Detailed information for compound 63750

Basic information

Technical information
  • TDR Targets ID: 63750
  • Name: 1-[[1-(2,4-dimethylphenyl)cyclopentyl]methyl] -3-[2,6-di(propan-2-yl)phenyl]urea
  • MW: 406.603 | Formula: C27H38N2O
  • H donors: 2 H acceptors: 1 LogP: 7.24 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1c(cccc1C(C)C)C(C)C)NCC1(CCCC1)c1ccc(cc1C)C
  • InChi: 1S/C27H38N2O/c1-18(2)22-10-9-11-23(19(3)4)25(22)29-26(30)28-17-27(14-7-8-15-27)24-13-12-20(5)16-21(24)6/h9-13,16,18-19H,7-8,14-15,17H2,1-6H3,(H2,28,29,30)
  • InChiKey: AQVVAYORIURKLH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,6-diisopropylphenyl)-3-[[1-(2,4-dimethylphenyl)cyclopentyl]methyl]urea
  • 3-(2,6-diisopropylphenyl)-1-[[1-(2,4-dimethylphenyl)cyclopentyl]methyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Acyl-CoA:cholesterol acyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl-CoA:cholesterol acyltransferase   305 aa 278 aa 21.9 %
Neospora caninum sterol O-acyltransferase, putative Acyl-CoA:cholesterol acyltransferase   305 aa 258 aa 20.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0078 0.0043 0.0795
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0741 0.0696 0.1136
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0047 0.0813
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0448 0.0407 0.0406
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0109 0.0074 0.0779
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0741 0.0696 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0025 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2475 0.2405 0.394
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0109 0.0074 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Onchocerca volvulus 0.0038 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2475 0.2405 0.394
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.0226 0.0281
Onchocerca volvulus 0.0038 0.0003 0.0029
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0083 0.0047 0.0813
Loa Loa (eye worm) TK/ALK protein kinase 0.0096 0.0061 0.0061
Giardia lamblia Tenascin precursor 0.006 0.0025 0.0011
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0052 0.0017 0.002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0036 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.0407 0.0663
Echinococcus multilocularis 0.8153 0.8002 1
Echinococcus granulosus c4b binding protein beta chain 0.0038 0.0003 0.0002
Onchocerca volvulus 0.006 0.0025 0.0355
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.0098 0.2201
Echinococcus granulosus furin 1.018 1 1
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0052 0.0017 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Giardia lamblia hypothetical protein 0.006 0.0025 0.0011
Schistosoma mansoni hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0052 0.0017 0.0023
Schistosoma mansoni biogenic amine receptor 0.0036 0.0001 0.0001
Mycobacterium tuberculosis Probable thioesterase TesA 0.0067 0.0032 0.0531
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0741 0.0696 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0047 0.0919
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0074 0.0074
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0062 0.0027 0.0291
Onchocerca volvulus 0.0038 0.0003 0.0029
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0125 0.0089 0.2127
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0741 0.0696 0.1136
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0043 0.0687
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0054 0.0019 0.0019
Giardia lamblia Tenascin-37 0.006 0.0025 0.0011
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0003 0.0003
Echinococcus granulosus protein kinase c epsilon type 0.0098 0.0063 0.0061
Schistosoma mansoni discoidin domain receptor 0.0052 0.0017 0.0017
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0112 0.0111
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0448 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0003 0.0002
Brugia malayi hypothetical protein 0.0134 0.0098 0.0097
Mycobacterium ulcerans thioesterase TesA 0.0067 0.0032 0.042
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0056 0.0021 0.0025
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0479 0.0438 0.6094
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0043 0.0795
Loa Loa (eye worm) subtilase 0.0448 0.0407 0.0407
Echinococcus granulosus growth factor receptor bound protein 2 0.0139 0.0102 0.0101
Schistosoma mansoni histamine h1 receptor 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni growth factor receptor-bound protein 0.0139 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0017 0.002
Brugia malayi Kringle domain containing protein 0.005 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.3957 0.3866 0.3866
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0001 0.0001
Onchocerca volvulus 0.0717 0.0673 1
Loa Loa (eye worm) proprotein convertase 2 0.2475 0.2405 0.2405
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0109 0.0074 0.009
