Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.003 | 0.0173 | 0.0167 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0001 | 0.0004 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0173 | 0.0963 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0255 | 0.1425 |
Schistosoma mansoni | coup transcription factor | 0.003 | 0.0173 | 0.0963 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.003 | 0.0173 | 0.0171 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0377 | 0.0962 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0255 | 0.0941 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0.0173 | 0.0171 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0255 | 0.0941 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.003 | 0.0173 | 0.044 |
Onchocerca volvulus | 0.0037 | 0.0255 | 0.0219 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0377 | 0.0704 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0001 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.003 | 0.0173 | 0.044 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.1261 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.003 | 0.0173 | 0.044 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0109 | 0.2855 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0963 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0001 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0255 | 0.1425 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.003 | 0.0173 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0167 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0173 | 0.044 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.003 | 0.0173 | 0.044 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.003 | 0.0173 | 0.044 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0173 | 0.0171 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0255 | 0.6738 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0217 | 0.1211 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0171 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0217 | 0.0553 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0255 | 0.0383 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.1115 | 0.4133 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0109 | 0.2855 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0255 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.1115 | 0.4133 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0255 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.003 | 0.0173 | 0.044 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0255 | 0.6738 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0337 | 0.3921 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0377 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0173 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0167 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0377 | 0.0963 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0255 | 0.065 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0.0173 | 0.0963 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0255 | 0.6738 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0377 | 0.0705 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.003 | 0.0173 | 0.044 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0377 | 0.0376 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0377 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.0173 | 0.044 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0255 | 0.0383 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0255 | 0.6738 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.003 | 0.0173 | 0.0167 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.3921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0167 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.0173 | 0.0963 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.003 | 0.0173 | 0.0167 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0377 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0255 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0255 | 0.0941 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0377 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0.0173 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0167 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0377 | 0.2114 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0963 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0109 | 0.2855 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0173 | 0.044 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0377 | 0.2114 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0255 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0255 | 0.0941 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0377 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0173 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0167 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0377 | 0.0705 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.1115 | 0.4133 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0255 | 0.0941 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0.0173 | 0.0963 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0.0173 | 0.0171 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0.0173 | 0.0963 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0.0173 | 0.0963 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0255 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0173 | 0.0963 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0255 | 0.6738 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0255 | 0.065 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0109 | 0.2855 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.0173 | 0.044 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0255 | 0.065 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0255 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.1261 | 0.4677 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.003 | 0.0173 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0255 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0217 | 0.0283 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0255 | 0.0253 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0173 | 0.0171 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0409 | 0.0787 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0173 | 0.044 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0.0173 | 0.0963 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0.0173 | 0.0963 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0162 | 0.1779 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0146 | 0.1583 | 0.1582 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.2695 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.1261 | 0.4677 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0109 | 0.2855 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0255 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0377 | 0.2114 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0109 | 0.2855 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0377 | 0.2114 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.0173 | 0.0963 |
Onchocerca volvulus | 0.0037 | 0.0255 | 0.0219 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.003 | 0.0173 | 0.0167 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0.0173 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0409 | 0.0787 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0167 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.0173 | 0.0963 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0.0173 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0255 | 0.0383 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0173 | 0.044 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0409 | 0.1042 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0173 | 0.0167 |
Loa Loa (eye worm) | steroid hormone receptor | 0.003 | 0.0173 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0255 | 0.0383 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.1115 | 0.4133 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0.0173 | 0.0963 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.1115 | 0.4133 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.003 | 0.0173 | 0.0167 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0173 | 0.044 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0108 | 0.1115 | 0.8544 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.1261 | 0.4677 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0377 | 0.0963 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0255 | 0.0941 |
Brugia malayi | ecdysteroid receptor | 0.0337 | 0.3921 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0.0173 | 0.0963 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0255 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0255 | 0.0383 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0377 | 0.2115 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0162 | 0.1779 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0255 | 0.1425 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0173 | 0.0171 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0377 | 0.0376 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0377 | 1 |
Onchocerca volvulus | 0.0037 | 0.0255 | 0.0219 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0255 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0109 | 0.2855 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0.0173 | 0.0963 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0255 | 0.065 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0109 | 0.2855 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0255 | 0.0941 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.003 | 0.0173 | 0.0167 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0377 | 0.0376 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.003 | 0.0173 | 0.0167 |
Brugia malayi | steroid hormone receptor | 0.003 | 0.0173 | 0.044 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.1115 | 0.4133 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0109 | 0.0277 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0255 | 0.0941 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0377 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0173 | 0.0171 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0255 | 0.6738 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0409 | 0.1042 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0255 | 0.0383 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0255 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0255 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0255 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0255 | 0.0941 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.003 | 0.0173 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0255 | 0.0383 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0377 | 0.1396 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0377 | 0.2114 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.