Detailed information for compound 646338

Basic information

Technical information
  • TDR Targets ID: 646338
  • Name: ethyl 2-[[4-(morpholin-4-ylmethyl)benzoyl]ami no]benzoate
  • MW: 368.426 | Formula: C21H24N2O4
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccccc1NC(=O)c1ccc(cc1)CN1CCOCC1
  • InChi: 1S/C21H24N2O4/c1-2-27-21(25)18-5-3-4-6-19(18)22-20(24)17-9-7-16(8-10-17)15-23-11-13-26-14-12-23/h3-10H,2,11-15H2,1H3,(H,22,24)
  • InChiKey: KNDKBQBKHCGWED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[[4-(morpholinomethyl)benzoyl]amino]benzoate
  • 2-[[[4-(morpholinomethyl)phenyl]-oxomethyl]amino]benzoic acid ethyl ester
  • 2-[[4-(morpholinomethyl)benzoyl]amino]benzoic acid ethyl ester
  • ethyl 2-[[4-(morpholin-4-ylmethyl)phenyl]carbonylamino]benzoate
  • Oprea1_086078

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis dihydrofolate reductase 0.0966 0.7099 1
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0659 0.0921
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0057 0.008
Loa Loa (eye worm) hypothetical protein 0.0047 0.0253 0.0356
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0165 0.0223
Echinococcus granulosus dnaJ subfamily B 0.0411 0.2965 0.2962
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0057 0.0053
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0282 0.104
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0599 0.0836
Schistosoma mansoni ets-related 0.0213 0.149 0.1485
Schistosoma mansoni coup transcription factor 0.0021 0.0057 0.0051
Brugia malayi hypothetical protein 0.0033 0.0148 0.02
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0075 0.0219
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0916 0.0912
Loa Loa (eye worm) RNA binding protein 0.0062 0.0363 0.0511
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0178 0.0242
Echinococcus multilocularis protein dispatched 1 0.0047 0.0251 0.0246
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0182 0.0841
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0115 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0182 0.5
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0363 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0253 0.0348
Onchocerca volvulus 0.0472 0.3417 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.005 0.0062
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0369 0.2655 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0623 0.0617
Mycobacterium tuberculosis Conserved protein 0.0072 0.0438 0.0609
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0178 0.025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.216 0.3042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0057 0.0072
Loa Loa (eye worm) hypothetical protein 0.0051 0.0282 0.0396
Schistosoma mansoni hypothetical protein 0.0328 0.2346 0.2341
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0438 0.0609
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0178 0.0649
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0208 0.0204
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0253 0.0348
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0282 0.104
Loa Loa (eye worm) hypothetical protein 0.0072 0.0438 0.0616
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0115 0.0411
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0008
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0966 0.7099 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0112 0.0106
Toxoplasma gondii ABC1 family protein 0.0072 0.0438 0.163
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0183 0.0177
Schistosoma mansoni hypothetical protein 0.0039 0.0197 0.0191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0253 0.0348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Schistosoma mansoni hypothetical protein 0.0047 0.0253 0.0247
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0182 0.0662
Schistosoma mansoni hypothetical protein 0.0039 0.0197 0.0191
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0253 0.0348
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.2091 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0529 0.0738
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0057 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0057 0.0053
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0208 0.0204
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0438 0.0616
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0689 0.5038 0.7094
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0079 0.0073
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0057 0.0053
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0026 0.0021
Schistosoma mansoni hypothetical protein 0.0101 0.0659 0.0653
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0182 0.0662
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0972 0.1362
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0438 0.0609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1286 0.1281
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0208 0.0292
Schistosoma mansoni hypothetical protein 0.0411 0.2965 0.296
Trichomonas vaginalis chaperonin, putative 0.0024 0.0079 0.0232
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0079 0.0276
Loa Loa (eye worm) hypothetical protein 0.0047 0.0253 0.0356
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0438 0.0434
Schistosoma mansoni survival motor neuron protein 0.0094 0.0602 0.0596
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0363 0.0357
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0057 0.0053
Brugia malayi Fli-1 protein 0.0213 0.149 0.2093
