Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2279 | 0.2275 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0011 | 0.0006 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0236 | 0.0347 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.164 | 0.1635 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0175 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0552 | 0.0809 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0264 | 0.0388 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0821 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.639 | 0.6388 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0821 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.639 | 0.6388 |
Onchocerca volvulus | 0.003 | 0.1141 | 0.1136 | |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0444 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0444 | 0.0651 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.034 | 0.0499 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0444 | 0.1272 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.034 | 0.0499 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0444 | 0.537 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0444 | 0.0651 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0444 | 0.0438 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0006 | 0.0008 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0011 | 0.0006 | 0.0008 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1459 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0264 | 0.0388 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.034 | 0.0499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.682 | 1 |
Echinococcus multilocularis | Chromo domain | 0.0011 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2279 | 0.2275 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1456 | 0.2135 |
Echinococcus granulosus | Chromobox protein 3 | 0.0011 | 0.0006 | 0.0008 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.164 | 0.4746 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0444 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0444 | 0.537 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2862 | 0.4196 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.034 | 0.0335 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0444 | 0.1272 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0013 | 0.0119 | 0.0174 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0013 | 0.0119 | 0.0174 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0444 | 0.5 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0013 | 0.0119 | 0.0113 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1459 | 0.2139 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0294 | 0.0288 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0013 | 0.0119 | 0.0174 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0264 | 0.0259 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0444 | 0.3545 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.682 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0264 | 0.0388 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0444 | 0.3545 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.3449 | 0.5057 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1459 | 0.2139 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2279 | 0.2275 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1459 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.3449 | 1 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0011 | 0.0006 | 0.0008 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0264 | 0.0259 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2279 | 0.2275 |
Schistosoma mansoni | chromobox protein | 0.0011 | 0.0006 | 0.0008 |
Schistosoma mansoni | chromobox protein | 0.0011 | 0.0006 | 0.0008 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.3073 | 0.4506 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1459 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.164 | 0.1635 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1347 | 0.1342 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0264 | 0.0388 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0444 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0444 | 0.3545 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0444 | 0.3014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0966 | 0.2789 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0552 | 0.0546 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0444 | 0.0651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.164 | 0.4746 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.164 | 0.1635 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0444 | 0.537 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 0.3449 | 0.3445 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0264 | 0.0259 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0821 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0665 | 0.0975 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0264 | 0.0259 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.3449 | 0.5057 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0264 | 0.0388 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.1815 | 0.181 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1347 | 0.1975 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.034 | 0.0499 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0011 | 0.0006 | 0.0008 |
Echinococcus multilocularis | chromobox protein 2 | 0.0011 | 0.0006 | 0.0008 |
Brugia malayi | Heterochromatin protein 1 | 0.0067 | 0.3449 | 0.3445 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0011 | 0.0006 | 0.0008 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.034 | 0.0499 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0665 | 0.0975 |
Brugia malayi | CHD4 protein | 0.0013 | 0.0119 | 0.0113 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.3449 | 0.5057 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.3449 | 0.5057 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0821 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0123 | 0.682 | 0.6819 |
Brugia malayi | TAR-binding protein | 0.0123 | 0.682 | 0.6819 |
Loa Loa (eye worm) | TAR-binding protein | 0.0123 | 0.682 | 0.6819 |
Echinococcus granulosus | tar DNA binding protein | 0.0123 | 0.682 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0264 | 0.0388 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0264 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3513 | 0.3509 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.034 | 0.0499 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0821 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0444 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1347 | 0.1342 |
Echinococcus granulosus | Chromo domain | 0.0011 | 0.0006 | 0.0008 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0123 | 0.682 | 0.6819 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0821 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0821 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0444 | 0.0651 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0665 | 0.0975 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0444 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.3449 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1815 | 0.5254 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1141 | 0.1136 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0489 | 0.0717 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0805 | 0.0799 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0821 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.16 | 0.1596 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0821 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.034 | 0.0499 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1459 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.3766 | 0.3762 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.3449 | 0.5057 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1596 | 0.1591 |
Echinococcus multilocularis | tar DNA binding protein | 0.0123 | 0.682 | 1 |
Echinococcus granulosus | chromobox protein 2 | 0.0011 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.174 | 0.1736 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0444 | 0.3545 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0821 | 0.0816 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0264 | 0.0388 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1456 | 0.2135 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1459 | 0.1454 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1853 | 0.1849 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1815 | 0.5254 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0.0236 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1459 | 0.2139 |
Brugia malayi | RNA binding protein | 0.0123 | 0.682 | 0.6819 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2862 | 0.4196 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1459 | 0.2139 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0489 | 0.0717 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0011 | 0.0006 | 0.0008 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.682 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0489 | 0.0717 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.3449 | 0.5057 |
Loa Loa (eye worm) | RNA binding protein | 0.0123 | 0.682 | 0.6819 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.682 | 1 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.034 | 0.0499 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0264 | 0.0388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.682 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.639 | 0.6388 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0011 | 0.0006 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0264 | 0.0388 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0966 | 0.2789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.