Detailed information for compound 645649

Basic information

Technical information
  • TDR Targets ID: 645649
  • Name: N-(3-chlorophenyl)-2-[(3-methoxyphenyl)-(4-me thylphenyl)sulfonylamino]acetamide
  • MW: 444.931 | Formula: C22H21ClN2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.49 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N(S(=O)(=O)c1ccc(cc1)C)CC(=O)Nc1cccc(c1)Cl
  • InChi: 1S/C22H21ClN2O4S/c1-16-9-11-21(12-10-16)30(27,28)25(19-7-4-8-20(14-19)29-2)15-22(26)24-18-6-3-5-17(23)13-18/h3-14H,15H2,1-2H3,(H,24,26)
  • InChiKey: BGGBMSFVFPBZBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chlorophenyl)-2-[(3-methoxyphenyl)-(4-methylphenyl)sulfonyl-amino]acetamide
  • N-(3-chlorophenyl)-2-[(3-methoxyphenyl)-(4-methylphenyl)sulfonyl-amino]ethanamide
  • ZINC02962854
  • Oprea1_170132

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0135 0.0291
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0135 0.0146
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0949 0.0947
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0313 0.031
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0531 0.0586
Echinococcus multilocularis dnaJ subfamily B 0.0416 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0177 0.0175
Mycobacterium ulcerans hypothetical protein 0.0024 0.0362 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0193
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0362 0.0231
Schistosoma mansoni thyroid hormone receptor 0.0157 0.364 0.3618
Loa Loa (eye worm) calpain 0.002 0.0261 0.0285
Loa Loa (eye worm) hypothetical protein 0.0046 0.0915 0.1007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0531 0.0586
Echinococcus granulosus lamin dm0 0.0054 0.1118 0.1115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0234
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0362 0.0431
Trypanosoma brucei calpain-like protein, putative 0.002 0.0261 0.0332
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0724 0.0722
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0531 0.0498
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0362 0.0399
Schistosoma mansoni topbp1 0.0015 0.0156 0.0122
Echinococcus multilocularis hypothetical protein 0.002 0.0261 0.0259
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0145 0.3332 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0902 0.0991
Loa Loa (eye worm) hypothetical protein 0.0053 0.1093 0.1203
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0949 0.1047
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0531 0.144
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0155 0.358 1
Echinococcus granulosus calpain 0.002 0.0261 0.0259
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0135 0.0146
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0135 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0902 0.0899
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1411 0.3951
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0135 0.0101
Schistosoma mansoni hypothetical protein 0.0072 0.1551 0.1521
Echinococcus granulosus calpain 5 0.002 0.0261 0.0259
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0313 0.031
Schistosoma mansoni hypothetical protein 0.0048 0.0949 0.0918
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0531 0.0583
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0949 0.0947
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0531 0.0586
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.014 0.3204 0.3203
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0332
Loa Loa (eye worm) hypothetical protein 0.0026 0.0426 0.0467
Loa Loa (eye worm) hypothetical protein 0.0018 0.0228 0.0248
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.3474 0.383
Brugia malayi ecdysteroid receptor 0.0031 0.0531 0.0586
Trypanosoma brucei calpain-like protein, putative 0.002 0.0261 0.0332
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0531 0.0586
Loa Loa (eye worm) intermediate filament protein 0.0054 0.1118 0.123
Brugia malayi nuclear receptor NHR-88 0.0014 0.0135 0.0149
Loa Loa (eye worm) hypothetical protein 0.0046 0.0915 0.1007
Loa Loa (eye worm) dihydrofolate reductase 0.0379 0.9069 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0177 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0531 0.0583
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0135 0.0101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0531 0.0583
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.1479 0.1449
Brugia malayi nuclear hormone receptor 0.0031 0.0531 0.0586
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0531 0.0583
Plasmodium vivax calpain, putative 0.002 0.0261 0.0332
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0531 0.0529
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.1411 0.4342
Entamoeba histolytica hypothetical protein 0.0072 0.1551 0.4783
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1411 0.3951
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0261 0.0259
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.0915 0.0913
Loa Loa (eye worm) calpain 5 0.002 0.0261 0.0285
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0949 0.0947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0902 0.087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0215 0.0066
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0145 0.3332 0.9277
Brugia malayi hypothetical protein 0.0015 0.0156 0.0172
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0135 0.0132
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0362 0.1032
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0498 0.0547
Schistosoma mansoni hypothetical protein 0.0048 0.0949 0.0918
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0145 0.3332 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0902 0.0899
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.014 0.3204 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0015 0.0156 0.0383
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0332
Treponema pallidum DNA ligase (lig) 0.0015 0.0156 0.5
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0066 0.1408 0.1378
Leishmania major kinesin, putative 0.002 0.0261 0.0108
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0531 0.0529
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0531 0.0586
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0193
Schistosoma mansoni hypothetical protein 0.0048 0.0949 0.0918
Schistosoma mansoni intermediate filament proteins 0.0054 0.1118 0.1087
Echinococcus granulosus lamin 0.0054 0.1118 0.1115
