Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.0172 | 0.1004 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0176 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0896 | 0.4099 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.2134 | 0.9706 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Onchocerca volvulus | 0.0121 | 0.2185 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.0172 | 0.0785 |
Mycobacterium tuberculosis | Conserved protein | 0.0347 | 0.782 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0102 | 0.1708 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0347 | 0.782 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2134 | 0.9767 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2185 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0102 | 0.1708 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.2185 | 0.2185 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1708 | 0.7816 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0102 | 0.1708 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0102 | 0.1708 | 0.7816 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0102 | 0.1708 | 0.1108 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0347 | 0.782 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0347 | 0.782 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0119 | 0.2134 | 0.9706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | 0 uM | Inhibition of dihydrosterculate synthesis in Crithidia fasciculata; No inhibition | ChEMBL. | 3398003 |
I50 (functional) | > 100 uM | The compound was tested for 50% growth inhibition against Crithidia fasciculata | ChEMBL. | 3398003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.