Detailed information for compound 63543

Basic information

Technical information
  • TDR Targets ID: 63543
  • Name: 1-[2-methyl-6-[3-[5-(methylsulfonylmethyl)-4- phenylimidazol-1-yl]propoxy]phenyl]-3-pentylu rea
  • MW: 512.664 | Formula: C27H36N4O4S
  • H donors: 2 H acceptors: 4 LogP: 4 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCNC(=O)Nc1c(OCCCn2cnc(c2CS(=O)(=O)C)c2ccccc2)cccc1C
  • InChi: 1S/C27H36N4O4S/c1-4-5-9-16-28-27(32)30-25-21(2)12-10-15-24(25)35-18-11-17-31-20-29-26(22-13-7-6-8-14-22)23(31)19-36(3,33)34/h6-8,10,12-15,20H,4-5,9,11,16-19H2,1-3H3,(H2,28,30,32)
  • InChiKey: SZEDNMLLVAYOTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-methyl-6-[3-[5-(methylsulfonylmethyl)-4-phenyl-imidazol-1-yl]propoxy]phenyl]-3-pentyl-urea
  • 1-[2-methyl-6-[3-[5-(methylsulfonylmethyl)-4-phenyl-1-imidazolyl]propoxy]phenyl]-3-pentylurea
  • 1-amyl-3-[2-[3-[5-(mesylmethyl)-4-phenyl-imidazol-1-yl]propoxy]-6-methyl-phenyl]urea
  • 3-[2-methyl-6-[3-[5-(methylsulfonylmethyl)-4-phenylimidazol-1-yl]propoxy]phenyl]-1-pentylurea
  • 3-[2-methyl-6-[3-[5-(methylsulfonylmethyl)-4-phenyl-imidazol-1-yl]propoxy]phenyl]-1-pentyl-urea
  • 3-[2-methyl-6-[3-[5-(methylsulfonylmethyl)-4-phenyl-1-imidazolyl]propoxy]phenyl]-1-pentylurea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Acyl-CoA:cholesterol acyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl-CoA:cholesterol acyltransferase   305 aa 278 aa 21.9 %
Neospora caninum sterol O-acyltransferase, putative Acyl-CoA:cholesterol acyltransferase   305 aa 258 aa 20.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0901
Mycobacterium ulcerans DNA polymerase IV 0.0139 0.1446 0.1322
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0131 0.0409
Echinococcus multilocularis musashi 0.0027 0.0146 0.0462
Echinococcus granulosus jun protein 0.0082 0.0781 0.2674
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0038 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0914 0.32
Schistosoma mansoni coup transcription factor 0.0038 0.0268 0.0887
Echinococcus multilocularis heat shock protein 0.0045 0.0357 0.1198
Loa Loa (eye worm) DR-78 0.0018 0.0038 0.0126
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0268 0.0901
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0356 0.1198
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0069 0.0629 0.2143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0268 0.0901
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0901
Trichomonas vaginalis DNA helicase recq1, putative 0.0048 0.0386 0.105
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0268 0.0901
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0357 0.24
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0061 0.0264
Plasmodium falciparum phd finger protein, putative 0.0029 0.0171 0.0873
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0268 0.0887
Loa Loa (eye worm) endoplasmin 0.0045 0.0357 0.1201
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0067 0.048
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0879 1 1
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0086 0.0832 0.2852
Brugia malayi MBOAT family protein 0.0026 0.0131 0.0439
Brugia malayi MBOAT family protein 0.0026 0.0131 0.0439
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0357 0.1902
Echinococcus granulosus geminin 0.017 0.1801 0.6223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0179 0.0578
Loa Loa (eye worm) hypothetical protein 0.005 0.0414 0.1392
Schistosoma mansoni heat shock protein 0.0045 0.0357 0.1198
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0325 0.0801
Leishmania major hypothetical protein, conserved 0.0026 0.0131 0.1056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0139 0.1446 1
Leishmania major hypothetical protein, conserved 0.005 0.0414 0.3606
Mycobacterium tuberculosis Conserved hypothetical protein 0.0086 0.0832 0.082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0001
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0087 0.0515
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0131 0.0439
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.0832 0.2801
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0171 0.055
Echinococcus granulosus dna polymerase eta 0.0112 0.1124 0.3867
Brugia malayi Pre-SET motif family protein 0.003 0.0179 0.0602
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0013 0.0043
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0662 0.2226
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.1194
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0146 0.049
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0061 0.0167
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1199 0.4037
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0304 0.1012
Entamoeba histolytica hypothetical protein 0.0107 0.1069 1
Leishmania major DNA polymerase kappa, putative 0.01 0.0985 0.8744
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0714 0.2439
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0171 0.0873
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0268 0.0902
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0414 0.2796
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0131 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0268 0.0901
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0131 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0414 0.2216
Brugia malayi photoreceptor-specific nuclear receptor 0.0271 0.2971 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0439
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0131 0.0819
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0414 0.2796
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0914 0.3076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Echinococcus granulosus peregrin 0.0029 0.0171 0.055
