Detailed information for compound 631715

Basic information

Technical information
  • TDR Targets ID: 631715
  • Name: N-(2,4-dimethoxyphenyl)-N'-(pyridin-4-ylmethy l)oxamide
  • MW: 315.324 | Formula: C16H17N3O4
  • H donors: 2 H acceptors: 3 LogP: 1.18 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=O)C(=O)NCc1ccncc1
  • InChi: 1S/C16H17N3O4/c1-22-12-3-4-13(14(9-12)23-2)19-16(21)15(20)18-10-11-5-7-17-8-6-11/h3-9H,10H2,1-2H3,(H,18,20)(H,19,21)
  • InChiKey: TWANGSPBWBKPCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethoxyphenyl)-N'-(4-pyridylmethyl)oxamide
  • N-(2,4-dimethoxyphenyl)-N'-(pyridin-4-ylmethyl)ethanediamide
  • N-(2,4-Dimethoxy-phenyl)-N'-pyridin-4-ylmethyl-oxalamide
  • BAS 00753500
  • MLS000563337
  • ZINC02915308
  • SMR000175968

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0187 0.041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0289 0.0465
Brugia malayi jmjC domain containing protein 0.001 0.0016 0.0026
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0287 0.0554
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0892 0.1146
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0024 0.0201 0.0294
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.018 0.0164
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0042 0.0041
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0042 0.0265
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0268 0.0432
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0287 0.0272
Schistosoma mansoni cytochrome P450 0.0024 0.0201 0.0367
Brugia malayi hypothetical protein 0.0012 0.0042 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0067
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0091 0.0075
Brugia malayi intermediate filament protein 0.0055 0.0599 0.0964
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0042 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0755 0.1216
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0067
Brugia malayi MH1 domain containing protein 0.0016 0.0091 0.0147
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0187 0.9218
Echinococcus granulosus lamin dm0 0.0055 0.0599 0.0941
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0042 0.0041
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0287 0.0537
Echinococcus granulosus geminin 0.0166 0.2031 0.3255
Brugia malayi PHD-finger family protein 0.0012 0.0039 0.0062
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0042 0.0067
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0187 0.041
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0287 0.2804
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.018 0.029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1156 0.1863
Echinococcus multilocularis peregrin 0.0038 0.0379 0.0363
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0042 0.0067
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0129 0.0208
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0037 0.0021
Echinococcus multilocularis geminin 0.0166 0.2031 0.2018
Leishmania major cytochrome p450-like protein 0.0024 0.0201 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0024 0.0201 0.0451
Echinococcus multilocularis aminopeptidase N 0.0012 0.0042 0.0026
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.018 0.8849
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0024 0.0201 0.0451
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0024 0.0201 0.0451
Echinococcus granulosus aminopeptidase N 0.0012 0.0042 0.0041
Echinococcus granulosus leukotriene A 4 hydrolase 0.0226 0.2801 0.4499
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0042 0.1381
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.018 0.1695
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.018 0.8849
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0187 0.0196
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0201 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0042 0.0026
Onchocerca volvulus 0.0028 0.025 0.1839
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0012 0.0042 0.0292
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0085 0.0983 0.1269
Brugia malayi Cytochrome P450 family protein 0.0024 0.0201 0.0325
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.06 0.0943
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0042 0.0067
Mycobacterium ulcerans hypothetical protein 0.0023 0.0187 0.041
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0287 0.3586 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0024 0.0201 0.0294
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0042 0.0041
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0042 0.1381
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0444 0.0691
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0187 0.0253
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0042 0.0041
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0085 0.0983 1
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0444 0.0429
Schistosoma mansoni hypothetical protein 0.0071 0.0803 0.1559
Onchocerca volvulus 0.0023 0.0187 0.128
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0091 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0217 0.035
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1198 0.191
Brugia malayi Cytochrome P450 family protein 0.0024 0.0201 0.0325
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0111 0.5
Brugia malayi hypothetical protein 0.049 0.6206 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0111 0.0196
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0187 0.0196
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0892 0.0978
Schistosoma mansoni cpg binding protein 0.003 0.0271 0.0505
Giardia lamblia PHD finger protein 15 0.0031 0.0287 0.0147
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0024 0.0201 0.0294
Treponema pallidum fructose-bisphosphate aldolase 0.0587 0.7458 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0024 0.0201 0.0294
Brugia malayi Cytochrome P450 family protein 0.0024 0.0201 0.0325
