Detailed information for compound 645049

Basic information

Technical information
  • TDR Targets ID: 645049
  • Name: N-[(E)-3-[(4-methoxyphenyl)amino]-1-(3-nitrop henyl)-3-oxoprop-1-en-2-yl]furan-2-carboxamid e
  • MW: 407.376 | Formula: C21H17N3O6
  • H donors: 2 H acceptors: 4 LogP: 3.43 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)/C(=C/c1cccc(c1)[N+](=O)[O-])/NC(=O)c1ccco1
  • InChi: 1S/C21H17N3O6/c1-29-17-9-7-15(8-10-17)22-20(25)18(23-21(26)19-6-3-11-30-19)13-14-4-2-5-16(12-14)24(27)28/h2-13H,1H3,(H,22,25)(H,23,26)/b18-13+
  • InChiKey: YZWFWCVTKPWILK-QGOAFFKASA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(E)-1-[(4-methoxyphenyl)carbamoyl]-2-(3-nitrophenyl)vinyl]furan-2-carboxamide
  • N-[(E)-1-[[(4-methoxyphenyl)amino]-oxomethyl]-2-(3-nitrophenyl)vinyl]-2-furancarboxamide
  • N-[(E)-1-[(4-methoxyphenyl)carbamoyl]-2-(3-nitrophenyl)vinyl]-2-furamide
  • N-[(E)-3-[(4-methoxyphenyl)amino]-1-(3-nitrophenyl)-3-oxo-prop-1-en-2-yl]furan-2-carboxamide
  • STOCK1S-55814
  • ZINC04837216

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0515
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0061 0.0392 0.1717
Onchocerca volvulus 0.0061 0.0392 0.0627
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0186 0.0186
Echinococcus granulosus tar DNA binding protein 0.0131 0.1497 0.1497
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0362 0.5156 0.5156
Schistosoma mansoni alkaline phosphatase 0.0543 0.8017 0.8017
Echinococcus multilocularis acetylcholinesterase 0.0362 0.5156 0.5156
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.014 0.1639 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0061 0.0392 0.0392
Toxoplasma gondii ABC1 family protein 0.0072 0.0568 0.2686
Schistosoma mansoni neuroligin 3 (S09 family) 0.0061 0.0392 0.0392
Schistosoma mansoni alpha glucosidase 0.0041 0.008 0.008
Onchocerca volvulus 0.0061 0.0392 0.0627
Leishmania major hypothetical protein, conserved 0.0072 0.0568 0.2686
Loa Loa (eye worm) hypothetical protein 0.0054 0.0281 0.0545
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0121 0.0235
Loa Loa (eye worm) hypothetical protein 0.0072 0.0568 0.1102
Loa Loa (eye worm) MBCTL1 0.0116 0.1259 0.2442
Loa Loa (eye worm) mbt repeat family protein 0.0102 0.1036 0.2009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0037 0.0037
Schistosoma mansoni BC026374 protein (S09 family) 0.0061 0.0392 0.0392
Brugia malayi follicle stimulating hormone receptor 0.0226 0.301 0.5807
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0638 0.0638
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0568 0.0568
Schistosoma mansoni myelin transcription factor 1 myt1 0.0116 0.1259 0.1259
Echinococcus multilocularis microtubule associated protein 2 0.0668 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.1766 0.3377
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2381 0.2381
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0281 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0568 0.2686
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0087 0.0801 0.1553
Loa Loa (eye worm) carboxylesterase 0.0061 0.0392 0.0761
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.6737 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0061 0.0392 0.0392
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0156 0.1898 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.1766 0.1766
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1036 0.1036
Loa Loa (eye worm) hypothetical protein 0.0091 0.0865 0.1678
Loa Loa (eye worm) hypothetical protein 0.014 0.1648 0.3196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.1766 0.1766
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0061 0.0392 0.0392
Loa Loa (eye worm) RNA binding protein 0.0131 0.1497 0.2902
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0156 0.1898 1
Brugia malayi RNA binding protein 0.0131 0.1497 0.2852
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0061 0.0392 0.0392
Echinococcus multilocularis inositol monophosphatase 1 0.0156 0.1898 0.1898
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0568 0.0278
Echinococcus granulosus acetylcholinesterase 0.0362 0.5156 0.5156
Brugia malayi Carboxylesterase family protein 0.0362 0.5156 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.1497 0.2902
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0568 0.0278
Echinococcus granulosus zinc finger protein 0.0042 0.0085 0.0085
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0186 0.0186
