Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glutathione reductase | 0.0047 | 0.2217 | 0.44 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0225 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1747 | 0.4348 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1562 | 0.2673 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.3454 | 0.3358 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2101 | 0.644 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.2217 | 0.5519 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.7677 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2101 | 0.1985 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.2217 | 0.6822 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.6772 | 0.8342 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.7677 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2101 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4018 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2101 | 0.4094 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1568 | 0.3902 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.2217 | 0.6822 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.6772 | 0.8342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2101 | 0.644 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1892 | 0.4709 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2101 | 0.644 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.2217 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.2217 | 0.44 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.2217 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0369 | 0.0739 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.2217 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.6772 | 0.8342 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0369 | 0.0228 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2101 | 0.5231 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.3183 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.2217 | 0.5519 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2101 | 0.644 |
Leishmania major | trypanothione reductase | 0.0047 | 0.2217 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1383 | 0.4076 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.2217 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.6772 | 0.8342 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.2217 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.4341 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.2217 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.2217 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1383 | 0.4076 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.7677 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.3183 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.7677 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0369 | 0.0739 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.6772 | 0.8342 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.6772 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0225 | 0.0081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2101 | 0.1985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.