Detailed information for compound 631390

Basic information

Technical information
  • TDR Targets ID: 631390
  • Name: 6-bromo-N-(2-methoxyphenyl)-4-phenylquinazoli n-2-amine
  • MW: 406.275 | Formula: C21H16BrN3O
  • H donors: 1 H acceptors: 2 LogP: 5.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1Nc1nc2ccc(cc2c(n1)c1ccccc1)Br
  • InChi: 1S/C21H16BrN3O/c1-26-19-10-6-5-9-18(19)24-21-23-17-12-11-15(22)13-16(17)20(25-21)14-7-3-2-4-8-14/h2-13H,1H3,(H,23,24,25)
  • InChiKey: OEAPGEVDEPWGEO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-bromo-N-(2-methoxyphenyl)-4-phenyl-quinazolin-2-amine
  • 6-bromo-N-(2-methoxyphenyl)-4-phenyl-2-quinazolinamine
  • (6-bromo-4-phenyl-quinazolin-2-yl)-(2-methoxyphenyl)amine
  • BAS 00899666
  • A2177/0091493
  • ZINC02294111
  • (6-Bromo-4-phenyl-quinazolin-2-yl)-(2-methoxy-phenyl)-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0039 0.0329 0.1815
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0021 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0107 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0407 0.206
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0302
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0107 0.0262
Brugia malayi DKFZp564C0469 protein 0.0011 0.0003 0.0007
Echinococcus multilocularis geminin 0.0166 0.1811 0.1811
Brugia malayi hypothetical protein 0.0011 0.0003 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0068 0.067 0.3702
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0107 0.0302
Schistosoma mansoni ap endonuclease 0.002 0.0114 0.0632
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0003 0.0014
Schistosoma mansoni hypothetical protein 0.0044 0.0388 0.2143
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0012 0.0021 0.1645
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0021 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0107 0.0302
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.1966 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0089 0.0348
Echinococcus multilocularis tar DNA binding protein 0.0068 0.067 0.067
Onchocerca volvulus Bile acid receptor homolog 0.0317 0.3564 1
Schistosoma mansoni hypothetical protein 0.0166 0.1811 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.067 0.3702
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0101 0.05
Loa Loa (eye worm) hypothetical protein 0.0019 0.0101 0.0283
Schistosoma mansoni DNA ligase IV 0.0011 0.0003 0.0014
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0003 0.0000017674
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0107 0.0593
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Brugia malayi CHE-14 protein 0.0045 0.0407 0.1142
Trypanosoma brucei pteridine reductase 1 0.0012 0.0021 0.1645
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0176 0.0795
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0107 0.0302
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0107 0.0107
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0021 0.0059
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.1108 0.1108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0089 0.0348
Loa Loa (eye worm) RNA binding protein 0.0068 0.067 0.1881
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0059
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0302
Loa Loa (eye worm) oxidoreductase 0.0012 0.0021 0.0059
Onchocerca volvulus 0.0053 0.0497 0.1388
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0003 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0107 0.0593
Schistosoma mansoni tar DNA-binding protein 0.0068 0.067 0.3702
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0107 0.0302
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Schistosoma mansoni hypothetical protein 0.0044 0.0388 0.2143
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0012 0.0021 0.0094
Chlamydia trachomatis oxoacy-ACP reductase 0.0012 0.0021 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0107 0.0107
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0114 0.0321
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0107 0.0593
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0114 0.057
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0101 0.05
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0012 0.0021 0.0094
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0012 0.0021 0.0094
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0114 0.1011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0176 0.0881
Entamoeba histolytica hypothetical protein 0.0039 0.0329 0.2949
Entamoeba histolytica hypothetical protein 0.0039 0.0329 0.2949
Brugia malayi TAR-binding protein 0.0068 0.067 0.1881
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0107 0.0302
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.1966 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0089 0.0348
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0107 0.0593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0107 0.0302
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.137 0.3843
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0021 0.0166
Brugia malayi steroid hormone receptor 0.002 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.1127 0.6227
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0012 0.0021 0.0094
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0176 0.0795
Schistosoma mansoni hypothetical protein 0.0166 0.1811 1
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0012 0.0021 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0107 0.0302
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0101 0.041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0329 0.0329
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0497 0.2744
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0176 0.0881
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0021 0.0094
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0407 0.1142
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0021 0.1645
Echinococcus granulosus tumor protein p63 0.0363 0.4097 1
Schistosoma mansoni coup transcription factor 0.002 0.0107 0.0593
Schistosoma mansoni patched 1 0.0045 0.0407 0.2248
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0407 0.0993
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0176 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0176 0.0493
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0003 0.0000017674
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0021 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0107 0.0302
Onchocerca volvulus 0.0012 0.0021 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0107 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0107 0.0302
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0107 0.0295
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0021 0.1645
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0101 0.0283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0114 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0107 0.0593
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0107 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0107 0.0302
Trichomonas vaginalis hypothetical protein 0.0179 0.1966 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0176 0.0493
Loa Loa (eye worm) hypothetical protein 0.0056 0.0526 0.1475
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.1966 1
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0003 0.0003
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0003 0.0000017674
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0021 0.0059
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0068 0.067 0.3702
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Entamoeba histolytica hypothetical protein 0.0039 0.0329 0.2949
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0176 0.0881
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0114 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.3564 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0302
Schistosoma mansoni thyroid hormone receptor 0.002 0.0107 0.0593
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0114 1
Brugia malayi hypothetical protein 0.0039 0.0329 0.0922
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0114 0.0279
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0176 0.0881
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0107 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0107 0.0302