Loa Loa (eye worm) pax transcription factor protein 2 0.0238 0.2588 0.8712
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0464
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0532 0.1789
Brugia malayi hypothetical protein 0.0107 0.1069 0.3597
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0131 0.0409
Plasmodium vivax heat shock protein, putative 0.0172 0.1821 1
Brugia malayi hypothetical protein 0.0064 0.0578 0.1943
Entamoeba histolytica hypothetical protein 0.0026 0.0131 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0139 0.1446 1
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.2886 1
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1069 0.3675
Schistosoma mansoni tsg101-related 0.0047 0.0374 0.1257
Trichomonas vaginalis DNA helicase recq, putative 0.0048 0.0386 0.105
Onchocerca volvulus 0.0238 0.2584 0.9983
Plasmodium vivax DNA repair protein REV1, putative 0.0027 0.0143 0.0716
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0038 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0914 0.32
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0038 0.0126
Trypanosoma brucei unspecified product 0.006 0.0522 0.3551
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0138 0.0464
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1069 0.3675
Schistosoma mansoni heat shock protein 0.003 0.0181 0.0585
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0087 0.0515
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0131 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0268 0.0901
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1199 0.4037
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0268 0.0887
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0131 0.0819
Schistosoma mansoni endoplasmin 0.0045 0.0357 0.1198
Onchocerca volvulus 0.0027 0.0146 0.0423
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0131 0.0026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0901
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0914 0.3076
Brugia malayi hypothetical protein 0.0018 0.0038 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.1194
Giardia lamblia DINP protein human, muc B family 0.01 0.0985 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0585 0.3989
Plasmodium vivax heat shock protein 90, putative 0.003 0.0181 0.0928
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0112 0.1124 0.7754
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0914 0.6288
Treponema pallidum heat shock protein 90 0.0043 0.0325 1
Echinococcus multilocularis endoplasmin 0.0043 0.0325 0.1085
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.01 0.0985 0.8744
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0018 0.0046 0.0155
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0268 0.0887
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0942 0.3232
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0027 0.0143 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0268 0.0901
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0171 0.055
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0038 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0756 0.5186
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0202 0.1046
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0268 0.0887
Trypanosoma cruzi DNA damage repair protein, putative 0.0027 0.0143 0.0904
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0357 0.0932
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0155
Brugia malayi Hhat protein 0.0026 0.0131 0.0439
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0013 0.0043
Echinococcus multilocularis geminin 0.017 0.1801 0.6223
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0268 0.0887
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0357 0.2433
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0131 0.0409
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0325 0.0801
Echinococcus granulosus dna polymerase kappa 0.0139 0.1446 0.4987
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0781 0.2674
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0061 0.0205
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0062 0.0172
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0065 0.0585 0.3989
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0268 0.0901
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0985 0.678
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0038 0.0126
Entamoeba histolytica hypothetical protein 0.0107 0.1069 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0131 0.0409
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0403 0.1357
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0062 0.0172
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0357 0.24
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0018 0.0046 0.0155
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0179 0.0578
Giardia lamblia DNA damage repair protein 0.0027 0.0143 0.0886
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.2886 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0042 0.0319 0.169
Trypanosoma brucei unspecified product 0.006 0.0522 0.3551
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0268 0.0902
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0067 0.0603 0.2029
Echinococcus granulosus heat shock protein 0.0045 0.0357 0.1198
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0018 0.0046 0.0155
Brugia malayi nuclear receptor NHR-88 0.0018 0.0038 0.0126
Brugia malayi tailless protein 0.0018 0.0038 0.0126
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0069 0.0629 0.2143
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0131 0.1056
Loa Loa (eye worm) hypothetical protein 0.0238 0.2588 0.871