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1198 0.1184
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5063 0.5055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0024 0.0201 0.0451
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0042 0.1381
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0042 0.0051
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0091 0.0121
Leishmania major cytochrome p450-like protein 0.0024 0.0201 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0012 0.0042 0.0292
Echinococcus granulosus Smad4 0.0016 0.0091 0.0121
Loa Loa (eye worm) cytochrome P450 0.0024 0.0201 0.0325
Echinococcus granulosus cpg binding protein 0.003 0.0271 0.0412
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.023 0.0371
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.023 0.0346
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0042 0.1381
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.06 0.0967
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0042 0.0052
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0024 0.0201 0.0294
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.0179
Toxoplasma gondii exonuclease III APE 0.0023 0.018 0.0335
Onchocerca volvulus 0.01 0.1176 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0587 0.7458 1
Brugia malayi jmjC domain containing protein 0.001 0.0016 0.0026
Brugia malayi TATA binding protein associated factor 0.0012 0.0042 0.0067
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.1176 0.1895
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0024 0.0201 1
Entamoeba histolytica hypothetical protein 0.0071 0.0803 0.1026
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0667 0.133
Loa Loa (eye worm) hypothetical protein 0.0055 0.0599 0.0964
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0187 0.9218
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0187 0.041
Brugia malayi cytochrome P450 0.0024 0.0201 0.0325
Echinococcus granulosus histone acetyltransferase KAT2B 0.0085 0.0983 0.1562
Trichomonas vaginalis bromodomain-containing protein, putative 0.0085 0.0983 0.1269
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0091 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.06 0.0943
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0287 0.0438
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.018 0.0265
Echinococcus granulosus peregrin 0.0038 0.0379 0.0586
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0042 0.1381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.06 0.1157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.0179
Loa Loa (eye worm) hypothetical protein 0.0053 0.0573 0.0924
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0024 0.0201 0.0451
Echinococcus multilocularis GPCR, family 2 0.0031 0.0289 0.0273
Echinococcus granulosus intermediate filament protein 0.0055 0.0599 0.0941
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0024 0.0201 0.0451
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0042 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0289 0.0465
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0026
Schistosoma mansoni hypothetical protein 0.0401 0.5063 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0187 0.041
Schistosoma mansoni lamin 0.0055 0.0599 0.1154
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0037 0.0033
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0042 0.0052
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0024 0.0201 0.0294
Schistosoma mansoni cpg binding protein 0.003 0.0271 0.0505
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0201 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0018 0.0088
Entamoeba histolytica hypothetical protein 0.0071 0.0803 0.1026
Schistosoma mansoni survival motor neuron protein 0.01 0.1176 0.2298
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0587 0.7458 1
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0929 0.1808
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0024 0.0201 0.0294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.06 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0024 0.0201 0.0294
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0016 0.0026
Brugia malayi jmjC domain containing protein 0.001 0.0016 0.0026
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0042 0.0051
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0803 0.1559
Schistosoma mansoni hypothetical protein 0.0166 0.2031 0.3993
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0091 0.0147
Schistosoma mansoni smad 0.0016 0.0091 0.0149
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0392 0.0608
Plasmodium falciparum phd finger protein, putative 0.0031 0.0287 0.3096
Schistosoma mansoni smad1 5 8 and 0.0016 0.0091 0.0149
Brugia malayi acetyltransferase, GNAT family protein 0.0289 0.3615 0.5825
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0289 0.0273
Echinococcus multilocularis survival motor neuron protein 1 0.049 0.6206 0.62
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0024 0.0201 0.0294
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0301
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0042 0.1381
Schistosoma mansoni ap endonuclease 0.0023 0.018 0.0325
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.0179
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.023 0.0215
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0042 0.0041
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0024 0.0201 0.0451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0067
Loa Loa (eye worm) acetyltransferase 0.0289 0.3615 0.5825
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0301
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0042 0.1381
Onchocerca volvulus Alhambra homolog 0.0031 0.0287 0.2165
Loa Loa (eye worm) hypothetical protein 0.0067 0.0755 0.1216
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0018 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0803 0.1271
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0091 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0187 0.0301
