Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0311 | 0.1791 | 0.5 |
Brugia malayi | hypothetical protein | 0.0313 | 0.1834 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0681 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0311 | 0.1791 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0311 | 0.1791 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0311 | 0.1791 | 0.5 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0311 | 0.1791 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0311 | 0.1791 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0681 | 1 | 1 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0311 | 0.1791 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.023 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0681 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.