Detailed information for compound 646229

Basic information

Technical information
  • TDR Targets ID: 646229
  • Name: N-(2,6-dimethylphenyl)-2-[(3-methoxyphenyl)-m ethylsulfonylamino]acetamide
  • MW: 362.443 | Formula: C18H22N2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N(S(=O)(=O)C)CC(=O)Nc1c(C)cccc1C
  • InChi: 1S/C18H22N2O4S/c1-13-7-5-8-14(2)18(13)19-17(21)12-20(25(4,22)23)15-9-6-10-16(11-15)24-3/h5-11H,12H2,1-4H3,(H,19,21)
  • InChiKey: DMTPTVOWDLPMOX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,6-dimethylphenyl)-2-[(3-methoxyphenyl)-methylsulfonyl-amino]acetamide
  • N-(2,6-dimethylphenyl)-2-[mesyl-(3-methoxyphenyl)amino]acetamide
  • N-(2,6-dimethylphenyl)-2-[(3-methoxyphenyl)-methylsulfonyl-amino]ethanamide
  • AG-690/15440563
  • Oprea1_483033
  • Oprea1_075092
  • ZINC00827509
  • BAS 02201227
  • N-(2,6-Dimethyl-phenyl)-2-[methanesulfonyl-(3-methoxy-phenyl)-amino]-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0209 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0388 0.315 0.3149
Onchocerca volvulus 0.0103 0.0763 0.2261
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1098 0.1278
Onchocerca volvulus 0.004 0.0232 0.0541
Schistosoma mansoni amine GPCR 0.0388 0.315 0.3671
Schistosoma mansoni hypothetical protein 0.0082 0.0582 0.0676
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0103 0.0473
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0049 0.0311 0.2137
Schistosoma mansoni adenoreceptor 0.0388 0.315 0.3671
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0209 0.2867
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus chromobox protein 1 0.0073 0.0507 0.0505
Schistosoma mansoni amine GPCR 0.0388 0.315 0.3671
Echinococcus multilocularis neuropeptide s receptor 0.0388 0.315 0.3149
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0066 0.0064
Onchocerca volvulus 0.0388 0.315 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0411 0.0409
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0411 0.0409
Brugia malayi Tachykinin-like peptides receptor 99D 0.0388 0.315 0.3149
Echinococcus granulosus survival motor neuron protein 1 0.0506 0.414 0.4139
Schistosoma mansoni hypothetical protein 0.0103 0.0763 0.0888
Schistosoma mansoni neuropeptide f receptor 76f 0.0388 0.315 0.3671
Trypanosoma brucei polo-like protein kinase 0.0098 0.0723 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni acetylcholinesterase 0.0175 0.1365 0.1589
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0307 0.1439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Echinococcus granulosus muscleblind protein 0.1205 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0388 0.315 0.3149
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0092 0.0623
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.1375 0.1374
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0024 0.0022
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0041 0.0242 0.4398
Echinococcus granulosus snurportin 1 0.0341 0.2758 0.2756
Brugia malayi Cytochrome P450 family protein 0.003 0.0147 0.0146
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.1449 0.7089
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0103 0.1792
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0299 0.2405 0.2803
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Brugia malayi Cytochrome P450 family protein 0.003 0.0147 0.0146
Schistosoma mansoni amine GPCR 0.0388 0.315 0.3671
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0021
Onchocerca volvulus 0.0388 0.315 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0066 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0076 0.0264
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0232 0.0231
Brugia malayi hypothetical protein 0.0175 0.1365 0.1363
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0066 0.0075
Schistosoma mansoni opsin-like receptor 0.0388 0.315 0.3671
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0411 0.0477
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0076 0.0264
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0582 0.058
Echinococcus granulosus tm gpcr rhodopsin 0.0388 0.315 0.3149
Echinococcus granulosus orexin receptor type 2 0.0388 0.315 0.3149
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0092 0.0623
Plasmodium vivax hypothetical protein, conserved 0.004 0.0232 0.3576
Schistosoma mansoni hypothetical protein 0.004 0.0231 0.0267
Brugia malayi acetyltransferase, GNAT family protein 0.0299 0.2405 0.2404
Trichomonas vaginalis esterase, putative 0.004 0.0232 0.1087
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0568 0.7787
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0388 0.315 0.3149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0103 0.0473
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0092 0.0623
Schistosoma mansoni hypothetical protein 0.004 0.0231 0.0267
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0043 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0092 0.009
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0147 0.2017
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0582 0.058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0122 0.014
Loa Loa (eye worm) acetylcholinesterase 1 0.1035 0.8578 0.8577
Schistosoma mansoni neuropeptide receptor 0.0388 0.315 0.3671
Loa Loa (eye worm) TYRA-2 protein 0.0388 0.315 0.3149
Echinococcus granulosus acetylcholinesterase 0.1035 0.8578 0.8577
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0076 0.0264
Onchocerca volvulus 0.0023 0.0092 0.0085
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0388 0.315 0.3149
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0076 0.0264
Loa Loa (eye worm) RNA binding protein 0.0061 0.0411 0.0409
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0374 0.0372
Echinococcus granulosus geminin 0.055 0.4507 0.4506
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0388 0.315 0.3671
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0076 0.0511
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0185 0.127
Loa Loa (eye worm) hypothetical protein 0.1035 0.8578 0.8577
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0076 0.0264
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0532 0.0619
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0041
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0122 0.012
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0388 0.315 0.3671
Brugia malayi Melatonin receptor type 1A 0.0388 0.315 0.3149
Loa Loa (eye worm) G-protein coupled receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0232 0.0231
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0723 0.2133
Loa Loa (eye worm) carboxylesterase 0.0175 0.1365 0.1363
Brugia malayi Cytochrome P450 family protein 0.006 0.0398 0.0397
Echinococcus multilocularis muscleblind protein 0.1205 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0388 0.315 0.3671
Schistosoma mansoni hypothetical protein 0.0022 0.0079 0.009