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0107 0.0262
Loa Loa (eye worm) hypothetical protein 0.0019 0.0101 0.0283
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0302
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.1108 0.311
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0176 0.0493
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007
Schistosoma mansoni hypothetical protein 0.0044 0.0388 0.2143
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0176 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0107 0.0107
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0003 0.0007
Brugia malayi hypothetical protein 0.0011 0.0003 0.0007
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0176 0.1565
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0021 0.0094
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0021 0.0059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0107 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0068 0.067 0.3702
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0114 0.0114
Echinococcus granulosus tar DNA binding protein 0.0068 0.067 0.1636
Schistosoma mansoni topbp1 0.0011 0.0003 0.0014
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0107 0.0302
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0114 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0107 0.0302
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0176 0.0493
Onchocerca volvulus 0.002 0.0107 0.0295
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0019 0.0101 0.0283
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0114 0.057
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0012 0.0021 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0176 0.0881
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.1966 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0101 0.05
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.1966 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.1966 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.1108 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0101 0.0283
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0176 0.1565
Brugia malayi nuclear receptor NHR-88 0.002 0.0107 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.137 0.3843
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0107 0.0302
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0021 0.1645
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0012 0.0021 0.0094
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.1636 0.3993
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Echinococcus multilocularis tumor protein p63 0.0363 0.4097 0.4097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0114 0.0321
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0021 0.0116
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0021 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0107 0.0302
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0107 0.0107
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0107 0.0593
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0107 0.0295
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0021 0.1645
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0021 0.0051
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0101 0.05
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.1636 0.1636
Echinococcus multilocularis expressed conserved protein 0.0099 0.1034 0.1034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0107 0.0302
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0302
Mycobacterium ulcerans hypothetical protein 0.0025 0.0176 0.0881
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0329 0.0802
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0302
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0107 0.0593
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0114 0.057
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0114 0.0481
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.067 0.1881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0107 0.0302
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.1108 0.2706
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0107 0.0593
Echinococcus granulosus FTZ F1 alpha 0.002 0.0107 0.0262
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0003 0.0000017674
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.1966 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0176 0.0881
Schistosoma mansoni nuclear hormone receptor 0.002 0.0107 0.0593
Mycobacterium ulcerans oxidoreductase 0.0012 0.0021 0.0094
Schistosoma mansoni hypothetical protein 0.0044 0.0388 0.2143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0107 0.0302
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0176 0.0881
Onchocerca volvulus 0.0012 0.0021 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0107 0.0302
Loa Loa (eye worm) hypothetical protein 0.0053 0.0497 0.1394
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0003 0.0000031374
Echinococcus multilocularis protein patched 0.0045 0.0407 0.0407
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0012 0.0021 0.0094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0106 0.1108 0.311
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0107 0.0593
Brugia malayi topoisomerase 0.0011 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0176 0.0493
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0107 0.0262
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0021 0.0094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0107 0.0302
Echinococcus granulosus geminin 0.0166 0.1811 0.442
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0114 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0107 0.0262
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0021 0.0116
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0114 0.6044
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0107 0.0302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0107 0.0593
Echinococcus multilocularis protein dispatched 1 0.0052 0.0481 0.0481
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.1966 1
Brugia malayi MH2 domain containing protein 0.0128 0.137 0.3843
Loa Loa (eye worm) hypothetical protein 0.0045 0.0407 0.1142
Schistosoma mansoni topbp1 0.0011 0.0003 0.0014
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0021 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0089 0.0348
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0107 0.0262
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0176 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0114 0.057
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0021 0.0021
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.067 0.1881
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0176 0.0881
Loa Loa (eye worm) TAR-binding protein 0.0068 0.067 0.1881
Toxoplasma gondii exonuclease III APE 0.002 0.0114 0.057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0107 0.0262
Entamoeba histolytica hypothetical protein 0.0039 0.0329 0.2949
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0021 0.0094
Brugia malayi nuclear hormone receptor 0.002 0.0107 0.0302
Echinococcus multilocularis nibrin 0.0011 0.0003 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0176 0.1565
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0114 0.057
Schistosoma mansoni ap endonuclease 0.002 0.0114 0.0632
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0021 0.0094
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0407 0.0993
Echinococcus granulosus nibrin 0.0011 0.0003 0.0006
Echinococcus granulosus expressed conserved protein 0.0099 0.1034 0.2524
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0114 0.057
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0176 0.0493
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0012 0.0021 0.0094
Brugia malayi ecdysteroid receptor 0.0317 0.3564 1
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0021 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0329 0.1815
Brugia malayi RNA binding protein 0.0068 0.067 0.1881
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0003 0.0006
Onchocerca volvulus 0.0025 0.0176 0.0486
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0176 0.0881
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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