0803
Loa Loa (eye worm) hypothetical protein 0.0377 0.4611 0.7492
Schistosoma mansoni alpha tubulin 0.0377 0.4611 0.7492
Mycobacterium ulcerans hypothetical protein 0.0171 0.199 1
Trypanosoma brucei beta tubulin 0.0499 0.6154 1
Loa Loa (eye worm) beta-tubulin 0.0499 0.6154 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1696 0.2755
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0063 0.0063
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0063 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0063 0.0102
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0046 0.0404 0.0657
Echinococcus multilocularis tubulin alpha chain 0.0377 0.4611 0.4611
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0063 0.0063
Trypanosoma brucei zeta tubulin 0.0117 0.131 0.2129
Loa Loa (eye worm) BEN-1 protein 0.0499 0.6154 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0063 0.0102
Schistosoma mansoni tubulin subunit beta 0.0499 0.6154 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0063 0.0102
Loa Loa (eye worm) tubulin beta-2A chain 0.0499 0.6154 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.2669 0.4337
Echinococcus granulosus peroxisome assembly protein 26 0.0377 0.4611 0.7492
Brugia malayi Tubulin gamma chain 0.027 0.3252 0.5284
Trichomonas vaginalis tubulin, putative 0.0153 0.1762 0.2663
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0404 0.0657
Loa Loa (eye worm) hypothetical protein 0.0039 0.0311 0.0505
Loa Loa (eye worm) hypothetical protein 0.0134 0.1527 0.2481
Schistosoma mansoni tubulin subunit alpha 0.0117 0.131 0.2129
Entamoeba histolytica tubulin alpha chain, putative 0.0377 0.4611 0.7376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1017 0.1653
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin, putative 0.0117 0.131 0.1909
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0063 0.0063
Brugia malayi Tubulin beta-1 chain 0.0499 0.6154 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0063 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0063 0.0102
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0049 0.0446 0.0725
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0063 0.0102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0446 0.0725
Entamoeba histolytica tubulin family protein 0.0499 0.6154 1
Echinococcus granulosus mitogen activated protein kinase 0.0046 0.0404 0.0657
Echinococcus multilocularis Tubulin beta 2C chain 0.0499 0.6154 0.6154
Loa Loa (eye worm) alpha-tubulin 0.0377 0.4611 0.7492
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.003
Leishmania major beta tubulin 0.0499 0.6154 1
Loa Loa (eye worm) hypothetical protein 0.026 0.3121 0.5071
Trichomonas vaginalis tubulin beta chain, putative 0.0377 0.4611 0.7422
Echinococcus multilocularis lysine specific demethylase 5A 0.0053 0.0494 0.0494
Loa Loa (eye worm) tubulin beta-1 chain 0.0499 0.6154 1
Echinococcus granulosus tubulin alpha chain 0.0377 0.4611 0.7492
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0446 0.0725
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0063 0.0102
Schistosoma mansoni hypothetical protein 0.0036 0.0272 0.0442
Trypanosoma brucei tubulin delta chain 0.0117 0.131 0.2129
Echinococcus multilocularis hypothetical protein 0.0377 0.4611 0.4611
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0053 0.0494 0.0803
Brugia malayi hypothetical protein 0.0036 0.0272 0.0442
Echinococcus granulosus tubulin alpha 1C chain 0.0377 0.4611 0.7492
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0046 0.0404 0.0657
Leishmania major beta tubulin 0.0499 0.6154 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.177 0.2875
Leishmania major beta tubulin 0.0499 0.6154 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0063 0.0102
Trypanosoma brucei alpha tubulin 0.0377 0.4611 0.7492
Leishmania major zeta tubulin, putative 0.0117 0.131 0.2129
Trichomonas vaginalis tubulin epsilon chain, putative 0.0377 0.4611 0.7422
Trypanosoma cruzi epsilon tubulin, putative 0.027 0.3252 0.5284
Echinococcus multilocularis Tubulin alpha 1 chain 0.0377 0.4611 0.4611
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0404 0.0395
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin epsilon chain, putative 0.0117 0.131 0.1909
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0063 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1017 0.1653
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0399 0.0649