Brugia malayi Sushi domain 0.0038 0.0003 0.0002
Echinococcus granulosus nmda type glutamate receptor 0.011 0.0075 0.0073
Echinococcus multilocularis tissue type plasminogen activator 0.005 0.0015 0.0017
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0448 0.0407 0.5761
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0002 0.0002
Loa Loa (eye worm) Carm1-pending protein 0.007 0.0035 0.0035
Schistosoma mansoni discoidin domain receptor 0.0052 0.0017 0.0017
Echinococcus multilocularis membrane bound transcription factor site 1 0.0448 0.0407 0.0507
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.0191 0.0191
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0011 0.0011
Schistosoma mansoni myosin xvIII 0.0036 0.0001 0.0001
Echinococcus granulosus c-Jun N-terminal kinases 0.0232 0.0195 0.0194
Loa Loa (eye worm) transcriptional regulator 0.0109 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0134 0.0098 0.2352
Toxoplasma gondii histone lysine-specific demethylase 0.0134 0.0098 0.2352
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.0001 0.0001
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0074 0.0074
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0109 0.0074 0.0857
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0001 0.0001
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0448 0.0407 0.0407
Echinococcus granulosus tissue type plasminogen activator 0.005 0.0015 0.0014
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0003 0.0002
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0125 0.0089 0.2127
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Brugia malayi pregnancy-associated plasma protein-A 0.0038 0.0003 0.0002
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.0226 0.0226
Echinococcus granulosus epidermal growth factor receptor 0.0658 0.0614 0.0613
Schistosoma mansoni neuropeptide receptor 0.0036 0.0001 0.0001
Mycobacterium ulcerans polyketide synthase 0.0083 0.0047 0.0813
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0677 0.0633 0.0632
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0118 0.0082 0.1786
Loa Loa (eye worm) hypothetical protein 0.0096 0.0061 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6223 0.61 1
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2475 0.2405 0.2405
Brugia malayi Furin-like cysteine rich region family protein 0.0658 0.0614 0.0613
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0677 0.0633 0.0789
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0109 0.0074 0.0579
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.015 0.0114 0.0112
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.0044 0.0835
Schistosoma mansoni tyrosine kinase 0.0658 0.0614 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0001 0.0001
Brugia malayi Subtilase family protein 0.0448 0.0407 0.0406
Loa Loa (eye worm) TK/EGFR protein kinase 0.0658 0.0614 0.0614
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0001 0.0001
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0261 0.0223 0.0277
Giardia lamblia Neurogenic locus notch-like protein 0.006 0.0025 0.0011
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0089 0.0141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0109 0.0074 0.0072
Plasmodium vivax cysteine repeat modular protein 1, putative 0.005 0.0015 0.0298
Plasmodium vivax plasmepsin V, putative 0.0426 0.0386 0.9473
Brugia malayi EGF-like domain containing protein 0.006 0.0025 0.0024
Onchocerca volvulus 0.0038 0.0003 0.0029
Loa Loa (eye worm) transcriptional regulator 0.0741 0.0696 0.0696
Mycobacterium leprae Possible secreted protease 0.0448 0.0407 1
Leishmania major silent information regulator 2, putative 0.0741 0.0696 1
Brugia malayi NAD-dependent deacetylase SIRT1 0.0109 0.0074 0.0072
Schistosoma mansoni btb and poz domain-containing protein 0.0052 0.0017 0.0017
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0448 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0397 0.0357 0.0357
Onchocerca volvulus 0.0075 0.004 0.0578
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0017 0.0351
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.0044 0.0728
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.007 0.0035 0.0035
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0078 0.0043 0.0041
Giardia lamblia High cysteine protein 0.006 0.0025 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0001 0.0001
Echinococcus granulosus methyltransferase protein 5 0.007 0.0035 0.0034
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0134 0.0098 0.2352
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0054 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0036 0.0001 0.0001
Brugia malayi celfurPC protein 0.8153 0.8002 0.8002
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0661 0.0617 0.077
Brugia malayi EGF-like domain containing protein 0.006 0.0025 0.0024
Leishmania major arginine N-methyltransferase-like protein 0.0125 0.0089 0.1086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0036 0.0001 0.0001
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0448 0.0407 0.0406
