Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3213 | 0.9262 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0134 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0134 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0134 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1149 | 0.5 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0038 | 0.1149 | 0.1149 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.006 | 0.3213 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0134 | 1 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0071 | 0.4172 | 0.4172 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0134 | 1 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.1149 | 0.3576 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.1149 | 0.5 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.1149 | 0.5 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0071 | 0.4172 | 0.3415 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0071 | 0.4172 | 0.3415 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0038 | 0.1149 | 1 |
Onchocerca volvulus | 0.006 | 0.3213 | 0.5 | |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.3404 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.006 | 0.3213 | 0.2332 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.1149 | 0.3576 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0134 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0059 | 0.3119 | 0.3119 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0071 | 0.4172 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0071 | 0.4172 | 0.3584 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.006 | 0.3213 | 0.3213 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0071 | 0.4172 | 0.3415 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.1149 | 0.3576 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0059 | 0.3119 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.006 | 0.3213 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0059 | 0.3119 | 0.9706 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0134 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0059 | 0.3119 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1149 | 0.1268 |
Schistosoma mansoni | 6-phosphofructokinase | 0.006 | 0.3213 | 0.2332 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0038 | 0.1149 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0134 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3119 | 0.8896 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0071 | 0.4172 | 0.3584 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.006 | 0.3213 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.006 | 0.3213 | 0.2332 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.