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0914 0.32
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0138 0.0435
Onchocerca volvulus 0.003 0.0179 0.0554
Schistosoma mansoni DNA polymerase IV / kappa 0.0027 0.0143 0.0452
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0914 0.3136
Loa Loa (eye worm) hhat protein 0.0026 0.0131 0.0439
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0281 0.0934
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0357 0.24
Trypanosoma cruzi DNA polymerase kappa, putative 0.0139 0.1446 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0403 0.1357
Echinococcus granulosus heat shock protein 90 0.0045 0.0357 0.1198
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0038 0.0126
Schistosoma mansoni nuclear receptor 0.0018 0.0038 0.0086
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0131 0.0026
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0128 0.0802
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0268 0.0887
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0179 0.0578
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0268 0.0887
Echinococcus multilocularis jun protein 0.0082 0.0781 0.2674
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0067 0.0295
Trichomonas vaginalis DNA polymerase eta, putative 0.0139 0.1446 0.5365
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0213 0.0346
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0268 0.0887
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0131 0.0649
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0268 0.0887
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0131 0.001
Leishmania major DNA polymerase eta, putative 0.0112 0.1124 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0131 0.0409
Brugia malayi jmjC domain containing protein 0.0096 0.0942 0.3169
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0268 0.0887
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0242 0.0798
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0131 0.0409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0268 0.0887
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0086 0.0832 0.2852
Echinococcus multilocularis expressed protein 0.0067 0.0603 0.2053
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Brugia malayi MBOAT family protein 0.0026 0.0131 0.0439
Loa Loa (eye worm) hypothetical protein 0.0123 0.1256 0.4226
Leishmania major hypothetical protein, conserved 0.0022 0.0087 0.0664
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0209
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0 0.5
Leishmania major glycerol uptake protein, putative 0.0026 0.0131 0.1056
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0357 0.24
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0179 0.0578
Echinococcus multilocularis lamin 0.0027 0.0146 0.0462
Brugia malayi nuclear receptor NHR-88 0.0038 0.0268 0.0901
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Loa Loa (eye worm) fli-1 protein 0.0218 0.235 0.791
Schistosoma mansoni hypothetical protein 0.0023 0.0093 0.0279
Onchocerca volvulus 0.0238 0.2588 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0038 0.0086
Trichomonas vaginalis rotamase, putative 0.0067 0.0603 0.1933
Onchocerca volvulus 0.0026 0.0138 0.0393
Brugia malayi Fli-1 protein 0.0218 0.235 0.791
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0052 0.0434 0.233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Trypanosoma brucei DNA polymerase IV, putative 0.0139 0.1446 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0575
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0209
Trypanosoma brucei DNA polymerase eta, putative 0.0112 0.1124 0.7754
Toxoplasma gondii peptidylprolyl isomerase 0.0065 0.0585 0.3161
Echinococcus multilocularis heat shock protein 90 0.0045 0.0357 0.1198
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0038 0.0086
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0914 0.8355
Brugia malayi intermediate filament protein 0.0027 0.0146 0.049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Toxoplasma gondii hypothetical protein 0.0026 0.0131 0.0649
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0001
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0268 0.0887
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0171 0.0873
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.01 0.0985 0.0973
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0038 0.0086
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0356 0.1198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0155
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0268 0.0887
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0242 0.0798
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0325 0.0312
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0067 0.0372
Brugia malayi heat shock protein 90 0.0045 0.0357 0.1201
Brugia malayi MBOAT family protein 0.0026 0.0131 0.0439
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0061 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0223 0.0749
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0357 0.24
Brugia malayi ecdysone receptor 0.0018 0.0038 0.0126
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0914 0.32
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0062 0.0209
Loa Loa (eye worm) hypothetical protein 0.008 0.0755 0.2542
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0038 0.0126
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0942 0.3232
Echinococcus granulosus intermediate filament protein 0.0027 0.0146 0.0462
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0281 0.1871
Entamoeba histolytica deoxycytidyl transferase, putative 0.0086 0.0832 0.7487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0268 0.0901