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6223 0.61 1
Echinococcus multilocularis discoidin domain receptor 0.0052 0.0017 0.002
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0058 0.0023 0.03
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus multilocularis protoporphyrinogen oxidase 0.0134 0.0098 0.0121
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Schistosoma mansoni biogenic amine receptor 0.0036 0.0001 0.0001
Echinococcus granulosus integrin alpha 3 0.0114 0.0078 0.0076
Mycobacterium ulcerans dehydrogenase 0.0134 0.0098 0.211
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0052 0.0017 0.0162
Brugia malayi amine oxidase, flavin-containing family protein 0.019 0.0153 0.0152
Brugia malayi proprotein convertase 2 0.6431 0.6305 0.6305
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0134 0.0098 0.2352
Loa Loa (eye worm) hypothetical protein 0.0121 0.0085 0.0085
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2475 0.2405 0.394
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0109 0.0074 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.007 0.0035 0.0795
Loa Loa (eye worm) hypothetical protein 1.018 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0006 0.0006
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0052 0.0017 0.0047
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0661 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Mycobacterium ulcerans thioesterase 0.0067 0.0032 0.042
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0196 0.0159 0.204
Echinococcus multilocularis integrin beta 2 0.191 0.1849 0.2309
Loa Loa (eye worm) fatty acid synthase 0.008 0.0044 0.0044
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0089 0.0089
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0076 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Onchocerca volvulus 0.0038 0.0003 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2475 0.2405 0.394
Loa Loa (eye worm) hypothetical protein 0.0052 0.0017 0.0017
Trypanosoma brucei subtilisin peptidase 0.0448 0.0407 0.5632
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0078 0.0043 0.0803
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.0001 0.0001
Schistosoma mansoni amine oxidase 0.0134 0.0098 0.0098
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0078 0.0043 0.0687
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0074 0.0074
Brugia malayi hypothetical protein 0.0059 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Toxoplasma gondii subtilisin SUB2 0.0448 0.0407 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0479 0.0438 0.621
Echinococcus multilocularis neuroendocrine convertase 2 0.6431 0.6305 0.7879
Giardia lamblia High cysteine membrane protein Group 2 0.3748 0.3661 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0661 0.0617 0.0616
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Toxoplasma gondii aspartyl protease ASP5 0.0388 0.0349 0.8549
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Schistosoma mansoni growth factor receptor-bound protein 0.0139 0.0102 0.0102
Echinococcus multilocularis 0.0134 0.0098 0.0121
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.2027 0.1964 0.3216
Entamoeba histolytica hypothetical protein, conserved 0.0109 0.0074 0.0779
Loa Loa (eye worm) sirtuin 4 0.0109 0.0074 0.0074
Brugia malayi Stress-activated protein kinase jnk-1 0.0232 0.0195 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.2027 0.1964 0.1964
Loa Loa (eye worm) hypothetical protein 0.0448 0.0407 0.0407
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0077 0.0041 0.0041
Schistosoma mansoni site-1 peptidase (S08 family) 0.0448 0.0407 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0063 0.0063
Plasmodium falciparum plasmepsin V 0.0426 0.0386 0.9473
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0134 0.0098 0.211
Loa Loa (eye worm) hypothetical protein 0.0082 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0056 0.0021 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0238 0.0201 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Brugia malayi Angiotensin-converting enzyme family protein 0.0682 0.0638 0.0637
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0448 0.0407 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0109 0.0074 0.009
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0741 0.0696 0.0695
Schistosoma mansoni neuropeptide receptor 0.0036 0.0001 0.0001
Brugia malayi Sex muscle abnormal protein 5 0.0139 0.0102 0.0101
Schistosoma mansoni protein kinase 0.0128 0.0092 0.0092
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0125 0.0089 0.011
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0017 0.0352
Loa Loa (eye worm) integrin beta-2 0.2587 0.2516 0.2516
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Echinococcus granulosus protein arginine N methyltransferase 8 0.0125 0.0089 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0017 0.0352
Schistosoma mansoni furin-1 (S08 family) 0.4405 0.4307 0.4307
Echinococcus multilocularis protein jagged 2 0.006 0.0025 0.003