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0046 0.0404 0.0657
Brugia malayi hypothetical protein 0.0134 0.1527 0.2481
Echinococcus granulosus Tubulin beta 2C chain 0.0499 0.6154 1
Schistosoma mansoni tubulin subunit epsilon 0.027 0.3252 0.5284
Trichomonas vaginalis tubulin beta chain, putative 0.0377 0.4611 0.7422
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0063 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0063 0.0102
Onchocerca volvulus Huntingtin homolog 0.0134 0.1527 0.8615
Entamoeba histolytica tubulin family protein 0.0499 0.6154 1
Loa Loa (eye worm) alpha-tubulin 0.0377 0.4611 0.7492
Trypanosoma brucei protein kinase, putative 0.0046 0.0404 0.0657
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0311 0.1457
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0063 0.0102
Loa Loa (eye worm) hypothetical protein 0.0134 0.1527 0.2481
Echinococcus multilocularis tubulin subunit beta 0.0499 0.6154 0.6154
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0063 0.0102
Trypanosoma cruzi zeta tubulin, putative 0.0117 0.131 0.2129
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0063 0.0102
Echinococcus multilocularis tubulin subunit TubB 0.0377 0.4611 0.4611
Trypanosoma brucei beta tubulin 0.0499 0.6154 1
Onchocerca volvulus 0.0153 0.1762 1
Entamoeba histolytica tubulin alpha-1 chain 0.0377 0.4611 0.7376
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0063 0.0102
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0399 0.0649
Brugia malayi MAP kinase sur-1 0.0046 0.0404 0.0657
Loa Loa (eye worm) tubulin alpha chain 0.0377 0.4611 0.7492
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0117 0.131 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0063 0.0102
Echinococcus granulosus Tubulin beta 2C chain 0.0499 0.6154 1
Plasmodium vivax tubulin epsilon chain, putative 0.027 0.3252 0.5284
Echinococcus multilocularis tubulin beta 1 chain 0.0499 0.6154 0.6154
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0063 0.0102
Echinococcus multilocularis tubulin alpha 0.027 0.3252 0.3252
Plasmodium falciparum tubulin epsilon chain, putative 0.027 0.3252 0.5284
Loa Loa (eye worm) tubulin gamma chain 0.027 0.3252 0.5284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1017 0.1653
Schistosoma mansoni tubulin subunit beta 0.0117 0.131 0.2129
Echinococcus multilocularis tubulin delta chain 0.0117 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0034 0.0248 0.0403
Echinococcus granulosus Tubulin alpha 1 chain 0.0377 0.4611 0.7492
Echinococcus multilocularis tubulin alpha 1C chain 0.0377 0.4611 0.4611
Plasmodium vivax delta tubulin, putative 0.0117 0.131 0.2129
Schistosoma mansoni tubulin subunit beta 0.0499 0.6154 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0063 0.0102
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0046 0.0404 0.0657
Trichomonas vaginalis tubulin, putative 0.0153 0.1762 0.2663
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0063 0.0102
Echinococcus granulosus geminin 0.0375 0.4579 0.744
Toxoplasma gondii beta-tubulin, putative 0.0499 0.6154 1
Echinococcus granulosus beta tubulin 0.0499 0.6154 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.026 0.3121 0.5071
Trichomonas vaginalis tubulin, putative 0.0499 0.6154 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0499 0.6154 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0224 0.2669 0.4179
Trypanosoma cruzi tubulin delta chain 0.0117 0.131 0.2129
Toxoplasma gondii hypothetical protein 0.0052 0.0485 0.0787
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0377 0.4611 0.7422
Leishmania major beta tubulin 0.0499 0.6154 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0063 0.0063
Trypanosoma brucei beta tubulin 0.0499 0.6154 1
Echinococcus granulosus GPCR family 2 0.0016 0.0018 0.003
Echinococcus granulosus Tubulin alpha 1 chain 0.0377 0.4611 0.7492
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0695 0.1129
Echinococcus multilocularis chromobox protein 1 0.0069 0.0695 0.0695
Echinococcus granulosus tubulin alpha 0.027 0.3252 0.5284
Trichomonas vaginalis tubulin beta chain, putative 0.0499 0.6154 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0063 0.0063
Trichomonas vaginalis tubulin epsilon chain, putative 0.0499 0.6154 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0499 0.6154 1
Brugia malayi Tubulin beta chain 0.0153 0.1762 0.2863
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0046 0.0404 0.0657