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0434 0.0434
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0434 0.0279
Brugia malayi beta-lactamase 0.0072 0.0568 0.1038
Echinococcus multilocularis geminin 0.0176 0.2214 0.2214
Echinococcus multilocularis neuroligin 0.0061 0.0392 0.0392
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.008 0.0232
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0568 0.0568
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0568 0.1102
Loa Loa (eye worm) inositol-1 0.0156 0.1898 0.3681
Echinococcus granulosus neuroligin 0.0061 0.0392 0.0392
Echinococcus granulosus para nitrobenzyl esterase 0.0061 0.0392 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1497 0.1497
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1898 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1898 1
Schistosoma mansoni zinc finger protein 0.0042 0.0085 0.0085
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.008 0.0232
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0434 0.0066
Mycobacterium ulcerans hypothetical protein 0.0072 0.0568 0.117
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0434 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0568 0.2686
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0568 0.2686
Echinococcus granulosus inositol monophosphatase 1 0.0156 0.1898 0.1898
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0116 0.1259 0.2388
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0127 0.1442 0.1442
Brugia malayi PAS domain containing protein 0.0047 0.0169 0.0259
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1731 0.3357
Echinococcus multilocularis carboxylesterase 5A 0.0362 0.5156 0.5156
Loa Loa (eye worm) hypothetical protein 0.0072 0.0568 0.1102
Brugia malayi Carboxylesterase family protein 0.0362 0.5156 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1898 1
Echinococcus granulosus intestinal type alkaline phosphatase 0.0543 0.8017 0.8017
Schistosoma mansoni hypothetical protein 0.0176 0.2214 0.2214
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0568 0.2686
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0568 0.0278
Brugia malayi hypothetical protein 0.014 0.1648 0.3147
Loa Loa (eye worm) hypothetical protein 0.0072 0.0568 0.1102
Brugia malayi hypothetical protein 0.0158 0.1925 0.3688
Echinococcus multilocularis tar DNA binding protein 0.0131 0.1497 0.1497
Brugia malayi PHD-finger family protein 0.0053 0.0266 0.0447
Trichomonas vaginalis inositol monophosphatase, putative 0.0156 0.1898 1
Schistosoma mansoni lamin 0.0054 0.0281 0.0281
Schistosoma mansoni single-minded 0.0047 0.0169 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0568 0.2686
Brugia malayi hypothetical protein 0.0061 0.0392 0.0694
Echinococcus granulosus histone acetyltransferase MYST2 0.0116 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.0072 0.0568 0.1102
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0543 0.8017 0.8017
Echinococcus multilocularis para nitrobenzyl esterase 0.0061 0.0392 0.0392
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.008 0.0155
Loa Loa (eye worm) carboxylesterase 0.0061 0.0392 0.0761
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.008 0.0084
Mycobacterium tuberculosis Conserved protein 0.0072 0.0568 0.0278
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.1898 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0568 0.1102
Loa Loa (eye worm) hypothetical protein 0.0061 0.0392 0.0761
Mycobacterium ulcerans lipase LipD 0.0072 0.0568 0.117
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0568 0.0278
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.1898 1
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0543 0.8017 0.8017
Echinococcus granulosus neuropeptide s receptor 0.0449 0.6535 0.6535
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0405 0.5844 0.5844
Loa Loa (eye worm) hypothetical protein 0.0082 0.0721 0.1397
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0568 0.117
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1497 0.1497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.1766 0.1766
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0116 0.1259 0.1259
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.2381 0.2381
Schistosoma mansoni alpha-glucosidase 0.0161 0.197 0.197
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.6535 0.6535
Brugia malayi hypothetical protein 0.0166 0.2053 0.3938
