Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8317 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8317 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8317 | 0.5 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0936 | 0.0936 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.8515 | 0.8515 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.8515 | 0.8515 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.8515 | 0.8515 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.3234 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.8515 | 0.8515 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 1 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.8515 | 0.8515 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.8317 | 0.8317 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.8317 | 0.8317 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.3234 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.3234 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.8515 | 0.8515 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.8317 | 0.8317 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.8515 | 0.8515 |
Brugia malayi | hypothetical protein | 0.0024 | 0.3234 | 0.3234 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.8317 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.3234 | 0.3234 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.8317 | 0.8317 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.8317 | 0.8317 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.8515 | 0.8515 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.8515 | 0.8515 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.