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0411 0.0477
Brugia malayi RNA binding protein 0.0061 0.0411 0.0409
Schistosoma mansoni hypothetical protein 0.0388 0.315 0.3671
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0024 0.0022
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0015 0.0028 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0723 0.3419
Schistosoma mansoni hypothetical protein 0.0341 0.2758 0.3214
Echinococcus granulosus rhodopsin orphan GPCR 0.0388 0.315 0.3149
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0316 0.0314
Onchocerca volvulus 0.0388 0.315 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0041 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0066 0.0075
Leishmania major hypothetical protein, conserved 0.0016 0.0032 0.021
Onchocerca volvulus 0.0032 0.0165 0.0324
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0388 0.315 0.3149
Brugia malayi steroid hormone receptor 0.002 0.0066 0.0064
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0076 0.0511
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0703 0.0701
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0049 0.0311 0.0309
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0232 0.3198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0066 0.0064
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0582 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0239 0.1119
Onchocerca volvulus Neuropeptide F receptor homolog 0.0388 0.315 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0052 0.0337 0.6337
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0076 0.0264
Echinococcus granulosus tachykinin peptides receptor 99D 0.0388 0.315 0.3149
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0232 0.3198
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0232 0.0231
Schistosoma mansoni neuroligin 3 (S09 family) 0.0175 0.1365 0.1589
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1098 0.1096
Loa Loa (eye worm) hypothetical protein 0.0176 0.1375 0.1374
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0723 0.0722
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0703 0.0701
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.065 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0388 0.315 0.3149
Mycobacterium tuberculosis Conserved protein 0.004 0.0232 0.1044
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.1449 0.1448
Echinococcus multilocularis dro:myosuppressin receptor 0.0388 0.315 0.3149
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0041 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0092 0.009
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0033 0.0171 0.2941
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0047 0.0046
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0103 0.1792
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0076 0.0264
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1003 0.1001
Schistosoma mansoni amine GPCR 0.0388 0.315 0.3671
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Brugia malayi Dopamine receptor protein 2 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni myosin xvIII 0.0388 0.315 0.3671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0066 0.0064
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0232 0.1595
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0053 0.0341 0.1582
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0703 0.0701
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0103 0.1407
Echinococcus multilocularis G protein coupled receptor 139 0.0388 0.315 0.3149
Echinococcus granulosus histone acetyltransferase KAT2B 0.0288 0.2315 0.2313
Loa Loa (eye worm) MBCTL1 0.0057 0.0374 0.0372
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0388 0.315 0.3149
Brugia malayi hypothetical protein 0.0016 0.003 0.0029
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0388 0.315 0.3149
Brugia malayi CXXC zinc finger family protein 0.0056 0.0364 0.0363
Brugia malayi ecdysteroid receptor 0.002 0.0066 0.0064
Echinococcus granulosus neuroligin 0.0175 0.1365 0.1363
Brugia malayi Serotonin receptor 0.0388 0.315 0.3149
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0066 0.0064
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0049 0.0311 0.1434
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0114 0.0849 0.0848
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.1544
Brugia malayi G-protein coupled receptor 0.0388 0.315 0.3149
Echinococcus multilocularis 0.0021 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0723 0.0722
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0041
Schistosoma mansoni hypothetical protein 0.0082 0.0582 0.0676
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0388 0.315 0.3149
Brugia malayi TAR-binding protein 0.0061 0.0411 0.0409
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1048 0.1047
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0232 0.1087
Loa Loa (eye worm) hypothetical protein 0.004 0.0232 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.0388 0.315 0.3149
Schistosoma mansoni alpha-1 adrenergic receptor 0.0388 0.315 0.3671
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0507 0.239
Echinococcus multilocularis carboxylesterase 5A 0.1035 0.8578 0.8577
Echinococcus multilocularis allatostatin A receptor 0.0388 0.315 0.3149
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0213 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.0388 0.315 0.3149
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Echinococcus granulosus neuropeptide Y receptor 0.0388 0.315 0.3149
Schistosoma mansoni hypothetical protein 0.004 0.0231 0.0267
Leishmania major cytochrome p450-like protein 0.0021 0.0076 0.0511
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0232 0.1087
Onchocerca volvulus 0.0388 0.315 1
Echinococcus multilocularis acetylcholinesterase 0.1035 0.8578 0.8577
Schistosoma mansoni hypothetical protein 0.0082 0.0582 0.0676
Brugia malayi ORL1-like opioid receptor 0.0388 0.315 0.3149
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0076 0.0264
Mycobacterium leprae Probable lipase LipE 0.004 0.0232 0.42
Schistosoma mansoni survival motor neuron protein 0.0103 0.0763 0.0888
Brugia malayi AKH receptor 0.0388 0.315 0.3149
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0316 0.0811
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0049 0.0311 0.1434
Echinococcus multilocularis sex peptide receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0175 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Toxoplasma gondii ABC1 family protein 0.004 0.0232 0.1595
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0265 0.1242
Schistosoma mansoni neuropeptide F-like receptor 0.0388 0.315 0.3671
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0066 0.0064
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0388 0.315 0.3149
Echinococcus multilocularis protein patched 0.0041 0.0243 0.0242
