Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1049 | 0.9865 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0144 | 0.1223 | 0.5 |
Echinococcus multilocularis | 0.0144 | 0.1223 | 0.1223 | |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1223 | 0.124 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1064 | 1 | 1 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0144 | 0.1223 | 0.124 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0144 | 0.1223 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0144 | 0.1223 | 0.124 |
Leishmania major | fk506-binding protein 1-like protein | 0.1049 | 0.9865 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1049 | 0.9865 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0144 | 0.1223 | 0.5 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0159 | 0.1358 | 0.1358 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0144 | 0.1223 | 0.124 |
Onchocerca volvulus | 0.0144 | 0.1223 | 0.9833 | |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0919 | 0.8621 | 0.8621 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1049 | 0.9865 | 0.9865 |
Trichomonas vaginalis | immunophilin, putative | 0.1049 | 0.9865 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0144 | 0.1223 | 0.124 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1049 | 0.9865 | 0.9976 |
Schistosoma mansoni | immunophilin | 0.1064 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0919 | 0.8621 | 0.8621 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1049 | 0.9865 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0144 | 0.1223 | 0.1223 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0144 | 0.1223 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0144 | 0.1223 | 0.124 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.1223 | 0.1223 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0144 | 0.1223 | 0.124 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0919 | 0.8621 | 0.8621 |
Onchocerca volvulus | 0.0147 | 0.1244 | 1 | |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1049 | 0.9865 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0144 | 0.1223 | 0.124 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1049 | 0.9865 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1049 | 0.9865 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0144 | 0.1223 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0144 | 0.1223 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1049 | 0.9865 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0144 | 0.1223 | 0.1223 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1049 | 0.9865 | 0.9865 |
Loa Loa (eye worm) | hypothetical protein | 0.0907 | 0.8507 | 0.8623 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1049 | 0.9865 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.1049 | 0.9865 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1049 | 0.9865 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0144 | 0.1223 | 0.124 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0144 | 0.1223 | 0.124 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1049 | 0.9865 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0144 | 0.1223 | 0.124 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1049 | 0.9865 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1049 | 0.9865 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1064 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0144 | 0.1223 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1049 | 0.9865 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0144 | 0.1223 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1049 | 0.9865 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1049 | 0.9865 | 1 |
Schistosoma mansoni | immunophilin | 0.1064 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1052 | 0.9886 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1064 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0144 | 0.1223 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0144 | 0.1223 | 0.124 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1049 | 0.9865 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1049 | 0.9865 | 1 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0144 | 0.1223 | 0.124 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0144 | 0.1223 | 0.124 |
Echinococcus multilocularis | fk506 binding protein | 0.1049 | 0.9865 | 0.9865 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0144 | 0.1223 | 0.1223 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0144 | 0.1223 | 0.124 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0144 | 0.1223 | 0.124 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 40 ug ml-1 | Antibacterial activity of the compound against Staphylococcus aureus 011HT3 | ChEMBL. | 10673102 |
MIC (functional) | > 40 ug ml-1 | Antibacterial activity against ofloxacin,oxacillin,erythromycin resistant Staphylococcus aureus 011GO64. | ChEMBL. | 10673102 |
MIC (functional) | > 40 ug ml-1 | Antibacterial activity of the compound tested against novobiocin resistant Staphylococcus aureus 011HT1 | ChEMBL. | 10673102 |
MIC (functional) | > 40 ug ml-1 | Antibacterial activity against oxacillin resistant Staphylococcus epidermidis 012GO42 | ChEMBL. | 10673102 |
MIC (functional) | > 40 ug ml-1 | Antibacterial activity of the compound tested against Streptococcus pyogenes 02AIUC1 | ChEMBL. | 10673102 |
MIC (functional) | > 40 ug ml-1 | Antibacterial activity against vancomycin, teicoplanin, erythromycin resistant Enterococcus faecium | ChEMBL. | 10673102 |
Ratio (functional) | = 0.025 | In vitro activity against E. coli DNA gyrase subunit B supercoiling, expressed as IC50 novobiocin / IC50 compound | ChEMBL. | 10673102 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.