Mycobacterium tuberculosis Conserved protein 0.0072 0.0568 0.0278
Loa Loa (eye worm) hypothetical protein 0.0116 0.1259 0.2442
Schistosoma mansoni hypothetical protein 0.0039 0.0037 0.0037
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0405 0.5844 0.5844
Echinococcus granulosus carboxylesterase 5A 0.0362 0.5156 0.5156
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0568 0.2686
Brugia malayi Inositol-1 0.0156 0.1898 0.3636
Echinococcus multilocularis SAM and MBT domain containing protein 0.0102 0.1036 0.1036
Schistosoma mansoni alpha-glucosidase 0.0161 0.197 0.197
Echinococcus granulosus BC026374 protein S09 family 0.0061 0.0392 0.0392
Echinococcus granulosus lamin dm0 0.0054 0.0281 0.0281
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0434 0.0279
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.1766 0.3424
Loa Loa (eye worm) beta-lactamase 0.0072 0.0568 0.1102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.1766 0.1766
Echinococcus granulosus SAM and MBT domain containing protein 0.0102 0.1036 0.1036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0568 0.0568
Onchocerca volvulus 0.0072 0.0568 0.1622
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0434 0.0776
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0568 0.2686
Onchocerca volvulus 0.0061 0.0392 0.0627
Echinococcus granulosus intermediate filament protein 0.0054 0.0281 0.0281
Brugia malayi MH2 domain containing protein 0.0116 0.1253 0.2376
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0434 0.0434
Echinococcus multilocularis musashi 0.0054 0.0281 0.0281
Brugia malayi intermediate filament protein 0.0054 0.0281 0.0477
Loa Loa (eye worm) hypothetical protein 0.0166 0.2053 0.3981
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.014 0.1639 0.1965
Echinococcus multilocularis histone acetyltransferase MYST2 0.0116 0.1259 0.1259
Onchocerca volvulus 0.0108 0.1134 0.4817
Onchocerca volvulus Huntingtin homolog 0.014 0.1648 0.7715
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0281 0.0545
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1497 0.1497
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0543 0.8017 0.8017
Loa Loa (eye worm) acetylcholinesterase 1 0.0362 0.5156 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0392 0.0761
Echinococcus multilocularis polycomb protein SCMH1 0.0102 0.1036 0.1036
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0568 0.0278
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1253 0.2431
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.301 0.5837
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0037 0.0037
Trichomonas vaginalis spcc417.12 protein, putative 0.0061 0.0392 0.1717
Loa Loa (eye worm) hypothetical protein 0.0362 0.5156 1
Echinococcus granulosus geminin 0.0176 0.2214 0.2214
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0568 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.1814 0.3518
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0156 0.1898 1
Brugia malayi Carboxylesterase family protein 0.0061 0.0392 0.0694
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.1766 0.1766
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0116 0.1259 0.1259
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1497 0.1497
Echinococcus multilocularis lamin 0.0054 0.0281 0.0281
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.1898 1
Onchocerca volvulus 0.0061 0.0392 0.0627
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1497 0.1497
Schistosoma mansoni inositol monophosphatase 0.0156 0.1898 0.1898
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2381 0.2381
Loa Loa (eye worm) hypothetical protein 0.0102 0.1036 0.2009
Loa Loa (eye worm) hypothetical protein 0.0061 0.0392 0.0761
Trichomonas vaginalis esterase, putative 0.0072 0.0568 0.2686
Brugia malayi beta-lactamase family protein 0.0072 0.0568 0.1038
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0127 0.1442 0.1442
Echinococcus granulosus lamin 0.0054 0.0281 0.0281
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0543 0.8017 0.8017
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0305 0.0591
Onchocerca volvulus 0.0072 0.0568 0.1622
Onchocerca volvulus 0.0102 0.1036 0.4261
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0021 0.004
Mycobacterium ulcerans beta-lactamase 0.0072 0.0568 0.117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.1766 0.1766
Loa Loa (eye worm) hypothetical protein 0.0061 0.0392 0.0761