Entamoeba histolytica hypothetical protein 0.0107 0.1069 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0131 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0143 0.0904
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0131 0.001
Brugia malayi polk-prov protein 0.008 0.0756 0.2545
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0414 0.2216
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0001
Schistosoma mansoni hypothetical protein 0.0126 0.1295 0.4461
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0181 0.117
Loa Loa (eye worm) hypothetical protein 0.0112 0.1124 0.3783
Brugia malayi hypothetical protein 0.0032 0.0208 0.0699
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0061 0.0205
Schistosoma mansoni DNA helicase recq1 0.002 0.0061 0.0167
Brugia malayi Pax transcription factor protein 2 0.0238 0.2588 0.8712
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0143 0.0904
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0131 0.0439
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0357 0.2433
Brugia malayi hypothetical protein 0.0018 0.0038 0.0126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0901
Schistosoma mansoni kinase 0.0048 0.0382 0.1285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0268 0.0901
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0143 0.0904
Schistosoma mansoni hypothetical protein 0.0029 0.0171 0.055
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0061 0.0167
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0131 0.0409
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0242 0.0798
Schistosoma mansoni DNA helicase recq5 0.002 0.0061 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0268 0.0887
Brugia malayi nuclear receptor RXR 0.0018 0.0038 0.0126
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0131 0.0409
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0171 0.055
Brugia malayi Bromodomain containing protein 0.0029 0.0171 0.0575
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0356 0.1194
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0357 0.1902
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0131 0.0409
Toxoplasma gondii Hsp90 domain-containing protein 0.0172 0.1821 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0781 0.2674
Trypanosoma cruzi DNA damage repair protein, putative 0.0027 0.0143 0.0904
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0268 0.0887
Schistosoma mansoni DNA polymerase eta 0.0112 0.1124 0.3867
Echinococcus multilocularis lamin dm0 0.0027 0.0146 0.0462
Schistosoma mansoni lamin 0.0027 0.0146 0.0462
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0038 0.0086
Echinococcus multilocularis peregrin 0.0029 0.0171 0.055
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0138 0.0435
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0181 0.0585
Onchocerca volvulus 0.0026 0.0131 0.0364
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0131 0.0409
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0914 0.3136
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0131 0.0439
Mycobacterium ulcerans proteasome PrcA 0.0879 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0062 0.0209
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0181 0.0561
Echinococcus multilocularis dna polymerase eta 0.0112 0.1124 0.3867
Brugia malayi isocitrate dehydrogenase 0.0016 0.0013 0.0044
Brugia malayi jmjC domain containing protein 0.0035 0.0242 0.0815
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1069 0.3675
Loa Loa (eye worm) hypothetical protein 0.003 0.0179 0.0602
Schistosoma mansoni ets-related 0.0218 0.235 0.8134
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0018 0.0046 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0368 0.0976
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.225 0.7573
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0166 0.0534
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0018 0.0046 0.0116
Leishmania major glycerol uptake protein, putative 0.0026 0.0131 0.1056
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0137 0.0686
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0143 0.0904
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0061 0.0167
Schistosoma mansoni gabp alpha 0.0072 0.0662 0.2258
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0093 0.0279
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0131 0.0026
Onchocerca volvulus 0.0038 0.0268 0.0902
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0131 0.0819
Leishmania major glycerol uptake protein, putative 0.0026 0.0131 0.1056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0439
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0662 0.2258
Giardia lamblia Kinase, PLK 0.0093 0.0914 0.9236
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0038 0.0086
Brugia malayi Pre-SET motif family protein 0.0209 0.225 0.7573
Leishmania major heat shock protein, putative 0.003 0.0181 0.1509
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0067 0.0372
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Brugia malayi Bloom's syndrome protein homolog 0.0048 0.0386 0.1299
Loa Loa (eye worm) hhat protein 0.0026 0.0131 0.0439
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0268 0.0887
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0131 0.0439
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0414 0.2216
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0131 0.0754
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0268 0.0887
Brugia malayi hypothetical protein 0.0026 0.0138 0.0464
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0357 0.1201
Leishmania major glycerol uptake protein, putative 0.0026 0.0131 0.1056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0268 0.0901