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0063 0.0063
Brugia malayi Tubulin alpha-2 chain 0.0377 0.4611 0.7492
Giardia lamblia Delta tubulin 0.0117 0.131 0.1576
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0018 0.003
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.003
Schistosoma mansoni tubulin subunit delta 0.0117 0.131 0.2129
Schistosoma mansoni tubulin subunit alpha 0.0377 0.4611 0.7492
Toxoplasma gondii beta tubulin 0.0499 0.6154 1
Leishmania major beta tubulin 0.0499 0.6154 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0063 0.0102
Echinococcus multilocularis tubulin alpha 3 chain 0.0377 0.4611 0.4611
Brugia malayi Tubulin alpha chain 0.0117 0.131 0.2129
Mycobacterium leprae cell division protein FtsZ 0.0117 0.131 0.5
Echinococcus granulosus chromobox protein 1 0.0069 0.0695 0.1129
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0063 0.0102
Echinococcus multilocularis Tubulin beta 2C chain 0.0499 0.6154 0.6154
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0046 0.0404 0.0657
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0348 0.0301
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0063 0.0102
Echinococcus granulosus tubulin beta 1 chain 0.0499 0.6154 1
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin beta chain, putative 0.0377 0.4611 0.7422
Leishmania major beta tubulin 0.0499 0.6154 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0046 0.0404 0.0657
Trypanosoma brucei beta tubulin 0.027 0.3252 0.5284
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0695 0.0881
Leishmania major mitochondrial DNA polymerase beta 0.0324 0.3939 0.6401
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Brugia malayi Tubulin beta chain 0.0117 0.131 0.2129
Brugia malayi tubulin alpha-2 chain 0.0377 0.4611 0.7492
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0063 0.0102
Echinococcus multilocularis tubulin alpha chain 0.0377 0.4611 0.4611
Giardia lamblia Gamma tubulin 0.027 0.3252 0.4953
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.131 0.1909
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.026 0.3121 0.4933
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0018
Trypanosoma cruzi alpha tubulin, putative 0.0377 0.4611 0.7492
Echinococcus multilocularis tubulin alpha 3 chain 0.0377 0.4611 0.4611
Echinococcus granulosus tubulin alpha 3 chain 0.0377 0.4611 0.7492
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0311 0.0239
Echinococcus granulosus tubulin alpha chain 0.0377 0.4611 0.7492
Echinococcus granulosus lysine specific demethylase 5A 0.0053 0.0494 0.0803
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0063 0.0102
Brugia malayi Muscleblind-like protein 0.0148 0.1696 0.2755
Giardia lamblia Beta tubulin 0.0499 0.6154 1
Echinococcus multilocularis tubulin alpha chain 0.0377 0.4611 0.4611
Loa Loa (eye worm) tubulin beta chain 0.0117 0.131 0.2129
Echinococcus granulosus Tubulin beta 2C chain 0.0499 0.6154 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0063 0.0102
Echinococcus granulosus tubulin alpha chain 0.0377 0.4611 0.7492
Echinococcus granulosus Tubulin beta 2C chain 0.0499 0.6154 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0526 0.0855
Schistosoma mansoni hypothetical protein 0.0375 0.4579 0.744
Brugia malayi chromobox protein homolog 3 0.0039 0.0311 0.0505
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.199 1
Loa Loa (eye worm) BEN-1 protein 0.0499 0.6154 1
Toxoplasma gondii beta-1 tubulin, putative 0.0499 0.6154 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0063 0.0102
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1017 0.1653
Schistosoma mansoni tubulin subunit beta 0.0499 0.6154 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1017 0.1017
Schistosoma mansoni coup transcription factor 0.0019 0.0063 0.0102
Echinococcus granulosus tubulin subunit TubB 0.0377 0.4611 0.7492
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.3939 0.6401
Trichomonas vaginalis tubulin beta chain, putative 0.0153 0.1762 0.2663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0063 0.0102
Schistosoma mansoni tubulin subunit alpha 0.0377 0.4611 0.7492
Plasmodium vivax tubulin beta chain, putative 0.0499 0.6154 1
Trypanosoma brucei tubulin gamma chain 0.027 0.3252 0.5284
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Echinococcus multilocularis tubulin alpha 1C chain 0.0377 0.4611 0.4611
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0063 0.0063
