Detailed information for compound 631576

Basic information

Technical information
  • TDR Targets ID: 631576
  • Name: N-[(4-bromophenyl)methylideneamino]-2-[(3,5-d ioxo-2H-1,2,4-triazin-6-yl)amino]propanamide
  • MW: 381.185 | Formula: C13H13BrN6O3
  • H donors: 4 H acceptors: 6 LogP: 1.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Nc1nnc(nc1O)O)C)NN=Cc1ccc(cc1)Br
  • InChi: 1S/C13H13BrN6O3/c1-7(16-10-12(22)17-13(23)20-18-10)11(21)19-15-6-8-2-4-9(14)5-3-8/h2-7H,1H3,(H,16,18)(H,19,21)(H2,17,20,22,23)/b15-6+
  • InChiKey: KAZBLLKXYVUEHA-GIDUJCDVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-bromophenyl)methyleneamino]-2-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)amino]propanamide
  • N-[(4-bromobenzylidene)amino]-2-[(3,5-diketo-2H-1,2,4-triazin-6-yl)amino]propionamide
  • ST022216

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.007 0.0866
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Leishmania major DNA polymerase eta, putative 0.0012 0.007 0.142
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0519 1
Schistosoma mansoni tar DNA-binding protein 0.0194 0.279 0.279
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0422 0.0422
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0056 0.1106
Schistosoma mansoni hypothetical protein 0.0011 0.0056 0.0056
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0458 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0196 0.0684
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0519 0.6923
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0146 0.0146
Brugia malayi hypothetical protein 0.001 0.0037 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0196 0.0684
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0037 0.0113
Schistosoma mansoni apoferritin-2 0.0009 0.003 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0054 0.0174
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0196 0.0196
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0011 0.0056 0.1106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0196 0.0196
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.007 0.142
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0271 0.0955
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0347 0.5066 0.5066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0458 0.0458
Echinococcus multilocularis 0.0011 0.0056 0.0056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0271 0.5873
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.0955
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Schistosoma mansoni ferritin 0.0009 0.003 0.003
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0018 0.0018
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0056 0.1884
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0399 0.1412
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0146 0.3099
Leishmania major DNA damage repair protein, putative 0.0012 0.007 0.142
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0037 0.0113
Brugia malayi nuclear receptor RXR 0.0011 0.0054 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0344 0.1216
Entamoeba histolytica hypothetical protein 0.0035 0.0422 0.9018
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0037 0.0037
Brugia malayi steroid hormone receptor 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.0955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0196 0.0684
Entamoeba histolytica hypothetical protein 0.0035 0.0422 0.9018
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0054 0.0174
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0018 0.0018
Giardia lamblia DINP protein human, muc B family 0.0038 0.0458 0.9772
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0458 0.9803
Schistosoma mansoni cpg binding protein 0.0028 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Schistosoma mansoni apoferritin-2 0.0009 0.003 0.003
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0458 1
Mycobacterium ulcerans hypothetical protein 0.0012 0.007 0.142
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0196 0.0196
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0458 0.0458
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0006 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0458 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0196 0.0684
Brugia malayi MH1 domain containing protein 0.0008 0.0018 0.0045
Leishmania major cytochrome p450-like protein 0.0011 0.0056 0.1106
Loa Loa (eye worm) Smad1 0.0008 0.0018 0.0045
Leishmania major cytochrome p450-like protein 0.0011 0.0056 0.1106
Schistosoma mansoni zinc finger protein 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Loa Loa (eye worm) DR-78 0.001 0.0037 0.0113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0613
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0011 0.0056 0.1106
Schistosoma mansoni tar DNA-binding protein 0.0194 0.279 0.279
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0056 0.1106
Leishmania major DNA polymerase eta, putative 0.0038 0.0458 1
Leishmania major cytochrome p450-like protein 0.0011 0.0056 0.1106
Onchocerca volvulus 0.001 0.0037 0.0137
Loa Loa (eye worm) hypothetical protein 0.0038 0.0458 0.1625
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0519 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0037 0.0037
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0196 0.0832
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0271 0.5758
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0196 0.0196
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0056 0.1106
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0196 0.0196
Brugia malayi Nuclear hormone receptor E75 0.001 0.0037 0.0113
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0146 0.0504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0271 0.5873
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.007 0.142
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0037 0.0113
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0196 0.0832
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0174
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0037 0.0037
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0056 0.1106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0613
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0056 0.1106
Loa Loa (eye worm) hypothetical protein 0.0161 0.2293 0.8216
Brugia malayi ecdysone receptor 0.001 0.0037 0.0113
Schistosoma mansoni hypothetical protein 0.0073 0.0983 0.0983
Schistosoma mansoni smad 0.0008 0.0018 0.0018
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0011 0.0056 0.1106
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0458 0.1625
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0056 0.1106
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0037 0.0113
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0054 0.0174
Echinococcus granulosus cpg binding protein 0.003 0.0342 0.0342
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0056 0.1106