Brugia malayi MH2 domain containing protein 0.0118 0.1199 0.4037
Brugia malayi MBOAT family protein 0.0026 0.0131 0.0439
Schistosoma mansoni hypothetical protein 0.0026 0.0131 0.0409
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0281 0.2385
Brugia malayi steroid hormone receptor 0.0038 0.0268 0.0901
Brugia malayi nuclear hormone receptor 0.0038 0.0268 0.0901
Entamoeba histolytica hypothetical protein 0.0107 0.1069 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0086 0.0832 0.2801
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0356 0.1194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0139 0.1446 1
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0756 0.5186
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0674 0.4614
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0062 0.0209
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0013 0.0001
Brugia malayi bZIP transcription factor family protein 0.0082 0.0781 0.2629
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0268 0.0901
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0268 0.0887
Schistosoma mansoni thyroid hormone receptor 0.0164 0.173 0.5977
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0281 0.1871
Brugia malayi hypothetical protein 0.005 0.0414 0.1392
Schistosoma mansoni tsg101-related 0.0057 0.0496 0.1679
Echinococcus granulosus bloom syndrome protein 0.0048 0.0386 0.1299
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0674 0.4614
Loa Loa (eye worm) hypothetical protein 0.005 0.0413 0.139
Brugia malayi ImpB/MucB/SamB family protein 0.0112 0.1124 0.3783
Brugia malayi Hsp90 protein 0.003 0.0181 0.0608
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0131 0.0439
Plasmodium falciparum flap endonuclease 1 0.0026 0.0131 0.0649
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.173 0.5977
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0038 0.0086
Brugia malayi hypothetical protein 0.0018 0.0046 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0368 0.0976
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0171 0.0873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.1194
Leishmania major DNA polymerase kappa, putative 0.0027 0.0143 0.1165
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Loa Loa (eye worm) hypothetical protein 0.0069 0.0629 0.2116
Onchocerca volvulus Alhambra homolog 0.0029 0.0171 0.0523
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0268 0.0887
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0038 0.0126
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0268 0.0887
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0901
Leishmania major DNA damage repair protein, putative 0.0027 0.0143 0.1165
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0131 0.0439
Brugia malayi nuclear hormone receptor 0.0018 0.0038 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0268 0.0901
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0914 0.3436
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0086 0.0832 0.2852
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0067 0.0603 0.2029
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0325 0.2805
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0131 0.0026
Brugia malayi hypothetical protein 0.0018 0.0046 0.0155
Echinococcus granulosus expressed protein 0.0067 0.0603 0.2053
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0414 0.2216
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0131 0.0439
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0128 0.1035
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0414 0.2796
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0357 0.3206
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0181 0.0561
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0131 0.0409
Schistosoma mansoni tsg101-related 0.0057 0.0496 0.1679
Echinococcus multilocularis dna polymerase kappa 0.0139 0.1446 0.4987
Loa Loa (eye worm) heat shock protein 75 0.003 0.0181 0.0608
Brugia malayi Endoplasmin precursor 0.0045 0.0357 0.1201
Schistosoma mansoni hypothetical protein 0.0067 0.0604 0.2055
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0439
Echinococcus granulosus lamin dm0 0.0027 0.0146 0.0462
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0357 0.24
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0268 0.0901
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0131 0.0409
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0914 0.32
Schistosoma mansoni lamin 0.0027 0.0146 0.0462
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0038 0.0126
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0131 0.0649
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0131 0.0409
Trypanosoma cruzi heat shock protein, putative 0.003 0.0181 0.117
Loa Loa (eye worm) hypothetical protein 0.0271 0.2971 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0131 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0268 0.0902
Giardia lamblia PHD finger protein 15 0.0029 0.0171 0.1192
Schistosoma mansoni thyroid hormone receptor 0.0164 0.173 0.5977
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0131 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.004 0.0295 0.1558
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0242 0.0798
Schistosoma mansoni zinc finger protein 0.0026 0.0131 0.0409
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0131 0.0409
Trypanosoma cruzi DNA polymerase eta, putative 0.0052 0.0434 0.294
Brugia malayi nuclear receptor RXR 0.002 0.0062 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0268 0.0901
Loa Loa (eye worm) hypothetical protein 0.0034 0.0223 0.0749
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1295 0.4461
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0131 0.0649