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0261 0.0228
Trypanosoma cruzi DNA repair protein, putative 0.0018 0.0228 0.0226
Brugia malayi nuclear receptor NHR-67 0.0014 0.0135 0.0149
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0234
Schistosoma mansoni hypothetical protein 0.0171 0.3965 0.3944
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0531 0.0529
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0077 0.1662 0.4741
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0724 0.0722
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0531 0.0498
Chlamydia trachomatis dihydrofolate reductase 0.0379 0.9069 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0402 0.044
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1411 0.3951
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0135 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0362 0.0231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0531 0.0529
Brugia malayi hypothetical protein 0.0151 0.3484 0.3841
Schistosoma mansoni dihydrofolate reductase 0.0379 0.9069 0.9066
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0145 0.3332 1
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0506
Brugia malayi calpain family protein 1 0.0066 0.1396 0.1539
Brugia malayi steroid hormone receptor 0.0031 0.0531 0.0586
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.1411 0.1556
Echinococcus multilocularis musashi 0.0054 0.1118 0.1115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0177 0.0175
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0135 0.0132
Echinococcus granulosus cpg binding protein 0.0031 0.0539 0.0537
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0313 0.031
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0531 0.0498
Loa Loa (eye worm) tnks protein 0.001 0.0035 0.0035
Onchocerca volvulus 0.0014 0.0135 0.0291
Schistosoma mansoni hypothetical protein 0.0127 0.289 0.2865
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0032 0.0566 0.0564
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0362 0.0431
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0135 0.0132
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0426 0.0423
Schistosoma mansoni poly [ADP-ribose] polymerase 0.014 0.3204 0.3181
Entamoeba histolytica calpain large subunit domain III containing protein 0.002 0.0261 0.0715
Schistosoma mansoni lamin 0.0054 0.1118 0.1087
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0261 0.0332
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0135 0.0291
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0261 0.0332
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0531 0.0586
Entamoeba histolytica hypothetical protein 0.0072 0.1551 0.4783
Brugia malayi hypothetical protein 0.0016 0.0177 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0531 0.0583
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.1396 0.1366
Brugia malayi hypothetical protein 0.0014 0.0135 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0531 0.0586
Trypanosoma cruzi kinesin, putative 0.002 0.0261 0.0332
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0145 0.3332 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0902 0.087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0177 0.0143
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0193
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0077 0.1662 0.4741
Brugia malayi calpain 7 0.002 0.0261 0.0288
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0135 0.0149
Brugia malayi tailless protein 0.0014 0.0135 0.0149
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0135 0.0132
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0135 0.0149
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.0228 0.0226
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1303 0.1272
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0396
Brugia malayi Dihydrofolate reductase 0.0379 0.9069 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0497 0.0545
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.1411 0.1381
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0332
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.1551 0.1548
Brugia malayi MH2 domain containing protein 0.0122 0.2774 0.3059
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0135 0.0132
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0108
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.1118 0.1233
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0531 0.0586
Brugia malayi nuclear hormone receptor 0.0014 0.0135 0.0149
Entamoeba histolytica hypothetical protein 0.0072 0.1551 0.4783
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0379 0.9069 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.1411 0.1408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0362 0.0231
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0169
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.1411 0.3811
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0531 0.0529
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0015 0.0156 1
Onchocerca volvulus 0.0029 0.0498 0.1344
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0077 0.1662 0.1633
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0531 0.0498
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0949 0.1047
Loa Loa (eye worm) hypothetical protein 0.0103 0.2305 0.254
Echinococcus multilocularis nibrin 0.0015 0.0156 0.0153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0261 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0531 0.0586
Echinococcus multilocularis replication factor c subunit 1 0.0015 0.0156 0.0153
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0015 0.0156 1
Loa Loa (eye worm) hypothetical protein 0.015 0.3474 0.3828
Echinococcus multilocularis calpain 5 0.002 0.0261 0.0259
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0531 0.144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0531 0.0583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Brugia malayi calpain 5 0.002 0.0261 0.0288
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.114 0.2875
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0135 0.0132
Schistosoma mansoni zinc finger protein 0.0014 0.0135 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0362 0.0231
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0531 0.0529
Brugia malayi hypothetical protein 0.0014 0.0135 0.0149
Echinococcus granulosus WGR domain containing protein 0.0043 0.0844 0.0842
Schistosoma mansoni hypothetical protein 0.0171 0.3965 0.3944