Brugia malayi CHD4 protein 0.0017 0.0041 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0388 0.315 0.3149
Echinococcus multilocularis chromobox protein 1 0.0073 0.0507 0.0505
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0062
Onchocerca volvulus 0.0388 0.315 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0076 0.1024
Mycobacterium ulcerans polyketide synthase MbtD 0.0015 0.0025 0.0161
Mycobacterium ulcerans polyketide synthase Pks9 0.0033 0.0171 0.1171
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0175 0.1365 0.1589
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0076 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0066 0.0064
Schistosoma mansoni importin beta-1 0.0032 0.0166 0.0191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0209 0.2867
Echinococcus multilocularis geminin 0.055 0.4507 0.4506
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0508 0.0507
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0092 0.0623
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0873 0.6023
Onchocerca volvulus 0.0388 0.315 1
Brugia malayi Serotonin receptor 0.0388 0.315 0.3149
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0049 0.0311 0.581
Schistosoma mansoni zinc finger protein 0.0016 0.0032 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0066 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0239 0.1119
Echinococcus multilocularis neuropeptides capa receptor 0.0388 0.315 0.3149
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0076 0.0511
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0209 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0052 0.0337 0.2314
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0388 0.315 0.3671
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0103 0.0473
Echinococcus granulosus rhodopsin orphan GPCR 0.0388 0.315 0.3149
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni chromobox protein 0.0073 0.0507 0.0589
Plasmodium vivax importin-beta 2, putative 0.0032 0.0166 0.2551
Onchocerca volvulus 0.0175 0.1365 0.4211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.2059 0.2058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0335 0.0333
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0175 0.1365 0.1589
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0053 0.0341 0.0339
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.1607 0.1606
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0374 0.0372
Schistosoma mansoni BC026374 protein (S09 family) 0.0175 0.1365 0.1589
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0175 0.1365 0.6465
Schistosoma mansoni opsin-like receptor 0.0388 0.315 0.3671
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0066 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0147 0.0146
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0048 0.0298 0.1371
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0849 0.0989
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0092 0.0623
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0012 0.0002 0.0025
Brugia malayi Carboxylesterase family protein 0.0175 0.1365 0.1363
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1449 1
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0076 0.0074
Mycobacterium tuberculosis Conserved protein 0.004 0.0232 0.1044
Schistosoma mansoni cpg binding protein 0.0061 0.0408 0.0473
Loa Loa (eye worm) hypothetical protein 0.0057 0.0374 0.0372
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0079 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni amine GPCR 0.0388 0.315 0.3671
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0066 0.0075
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0388 0.315 0.3149
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0232 0.1044
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0316 0.0366
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0265 0.1242
Loa Loa (eye worm) hypothetical protein 0.0175 0.1365 0.1363
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0165 0.0163
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0047 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0388 0.315 0.3149
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0048 0.0298 0.1371
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.1842 0.184
Leishmania major hypothetical protein, conserved 0.0024 0.0103 0.0701
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0166 0.1134
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0175 0.1365 0.1363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0103 0.0473
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0723 0.3419
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0209 0.0207
Onchocerca volvulus 0.0388 0.315 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0232 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0066 0.0064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0066 0.0064
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0076 0.0511
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0035 0.0195 0.0856
Echinococcus multilocularis neuropeptide receptor 0.0388 0.315 0.3149
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0175 0.1365 0.1589
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0066 0.0075
Schistosoma mansoni hypothetical protein 0.0388 0.315 0.3671
Mycobacterium ulcerans lipase LipD 0.004 0.0232 0.1595
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.065 0.307
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0076 0.0511
Loa Loa (eye worm) hypothetical protein 0.0055 0.0359 0.0357
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0209 0.2656
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni biogenic amine receptor 0.0388 0.315 0.3671
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0043 0.0659
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0052 0.0051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0232 0.0231
Brugia malayi larval opioid receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0066 0.0075
Mycobacterium tuberculosis Probable thioesterase TesA 0.0041 0.0242 0.1092
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0723 0.3419
Echinococcus multilocularis acetylcholinesterase 0.1035 0.8578 0.8577
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0115 0.053
Echinococcus granulosus neuropeptide receptor 0.0388 0.315 0.3149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0232 0.0269
Trypanosoma brucei ISWI complex protein 0.0016 0.0032 0.042
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0043 0.0727
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0115 0.053
Loa Loa (eye worm) hypothetical protein 0.004 0.0232 0.0231
Echinococcus granulosus alpha 1A adrenergic receptor 0.0388 0.315 0.3149
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0568 0.7544
Echinococcus multilocularis neuropeptide Y receptor 0.0388 0.315 0.3149
Brugia malayi Carboxylesterase family protein 0.1035 0.8578 0.8577
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0049 0.0311 0.581