Schistosoma mansoni neuropeptide receptor 0.0036 0.0001 0.0001
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0011 0.0011
Toxoplasma gondii subtilisin SUB12 0.0448 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Onchocerca volvulus 0.0096 0.0061 0.0888
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0079 0.0044 0.5
Mycobacterium ulcerans NAD-dependent deacetylase 0.0109 0.0074 0.1479
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0003 0.0002
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0109 0.0074 0.1578
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.0001 0.0001
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0112 0.0076 0.0076
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0089 0.0089
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0001 0.0001
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0079 0.0044 0.5
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1341 0.1288 0.1288
Loa Loa (eye worm) endoprotease bli-4 1.018 1 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0682 0.0638 0.0638
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0003 0.0003
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0017 0.0016
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0063 0.0028 0.0429
Loa Loa (eye worm) DEAH box polypeptide 35 0.0067 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0134 0.0098 0.2352
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0047 0.0813
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0232 0.0195 0.0195
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0134 0.0098 0.0098
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6223 0.61 0.6099
Echinococcus multilocularis integrin alpha ps 0.0066 0.0031 0.0038
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.005 0.0015 0.0014
Giardia lamblia Sirtuin type 2 0.0109 0.0074 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.0407 0.0663
Toxoplasma gondii subtilisin SUB7 0.0448 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Toxoplasma gondii subtilisin SUB1 0.0448 0.0407 1
Schistosoma mansoni integrin alpha-ps 0.0066 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Loa Loa (eye worm) hypothetical protein 0.0042 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0109 0.0074 0.1741
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0017 0.0352
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0134 0.0098 0.2352
Loa Loa (eye worm) hypothetical protein 0.0052 0.0017 0.0017
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0043 0.0687
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0075 0.004 0.0039
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Giardia lamblia Hypothetical protein 0.0741 0.0696 0.1854
Trypanosoma cruzi arginine N-methyltransferase, type III 0.007 0.0035 0.0295
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Onchocerca volvulus 0.005 0.0015 0.0208
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0012 0.0013
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0017 0.0352
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0015 0.0015
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0134 0.0098 0.2352
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Trichomonas vaginalis WD repeat domain, putative 0.0144 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Echinococcus granulosus histone arginine methyltransferase CARMER 0.007 0.0035 0.0034
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0078 0.0043 0.0803
Echinococcus multilocularis integrin alpha 3 0.0114 0.0078 0.0096
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.011 0.0075 0.0092
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.0001 0.0001
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0075 0.004 0.0733
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0083 0.0047 0.0813
Brugia malayi hypothetical protein 0.0096 0.0061 0.006
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0128 0.0092 0.0091
Schistosoma mansoni amine GPCR 0.0036 0.0001 0.0001
Brugia malayi Integrin beta pat-3 precursor 0.2587 0.2516 0.2515
Toxoplasma gondii rhoptry neck protein RON9 0.0038 0.0003 0.0001
Onchocerca volvulus 0.0038 0.0003 0.0028
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0017 0.0023
Schistosoma mansoni c4b-binding protein beta chain 0.0038 0.0003 0.0003
Loa Loa (eye worm) WD40 repeat protein 0.0144 0.0108 0.0108
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Onchocerca volvulus 0.014 0.0104 0.1532
Toxoplasma gondii SWIRM domain-containing protein 0.0056 0.0021 0.044
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0448 0.0407 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0232 0.0195 0.0242
Plasmodium falciparum subtilisin-like protease 1 0.0448 0.0407 1
Schistosoma mansoni hypothetical protein 0.0096 0.0061 0.0061
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0125 0.0089 0.2127
Schistosoma mansoni neuropeptide receptor 0.0036 0.0001 0.0001
Plasmodium vivax NAD-dependent deacetylase, putative 0.0109 0.0074 0.1741