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0057 0.0053
Onchocerca volvulus 0.0094 0.0602 0.1746
Echinococcus multilocularis protein patched 0.0041 0.0208 0.0204
Plasmodium falciparum thioredoxin reductase 0.0037 0.0178 0.0649
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0354 0.1315
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0253 0.1183
Brugia malayi glutaminase DH11.1 0.0269 0.1908 0.2681
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0057 0.0072
Schistosoma mansoni gabp alpha 0.007 0.0426 0.042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0057 0.0072
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0602 0.0839
Trypanosoma brucei trypanothione reductase 0.0037 0.0178 0.0649
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0079 0.0276
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0182 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0253 0.0348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0057 0.0149
Schistosoma mansoni hypothetical protein 0.0037 0.0183 0.0177
Loa Loa (eye worm) histone methyltransferase 0.002 0.0051 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0203
Schistosoma mansoni dihydrofolate reductase 0.0966 0.7099 0.7097
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0079 0.0276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0354 0.035
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0006 0.0002
Mycobacterium tuberculosis Conserved protein 0.0072 0.0438 0.0609
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0057 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1009 0.1414
Brugia malayi RNA binding protein 0.0062 0.0363 0.0503
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0369 0.2655 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.1286 0.1805
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0057 0.008
Schistosoma mansoni lamin 0.0028 0.0112 0.0106
Loa Loa (eye worm) hypothetical protein 0.0453 0.3275 0.4614
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0026 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0354 0.0349
Echinococcus granulosus importin subunit beta 1 0.0028 0.0115 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.1286 0.1283
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0183 0.0178
Brugia malayi MH2 domain containing protein 0.0118 0.0785 0.1097
Onchocerca volvulus 0.0072 0.0438 0.1266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0057 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0253 0.0249
Onchocerca volvulus 0.0061 0.0354 0.1021
Loa Loa (eye worm) glutaminase 0.0269 0.1908 0.2687
Brugia malayi steroid hormone receptor 0.0021 0.0057 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0057 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0438 0.163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0253 0.0349
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0363 0.0511
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0599 0.0836
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0165 0.0598
Loa Loa (eye worm) hypothetical protein 0.0459 0.3325 0.4684
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0231
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Loa Loa (eye worm) hypothetical protein 0.0047 0.0253 0.0356
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0426 0.0422
Plasmodium vivax importin-beta 2, putative 0.0028 0.0115 0.0411
Loa Loa (eye worm) hypothetical protein 0.0047 0.0253 0.0356
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0057 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0182 0.0662
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.2965 0.2962
Onchocerca volvulus 0.0028 0.0112 0.031
Echinococcus multilocularis expressed conserved protein 0.0089 0.0569 0.0565
Entamoeba histolytica hypothetical protein 0.0037 0.0183 0.0846
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0057 0.0053
Brugia malayi CXXC zinc finger family protein 0.0057 0.0329 0.0455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0354 0.0349
Echinococcus granulosus snurportin 1 0.0303 0.216 0.2157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0438 0.0609
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0785 0.1105
Trichomonas vaginalis esterase, putative 0.0072 0.0438 0.1282
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0354 0.035
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0253 0.0349
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0079 0.0276
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0182 0.0662
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0182 0.0255
Schistosoma mansoni hypothetical protein 0.0328 0.2346 0.2341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0057 0.0051
Brugia malayi intermediate filament protein 0.0028 0.0112 0.0149
Brugia malayi hypothetical protein 0.0459 0.3325 0.468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0057 0.008
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0112 0.0157
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0026 0.0021
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0438 0.0609
Schistosoma mansoni hypothetical protein 0.0047 0.0253 0.0247
Toxoplasma gondii thioredoxin reductase 0.0037 0.0178 0.0649
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0057 0.0051
Schistosoma mansoni cpg binding protein 0.0057 0.0329 0.0323
Schistosoma mansoni ap endonuclease 0.0037 0.0182 0.0176
Schistosoma mansoni cpg binding protein 0.006 0.0353 0.0347
Mycobacterium ulcerans beta-lactamase 0.0072 0.0438 0.0609
Schistosoma mansoni microtubule-associated protein tau 0.1356 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0178 0.0649