Echinococcus granulosus carboxylesterase 5A 0.1035 0.8578 0.8577
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0582 0.058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0066 0.0075
Loa Loa (eye worm) hypothetical protein 0.0175 0.1365 0.1363
Schistosoma mansoni hypothetical protein 0.031 0.25 0.2914
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0066 0.0064
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0209 0.3652
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0147 0.0146
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0582 0.058
Leishmania major importin beta-1 subunit, putative 0.0026 0.0115 0.0784
Onchocerca volvulus 0.0388 0.315 1
Echinococcus multilocularis g-protein coupled receptor 0.0388 0.315 0.3149
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0066 0.0064
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0213 0.0211
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0532 0.0619
Brugia malayi neuropeptide F receptor 0.0388 0.315 0.3149
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0092 0.0623
Giardia lamblia Kinase, PLK 0.0098 0.0723 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0049 0.0311 0.1434
Brugia malayi Carboxylesterase family protein 0.1035 0.8578 0.8577
Loa Loa (eye worm) neuropeptide F receptor 0.0388 0.315 0.3149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1098 0.1096
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0076 0.0511
Brugia malayi CHE-14 protein 0.0041 0.0243 0.0242
Brugia malayi SET domain containing protein 0.0014 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0114 0.0849 0.0848
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0076 0.0264
Loa Loa (eye worm) acyl carrier protein 0.0023 0.0088 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0209 0.0207
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis snurportin 1 0.0341 0.2758 0.2756
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0052 0.0337 0.6337
Schistosoma mansoni hypothetical protein 0.0082 0.0582 0.0676
Echinococcus granulosus rhodopsin orphan GPCR 0.0388 0.315 0.3149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0335 0.0333
Brugia malayi Cytochrome P450 family protein 0.0021 0.0076 0.0074
Mycobacterium ulcerans fatty acid synthase Fas 0.0015 0.0028 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Schistosoma mansoni biogenic amine (5HT) receptor 0.0388 0.315 0.3671
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0032 0.0166 0.1135
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0103 0.1587
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.1544
Brugia malayi Bromodomain containing protein 0.0089 0.0642 0.0641
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis g protein coupled receptor 0.0388 0.315 0.3149
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0243 0.1139
Echinococcus granulosus neuropeptide Y receptor 0.0388 0.315 0.3149
Echinococcus granulosus 7TM GPCR rhodopsin 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.004 0.0232 0.0231
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0043 0.0102
Echinococcus multilocularis g protein coupled receptor 0.0388 0.315 0.3149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0066 0.0064
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0232 0.1044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1098 0.1096
Echinococcus granulosus acetylcholinesterase 0.1035 0.8578 0.8577
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0076 0.0511
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0035
Echinococcus multilocularis BC026374 protein (S09 family) 0.0175 0.1365 0.1363
Schistosoma mansoni ap endonuclease 0.0037 0.0209 0.0241
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0076 0.0511
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0076 0.0511
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0388 0.315 0.3671
Brugia malayi MH2 domain containing protein 0.0132 0.1003 0.1001
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0041 0.0239 0.0238
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0209 0.2867
Loa Loa (eye worm) hypothetical protein 0.1205 1 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis orexin receptor type 2 0.0388 0.315 0.3149
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0052 0.0051
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0411 0.0409
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0316 0.0314
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0723 1
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0232 0.1595
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1098 0.1096
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0074 0.0515 0.2449
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0316 0.0314
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.065 0.4479
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0028 0.0133 0.0548
Onchocerca volvulus Fatty acid synthase homolog 0.0089 0.0642 0.187
Brugia malayi G protein-coupled receptor 0.0388 0.315 0.3149
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0703 0.9677
Onchocerca volvulus 0.0264 0.2109 0.6624
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0316 0.0366
Echinococcus granulosus dnaJ subfamily B 0.0792 0.654 0.654
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.1544
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0033 0.0171 0.1171
Echinococcus granulosus peptide allatostatin:somatostatin 0.0388 0.315 0.3149
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0076 0.0264
Brugia malayi putative neuropeptide receptor 0.0388 0.315 0.3149
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0076 0.1024
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0316 0.0314
Echinococcus multilocularis zinc finger protein 0.0031 0.0157 0.0155
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0715 0.0832
Toxoplasma gondii type I fatty acid synthase, putative 0.0035 0.0192 0.1315
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0076 0.0511
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0723 0.0842
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0076 0.0511
Echinococcus multilocularis somatostatin receptor 0.0388 0.315 0.3149
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.1607 0.1606
Schistosoma mansoni hypothetical protein 0.0021 0.0076 0.0086
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0076 0.0511
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.004 0.023 0.1579
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0092 0.0345
Mycobacterium ulcerans polyketide synthase 0.0049 0.0311 0.2137
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0103 0.1407
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0723 0.3419
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0067 0.0066
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0265 0.0647
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0335 0.0389
