Detailed information for compound 645311

Basic information

Technical information
  • TDR Targets ID: 645311
  • Name: N-[3-[(2-chlorobenzoyl)amino]phenyl]-4-nitrob enzamide
  • MW: 395.796 | Formula: C20H14ClN3O4
  • H donors: 2 H acceptors: 4 LogP: 4.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)[N+](=O)[O-])Nc1cccc(c1)NC(=O)c1ccccc1Cl
  • InChi: 1S/C20H14ClN3O4/c21-18-7-2-1-6-17(18)20(26)23-15-5-3-4-14(12-15)22-19(25)13-8-10-16(11-9-13)24(27)28/h1-12H,(H,22,25)(H,23,26)
  • InChiKey: MWVHGFXMXXWOLV-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[3-[(2-chlorobenzoyl)amino]phenyl]-4-nitro-benzamide
  • N-[3-[[(2-chlorophenyl)-oxomethyl]amino]phenyl]-4-nitrobenzamide
  • N-[3-[(2-chlorophenyl)carbonylamino]phenyl]-4-nitro-benzamide
  • ZINC02878975
  • STK129997

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0016 0.7441 0.7013
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 1 1
Echinococcus granulosus Immunoglobulin 0.0015 0.6198 0.6198
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Entamoeba histolytica recQ family helicase, putative 0.0019 1 1
Echinococcus multilocularis neuroglian 0.0015 0.6198 0.6198
Loa Loa (eye worm) RecQ helicase 0.0019 1 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 1 1
Echinococcus granulosus roundabout 2 0.0015 0.6198 0.6198
Echinococcus granulosus twitchin 0.0015 0.6198 0.6198
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 1 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0 0.5
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 1 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0 0.5
Brugia malayi Bloom's syndrome protein homolog 0.0019 1 1
Entamoeba histolytica recQ family DNA helicase 0.001 0.1432 0.0381
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 1 1
Schistosoma mansoni cell adhesion molecule 0.0015 0.6198 0.6198
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 1 0.5
Echinococcus granulosus bloom syndrome protein 0.0019 1 1
Echinococcus multilocularis Immunoglobulin 0.0015 0.6198 0.6198
Echinococcus multilocularis Immunoglobulin 0.0015 0.6198 0.6198
Echinococcus multilocularis bloom syndrome protein 0.0019 1 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 1 0.5
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.6198 0.6198
Loa Loa (eye worm) hypothetical protein 0.001 0.1432 0.00000000841
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Echinococcus granulosus neuroglian 0.0015 0.6198 0.6198
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 1 0.5
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 1 0.5
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.7441 0.3268
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0 0.5
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0019 1 1
Schistosoma mansoni vesicular amine transporter 0.0015 0.6198 0.6198
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Schistosoma mansoni DNA helicase recq1 0.0019 1 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0 0.5
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 1 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.6198 0.6198
Echinococcus granulosus defective proboscis extension response 0.0015 0.6198 0.6198
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.1432 1
Trichomonas vaginalis DNA helicase recq, putative 0.0019 1 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0015 0.6198 0.6198
Echinococcus multilocularis roundabout 2 0.0015 0.6198 0.6198
Schistosoma mansoni nephrin 0.0015 0.6198 0.6198
Schistosoma mansoni DNA helicase recq5 0.0019 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.1432 0.0381
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.1432 0.1432
Treponema pallidum ATP-dependent DNA helicase 0.001 0.1432 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.6198 0.5563
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0015 0.6198 0.6198
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.1093 0.1093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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