Brugia malayi nuclear receptor NHR-88 0.0031 0.0531 0.0586
Echinococcus multilocularis lamin dm0 0.0054 0.1118 0.1115
Schistosoma mansoni coup transcription factor 0.0031 0.0531 0.0498
Brugia malayi DKFZp564C0469 protein 0.0015 0.0156 0.0172
Schistosoma mansoni calpain (C02 family) 0.002 0.0261 0.0228
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0531 0.0529
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0531 0.0529
Loa Loa (eye worm) hypothetical protein 0.0077 0.1662 0.183
Brugia malayi WGR domain containing protein 0.0077 0.1662 0.1832
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0261 0.0332
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Brugia malayi dihydrofolate reductase family protein 0.0379 0.9069 1
Onchocerca volvulus 0.0151 0.3484 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0234
Onchocerca volvulus 0.0046 0.0915 0.2554
Echinococcus granulosus poly ADP ribose polymerase 1 0.014 0.3204 0.3203
Giardia lamblia Replication factor C, subunit 1 0.0015 0.0156 0.5
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0015 0.0156 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0396
Echinococcus granulosus GPCR family 2 0.0048 0.0949 0.0947
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0362 0.0399
Schistosoma mansoni hypothetical protein 0.0103 0.2305 0.2279
Loa Loa (eye worm) hypothetical protein 0.0048 0.0949 0.1044
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0135 0.0101
Echinococcus granulosus replication factor c subunit 1 0.0015 0.0156 0.0153
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0135 0.0149
Brugia malayi hypothetical protein 0.0016 0.0177 0.0196
Trypanosoma cruzi kinesin, putative 0.002 0.0261 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0531 0.0586
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.289 0.2888
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0531 0.0529
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0177 0.0143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0362 0.1032
Schistosoma mansoni nuclear receptor 0.0014 0.0135 0.0101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0902 0.0899
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0362 0.0231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0902 0.0899
Entamoeba histolytica hypothetical protein 0.0072 0.1551 0.4783
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0531 0.144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0396
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0135 0.0101
Onchocerca volvulus 0.0015 0.0156 0.0352
Brugia malayi nuclear receptor RXR 0.0016 0.0177 0.0196
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0531 0.0529
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0949 0.1044
Onchocerca volvulus 0.0031 0.0531 0.144
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0015 0.0156 1
Brugia malayi Pax transcription activation domain interacting protein 0.0015 0.0156 0.0172
Echinococcus granulosus calpain A 0.002 0.0261 0.0259
Loa Loa (eye worm) hypothetical protein 0.0066 0.1396 0.1537
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.0228 0.0226
Echinococcus multilocularis calpain A 0.0069 0.1479 0.1476
Echinococcus granulosus nibrin 0.0015 0.0156 0.0153
Trypanosoma brucei antigen, putative 0.002 0.0261 0.0332
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0362 0.0231
Onchocerca volvulus 0.0054 0.1118 0.314
Entamoeba histolytica hypothetical protein 0.0015 0.0156 0.0383
Brugia malayi conserved hypotetical protein 0.0014 0.0135 0.0149
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0077 0.1662 0.1659
Echinococcus granulosus intermediate filament protein 0.0054 0.1118 0.1115
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0069 0.1479 0.1476
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0362 0.0231
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0261 0.0228
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0531 0.0529
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.289 0.2888
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0531 0.0586
Echinococcus multilocularis calpain 0.002 0.0261 0.0259
Echinococcus multilocularis geminin 0.0171 0.3965 0.3963
Trypanosoma brucei calpain-like protein, putative 0.002 0.0261 0.0332
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.1551 0.1548
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0108
Loa Loa (eye worm) calpain family protein 1 0.0046 0.0915 0.1007
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0531 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0531 0.0586
Echinococcus multilocularis dihydrofolate reductase 0.0379 0.9069 0.9069
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2774 0.3057
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0531 0.0529
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0531 0.0529
Echinococcus granulosus dihydrofolate reductase 0.0379 0.9069 0.9069
Schistosoma mansoni thyroid hormone receptor 0.0157 0.364 0.3618
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0497 0.0548
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0135 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0156 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0215 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0531 0.0498
Brugia malayi hypothetical protein 0.0015 0.0156 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0531 0.0498
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0145 0.3332 1
Entamoeba histolytica hypothetical protein 0.0022 0.0313 0.0877
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0015 0.0156 0.0172
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0261 0.0332
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0332
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Trypanosoma brucei DNA repair protein, putative 0.0018 0.0228 0.0226
Brugia malayi topoisomerase 0.0015 0.0156 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0531 0.0586
Echinococcus granulosus poly adp ribose polymerase 2 0.0077 0.1662 0.1659
Schistosoma mansoni cpg binding protein 0.0029 0.0498 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0156 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.1411 0.1408
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0362 0.0431
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0531 0.0529
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.3474 0.383
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0156 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0177 0.0193
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0362 0.1032