Trypanosoma cruzi arginine N-methyltransferase, type I 0.007 0.0035 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Loa Loa (eye worm) hypothetical protein 0.0096 0.0061 0.0061
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0109 0.0074 0.0072
Echinococcus granulosus glutamate receptor 2 0.0047 0.0012 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Leishmania major arginine N-methyltransferase, type I 0.007 0.0035 0.0295
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0048 0.0013 0.0013
Giardia lamblia High cysteine protein 0.006 0.0025 0.0011
Mycobacterium leprae Probable polyketide synthase Pks1 0.0083 0.0047 0.0813
Loa Loa (eye worm) hypothetical protein 0.0096 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.0407 0.0663
Schistosoma mansoni hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Echinococcus granulosus neuroendocrine convertase 2 0.6431 0.6305 0.6305
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0001 0.0001
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0043 0.0795
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0083 0.0047 0.0919
Echinococcus granulosus lysine specific histone demethylase 1A 0.0134 0.0098 0.0097
Loa Loa (eye worm) transcriptional regulator 0.0109 0.0074 0.0074
Giardia lamblia Neurogenic locus Notch protein precursor 0.006 0.0025 0.0011
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0017 0.002
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.0006 0.0069
Brugia malayi EGF-like domain containing protein 0.006 0.0025 0.0024
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0448 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0112 0.0076 0.0076
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0001 0.0001
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0024 0.0024
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0109 0.0074 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Plasmodium falciparum cysteine repeat modular protein 1 0.005 0.0015 0.0298
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0448 0.0407 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0448 0.0407 1
Echinococcus multilocularis adam 0.0119 0.0084 0.0103
Brugia malayi transcriptional regulator, Sir2 family protein 0.0741 0.0696 0.0695
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0022 0.0475
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus multilocularis protein arginine N methyltransferase 7 0.007 0.0035 0.0043
Echinococcus granulosus serine:threonine protein kinase N2 0.008 0.0045 0.0044
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0741 0.0696 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0001 0.0001
Leishmania major UDP-galactopyranose mutase 0.0134 0.0098 0.122
Mycobacterium leprae Polyketide synthase Pks13 0.0118 0.0082 0.169
Schistosoma mansoni amine GPCR 0.0036 0.0001 0.0001
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0089 0.0141
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0001 0.0001
Trypanosoma cruzi subtilisin peptidase 0.0448 0.0407 0.5761
Echinococcus granulosus C type lectin domian containing protein 0.0038 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0661 0.0617 0.0617
Schistosoma mansoni protein kinase 0.0128 0.0092 0.0092
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0448 0.0407 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Mycobacterium ulcerans polyketide synthase Pks13 0.0118 0.0082 0.169
Loa Loa (eye worm) hypothetical protein 0.0134 0.0098 0.0098
Echinococcus multilocularis Furin 1 0.2475 0.2405 0.3005
Schistosoma mansoni chromatin regulatory protein sir2 0.0741 0.0696 0.0696
Echinococcus multilocularis fibrillin 2 0.006 0.0025 0.003
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0448 0.0407 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0003 0.0003
Trichomonas vaginalis hypothetical protein 0.006 0.0025 0.0036
Schistosoma mansoni hypothetical protein 0.0052 0.0017 0.0017
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0043 0.0687
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0001 0.0001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0109 0.0074 0.0144
Echinococcus multilocularis protein arginine methyltransferase 0.0125 0.0089 0.011
Echinococcus multilocularis integrin alpha ps 0.0066 0.0031 0.0038
Onchocerca volvulus Fatty acid synthase homolog 0.0145 0.0109 0.1605
Loa Loa (eye worm) hypothetical protein 0.006 0.0025 0.0025
Mycobacterium ulcerans oxidoreductase 0.0134 0.0098 0.211
Toxoplasma gondii histone deacetylase SIR2-like 0.0109 0.0074 0.1741
Plasmodium falciparum subtilisin-like protease 2 0.0448 0.0407 1
Brugia malayi SWIRM domain containing protein 0.0056 0.0021 0.002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0196 0.0159 0.2107
Giardia lamblia Tenascin-like 0.006 0.0025 0.0011
Plasmodium falciparum apical sushi protein 0.0038 0.0003 0.0001
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0128 0.0092 0.0113
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.006 0.0025 0.0036
Schistosoma mansoni hypothetical protein 0.0096 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0054 0.0019 0.0019