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0006 0.0006
Loa Loa (eye worm) TAR-binding protein 0.0194 0.279 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0399 0.1412
Onchocerca volvulus 0.0025 0.0271 0.1162
Brugia malayi hypothetical protein 0.001 0.0037 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0196 0.0684
Schistosoma mansoni tar DNA-binding protein 0.0194 0.279 0.279
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0056 0.1106
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0056 0.1106
Echinococcus granulosus smad 0.0008 0.0018 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0056 0.1106
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0056 0.1106
Leishmania major DNA polymerase kappa, putative 0.0038 0.0458 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0011 0.0056 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0176 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0422 0.9018
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0056 0.018
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.003 0.0906
Trypanosoma brucei unspecified product 0.0026 0.0283 0.6139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0161 0.3432
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0037 0.0137
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0271 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0018 0.0018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0196 0.0832
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0458 0.1625
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0011 0.0056 0.1106
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0176 0.3771
Onchocerca volvulus 0.001 0.0037 0.0137
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0011 0.0056 0.1106
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0196 0.0196
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0271 0.5873
Schistosoma mansoni hypothetical protein 0.0034 0.0399 0.0399
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.007 0.142
Brugia malayi Cytochrome P450 family protein 0.0011 0.0056 0.018
Brugia malayi Smad1 0.0008 0.0018 0.0045
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0056 0.0675
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.0073 0.0983 0.351
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0196 0.0196
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0271 0.5873
Echinococcus multilocularis cpg binding protein 0.003 0.0342 0.0342
Brugia malayi Cytochrome P450 family protein 0.0011 0.0056 0.018
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0011 0.0056 0.1106
Brugia malayi hypothetical protein 0.0011 0.0054 0.0174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0613
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1487 0.5319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0196 0.0684
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0519 0.0519
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0399 0.0399
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0056 0.1106
Brugia malayi tailless protein 0.001 0.0037 0.0113
Brugia malayi conserved hypotetical protein 0.001 0.0037 0.0113
Echinococcus multilocularis GPCR, family 2 0.0034 0.0399 0.0399
Brugia malayi cytochrome P450 0.0011 0.0056 0.018
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0271 0.5873
Mycobacterium leprae putative cytochrome p450 0.0011 0.0056 0.1884
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0037 0.0037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0458 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0011 0.0056 0.1106
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0146 0.3099
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0467 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0196 0.0684
Schistosoma mansoni ferritin 0.0009 0.003 0.003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0196 0.0196
Onchocerca volvulus 0.0161 0.2293 1
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0056 0.018
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0399 0.1412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0613
Brugia malayi hypothetical protein 0.0011 0.0054 0.0174
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0196 0.0196
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0054 0.0054
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0196 0.0196
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1701 0.6087
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0054 0.0054
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0146 0.3099
Brugia malayi MH1 domain containing protein 0.0008 0.0018 0.0045
Schistosoma mansoni thyroid hormone receptor 0.002 0.0196 0.0196
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0146 0.0146
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.007 0.142
Echinococcus granulosus dna polymerase kappa 0.0038 0.0458 0.0458
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0146 0.1891
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.003 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0271 0.5873
Brugia malayi CXXC zinc finger family protein 0.0028 0.0318 0.112
Echinococcus multilocularis tar DNA binding protein 0.0194 0.279 0.279
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0747 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0196 0.0196
Brugia malayi nuclear hormone receptor 0.002 0.0196 0.0684
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.279 1
Echinococcus granulosus dnaJ subfamily B 0.0404 0.5912 0.5912
Onchocerca volvulus 0.002 0.0196 0.0832
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0056 0.1106
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0056 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0196 0.0684
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.003 0.0532
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0037 0.0037
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0467 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0056 0.1106
Brugia malayi hypothetical protein 0.0035 0.0422 0.1495
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0161 0.3432
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0056 0.1106
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0271 0.5873
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0458 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0037 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0791 0.0791
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.007 0.142
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0196 0.0196
Leishmania major DNA polymerase kappa, putative 0.0012 0.007 0.142
Brugia malayi RNA binding protein 0.0194 0.279 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0037 0.0113
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Schistosoma mansoni hypothetical protein 0.0404 0.5912 0.5912
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0196 0.0684
