Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.1478 | 0.7071 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1051 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1051 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.1051 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity was determined in Subcutaneous metrazole (scMet) test 0.5 h after administration of 300 mg/kg in (mice/rat); no activity or toxicityup to 300 mg/kg. | ChEMBL. | 2296016 | |
Activity (ADMET) | Rotorod test was used to evaluate neurotoxicity in mice. Values are reported after 0.5 h, at 300 mg/kg; no activity or toxicity up to 300 mg/kg. | ChEMBL. | 2296016 | |
Activity (functional) | Subcutaneous metrazole (scMet) test was done, 4.0 h after administration; no activity or toxicity up to 300 mg/kg. | ChEMBL. | 2296016 | |
Activity (functional) | Anticonvulsant activity was determined in maximal electroshock seizure test 4.0 h after administration of 300 mg/kg in (mice/rat); no activity or toxicityup to 300 mg/kg. | ChEMBL. | 2296016 | |
Activity (functional) | Anticonvulsant activity was determined in maximal electroshock seizure test 0.5 h after administration of 300 mg/kg in (mice/rat); no activity or toxicityup to 300 mg/kg. | ChEMBL. | 2296016 | |
Activity (functional) | NT 0 | Anticonvulsant activity was determined in maximal electroshock seizure test 0.5 h after administration of 300 mg/kg in (mice/rat); no activity or toxicityup to 300 mg/kg. | ChEMBL. | 2296016 |
Activity (functional) | NT 0 | Anticonvulsant activity was determined in maximal electroshock seizure test 4.0 h after administration of 300 mg/kg in (mice/rat); no activity or toxicityup to 300 mg/kg. | ChEMBL. | 2296016 |
Activity (functional) | NT 0 | Anticonvulsant activity was determined in Subcutaneous metrazole (scMet) test 0.5 h after administration of 300 mg/kg in (mice/rat); no activity or toxicityup to 300 mg/kg. | ChEMBL. | 2296016 |
Activity (functional) | NT 0 | Subcutaneous metrazole (scMet) test was done, 4.0 h after administration; no activity or toxicity up to 300 mg/kg. | ChEMBL. | 2296016 |
Activity (ADMET) | NT 0 | Rotorod test was used to evaluate neurotoxicity in mice. Values are reported after 0.5 h, at 300 mg/kg; no activity or toxicity up to 300 mg/kg. | ChEMBL. | 2296016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.