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0392 0.0745
Loa Loa (eye worm) Smad1 0.0016 0.0091 0.0147
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0201 0.0451
Brugia malayi Bromodomain containing protein 0.0038 0.0379 0.061
Leishmania major cytochrome p450-like protein 0.0024 0.0201 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0226 0.2801 0.2789
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.018 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0024 0.0201 0.0294
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0042 0.0026
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.018 0.029
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0201 0.0325
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0287 0.3586 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0201 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0018 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0024 0.0201 0.0294
Schistosoma mansoni hypothetical protein 0.0031 0.0289 0.054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0187 0.0196
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0187 0.041
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0042 0.1381
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.018 0.039
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0042 0.0265
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5063 0.8153
Echinococcus granulosus smad 0.0016 0.0091 0.0121
Loa Loa (eye worm) hypothetical protein 0.0031 0.0287 0.0463
Brugia malayi Cytochrome P450 family protein 0.0024 0.0201 0.0325
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0392 0.0745
Plasmodium vivax hypothetical protein, conserved 0.0012 0.004 0.0246
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.018 0.8849
Schistosoma mansoni Smad4 0.0016 0.0091 0.0149
Loa Loa (eye worm) hypothetical protein 0.0031 0.0289 0.0465
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0024 0.0201 0.0294
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0187 0.041
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0042 0.0067
Brugia malayi Smad1 0.0016 0.0091 0.0147
Brugia malayi MH2 domain containing protein 0.0232 0.2887 0.4651
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0289 0.044
Brugia malayi jmjC domain containing protein 0.0039 0.0392 0.0632
Schistosoma mansoni hypothetical protein 0.0031 0.0289 0.054
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0024 0.0201 0.0294
Toxoplasma gondii cytochrome p450 superfamily protein 0.0389 0.4909 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0091 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0187 0.0301
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0024 0.0201 0.0451
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.025 0.0403
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0042 0.0026
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0372 0.0356
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0599 0.0964
Echinococcus multilocularis lamin dm0 0.0055 0.0599 0.0583
Brugia malayi MH2 domain containing protein 0.0016 0.0091 0.0147
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0042 0.0051
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0024 0.0201 0.0451
Loa Loa (eye worm) hypothetical protein 0.049 0.6206 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0042 0.0051
Schistosoma mansoni hypothetical protein 0.0024 0.0201 0.0367
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1156 0.1863
Mycobacterium leprae Conserved hypothetical protein 0.0024 0.0201 0.0043
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0289 0.044
Echinococcus multilocularis 0.0024 0.0201 0.0186
Schistosoma mansoni hypothetical protein 0.0067 0.0755 0.1463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0289 0.3615 0.3605
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0024 0.0201 0.0451
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.018 0.1872
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0281 0.3511 0.5645
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0024 0.0201 0.0294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0658 0.1271
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0024 0.0201 0.0451
Onchocerca volvulus 0.0055 0.0599 0.4909
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0287 0.0463
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0024 0.0201 0.0451
Giardia lamblia Fructose-bisphosphate aldolase 0.0587 0.7458 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0042 0.1381
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0026
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0024 0.0201 0.0451
Entamoeba histolytica hypothetical protein 0.0071 0.0803 0.1026
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0201 0.0325
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0024 0.0201 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0201 0.0325
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0024 0.0201 0.0451
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0201 1
Echinococcus multilocularis Smad4 0.0016 0.0091 0.0075
Schistosoma mansoni intermediate filament proteins 0.0055 0.0599 0.1154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.06 0.1157
Entamoeba histolytica hypothetical protein 0.0071 0.0803 0.1026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.0179
Echinococcus granulosus GPCR family 2 0.0031 0.0289 0.044
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0111 0.0982
Schistosoma mansoni hypothetical protein 0.0031 0.0289 0.054
Brugia malayi PHD-finger family protein 0.0031 0.0287 0.0463
Brugia malayi MH2 domain containing protein 0.0016 0.0091 0.0147
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.2887 0.4651
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0042 0.1381
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0187 0.041
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0024 0.0201 0.0294
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0392 0.0632