Trichomonas vaginalis tubulin gamma chain, putative 0.0117 0.131 0.1909
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin beta chain, putative 0.0377 0.4611 0.7422
Leishmania major beta tubulin 0.0499 0.6154 1
Onchocerca volvulus 0.003 0.0205 0.0834
Echinococcus granulosus tubulin delta chain 0.0117 0.131 0.2129
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0153 0.177 0.2875
Leishmania major beta tubulin 0.0499 0.6154 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1762 0.2663
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0063 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1017 0.1653
Echinococcus multilocularis Tubulin beta 2C chain 0.0499 0.6154 0.6154
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0248 0.0403
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0324 0.3939 0.6401
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.027 0.3252 0.5284
Giardia lamblia Beta tubulin 0.0499 0.6154 1
Leishmania major beta tubulin 0.0499 0.6154 1
Schistosoma mansoni tubulin subunit beta 0.0499 0.6154 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Trypanosoma brucei alpha tubulin, putative 0.0153 0.1762 0.2863
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin epsilon chain, putative 0.0377 0.4611 0.7422
Echinococcus multilocularis Tubulin alpha 1 chain 0.0377 0.4611 0.4611
Giardia lamblia Epsilon tubulin 0.0117 0.131 0.1576
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0272 0.0442
Trichomonas vaginalis tubulin gamma chain, putative 0.027 0.3252 0.5152
Giardia lamblia Beta tubulin 0.0499 0.6154 1
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Echinococcus multilocularis tubulin epsilon chain 0.027 0.3252 0.3252
Brugia malayi beta-tubulin, identical 0.0499 0.6154 1
Leishmania major gamma-tubulin 0.027 0.3252 0.5284
Brugia malayi Cell division protein ftsZ 0.0117 0.131 0.2129
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0063 0.0102
Echinococcus multilocularis mitogen activated protein kinase 0.0046 0.0404 0.0404
Loa Loa (eye worm) tubulin alpha 2 0.0107 0.1179 0.1916
Loa Loa (eye worm) hypothetical protein 0.0148 0.1696 0.2755
Brugia malayi nuclear hormone receptor 0.0019 0.0063 0.0102
Plasmodium falciparum tubulin beta chain 0.0499 0.6154 1
Brugia malayi jmjC domain containing protein 0.0053 0.0494 0.0803
Loa Loa (eye worm) tubulin beta chain 0.0499 0.6154 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin beta chain, putative 0.0377 0.4611 0.7422
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0046 0.0404 0.0657
Echinococcus granulosus tubulin epsilon chain 0.027 0.3252 0.5284
Plasmodium falciparum alpha tubulin 2 0.0377 0.4611 0.7492
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0117 0.131 0.2129
Schistosoma mansoni hypothetical protein 0.0034 0.0248 0.0403
Brugia malayi Heterochromatin protein 1 0.0069 0.0695 0.1129
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0153 0.1762 0.2663
Trypanosoma cruzi zeta tubulin, putative 0.0117 0.131 0.2129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.0494 0.0803
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0063 0.0102
Leishmania major beta tubulin 0.0499 0.6154 1
Trypanosoma cruzi tubulin gamma chain 0.027 0.3252 0.5284
Echinococcus multilocularis tubulin alpha chain 0.0377 0.4611 0.4611
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0499 0.6154 0.6154
Loa Loa (eye worm) tubulin alpha chain 0.0377 0.4611 0.7492
Echinococcus granulosus beta tubulin 0.0499 0.6154 1
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0404 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.131 0.1909
Leishmania major beta tubulin 0.0499 0.6154 1
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Loa Loa (eye worm) tubulin alpha 2 0.026 0.3121 0.5071
Treponema pallidum cell division protein FtsZ 0.0117 0.131 0.5
Trypanosoma brucei zeta tubulin, putative 0.0117 0.131 0.2129
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0348 0.1677
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0063 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0063 0.0102
Echinococcus granulosus tubulin alpha 1C chain 0.0377 0.4611 0.7492
Leishmania major delta tubulin, putative 0.0117 0.131 0.2129
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0494 0.0803
Leishmania major epsilon tubulin, putative 0.027 0.3252 0.5284
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0399 0.0649
Toxoplasma gondii alpha-tubulin I, putative 0.0377 0.4611 0.7492