Loa Loa (eye worm) hypothetical protein 0.0054 0.1118 0.123
Onchocerca volvulus 0.0011 0.0047 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Brugia malayi hypothetical protein 0.0072 0.1551 0.171
Trypanosoma brucei poly(adp-ribose) polymerase 0.0077 0.1662 0.4741
Echinococcus granulosus calpain 7 C02 family 0.002 0.0261 0.0259
Loa Loa (eye worm) hypothetical protein 0.0066 0.1396 0.1537
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0902 0.087
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0135 0.0132
Echinococcus granulosus tankyrase 0.001 0.0035 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0362 0.0399
Echinococcus multilocularis GPCR, family 2 0.0048 0.0949 0.0947
Schistosoma mansoni DNA ligase IV 0.0015 0.0156 0.0122
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.1411 0.1553
Brugia malayi Tnks protein 0.001 0.0035 0.0038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0261 0.0332
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0135 0.0291
Onchocerca volvulus 0.0054 0.1118 0.314
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0531 0.0498
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0949 0.0947
Echinococcus multilocularis lamin 0.0054 0.1118 0.1115
Brugia malayi CXXC zinc finger family protein 0.0029 0.0498 0.055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0193
Echinococcus granulosus poly (ADP ribose) polymerase 0.0043 0.0844 0.0842
Entamoeba histolytica protein kinase, putative 0.002 0.0261 0.0715
Loa Loa (eye worm) DR-78 0.0014 0.0135 0.0146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0215 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0531 0.0583
Echinococcus multilocularis cpg binding protein 0.0031 0.0539 0.0537
Trypanosoma brucei calpain-like protein, putative 0.002 0.0261 0.0332
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0531 0.0583
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0177 0.0196
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0531 0.0529
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0531 0.0529
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0169
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0379 0.9069 1
Schistosoma mansoni lamin 0.0054 0.1118 0.1087
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0215 0.0066
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0506
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0261 0.0332
Trypanosoma brucei kinesin, putative 0.002 0.0261 0.0332
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0135 0.0149
Loa Loa (eye worm) hypothetical protein 0.0106 0.2387 0.263
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0379 0.9069 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0156 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0156 1
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2774 0.3057
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.1479 0.1449
Loa Loa (eye worm) hypothetical protein 0.0025 0.0402 0.044
Brugia malayi calpain family protein 1 0.0066 0.1396 0.1539
Brugia malayi intermediate filament protein 0.0054 0.1118 0.1233
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0135 0.0101
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0362 0.0192
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0362 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0193
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0069 0.1479 0.1476
Brugia malayi WGR domain containing protein 0.014 0.3204 0.3533
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0215 0.0185
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0261 0.0228
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0135 0.0132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.1118 0.123
Schistosoma mansoni calpain C (C02 family) 0.002 0.0261 0.0228
Schistosoma mansoni hypothetical protein 0.0048 0.0949 0.0918
Loa Loa (eye worm) hypothetical protein 0.0151 0.3484 0.3839
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0135 0.0149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0902 0.0994
Echinococcus granulosus geminin 0.0171 0.3965 0.3963
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0531 0.0498
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Onchocerca volvulus 0.0024 0.0362 0.0948
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0169
Brugia malayi ecdysone receptor 0.0014 0.0135 0.0149
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0332
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0531 0.0529
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0261 0.0108
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0215 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0531 0.0586
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0135 0.0132
Schistosoma mansoni chromosome transmission fidelity factor 0.0015 0.0156 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.3474 0.3828
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0362 0.0192
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0169
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0015 0.0156 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0157 0.364 0.3638
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0362 0.0231
Loa Loa (eye worm) calpain family protein 1 0.0066 0.1396 0.1537
Trichomonas vaginalis replication factor C large subunit, putative 0.0015 0.0156 1
Onchocerca volvulus DNA ligase 3 homolog 0.0018 0.0228 0.056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0531 0.0586
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0531 0.0498
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0583
Echinococcus granulosus calpain A 0.0069 0.1479 0.1476
Schistosoma mansoni nuclear receptor 0.0014 0.0135 0.0101
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.2305 0.2542
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0135 0.0132
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0426 0.0423
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.1551 0.1521
Schistosoma mansoni hypothetical protein 0.0416 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0531 0.0498
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0055 0.113 0.1243
Schistosoma mansoni topbp1 0.0015 0.0156 0.0122
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0135 0.0146
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0169
Echinococcus multilocularis tankyrase 0.001 0.0035 0.0032
Brugia malayi nuclear receptor RXR 0.0014 0.0135 0.0149

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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