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0226 0.2801 0.4513
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0287 0.0554
Schistosoma mansoni hypothetical protein 0.0166 0.2031 0.3993
Trypanosoma cruzi Aminopeptidase M1, putative 0.0012 0.0042 0.1381
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.0179
Echinococcus granulosus lamin 0.0055 0.0599 0.0941
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0042 0.1381
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.018 0.8849
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.2887 0.4651
Schistosoma mansoni hypothetical protein 0.0031 0.0287 0.0537
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0042 0.1381
Schistosoma mansoni hypothetical protein 0.001 0.0018 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1156 0.1863
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0042 0.0026
Echinococcus multilocularis smad 0.0016 0.0091 0.0075
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.004 0.0272
Brugia malayi jmjC domain containing protein 0.001 0.0016 0.0026
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0599 0.0964
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.018 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0024 0.0201 0.0451
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0599 0.0964
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.018 0.0187
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0803 0.0788
Brugia malayi jmjC domain containing protein 0.0102 0.1198 0.1931
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0018 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0187 0.0301
Echinococcus multilocularis musashi 0.0055 0.0599 0.0583
Schistosoma mansoni lamin 0.0055 0.0599 0.1154
Loa Loa (eye worm) hypothetical protein 0.0054 0.0586 0.0943
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0042 0.1381
Brugia malayi CXXC zinc finger family protein 0.0028 0.025 0.0403
Schistosoma mansoni ap endonuclease 0.0023 0.018 0.0325
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0024 0.0201 0.0294
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0016 0.0026
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0289 0.0465
Brugia malayi hypothetical protein 0.0104 0.1227 0.1977
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0187 0.9218
Mycobacterium leprae putative cytochrome p450 0.0024 0.0201 0.0043
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0226 0.2801 0.5518
Schistosoma mansoni smad1 5 8 and 0.0016 0.0091 0.0149
Echinococcus multilocularis lamin 0.0055 0.0599 0.0583
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.018 0.0187
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0201 0.0299
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0091 0.0149
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0024 0.0201 0.0451
Brugia malayi hypothetical protein 0.0071 0.0803 0.1294
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0042 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0201 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.06 0.1157
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0268 0.0432
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0024 0.0201 0.0294
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0024 0.0201 0.0451
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0108 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.06 0.0585
Brugia malayi AF-10 protein 0.001 0.0018 0.0029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0187 0.0253
Echinococcus multilocularis cpg binding protein 0.003 0.0271 0.0255
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0016 0.0026
Schistosoma mansoni hypothetical protein 0.0031 0.0289 0.054
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0201 1
Echinococcus granulosus survival motor neuron protein 1 0.049 0.6206 1
Onchocerca volvulus 0.0055 0.0599 0.4909
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0024 0.0201 0.0294
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0042 0.1381
Brugia malayi MH1 domain containing protein 0.0016 0.0091 0.0147
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0024 0.0201 0.0451
Schistosoma mansoni cpg binding protein 0.0028 0.025 0.0464
Loa Loa (eye worm) hypothetical protein 0.0098 0.1156 0.1863
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0085 0.0983 0.1976
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0111 0.1084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0289 0.3615 0.7131
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0024 0.0201 0.0294
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0892 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0587 0.7458 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0714 0.115
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0024 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0301
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0042 0.1381
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.06 0.0967
Loa Loa (eye worm) hypothetical protein 0.0026 0.0217 0.035
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0042 0.0041
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0024 0.0201 0.0451
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0085 0.0983 0.1976
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0024 0.0201 0.0294
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0289 0.0273
Schistosoma mansoni hypothetical protein 0.01 0.1176 0.2298
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.018 0.0187
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0042 0.0067
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0024 0.0201 0.0451
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0042 0.0067
Brugia malayi hypothetical protein 0.0012 0.0042 0.0067
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0287 0.3586 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0111 0.0035

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0056 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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