Schistosoma mansoni hypothetical protein 0.0176 0.2214 0.2214
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.6535 0.6535
Echinococcus multilocularis alkaline phosphatase 0.0543 0.8017 0.8017
Onchocerca volvulus 0.0061 0.0392 0.0627
Schistosoma mansoni intermediate filament proteins 0.0054 0.0281 0.0281
Brugia malayi beta-lactamase family protein 0.0072 0.0568 0.1038
Brugia malayi mbt repeat family protein 0.0102 0.1036 0.1952
Loa Loa (eye worm) hypothetical protein 0.0072 0.0568 0.1102
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0186 0.0186
Brugia malayi Carboxylesterase family protein 0.0061 0.0392 0.0694
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.2381 0.458
Echinococcus multilocularis zinc finger protein 0.0042 0.0085 0.0085
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.6535 0.6535
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.1497 0.2852
Loa Loa (eye worm) hypothetical protein 0.0158 0.1925 0.3733
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1253 0.2431
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0061 0.0392 0.0392
Brugia malayi Carboxylesterase family protein 0.0061 0.0392 0.0694
Onchocerca volvulus 0.0166 0.2053 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0102 0.1036 0.1036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0061 0.0392 0.0761
Onchocerca volvulus 0.0072 0.0568 0.1622
Brugia malayi Carboxylesterase family protein 0.0061 0.0392 0.0694
Echinococcus multilocularis acetylcholinesterase 0.0362 0.5156 0.5156
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0156 0.1898 0.5
Schistosoma mansoni alkaline phosphatase 0.0543 0.8017 0.8017
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0121
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.008 0.008
Echinococcus multilocularis lamin dm0 0.0054 0.0281 0.0281
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0638 0.0638
Schistosoma mansoni hypothetical protein 0.0282 0.3889 0.3889
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0169 0.0169
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0568 0.117
Brugia malayi Bromodomain containing protein 0.0082 0.0718 0.1331
Brugia malayi Bromodomain containing protein 0.016 0.1959 0.3754
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0568 0.2686
Brugia malayi hypoxia-induced factor 1 0.0146 0.1731 0.331
Brugia malayi TAR-binding protein 0.0131 0.1497 0.2852
Schistosoma mansoni inositol monophosphatase 0.0156 0.1898 0.1898
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0543 0.8017 0.8017
Schistosoma mansoni microtubule-associated protein tau 0.0668 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0568 0.1038
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0434 0.1948
Brugia malayi mbt repeat family protein 0.0102 0.1036 0.1952
Loa Loa (eye worm) carboxylesterase 0.0362 0.5156 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.2381 0.4619
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.1766 0.1766
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0568 0.0278
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0281 0.0545
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0568 0.0278
Schistosoma mansoni acetylcholinesterase 0.0061 0.0392 0.0392
Mycobacterium tuberculosis Conserved protein 0.0072 0.0568 0.0278
Loa Loa (eye worm) hypothetical protein 0.0061 0.0392 0.0761
Echinococcus multilocularis BC026374 protein (S09 family) 0.0061 0.0392 0.0392
Onchocerca volvulus Huntingtin homolog 0.014 0.1648 0.7715
Loa Loa (eye worm) hypothetical protein 0.0362 0.5156 1
Loa Loa (eye worm) hypothetical protein 0.014 0.1648 0.3196
Schistosoma mansoni gliotactin 0.0061 0.0392 0.0392
Schistosoma mansoni bromodomain containing protein 0.0135 0.1563 0.1563
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0037 0.0037
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0102 0.1036 0.4261
Loa Loa (eye worm) TAR-binding protein 0.0131 0.1497 0.2902
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.1036 0.1036
Echinococcus granulosus alkaline phosphatase 0.0543 0.8017 0.8017
Echinococcus granulosus acetylcholinesterase 0.0362 0.5156 0.5156
Loa Loa (eye worm) hypothetical protein 0.0061 0.0392 0.0761
Schistosoma mansoni hypothetical protein 0.0623 0.9292 0.9292
Schistosoma mansoni lamin 0.0054 0.0281 0.0281
Echinococcus granulosus polycomb protein SCMH1 0.0102 0.1036 0.1036

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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