Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.1476 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1476 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0688 | 0.0579 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.064 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1476 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1476 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1476 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1476 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1476 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1476 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1476 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1476 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1476 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1476 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0688 | 0.0579 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | In vitro antibacterial activity of ATCC6303 strain of Gram positive bacteria S. pneumoniae | ChEMBL. | 9572891 |
MIC (functional) | = 0.05 ug ml-1 | In vitro antibacterial activity of A5177 strain of Gram positive bacteria S. aureus | ChEMBL. | 9572891 |
MIC (functional) | = 0.1 ug ml-1 | In vitro antibacterial activity of 6538P strain of Gram positive bacteria S. aureus | ChEMBL. | 9572891 |
MIC (functional) | = 0.125 ug ml-1 | In vitro antibacterial activity of EES61 strain of Gram positive bacteria S. pyogenes | ChEMBL. | 9572891 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity of PIU2584 strain of Gram positive bacteria S. pyogenes | ChEMBL. | 9572891 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity of 5649 strain of Gram positive bacteria S. pneumoniae | ChEMBL. | 9572891 |
MIC (functional) | = 16 ug ml-1 | In vitro antibacterial activity of 930 strain of Gram positive bacteria S. pyogenes | ChEMBL. | 9572891 |
MIC (functional) | = 16 ug ml-1 | In vitro antibacterial activity of 5979 strain of Gram positive bacteria S. pneumoniae | ChEMBL. | 9572891 |
MIC (functional) | = 16 ug ml-1 | In vitro antibacterial activity of DILL strain of Gram positive bacteria Haemophilus influenzae | ChEMBL. | 9572891 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity of A-5278 strain of Gram positive bacteria S. aureus | ChEMBL. | 9572891 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.