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0171 0.0575
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Loa Loa (eye worm) hypothetical protein 0.0241 0.262 0.8818
Trypanosoma brucei DNA damage repair protein, putative 0.0027 0.0143 0.0904
Loa Loa (eye worm) hypothetical protein 0.0123 0.1256 0.4226
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0131 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0179 0.0578
Plasmodium falciparum heat shock protein 90, putative 0.0172 0.1821 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0131 0.0409
Trypanosoma brucei unspecified product 0.0126 0.1294 0.8938
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0067 0.0372
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0131 0.0819
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0131 0.0819
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0131 0.001
Schistosoma mansoni blooms syndrome DNA helicase 0.0038 0.027 0.0893
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0013 0.0044
Onchocerca volvulus Protein cycle homolog 0.0018 0.0046 0.0033
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0049 0.0403 0.1357
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0357 0.1902
Plasmodium vivax SET domain protein, putative 0.003 0.0179 0.0918
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0603 0.1933
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0131 0.0409
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0131 0.0649
Brugia malayi PHD-finger family protein 0.0029 0.0171 0.0575
Leishmania major DNA polymerase eta, putative 0.0052 0.0434 0.3791
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0209
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Onchocerca volvulus 0.0064 0.0578 0.2116
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0268 0.0901
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0093 0.0279
Giardia lamblia Grp94/Hsp90 0.0043 0.0325 0.2857
Schistosoma mansoni terminal deoxycytidyl transferase 0.0086 0.0832 0.2852
Trypanosoma brucei DNA damage repair protein, putative 0.0027 0.0143 0.0904
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Schistosoma mansoni heat shock protein 0.0045 0.0357 0.1198
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Loa Loa (eye worm) hypothetical protein 0.008 0.0756 0.2545
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0901
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0038 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0914 0.32
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0357 0.24
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0268 0.0887
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0268 0.0901
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0013 0.0043
Schistosoma mansoni hypothetical protein 0.0034 0.0223 0.073
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0179 0.0578
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Brugia malayi ecdysteroid receptor 0.0038 0.0268 0.0901
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0052 0.0271
Brugia malayi conserved hypotetical protein 0.0018 0.0038 0.0126
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0662 0.2258
Echinococcus granulosus lamin 0.0027 0.0146 0.0462
Brugia malayi Ets-domain containing protein 0.0072 0.0662 0.2226
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0181 0.0585
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0268 0.0887
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0062 0.0172
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0137 0.0037
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.2886 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0541 0.1822
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0674 0.4614
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0038 0.0086
Brugia malayi Flap endonuclease-1 0.0026 0.0131 0.0439
Onchocerca volvulus Huntingtin homolog 0.0123 0.1256 0.4774
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.0325 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0061 0.0264
Echinococcus multilocularis heat shock protein 90 0.0039 0.0281 0.0934
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0209
Leishmania major glycerol uptake protein, putative 0.0026 0.0131 0.1056
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0281 0.0623
Brugia malayi hypothetical protein 0.002 0.0062 0.0209
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0038 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0268 0.0901
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0213 0.0346
Trypanosoma brucei DNA polymerase IV, putative 0.0126 0.1294 0.8938
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0242 0.0815
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0061 0.0264
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0914 0.8109
Schistosoma mansoni hypothetical protein 0.017 0.1801 0.6223
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Onchocerca volvulus 0.0027 0.0146 0.0423
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0061 0.0167
Schistosoma mansoni flap endonuclease-1 0.0023 0.0102 0.031
Trypanosoma brucei heat shock protein, putative 0.0045 0.0357 0.24
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1295 0.4461
Trichomonas vaginalis hypothetical protein 0.0034 0.022 0.0375
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0013 0.0044
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0585 0.3989
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0325 0.0185
Schistosoma mansoni hypothetical protein 0.0052 0.0433 0.1462
Trypanosoma cruzi GUP1, putative 0.0026 0.0131 0.0819
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0268 0.0887
Mycobacterium ulcerans DNA polymerase IV 0.0139 0.1446 0.1322