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0458 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0056 0.1106
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0037 0.0037
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0176 0.3323
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0458 0.8811
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0146 0.0146
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0146 0.1891
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0422 0.0422
Trypanosoma brucei unspecified product 0.0038 0.0458 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0037 0.0037
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0519 0.6923
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0146 0.3039
Schistosoma mansoni ferritin 0.0009 0.003 0.003
Loa Loa (eye worm) cytochrome P450 0.0011 0.0056 0.018
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0011 0.0056 0.1106
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1958 0.1958
Schistosoma mansoni cpg binding protein 0.003 0.0342 0.0342
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0037 0.0037
Brugia malayi nuclear receptor NHR-67 0.001 0.0037 0.0113
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.007 0.142
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0458 0.0458
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0011 0.0056 0.1106
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0018 0.0045
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0037 0.0037
Schistosoma mansoni smad1 5 8 and 0.0008 0.0018 0.0018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0196 0.0684
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.007 0.142
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0146 0.2731
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0458 0.8811
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0196 0.0684
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0018 0.0018
Schistosoma mansoni ferritin light chain 0.0009 0.003 0.003
Brugia malayi ecdysteroid receptor 0.002 0.0196 0.0684
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0271 0.5873
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0037 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0271 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0467 1
Entamoeba histolytica hypothetical protein 0.0035 0.0422 0.9018
Schistosoma mansoni cytochrome P450 0.0011 0.0056 0.0056
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0146 0.3099
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0196 0.0196
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0983 0.351
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0146 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0271 0.5758
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0056 0.1106
Echinococcus multilocularis dna polymerase eta 0.0038 0.0458 0.0458
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0056 0.1106
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.0107 0.1487 0.5319
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0056 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.0955
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0458 0.1625
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.007 0.142
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0196 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.007 0.142
Echinococcus granulosus Smad4 0.0008 0.0018 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0458 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0024 0.0067
Schistosoma mansoni hypothetical protein 0.0347 0.5066 0.5066
Schistosoma mansoni tar DNA-binding protein 0.0194 0.279 0.279
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0196 0.0684
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.007 0.142
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.003 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0056 0.1106
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0271 0.5873
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0037 0.0037
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0176 0.3697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0196 0.0196
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0422 0.0422
Schistosoma mansoni smad1 5 8 and 0.0008 0.0018 0.0018
Brugia malayi TAR-binding protein 0.0194 0.279 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0271 0.5873
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0458 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0174
Schistosoma mansoni hypothetical protein 0.0034 0.0399 0.0399
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0519 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0011 0.0056 0.1106
Brugia malayi isocitrate dehydrogenase 0.0017 0.0146 0.0504
Brugia malayi MH2 domain containing protein 0.0008 0.0018 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0196 0.0684
Brugia malayi Cytochrome P450 family protein 0.0011 0.0056 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0056 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0231
Loa Loa (eye worm) acetyltransferase 0.0142 0.2017 0.7225
Echinococcus granulosus dna polymerase eta 0.0038 0.0458 0.0458
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0196 0.0684
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0196 0.0196
Echinococcus multilocularis geminin 0.0347 0.5066 0.5066
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0458 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0146 0.3099
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0056 0.1106
Brugia malayi nuclear receptor NHR-88 0.001 0.0037 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0271 0.0955
Schistosoma mansoni hypothetical protein 0.0034 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Echinococcus multilocularis smad 0.0008 0.0018 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1487 0.5319
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0011 0.0056 0.1106
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.007 0.142
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0196 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0196 0.0684
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0026 0.0073
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.2017 0.2017
Brugia malayi nuclear receptor RXR 0.001 0.0037 0.0113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0196 0.0196
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0146 0.0146
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0018 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0271 0.5873
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0056 0.1106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0458 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0056 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0037 0.0113
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0399 0.0399
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0146 0.0504