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0028 0.0129 0.0128
Trichomonas vaginalis spcc417.12 protein, putative 0.0175 0.1365 0.6465
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.002 0.0065 0.0212
Toxoplasma gondii type I fatty acid synthase, putative 0.0053 0.0344 0.2369
Echinococcus granulosus importin subunit beta 1 0.0032 0.0166 0.0164
Brugia malayi mbt repeat family protein 0.005 0.0316 0.0314
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0092 0.009
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0189 0.0219
Loa Loa (eye worm) acetyltransferase 0.0299 0.2405 0.2404
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Brugia malayi Dopamine receptor 0.0388 0.315 0.3149
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0076 0.0982
Echinococcus multilocularis GPCR, family 2 0.0082 0.0582 0.058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0103 0.0473
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0052 0.0337 0.6337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.2059 0.2058
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0568 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0076 0.0264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0092 0.1316
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.1449 0.1448
Onchocerca volvulus 0.0056 0.0364 0.0969
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0033 0.0214
Echinococcus multilocularis serotonin receptor 0.0388 0.315 0.3149
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0074 0.0515 0.2449
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1048 0.1047
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0076 0.0264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0092 0.1316
Onchocerca volvulus 0.0046 0.0285 0.0712
Onchocerca volvulus 0.0388 0.315 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0232 0.1087
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.6984 0.6983
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0166 0.2275
Mycobacterium leprae Polyketide synthase Pks13 0.0074 0.0515 1
Echinococcus granulosus neuropeptides capa receptor 0.0388 0.315 0.3149
Echinococcus granulosus biogenic amine 5HT receptor 0.0388 0.315 0.3149
Schistosoma mansoni thyroid hormone receptor 0.002 0.0066 0.0075
Brugia malayi Melibiase family protein 0.0076 0.0532 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0411 0.0477
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0026 0.0115 0.078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Brugia malayi nuclear hormone receptor 0.002 0.0066 0.0064
Brugia malayi sulfakinin receptor protein 0.0388 0.315 0.3149
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0076 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0285 0.0331
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0388 0.315 0.3149
Mycobacterium ulcerans Type I modular polyketide synthase 0.0049 0.0311 0.2137
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0114 0.0112
Echinococcus granulosus zinc finger protein 0.0031 0.0157 0.0155
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0374 0.0372
Brugia malayi beta-lactamase 0.004 0.0232 0.0231
Brugia malayi hypothetical protein 0.0035 0.0189 0.0188
Echinococcus multilocularis dnaJ subfamily B 0.0792 0.654 0.654
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0388 0.315 0.3149
Schistosoma mansoni bromodomain containing protein 0.0077 0.054 0.0627
Schistosoma mansoni chromobox protein 0.0073 0.0507 0.0589
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0723 0.3419
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0723 0.3419
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.004 0.023 0.4155
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0103 0.1407
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0388 0.315 0.3671
Onchocerca volvulus 0.0388 0.315 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0066 0.0064
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0066 0.0064
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0076 0.1024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.009
Loa Loa (eye worm) hypothetical protein 0.0175 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0388 0.315 0.3671
Echinococcus granulosus GPCR family 2 0.0082 0.0582 0.058
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0074 0.0517 0.0516
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0017 0.004 0.0087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0232 0.1044
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.1449 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0066 0.0064
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0723 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0232 0.1044
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.1449 1
Schistosoma mansoni bromodomain containing protein 0.0015 0.0023 0.0025
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0103 0.0701
Echinococcus multilocularis neuropeptide FF receptor 2 0.0388 0.315 0.3149
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0388 0.315 0.3149
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0076 0.0511
Echinococcus granulosus neuropeptide FF receptor 2 0.0388 0.315 0.3149
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0723 0.3419
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0122 0.012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0052 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0047 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Echinococcus multilocularis expressed conserved protein 0.009 0.0654 0.0653
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0092 0.0623
Echinococcus multilocularis survival motor neuron protein 1 0.0506 0.414 0.4139
Onchocerca volvulus 0.004 0.0232 0.0541
Loa Loa (eye worm) hypothetical protein 0.004 0.0234 0.0232
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0388 0.315 0.3149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0582 0.058
Plasmodium falciparum importin beta, putative 0.0032 0.0166 0.2898
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0062
Mycobacterium ulcerans polyketide synthase Pks13 0.0074 0.0515 0.3548
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0089
Echinococcus granulosus tm gpcr rhodopsin 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0134 0.066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1098 0.1096
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0047 0.0053
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni neuropeptide receptor 0.0388 0.315 0.3671
Onchocerca volvulus 0.0388 0.315 1
Echinococcus granulosus g protein coupled receptor 0.0388 0.315 0.3149
Mycobacterium ulcerans thioesterase TesA 0.0041 0.0242 0.1661
Schistosoma mansoni ap endonuclease 0.0037 0.0209 0.0241
Echinococcus granulosus neuropeptide s receptor 0.0388 0.315 0.3149
Echinococcus multilocularis neuroligin 0.0175 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.0506 0.414 0.4139
Mycobacterium ulcerans hypothetical protein 0.0023 0.0092 0.0623