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0038 0.0086
Echinococcus multilocularis bloom syndrome protein 0.0048 0.0386 0.1299
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0038 0.0126
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.0374 0.2613
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0268 0.0901
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0914 0.3136
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0038 0.0126
Brugia malayi hypothetical protein 0.0069 0.0629 0.2116
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0205
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0179 0.0918
Plasmodium falciparum endoplasmin, putative 0.0033 0.0213 0.1106
Schistosoma mansoni zinc finger protein 0.0018 0.0038 0.0086
Plasmodium vivax endoplasmin, putative 0.0045 0.0357 0.1902
Schistosoma mansoni intermediate filament proteins 0.0027 0.0146 0.0462
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.047
Onchocerca volvulus Huntingtin homolog 0.0123 0.1256 0.4774
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0146 0.049
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0131 0.0649
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0131 0.0819
Echinococcus granulosus flap endonuclease 1 0.0026 0.0131 0.0409
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Plasmodium falciparum heat shock protein 90 0.0045 0.0357 0.1902
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0139 0.1446 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.0207 0.107
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0914 0.6288
Schistosoma mansoni hypothetical protein 0.0107 0.1069 0.3675
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0013 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0139 0.1446 1
Echinococcus granulosus heat shock protein 90 0.0039 0.0281 0.0934
Echinococcus granulosus endoplasmin 0.0043 0.0325 0.1085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0268 0.0901
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0131 0.0409
Trichomonas vaginalis porcupine, putative 0.0026 0.0131 0.001
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0585 0.4853
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0065 0.0585 0.5144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0268 0.0901
Brugia malayi nuclear receptor NHR-67 0.0018 0.0038 0.0126
Trypanosoma brucei polo-like protein kinase 0.0093 0.0914 0.6288
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0268 0.0887
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0131 0.0025
Loa Loa (eye worm) hypothetical protein 0.0264 0.2886 0.9714
Schistosoma mansoni rotamase 0.0067 0.0603 0.2053
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0901
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0403 0.1357
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0146 0.049
Schistosoma mansoni hypothetical protein 0.017 0.1801 0.6223
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0131 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0356 0.1194
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0268 0.0887
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0179 0.0578
Schistosoma mansoni endoplasmin 0.0045 0.0357 0.1198
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0357 0.24
Trichomonas vaginalis rotamase, putative 0.0065 0.0585 0.1859
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0304 0.1012
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0268 0.0901
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0013 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0238 0.2584 1
Brugia malayi Ets-domain containing protein 0.0072 0.0662 0.2226
Plasmodium falciparum DNA repair protein REV1, putative 0.0027 0.0143 0.0716
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0914 0.32
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0128 0.0802
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0131 0.0649
Brugia malayi hypothetical protein 0.002 0.0062 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0268 0.0901
Schistosoma mansoni nuclear receptor 0.0018 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0126
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0268 0.0887
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0268 0.0901
Trypanosoma cruzi GUP1, putative 0.0026 0.0131 0.0819
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0139 0.1446 0.5365
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0181 0.0928
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0131 0.0409
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0209
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Brugia malayi hypothetical protein 0.0123 0.1256 0.4226
Loa Loa (eye worm) RecQ helicase 0.0048 0.0386 0.1299
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0062 0.0172
Leishmania major heat shock protein 83-1 0.0045 0.0357 0.3095
Schistosoma mansoni jun-related protein 0.0067 0.0604 0.2055
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0131 0.0409
Trypanosoma brucei chrX additional, unordered contigs 0.0027 0.0143 0.0904
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0268 0.0887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0356 0.1194

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.41 uM Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes ChEMBL. 8496931
IC50 (binding) = 0.41 uM Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit intestine microsomes ChEMBL. 8496931
IC50 (binding) > 1 uM Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate ChEMBL. 8496931
IC50 (binding) > 1 uM Inhibition against acyl coenzyme A:cholesterol acyltransferase derived from rabbit aorta homogenate ChEMBL. 8496931

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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