Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0254 | 1 | 1 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0036 | 0.0795 | 0.1629 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.0547 | 0.0547 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3342 | 0.7739 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.3704 | 0.8577 |
Leishmania major | basic transcription factor 3a, putative | 0.0036 | 0.0795 | 0.0795 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.1323 | 0.2985 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.3342 | 0.3342 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3342 | 0.7739 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0809 | 0.0809 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0024 | 0.03 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.1323 | 0.0821 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0024 | 0.03 | 0.03 |
Schistosoma mansoni | transcription factor btf3 | 0.0036 | 0.0795 | 0.0795 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0105 | 0.3704 | 0.3704 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0547 | 0.0547 |
Schistosoma mansoni | kinase | 0.0049 | 0.1354 | 0.1354 |
Leishmania major | trypanothione reductase | 0.0048 | 0.1323 | 0.1323 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0254 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.3342 | 0.3342 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0024 | 0.03 | 0.2265 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0105 | 0.3704 | 0.3704 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0085 | 0.2858 | 0.2858 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.011 | 0.3916 | 0.8837 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0085 | 0.2858 | 0.2858 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0119 | 0.4319 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0795 | 0.0795 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0809 | 0.0278 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0795 | 0.1841 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.1323 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.1035 | 0.1035 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0809 | 0.0809 |
Loa Loa (eye worm) | ICD-1 protein | 0.0036 | 0.0795 | 0.0263 |
Echinococcus granulosus | transcription factor btf3 | 0.0036 | 0.0795 | 0.0795 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0254 | 1 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0795 | 0.0795 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0547 | 0.0547 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0795 | 0.1629 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0096 | 0.3342 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.3342 | 0.3342 |
Onchocerca volvulus | 0.0085 | 0.2858 | 0.8267 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.1323 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0036 | 0.0795 | 0.6012 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0795 | 0.1841 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3364 | 0.298 |
Brugia malayi | jmjC domain containing protein | 0.0097 | 0.3386 | 0.3386 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0809 | 0.0809 |
Brugia malayi | glutathione reductase | 0.0048 | 0.1323 | 0.1323 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.1323 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0024 | 0.03 | 0.03 |
Echinococcus multilocularis | protein patched | 0.0105 | 0.3704 | 0.3704 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0119 | 0.4319 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.1323 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0024 | 0.03 | 0.2265 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0024 | 0.03 | 0.03 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0547 | 0.0547 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0024 | 0.03 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.3342 | 0.3342 |
Giardia lamblia | Kinase, PLK | 0.0096 | 0.3342 | 0.7739 |
Schistosoma mansoni | patched 1 | 0.0105 | 0.3704 | 0.3704 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.3342 | 0.3342 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0036 | 0.0795 | 0.6012 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0547 | 0.4132 |
Brugia malayi | CHE-14 protein | 0.0105 | 0.3704 | 0.3704 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.0547 | 0.1266 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.011 | 0.3916 | 0.8837 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3342 | 0.7739 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.03 | 0.03 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0105 | 0.3704 | 0.3704 |
Echinococcus multilocularis | protein dispatched 1 | 0.0105 | 0.3704 | 0.3704 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0254 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0254 | 1 | 1 |
Echinococcus multilocularis | transcription factor btf3 | 0.0036 | 0.0795 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1438 | 0.0943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0795 | 0.1841 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.011 | 0.3916 | 0.8837 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0809 | 0.0809 |
Echinococcus granulosus | peregrin | 0.003 | 0.0547 | 0.0547 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0024 | 0.03 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0036 | 0.0795 | 0.0795 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0048 | 0.13 | 0.3011 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.1876 | 0.1406 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.4431 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.3342 | 0.3342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.1323 | 0.1323 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0048 | 0.13 | 0.3011 |
Mycobacterium tuberculosis | Probable reductase | 0.011 | 0.3916 | 0.8837 |
Echinococcus multilocularis | peregrin | 0.003 | 0.0547 | 0.0547 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0097 | 0.3364 | 0.3364 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0547 | 0.0547 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.011 | 0.3916 | 0.8837 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0024 | 0.03 | 0.2265 |
Brugia malayi | beta-NAC-like protein | 0.0036 | 0.0795 | 0.0795 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.3342 | 0.3342 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.1323 | 0.1323 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0036 | 0.0795 | 0.6012 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2858 | 0.2445 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0105 | 0.3704 | 0.334 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0024 | 0.03 | 0.2265 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.011 | 0.3916 | 0.8837 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0097 | 0.3386 | 0.3386 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0096 | 0.3342 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3342 | 0.7739 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0254 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3342 | 0.7739 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0547 | 0.4132 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0097 | 0.3386 | 0.3386 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.4431 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0105 | 0.3704 | 0.3704 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.1323 | 0.1323 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0254 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.1323 | 0.1323 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.3342 | 0.3342 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3704 | 0.334 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0085 | 0.2858 | 0.2858 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.0547 | 0.4132 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0119 | 0.4319 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.4431 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0547 | 0.4132 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0547 | 0.0547 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0119 | 0.4319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.2967 | 0.256 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0097 | 0.3364 | 0.3364 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0105 | 0.3704 | 0.3704 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0105 | 0.3704 | 0.3704 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0809 | 0.0809 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3342 | 0.7739 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.011 | 0.3916 | 0.8753 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.1323 | 0.1323 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3342 | 0.7739 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.2546 | 0.2546 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0085 | 0.2858 | 0.2858 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.1323 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.3342 | 0.2957 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0024 | 0.03 | 0.0676 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.1323 | 0.0821 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.1035 | 0.1035 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0097 | 0.3364 | 0.3364 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.4431 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.