Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | FBJ murine osteosarcoma viral oncogene homolog | Starlite/ChEMBL | References |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR011616,bZIP transcription factor, bZIP_1;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic tran | Get druggable targets OG5_142533 | All targets in OG5_142533 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0242 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0209 | 0.8517 | 0.8517 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0242 | 1 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0242 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0033 | 0.0709 | 0.5 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.3188 | 0.3188 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0709 | 0.0703 |
Onchocerca volvulus | 0.0033 | 0.0709 | 0.5 | |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0007 | 0.0007 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0033 | 0.0709 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0242 | 1 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.0709 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0033 | 0.0709 | 0.0709 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0033 | 0.0709 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0033 | 0.0709 | 0.0703 |
Leishmania major | fk506-binding protein 1-like protein | 0.0242 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0242 | 1 | 1 |
Echinococcus multilocularis | 0.0033 | 0.0709 | 0.0709 | |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0242 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0242 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0033 | 0.0709 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0242 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0242 | 1 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0242 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.0709 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.8517 | 0.8516 |
Schistosoma mansoni | fk506 binding protein | 0.0033 | 0.0709 | 0.0709 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0242 | 1 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0242 | 1 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0033 | 0.0709 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0242 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0242 | 1 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0007 | 0.0007 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0242 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0033 | 0.0709 | 0.0703 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0033 | 0.0709 | 0.0709 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0242 | 1 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0033 | 0.0709 | 0.0709 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.3188 | 0.3188 |
Echinococcus multilocularis | fk506 binding protein | 0.0242 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0242 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0209 | 0.8517 | 0.8517 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0033 | 0.0709 | 0.0703 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0033 | 0.0709 | 0.0709 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0709 | 0.0709 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0242 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0242 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0242 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0033 | 0.0709 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0242 | 1 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0033 | 0.0709 | 0.0709 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0033 | 0.0709 | 0.0709 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0242 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0242 | 1 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0033 | 0.0709 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0033 | 0.0709 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0242 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0242 | 1 | 1 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0007 | 0.0007 |
Schistosoma mansoni | immunophilin | 0.0209 | 0.8517 | 0.8517 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7 uM | Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells | ChEMBL. | 10937715 |
IC50 (functional) | = 7 uM | Inhibition of NF-kB mediated transcriptional activation in Jurkat T-cells | ChEMBL. | 10937715 |
IC50 (functional) | = 7 uM | Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells | ChEMBL. | 10937715 |
IC50 (functional) | = 7 uM | Inhibition of NF-kB mediated transcriptional activation in Jurkat T-cells | ChEMBL. | 10937715 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.