Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.3331 | 0.3246 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.009 | 0.2742 | 0.2651 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0653 | 0.0754 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0653 | 0.0754 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3892 | 0.3815 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.6094 | 0.4333 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.6094 | 0.4333 |
Echinococcus granulosus | geminin | 0.0187 | 0.7128 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.3108 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.009 | 0.2742 | 0.3738 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 1 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.3108 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.6094 | 0.4333 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2742 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.3331 | 0.3246 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.6094 | 0.4333 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0653 | 0.0754 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0239 | 0.9469 | 0.9462 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0653 | 0.0754 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.009 | 0.2742 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 1 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0031 | 0.0064 | 0.5 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.009 | 0.2742 | 0.2651 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0653 | 0.0535 |
Echinococcus multilocularis | geminin | 0.0187 | 0.7128 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.6495 | 0.4915 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0099 | 0.3108 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1847 | 0.1744 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.6094 | 0.4333 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2742 | 0.5 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2742 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2742 | 0.3738 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1847 | 0.2459 |
Brugia malayi | follicle stimulating hormone receptor | 0.0225 | 0.8828 | 0.8813 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0653 | 0.0754 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0653 | 0.0754 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0099 | 0.3108 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0653 | 0.0535 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.7128 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0164 | 0.6094 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 0.8828 | 0.8813 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3892 | 0.3815 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3892 | 0.3815 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.009 | 0.2742 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.6094 | 0.4333 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2742 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0653 | 0.0754 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.6094 | 0.4333 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.3331 | 0.3246 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.6495 | 0.4915 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.7128 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1847 | 0.1744 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.9469 | 0.9462 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.009 | 0.2742 | 0.3738 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.3331 | 0.3246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.