Toxoplasma gondii bicoid-interacting protein BIN3 0.007 0.0035 0.0795
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0661 0.0617 0.0617
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0001 0.0001
Onchocerca volvulus 0.0052 0.0017 0.024
Loa Loa (eye worm) hypothetical protein 0.0116 0.0081 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Plasmodium vivax subtilisin-like serine protease, putative 0.0448 0.0407 1
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.007 0.0035 0.0295
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.2027 0.1964 0.3216
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0741 0.0696 0.0868
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Toxoplasma gondii subtilisin SUB6 0.0448 0.0407 1
Trichomonas vaginalis hypothetical protein 0.2027 0.1964 0.3216
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0003 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Mycobacterium tuberculosis Possible oxidoreductase 0.0134 0.0098 0.2201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.007 0.0035 0.0795
Echinococcus granulosus protein arginine N methyltransferase 7 0.007 0.0035 0.0034
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0109 0.0074 0.009
Echinococcus multilocularis epidermal growth factor receptor 0.0658 0.0614 0.0766
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0017 0.0016
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0134 0.0098 0.211
Schistosoma mansoni protein kinase 0.0128 0.0092 0.0092
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0006 0.0004
Trypanosoma brucei SIR2-like protein 4, putative 0.0109 0.0074 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0021 0.0029
Echinococcus multilocularis chromatin regulatory protein sir2 0.0741 0.0696 0.0868
Brugia malayi Carm1-pending protein 0.007 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.007 0.0035 0.0295
Toxoplasma gondii histone deacetylase SIR2 0.0109 0.0074 0.1741
Trypanosoma cruzi arginine N-methyltransferase, type I 0.007 0.0035 0.0295
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0001 0.0001
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0083 0.0047 0.0919
Schistosoma mansoni adenoreceptor 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Plasmodium vivax apical sushi protein, putative 0.0038 0.0003 0.0001
Echinococcus multilocularis fibrillin 1 0.0063 0.0028 0.0033
Toxoplasma gondii subtilisin SUB4 0.0448 0.0407 1
Schistosoma mansoni integrin alpha 0.0148 0.0112 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0067 0.0032 0.042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0448 0.0407 0.0407
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0001 0.0001
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0062 0.0027 0.0291
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0098 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0003 0.0003
Brugia malayi hypothetical protein 0.0397 0.0357 0.0356
Onchocerca volvulus 0.0038 0.0003 0.0029
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.006 0.0025 0.0025
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0012 0.0013
Plasmodium falciparum subtilisin-like protease 3 0.0448 0.0407 1
Echinococcus granulosus Furin 1 0.2475 0.2405 0.2404
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.0001 0.0001
Echinococcus granulosus fibrillin 1 0.0063 0.0028 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0054 0.0019 0.0018
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0448 0.0407 0.0406
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.0001 0.0001
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0428 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.019 0.0153 0.0153
Onchocerca volvulus 0.0038 0.0003 0.0029
Onchocerca volvulus 0.0038 0.0003 0.0028
Echinococcus granulosus MAM 0.0096 0.0061 0.006
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0244 0.0206 0.0206
Onchocerca volvulus Putative cubilin 0.004 0.0006 0.0065
Onchocerca volvulus 0.0096 0.0061 0.0888
Echinococcus granulosus protein arginine methyltransferase 0.0125 0.0089 0.0088
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0035 0.0053
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0109 0.0074 0.1741
Echinococcus granulosus integrin alpha ps 0.0066 0.0031 0.003
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0139 0.0102 0.0102
Plasmodium falciparum protoporphyrinogen oxidase 0.0134 0.0098 0.2352
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Echinococcus multilocularis c4b binding protein beta chain 0.0038 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0017 0.0016
Echinococcus multilocularis MAM 0.0096 0.0061 0.0074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0001 0.0001
Leishmania major sir2-family protein-like protein 0.0109 0.0074 0.0857
Onchocerca volvulus 0.018 0.0143 0.211
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.0407 0.0663
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Giardia lamblia Furin precursor putative serine protease 0.2027 0.1964 0.5338
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0479 0.0438 0.621