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0053 0.0494 0.0494
Trypanosoma brucei alpha tubulin 0.0377 0.4611 0.7492
Echinococcus granulosus tubulin alpha chain 0.0377 0.4611 0.7492
Trypanosoma brucei epsilon tubulin 0.027 0.3252 0.5284
Schistosoma mansoni tubulin subunit beta 0.0499 0.6154 1
Echinococcus granulosus muscleblind protein 0.0148 0.1696 0.2755
Leishmania major beta tubulin 0.0499 0.6154 1
Loa Loa (eye worm) tubulin alpha 2 0.026 0.3121 0.5071
Trichomonas vaginalis tubulin epsilon chain, putative 0.0499 0.6154 1
Leishmania major beta tubulin 0.0499 0.6154 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0046 0.0404 0.0657
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0046 0.0404 0.0657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0063 0.0102
Trypanosoma cruzi epsilon tubulin, putative 0.027 0.3252 0.5284
Brugia malayi alpha-tubulin 0.0377 0.4611 0.7492
Trypanosoma brucei epsilon tubulin 0.027 0.3252 0.5284
Schistosoma mansoni hypothetical protein 0.0375 0.4579 0.744
Leishmania major beta tubulin 0.0499 0.6154 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0499 0.6154 0.6154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.003
Echinococcus multilocularis muscleblind protein 0.0148 0.1696 0.1696
Giardia lamblia Alpha-tubulin 0.0377 0.4611 0.7316
Loa Loa (eye worm) tubulin beta-4 chain 0.0499 0.6154 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0063 0.0102
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0117 0.131 0.2129
Brugia malayi tubulin alpha chain - mouse 0.0377 0.4611 0.7492
Echinococcus multilocularis geminin 0.0375 0.4579 0.4579
Echinococcus granulosus chromobox protein 1 0.0069 0.0695 0.1129
Plasmodium vivax tubulin alpha chain, putative 0.0377 0.4611 0.7492
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Schistosoma mansoni alpha tubulin 0.0377 0.4611 0.7492
Echinococcus multilocularis mitogen activated protein kinase 3 0.0046 0.0404 0.0404
Echinococcus granulosus Tubulin beta 2C chain 0.0499 0.6154 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0446 0.0725
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0333
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Loa Loa (eye worm) tubulin alpha-2 chain 0.0377 0.4611 0.7492
Trypanosoma brucei alpha tubulin 0.0377 0.4611 0.7492
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0695 0.0881
Schistosoma mansoni alpha tubulin 0.0377 0.4611 0.7492
Leishmania major beta tubulin 0.0499 0.6154 1
Echinococcus multilocularis tubulin alpha chain 0.0377 0.4611 0.4611
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1017 0.1653
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0272 0.0442
Echinococcus granulosus alpha tubulin 0.0377 0.4611 0.7492
Brugia malayi steroid hormone receptor 0.0019 0.0063 0.0102
Echinococcus multilocularis chromobox protein 1 0.0069 0.0695 0.0695
Echinococcus multilocularis beta tubulin 0.0499 0.6154 0.6154
Leishmania major alpha tubulin 0.0377 0.4611 0.7492
Echinococcus multilocularis Tubulin beta 2C chain 0.0499 0.6154 0.6154
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.003
Plasmodium falciparum tubulin delta chain, putative 0.0117 0.131 0.2129
Echinococcus multilocularis peroxisome assembly protein 26 0.0377 0.4611 0.4611
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.177 0.2875
Schistosoma mansoni tubulin subunit gamma 0.027 0.3252 0.5284
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0063 0.0102
Trypanosoma brucei epsilon tubulin 0.027 0.3252 0.5284
Leishmania major beta tubulin 0.0499 0.6154 1
Trypanosoma brucei alpha tubulin 0.0377 0.4611 0.7492
Echinococcus granulosus tubulin subunit beta 0.0499 0.6154 1
Entamoeba histolytica tubulin gamma chain 0.027 0.3252 0.5066
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0348 0.0301
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0063 0.0102
Plasmodium vivax tubulin alpha chain, putative 0.0377 0.4611 0.7492
Schistosoma mansoni jumonji/arid domain-containing protein 0.0053 0.0494 0.0803
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.3939 0.6401
Trichomonas vaginalis tubulin gamma chain, putative 0.027 0.3252 0.5152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0102
Trichomonas vaginalis tubulin alpha chain, putative 0.027 0.3252 0.5152
Echinococcus multilocularis tubulin gamma 1 chain 0.027 0.3252 0.3252

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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