Echinococcus multilocularis ferritin 0.0009 0.003 0.003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Trichomonas vaginalis ferritin, putative 0.0009 0.003 0.0469
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.002 0.0196 0.0684
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0613
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0011 0.0056 0.1106
Brugia malayi polk-prov protein 0.0012 0.007 0.0231
Echinococcus granulosus GPCR family 2 0.0034 0.0399 0.0399
Schistosoma mansoni cpg binding protein 0.003 0.0342 0.0342
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.003 0.0532
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0283 0.6139
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1701 0.6087
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0011 0.0056 0.1106
Echinococcus multilocularis Smad4 0.0008 0.0018 0.0018
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0037 0.0037
Echinococcus granulosus expressed protein 0.0009 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0037 0.0113
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0196 0.0196
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.279 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0196 0.0684
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0399 0.0399
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0146 0.0146
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0056 0.1106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0161 0.3432
Schistosoma mansoni nuclear receptor 0.001 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0056 0.1106
Echinococcus granulosus tar DNA binding protein 0.0194 0.279 0.279
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0161 0.3432
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0056 0.018
Echinococcus granulosus FTZ F1 alpha 0.002 0.0196 0.0196
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0399 0.0399
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0011 0.0056 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0283 0.6139
Schistosoma mansoni Smad4 0.0008 0.0018 0.0018
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.007 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0271 0.5758
Echinococcus multilocularis expressed protein 0.0009 0.003 0.003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0146 0.3099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0054 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0194 0.279 0.279
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0011 0.0056 0.1106
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0011 0.0056 0.1106
Brugia malayi nuclear hormone receptor 0.001 0.0037 0.0113
Schistosoma mansoni coup transcription factor 0.002 0.0196 0.0196
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0271 0.5873
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0196 0.0684
Echinococcus granulosus geminin 0.0347 0.5066 0.5066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0196 0.0684
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0458 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0196 0.0196
Schistosoma mansoni DNA polymerase eta 0.0038 0.0458 0.0458
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0037 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0271 0.0955
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0196 0.0196
Brugia malayi hypothetical protein 0.0161 0.2293 0.8216
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0037 0.0037
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.002 0.0196 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0196 0.0684
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.003 0.0532
Loa Loa (eye worm) RNA binding protein 0.0194 0.279 1
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.2017 0.7225
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0146 0.0146
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.003 0.0532
Mycobacterium ulcerans hypothetical protein 0.0025 0.0271 0.5873
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0196 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Schistosoma mansoni hypothetical protein 0.0034 0.0399 0.0399
Schistosoma mansoni hypothetical protein 0.0035 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0174
Brugia malayi MH2 domain containing protein 0.0008 0.0018 0.0045
Schistosoma mansoni ferritin light chain 0.0009 0.003 0.003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.007 0.0866
Schistosoma mansoni ferritin 0.0009 0.003 0.003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0318 0.112
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.007 0.1251
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0458 1
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0458 0.0458
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0458 0.0458
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.007 0.1392
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0011 0.0056 0.1106
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.2017 0.2017
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0011 0.0056 0.1106
Brugia malayi Cytochrome P450 family protein 0.003 0.0344 0.1216
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0283 0.6139
Brugia malayi MH2 domain containing protein 0.0121 0.1701 0.6087
Onchocerca volvulus 0.0028 0.0318 0.1364
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.1487 0.5319
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0113
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0176 0.3771
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0196 0.0196
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0399 0.1412
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0056 0.1106
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0458 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0011 0.0056 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.007 0.142
Schistosoma mansoni nuclear hormone receptor 0.001 0.0037 0.0037
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0018 0.0045
Echinococcus granulosus ferritin 0.0009 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0196 0.0196
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0458 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0196 0.0196
Trypanosoma brucei unspecified product 0.0026 0.0283 0.6139
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.5912 0.5912
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0196 0.0196
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0056 0.1106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0196 0.0684
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.007 0.0866
Brugia malayi nuclear receptor NHR-88 0.002 0.0196 0.0684
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0196 0.0196
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0196 0.0196
Schistosoma mansoni nuclear receptor 0.001 0.0037 0.0037

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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