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0012 0.0013
Schistosoma mansoni amine GPCR 0.0036 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0096 0.0061 0.006
Toxoplasma gondii hypothetical protein 0.006 0.0025 0.0543
Echinococcus granulosus adam 0.0119 0.0084 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Schistosoma mansoni site-1 peptidase (S08 family) 0.0448 0.0407 0.0407
Giardia lamblia Transcriptional regulator, Sir2 family 0.0109 0.0074 0.0144
Brugia malayi Protein kinase domain containing protein 0.0052 0.0017 0.0016
Echinococcus granulosus integrin beta 2 0.191 0.1849 0.1847
Brugia malayi hypothetical protein 0.0038 0.0003 0.0002
Trypanosoma cruzi UDP-galactopyranose mutase 0.0134 0.0098 0.122
Onchocerca volvulus 0.0448 0.0407 0.6049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0048 0.0013 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Loa Loa (eye worm) hypothetical protein 0.0196 0.0159 0.0159
Schistosoma mansoni protein arginine n-methyltransferase 0.007 0.0035 0.0035
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Brugia malayi Protein arginine N-methyltransferase 0.007 0.0035 0.0034
Trypanosoma cruzi UDP-galactopyranose mutase 0.0134 0.0098 0.122
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0011 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Echinococcus granulosus membrane bound transcription factor site 1 0.0448 0.0407 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.0407 0.0663
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0089 0.0089
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0134 0.0098 0.0098
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0089 0.0141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Toxoplasma gondii PA14 domain-containing protein 0.0052 0.0017 0.0352
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0144 0.0108 0.0108
Plasmodium vivax subtilisin-like protease 1 0.0448 0.0407 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0261 0.0223 0.0222
Echinococcus granulosus fibrillin 2 0.006 0.0025 0.0024
Echinococcus multilocularis protein will die slowly 0.0144 0.0108 0.0134
Schistosoma mansoni dock 0.0052 0.0017 0.0017
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0195 0.0195
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0196 0.0159 0.1867
Onchocerca volvulus 0.0038 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0074 0.0074
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0056 0.0021 0.002
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0052 0.0017 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2475 0.2405 0.394
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0078 0.0043 0.0687
Mycobacterium ulcerans polyketide synthase 0.0078 0.0043 0.0687
Brugia malayi Probable ATP-dependent helicase DHX35 0.0067 0.0032 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0012 0.0011
Schistosoma mansoni glutamate receptor NMDA 0.0261 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) protein arginine N-methyltransferase 0.007 0.0035 0.0035
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0054 0.0019 0.0022
Echinococcus granulosus discoidin domain receptor 0.0052 0.0017 0.0016
Schistosoma mansoni amine oxidase 0.0134 0.0098 0.0098
Onchocerca volvulus 0.0052 0.0017 0.024
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0448 0.0407 0.0507
Brugia malayi SWIRM domain containing protein 0.0717 0.0673 0.0671
Loa Loa (eye worm) hypothetical protein 0.0054 0.0019 0.0019
Mycobacterium ulcerans monoamine oxidase 0.0134 0.0098 0.211
Loa Loa (eye worm) hypothetical protein 0.0133 0.0097 0.0097
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0134 0.0098 0.211
Echinococcus multilocularis growth factor receptor bound protein 2 0.0139 0.0102 0.0126
Brugia malayi protein kinase C II. 0.0098 0.0063 0.0061
Schistosoma mansoni opsin-like receptor 0.0036 0.0001 0.0001
Onchocerca volvulus 0.0038 0.0003 0.0029
Toxoplasma gondii subtilisin SUB5 0.0448 0.0407 1
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.0226 0.0225
Entamoeba histolytica PH domain containing protein kinase, putative 0.008 0.0045 0.0356
Schistosoma mansoni apoptosis regulator bax 0.0054 0.0019 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2475 0.2405 0.394
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0196 0.0159 0.2107
Giardia lamblia Tenascin-X 0.006 0.0025 0.0011
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0043 0.0687
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.0001 0.0001
Schistosoma mansoni chromatin regulatory protein sir2 0.0741 0.0696 0.0696
Schistosoma mansoni chromatin regulatory protein sir2 0.0741 0.0696 0.0696
Brugia malayi hypothetical protein 0.0196 0.0159 0.0157
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0038 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Toxoplasma gondii subtilisin SUB10 0.0448 0.0407 1
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0109 0.0074 0.0779
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0017 0.0352