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.2059 0.2058
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0041 0.0039
Echinococcus granulosus allatostatin A receptor 0.0388 0.315 0.3149
Brugia malayi GnHR receptor homolog 0.0388 0.315 0.3149
Loa Loa (eye worm) melatonin receptor type 1A 0.0388 0.315 0.3149
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Onchocerca volvulus 0.0388 0.315 1
Onchocerca volvulus 0.0175 0.1365 0.4211
Brugia malayi Carboxylesterase family protein 0.0175 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0232 0.1087
Brugia malayi PHD-finger family protein 0.0036 0.0204 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0066 0.0064
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0052 0.0337 0.1561
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0102
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0723 1
Brugia malayi hypothetical protein 0.0506 0.414 0.4139
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0508 0.0507
Brugia malayi Importin beta-1 subunit 0.0032 0.0166 0.0164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0035 0.0062
Brugia malayi RE15519p 0.0388 0.315 0.3149
Loa Loa (eye worm) CYP4Cod1 0.003 0.0147 0.0146
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0232 0.1044
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0147 0.2017
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0316 0.0366
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.0897 0.1045
Loa Loa (eye worm) hypothetical protein 0.1205 1 1
Mycobacterium leprae conserved hypothetical protein 0.004 0.0232 0.42
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0052 0.0337 0.2314
Mycobacterium tuberculosis Carboxylesterase LipT 0.0175 0.1365 0.6669
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0209 0.3209
Schistosoma mansoni histamine h1 receptor 0.0388 0.315 0.3671
Schistosoma mansoni cpg binding protein 0.0056 0.0364 0.0423
Onchocerca volvulus 0.0093 0.0674 0.1972
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0041
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0411 0.0409
Loa Loa (eye worm) hypothetical protein 0.0084 0.06 0.0598
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.009
Brugia malayi hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1098 0.1096
Schistosoma mansoni neuropeptide F-like receptor 0.0388 0.315 0.3671
Echinococcus granulosus g protein coupled receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0076 0.0511
Schistosoma mansoni hypothetical protein 0.0035 0.0189 0.0219
Echinococcus granulosus neuropeptides capa receptor 0.0388 0.315 0.3149
Schistosoma mansoni cpg binding protein 0.0061 0.0408 0.0473
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0209 0.0974
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0849 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.014 0.0646
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0076 0.0532 0.2512
Brugia malayi Heterochromatin protein 1 0.0073 0.0507 0.0505
Schistosoma mansoni biogenic amine (5HT) receptor 0.0388 0.315 0.3671
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0364 0.0363
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0209 0.0925
Entamoeba histolytica hypothetical protein 0.0026 0.0115 0.037
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0066 0.0064
Schistosoma mansoni neuropeptide receptor 0.0388 0.315 0.3671
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0723 0.0722
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0054 0.0241
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0388 0.315 0.3671
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0243 0.0242
Trypanosoma cruzi ISWI complex protein 0.0016 0.0032 0.042
Schistosoma mansoni kinase 0.005 0.0317 0.0368
Mycobacterium ulcerans polyketide synthase 0.0052 0.0337 0.2314
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0076 0.0511
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1003 0.1001
Brugia malayi neuropeptide F receptor 0.0388 0.315 0.3149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0066 0.0064
Schistosoma mansoni coup transcription factor 0.002 0.0066 0.0075
Schistosoma mansoni biogenic amine receptor 0.0388 0.315 0.3671
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0076 0.0264
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0189 0.0188
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0209 0.1849
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0232 0.1044
Echinococcus multilocularis neuropeptide receptor 0.0388 0.315 0.3149
Mycobacterium ulcerans beta-lactamase 0.004 0.0232 0.1595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0103 0.0473
Mycobacterium ulcerans carboxylesterase, LipT 0.0175 0.1365 0.9415
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0041 0.0039
Echinococcus multilocularis cpg binding protein 0.0061 0.0408 0.0406
Brugia malayi Bromodomain containing protein 0.0047 0.0294 0.0293
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus cpg binding protein 0.0061 0.0408 0.0406
Onchocerca volvulus 0.0053 0.0341 0.0892
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0763 0.0762
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0015 0.0025 0.0013
Onchocerca volvulus 0.005 0.0316 0.0811
Schistosoma mansoni hypothetical protein 0.0792 0.654 0.7624
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0411 0.0477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0066 0.0064
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0093 0.0681 0.0679
Brugia malayi putative neuropeptide receptor NPR1 0.0388 0.315 0.3149
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1035 0.8578 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0066 0.0075
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0166 0.2275
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0103 0.0473
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0388 0.315 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0166 0.0164
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0374 0.0372
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0723 0.0722
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0232 0.1044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0115 0.053
Loa Loa (eye worm) hypothetical protein 0.0175 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Schistosoma mansoni zinc finger protein 0.0031 0.0157 0.0181
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0243 0.0242
Onchocerca volvulus 0.0175 0.1365 0.4211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0066 0.0064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0066 0.0064
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0052 0.0337 0.1561
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0052 0.0337 0.1561
Schistosoma mansoni opsin-like receptor 0.0388 0.315 0.3671
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0189 0.0188
Schistosoma mansoni methyltransferase-related 0.0015 0.0022 0.0024
