TDR Targets

Basic information

Technical information

TDR Targets ID: 631690
Name: 3-(2,3-dimethoxyphenyl)-1-(4-ethoxyphenyl)pro p-2-en-1-one
MW: 312.36 | Formula: C19H20O4
H donors: 0 H acceptors: 1 LogP: 3.97 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)C(=O)C=Cc1cccc(c1OC)OC
InChi: 1S/C19H20O4/c1-4-23-16-11-8-14(9-12-16)17(20)13-10-15-6-5-7-18(21-2)19(15)22-3/h5-13H,4H2,1-3H3/b13-10+
InChiKey: KXEAJKVQYROPFW-JLHYYAGUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(E)-3-(2,3-dimethoxyphenyl)-1-(4-ethoxyphenyl)prop-2-en-1-one
PB-11397710
ZINC05018536

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0333	0.4911	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0157	0.025
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0644	0.5
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0015	0.0128	0.026
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Brugia malayi	jmjC domain containing protein	0.0015	0.0128	0.026
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0046	0.0046
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0245	0.0499
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.1856	0.5514
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0046	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0046	0.0094
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0644	0.1311
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0389
Trypanosoma brucei	protein kinase, putative	0.005	0.0644	0.1311
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0319	0.0319
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0128	0.0128
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0759	0.0759
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Brugia malayi	jmjC domain containing protein	0.0057	0.0759	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0203
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0245	0.1321
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0128	0.0128
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0245	0.0499
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.013	0.1856	0.5514
Plasmodium vivax	SET domain protein, putative	0.0029	0.0335	0.0682
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0644	0.1311
Leishmania major	hypothetical protein, conserved	0.0015	0.0128	0.026
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0759	0.0759
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0046	0.0073
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0644	0.0644
Brugia malayi	steroid hormone receptor	0.001	0.0046	0.0094
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0759	0.0759
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0128	0.0128
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0245	0.0499
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0046	0.0094
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.1856	0.5514
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0333	0.4911	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0128	0.0128
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0015	0.0128	0.0128
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0644	0.0644
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0046	0.0046
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0644	0.0644
Brugia malayi	Phospholipase A2 family protein	0.0089	0.1245	0.2535
Brugia malayi	Pre-SET motif family protein	0.0029	0.0335	0.0682
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0046	0.0046
Onchocerca volvulus		0.0029	0.0335	0.0532
Brugia malayi	ecdysteroid receptor	0.001	0.0046	0.0094
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.013	0.1856	0.1856
Brugia malayi	Pre-SET motif family protein	0.0202	0.2945	0.5996
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0015	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0425	0.6296	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0335	0.0335
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0335	0.0335
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0046	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0046	0.0094
Brugia malayi	nuclear hormone receptor	0.001	0.0046	0.0094
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0333	0.4911	1
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0128	0.0128
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0128	0.0128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0046	0.0073
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.1856	0.5514
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0644	0.1913
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0389
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.013	0.1856	0.1856
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0335	0.0335
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0046	0.0094
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0143	0.0292
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0046	0.0046
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.013	0.1856	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0644	0.1023
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0759	0.0759
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0245	0.0499
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0333	0.4911	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0128	0.0203
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0046	0.0073
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0157	0.0321
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0333	0.4911	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.1856	0.5514
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0046	0.0094
Brugia malayi	jmjC domain containing protein	0.0015	0.0128	0.026
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0245	0.0499
Leishmania major	dihydroorotate dehydrogenase	0.0333	0.4911	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0335	0.0335
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0128	0.0128
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0046	0.0046
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0644	0.1311
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0046	0.0073
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0335	0.0335
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0046	0.0094
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0143	0.0292
Onchocerca volvulus	Phospholipase A2 homolog	0.0089	0.1245	0.1977
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0046	0.0094
Brugia malayi	jmjC domain containing protein	0.0057	0.0759	0.1546
Schistosoma mansoni	coup transcription factor	0.001	0.0046	0.0046
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0245	0.0499
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0046	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0046	0.0073
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0245	0.0499
Brugia malayi	jmjC domain containing protein	0.0015	0.0128	0.026
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0157	0.0321
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0759	0.0759
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0128	0.0203
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0157	0.0321
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0389
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0046	0.0046
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0333	0.4911	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0046	0.0046
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0128	0.0128
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0046	0.0046
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0245	0.0499
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0046	0.0046
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.013	0.1856	0.1856
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0046	0.0094
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0046	0.0073
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0128	0.0128
Brugia malayi	nuclear receptor NHR-88	0.001	0.0046	0.0094
Brugia malayi	Zinc finger, C2H2 type family protein	0.013	0.1856	0.3778
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0644	0.1913
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0128	0.026
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0335	0.0335
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0046	0.0094
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0333	0.4911	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0245	0.1321
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0644	0.1311
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0143	0.0292
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0759	0.1206
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0046	0.0046
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0157	0.0321
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0333	0.4911	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0046	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0157	0.025
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0046	0.0094
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0046	0.0046
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0333	0.4911	0.4911
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0046	0.0046
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0046	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0046	0.0073
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0644	0.1913
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0046	0.0073
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0333	0.4911	1
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.013	0.1856	0.3778
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0245	0.0499
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0644	0.0644
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0157	0.5
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0644	0.1311
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0759	0.0759
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0046	0.0094
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0157	0.025
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0157	0.025
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0335	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0335	0.0532
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0644	0.1311
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0046	0.0094
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0333	0.4911	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0046	0.0094
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0128	0.0128
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0128	0.026
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0245	0.0499
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0128	0.0128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0046	0.0073
Onchocerca volvulus		0.023	0.3366	0.5346
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0015	0.0128	0.026
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0046	0.0094
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0046	0.0046
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0245	0.0499
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0046	0.0094
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0644	0.1311
Echinococcus multilocularis	microtubule associated protein 2	0.0671	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0046	0.0046
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0245	0.0499
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0245	0.0499
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2945	0.4677
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0015	0.0128	0.026
Onchocerca volvulus		0.0023	0.0245	0.0389
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0046	0.0046
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0333	0.4911	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0046	0.0046
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0245	0.0499
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.0759	0.0759
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0128	0.026
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0046	0.0046
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.013	0.1856	0.5514
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.013	0.1856	0.1856
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0644	0.1913
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0046	0.0046
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0046	0.0046
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0128	0.0128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0046	0.0073
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0046	0.0046
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0644	0.0644
Plasmodium vivax	JmjC domain containing protein	0.0015	0.0128	0.026
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0203
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0046	0.0046
Trichomonas vaginalis	set domain proteins, putative	0.023	0.3366	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0245	0.0499
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0333	0.4911	1
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0333	0.4911	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1245	0.1977
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0245	0.0499
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0046	0.0094
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0644	0.1311
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0245	0.1321
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0128	0.0203
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0046	0.0046
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0046	0.0046
Brugia malayi	jmjC domain containing protein	0.0015	0.0128	0.026
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.001	0.0046	0.0073
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0245	0.0499
Onchocerca volvulus	Phospholipase A2 homolog	0.0425	0.6296	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0143	0.0292
Brugia malayi	MAP kinase sur-1	0.005	0.0644	0.1311
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0157	0.025
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0245	0.0499
Onchocerca volvulus		0.001	0.0046	0.0073
Schistosoma mansoni	microtubule-associated protein tau	0.0671	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 631690