Toxoplasma gondii rhoptry neck protein RON1 0.0038 0.0003 0.0001
Toxoplasma gondii subtilisin SUB8 0.0448 0.0407 1
Brugia malayi EGF-like domain containing protein 0.006 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.0001 0.0001
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0017 0.0352
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Brugia malayi Kelch motif family protein 0.0428 0.0387 0.0386
Echinococcus granulosus chromatin regulatory protein sir2 0.0741 0.0696 0.0695
Loa Loa (eye worm) hypothetical protein 0.0717 0.0673 0.0673
Mycobacterium ulcerans Sir2-like regulatory protein 0.0109 0.0074 0.1479
Trichomonas vaginalis hypothetical protein 0.0052 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0001 0.0001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0196 0.0159 0.204
Brugia malayi Will die slowly protein 0.0144 0.0108 0.0107
Brugia malayi GCC2 and GCC3 family protein 0.0047 0.0013 0.0011
Chlamydia trachomatis protoporphyrinogen oxidase 0.0134 0.0098 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.0407 0.0663
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0067 0.0032 0.0032
Brugia malayi neuroendocrine convertase 1 precursor 0.6431 0.6305 0.6305
Echinococcus multilocularis serine:threonine protein kinase N2 0.009 0.0055 0.0066
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.0001 0.0001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0012 0.0013
Brugia malayi transcriptional regulator, Sir2 family protein 0.0109 0.0074 0.0072
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.0264 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Brugia malayi Pepsin A precursor 0.0038 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.005 0.0015 0.0015
Onchocerca volvulus 0.0038 0.0003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0017 0.002
Leishmania major subtilisin-like serine peptidase 0.0448 0.0407 0.5761
Schistosoma mansoni biogenic amine receptor 0.0036 0.0001 0.0001
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6223 0.61 0.7623
Schistosoma mansoni septate junction protein 0.0062 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0074 0.1741
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0741 0.0696 1
Toxoplasma gondii subtilisin SUB11 0.0448 0.0407 1
Onchocerca volvulus 0.0144 0.0108 0.1591
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0054 0.0019 0.0019
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0075 0.004 0.004
Loa Loa (eye worm) apoptosis regulator protein 0.0054 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0021 0.0029
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.007 0.0035 0.0213
Schistosoma mansoni SWI/SNF complex-related 0.0056 0.0021 0.0021
Echinococcus multilocularis protein kinase c epsilon type 0.0098 0.0063 0.0077
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0017 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0023
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0054 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0047 0.0013 0.0013
Loa Loa (eye worm) reprolysin 0.0045 0.0011 0.0011
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0062 0.0027 0.0291
Plasmodium vivax subtilisin-like protease 2, putative 0.0448 0.0407 1
Toxoplasma gondii kringle domain-containing protein 0.005 0.0015 0.0298
Echinococcus multilocularis C type lectin domian containing protein 0.0038 0.0003 0.0002
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.007 0.0035 0.0043
Toxoplasma gondii subtilisin SUB9 0.0448 0.0407 1
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0134 0.0098 0.211
Toxoplasma gondii type I fatty acid synthase, putative 0.0083 0.0047 0.1094
Brugia malayi transcriptional regulator, Sir2 family protein 0.0109 0.0074 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0134 0.0098 0.2352
Loa Loa (eye worm) hypothetical protein 0.0109 0.0074 0.0074
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0118 0.0082 0.1786
Echinococcus multilocularis nmda type glutamate receptor 0.011 0.0075 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.2027 0.1964 0.3216
Schistosoma mansoni integrin beta subunit 0.1513 0.1458 0.1458
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0741 0.0696 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0003
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0112 0.0076 0.0075
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.018 1 1
Echinococcus granulosus protein will die slowly 0.0144 0.0108 0.0107
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.2027 0.1964 0.3216

Activities

Activity type Activity value Assay description Source Reference
Delta TC (functional) = -50 % Percent change in total cholesterol in peanut oil (5.5%) - cholic acid (0.3%) - Cholesterol (1.5%) fed rats after a single dose ChEMBL. 8201599
IC50 (binding) = 0.05 uM Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbits ChEMBL. 8201599
IC50 (binding) = 0.05 uM Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbits ChEMBL. 8201599

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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