Onchocerca volvulus 0.0388 0.315 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.1365 0.1363
Mycobacterium tuberculosis Conserved protein 0.004 0.0232 0.1044
Echinococcus granulosus 7tm_1 domain containing protein 0.0388 0.315 0.3149
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0582 0.058
Echinococcus granulosus g-protein coupled receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0041
Brugia malayi Carboxylesterase family protein 0.0175 0.1365 0.1363
Echinococcus multilocularis g protein coupled receptor 0.0388 0.315 0.3149
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0849 0.0989
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0066 0.0064
Mycobacterium ulcerans thioesterase 0.0041 0.0242 0.1661
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0076 0.0264
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1449 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0209 0.0974
Echinococcus granulosus FTZ F1 alpha 0.002 0.0066 0.0064
Loa Loa (eye worm) carboxylesterase 0.0175 0.1365 0.1363
Schistosoma mansoni thyroid hormone receptor 0.002 0.0066 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0066 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1449 0.1688
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0147 0.1006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0341 0.2758 0.2756
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0232 0.0269
Echinococcus granulosus fmrfamide receptor 0.0388 0.315 0.3149
Schistosoma mansoni nuclear hormone receptor 0.002 0.0066 0.0075
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) cytochrome P450 0.0021 0.0076 0.0074
Echinococcus granulosus neuropeptide receptor 0.0388 0.315 0.3149
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0092 0.0623
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.009
Brugia malayi G-protein coupled receptor 0.0388 0.315 0.3149
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0076 0.0511
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.004 0.023 0.1579
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0388 0.315 0.3671
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0388 0.315 0.3149
Echinococcus granulosus somatostatin receptor 0.0388 0.315 0.3149
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0054 0.0241
Loa Loa (eye worm) hypothetical protein 0.0096 0.0703 0.0701
Brugia malayi G protein-coupled receptor F59B2.13 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.0314
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0076 0.0511
Schistosoma mansoni hypothetical protein 0.0388 0.315 0.3671
Brugia malayi beta-lactamase family protein 0.004 0.0232 0.0231
Trypanosoma brucei cytochrome P450, putative 0.003 0.0147 0.2017
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0166 0.0164
Schistosoma mansoni hypothetical protein 0.0176 0.1375 0.1602
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0115 0.1573
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0243 0.0242
Loa Loa (eye worm) hypothetical protein 0.004 0.0232 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0076 0.0264
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0076 0.0511
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0043 0.0285
Echinococcus multilocularis fmrfamide receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) beta-lactamase 0.004 0.0232 0.0231
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0388 0.315 0.3149
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0076 0.0511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Leishmania major hypothetical protein, conserved 0.004 0.0232 0.1595
Brugia malayi cytochrome P450 0.0021 0.0076 0.0074
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0175 0.1365 0.6669
Onchocerca volvulus 0.0388 0.315 1
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0507 0.239
Echinococcus granulosus g protein coupled receptor 0.0388 0.315 0.3149
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0209 0.143
Echinococcus granulosus rhodopsin orphan GPCR 0.0388 0.315 0.3149
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0066 0.0064
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0388 0.315 0.3149
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0316 0.0314
Echinococcus multilocularis protein dispatched 1 0.0047 0.0292 0.0291
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0388 0.315 0.3671
Brugia malayi Pre-SET motif family protein 0.0034 0.0185 0.0184
Echinococcus granulosus para nitrobenzyl esterase 0.0175 0.1365 0.1363
Schistosoma mansoni hypothetical protein 0.055 0.4507 0.5254
Echinococcus multilocularis fmrfamide receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0082 0.0582 0.058
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0066 0.0075
Brugia malayi Carboxylesterase family protein 0.0175 0.1365 0.1363
Loa Loa (eye worm) fatty acid synthase 0.0049 0.0305 0.0304
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0388 0.315 0.3671
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0175 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.0032 0.0165 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.014 0.0646
Schistosoma mansoni hypothetical protein 0.004 0.0231 0.0267
Brugia malayi hypothetical protein 0.0024 0.0103 0.0102
Trichomonas vaginalis set domain proteins, putative 0.0264 0.2109 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0041 0.0243 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0307 0.1439
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0232 0.3198
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0388 0.315 0.3149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0239 0.0563
Onchocerca volvulus 0.0388 0.315 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0321 0.032
Leishmania major cytochrome p450-like protein 0.003 0.0147 0.1006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0066 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0388 0.315 0.3149
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0076 0.0264
Onchocerca volvulus 0.004 0.0232 0.0541
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0374 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0341 0.0339
Echinococcus multilocularis muscleblind protein 1 0.1205 1 1
Schistosoma mansoni hypothetical protein 0.0388 0.315 0.3671
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.004 0.0236 0.106
Echinococcus multilocularis neuropeptide receptor A26 0.0388 0.315 0.3149
Echinococcus granulosus neuropeptide receptor A26 0.0388 0.315 0.3149
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0849 0.0989
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0066 0.0064
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0388 0.315 0.3149
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.2035 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0049 0.0311 0.2137
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0092 0.0623
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1449 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0388 0.315 0.3149
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.065 0.307
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0024 0.0022
Echinococcus granulosus G protein coupled receptor 139 0.0388 0.315 0.3149
Schistosoma mansoni cytochrome P450 0.0021 0.0076 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0388 0.315 0.3671
Schistosoma mansoni gliotactin 0.0175 0.1365 0.1589
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0209 0.143
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Brugia malayi mbt repeat family protein 0.005 0.0316 0.0314
Onchocerca volvulus 0.0175 0.1365 0.4211
Loa Loa (eye worm) carboxylesterase 0.1035 0.8578 0.8577
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1449 0.1688
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0076 0.1024
Echinococcus granulosus chromobox protein 1 0.0073 0.0507 0.0505
Loa Loa (eye worm) hypothetical protein 0.0052 0.0335 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0066 0.0064
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0388 0.315 0.3149
Brugia malayi follicle stimulating hormone receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0033 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0209 0.0207
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0388 0.315 0.3149
Mycobacterium leprae putative cytochrome p450 0.0021 0.0076 0.0982
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0388 0.315 0.3671
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0388 0.315 0.3149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1098 0.1278
Brugia malayi Dopamine receptor protein 1 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis serotonin receptor 0.0388 0.315 0.3149
Brugia malayi nuclear receptor NHR-88 0.002 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0066 0.0064
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0076 0.0511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0335 0.0389
Echinococcus granulosus tar DNA binding protein 0.0061 0.0411 0.0409
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.0314
Schistosoma mansoni growth hormone secretagogue receptor 0.0388 0.315 0.3671
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.065 0.4479
Echinococcus granulosus expressed conserved protein 0.009 0.0654 0.0653
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0066 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0185 0.0214
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0047 0.0053
Onchocerca volvulus 0.0388 0.315 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.065 0.0648
Brugia malayi Methyltransferase-like protein 4 0.0015 0.0022 0.0021
Onchocerca volvulus 0.0175 0.1365 0.4211
Brugia malayi beta-lactamase family protein 0.004 0.0232 0.0231
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0066 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0066 0.0064
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0243 0.0242
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0114 0.0849 0.0848
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0076 0.0264
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0175 0.1365 0.1363
Echinococcus granulosus biogenic amine 5HT receptor 0.0388 0.315 0.3149
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0232 0.1087
Echinococcus granulosus serotonin receptor 0.0388 0.315 0.3149
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0076 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0066 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0092 0.0623
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0092 0.0345
Onchocerca volvulus 0.0388 0.315 1
Brugia malayi Pre-SET motif family protein 0.0232 0.1842 0.184
Mycobacterium ulcerans Type I modular polyketide synthase 0.0049 0.0311 0.2137
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0388 0.315 0.3149
Plasmodium vivax SET domain protein, putative 0.0034 0.0185 0.2854
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0388 0.315 0.3149
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0398 0.0397
Schistosoma mansoni neuropeptide receptor 0.0388 0.315 0.3671
Trypanosoma cruzi ISWI complex protein 0.0016 0.0032 0.042
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0723 0.4986
Leishmania major hypothetical protein, conserved 0.0015 0.0022 0.0143
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0066 0.0064
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0076 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0066 0.0064
Echinococcus multilocularis neuropeptides capa receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0076 0.0511
Brugia malayi chromobox protein homolog 3 0.0041 0.0239 0.0238
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0066 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1098 0.1278
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0507 0.0505
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0024 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0209 0.0207
Echinococcus multilocularis para nitrobenzyl esterase 0.0175 0.1365 0.1363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0388 0.315 0.3671
Echinococcus multilocularis chromobox protein 1 0.0073 0.0507 0.0505
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.1544
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0103 0.0473
Loa Loa (eye worm) hypothetical protein 0.004 0.0232 0.0231
Loa Loa (eye worm) hypothetical protein 0.0258 0.2059 0.2058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0066 0.0064
Echinococcus granulosus dro:myosuppressin receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0076 0.0532 0.0531
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0411 0.0477
Schistosoma mansoni patched 1 0.0041 0.0243 0.0282
Mycobacterium ulcerans hypothetical protein 0.004 0.0232 0.1595
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0299 0.2405 0.2404
Toxoplasma gondii exonuclease III APE 0.0037 0.0209 0.143
Loa Loa (eye worm) hypothetical protein 0.1035 0.8578 0.8577
Echinococcus granulosus sex peptide receptor 0.0388 0.315 0.3149
Brugia malayi RNA, U transporter 1 0.0091 0.066 0.0658
Schistosoma mansoni biogenic amine receptor 0.0388 0.315 0.3671
Loa Loa (eye worm) neuropeptide F receptor 0.0388 0.315 0.3149
Loa Loa (eye worm) hypothetical protein 0.0388 0.315 0.3149
Echinococcus granulosus BC026374 protein S09 family 0.0175 0.1365 0.1363
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0388 0.315 0.3149
Leishmania major cytochrome p450-like protein 0.0021 0.0076 0.0511
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0175 0.1365 0.6669
Toxoplasma gondii melibiase subfamily protein 0.0114 0.0849 0.5857
Schistosoma mansoni hypothetical protein 0.055 0.4507 0.5254
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0374 0.0434
Echinococcus multilocularis neuropeptide Y receptor 0.0388 0.315 0.3149

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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