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0253 0.0931
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0057 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0438 0.0432
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0208 0.0204
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0057 0.0053
Plasmodium vivax glutathione reductase, putative 0.0037 0.0178 0.0649
Brugia malayi hypothetical protein 0.0037 0.0183 0.0249
Echinococcus granulosus lamin dm0 0.0028 0.0112 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Entamoeba histolytica hypothetical protein 0.0037 0.0183 0.0846
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0438 0.0609
Onchocerca volvulus 0.0028 0.0112 0.031
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0253 0.1183
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0057 0.0053
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0006 0.0018
Mycobacterium ulcerans glutaminase 0.0269 0.1908 0.2681
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0369 0.2655 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0182 0.0177
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0426 0.0422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1009 0.1414
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0079 0.0276
Loa Loa (eye worm) hypothetical protein 0.0072 0.0438 0.0616
Entamoeba histolytica hypothetical protein 0.0037 0.0183 0.0846
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0165 0.0598
Brugia malayi ecdysteroid receptor 0.0021 0.0057 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0253 0.0931
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0079 0.0073
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0057 0.008
Brugia malayi Thioredoxin reductase 0.0037 0.0178 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0057 0.0072
Brugia malayi TAR-binding protein 0.0062 0.0363 0.0503
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0253 0.0931
Schistosoma mansoni hypothetical protein 0.0047 0.0253 0.0247
Leishmania major importin beta-1 subunit, putative 0.0023 0.0075 0.026
Brugia malayi Importin beta-1 subunit 0.0028 0.0115 0.0153
Schistosoma mansoni hypothetical protein 0.0047 0.0253 0.0247
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0182 0.0247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0057 0.0072
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0079 0.0103
Mycobacterium ulcerans hypothetical protein 0.0072 0.0438 0.0609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0253 0.0348
Loa Loa (eye worm) hypothetical protein 0.0072 0.0438 0.0616
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0152
Schistosoma mansoni lamin 0.0028 0.0112 0.0106
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.2091 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.5757 0.5755
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0057 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1286 0.1281
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0079 0.035
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0369 0.2655 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1286 0.1281
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0612 0.2906
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0079 0.0103
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0182 0.0509
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0253 0.0348
Schistosoma mansoni hypothetical protein 0.0039 0.0197 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0231
Leishmania major trypanothione reductase 0.0037 0.0178 0.0649
Echinococcus granulosus cpg binding protein 0.006 0.0353 0.0349
Echinococcus granulosus survival motor neuron protein 1 0.0459 0.3325 0.3323
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0363 0.0511
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1009 0.1421
Mycobacterium ulcerans lipase LipD 0.0072 0.0438 0.0609
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0051 0.0047
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0073 0.0069
Plasmodium falciparum importin beta, putative 0.0028 0.0115 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0057 0.0072
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0051 0.0047
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0972 0.1362
Loa Loa (eye worm) hypothetical protein 0.0148 0.1009 0.1421
Schistosoma mansoni hypothetical protein 0.0039 0.0197 0.0191
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0115 0.0411
Echinococcus multilocularis geminin 0.0328 0.2346 0.2343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0438 0.0432
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Brugia malayi Pre-SET motif family protein 0.0415 0.2991 0.4209
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0426 0.06
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0438 0.0609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.1286 0.1283
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0253 0.0348
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.2991 0.4214
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0253 0.0249
Loa Loa (eye worm) hypothetical protein 0.0072 0.0438 0.0616
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0972 0.1362
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0599 0.0836
Echinococcus multilocularis survival motor neuron protein 1 0.0459 0.3325 0.3323
Onchocerca volvulus 0.0072 0.0438 0.1266
Brugia malayi CHE-14 protein 0.0041 0.0208 0.0284
Brugia malayi beta-lactamase family protein 0.0072 0.0438 0.0609
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0079 0.0075
Brugia malayi Ets-domain containing protein 0.007 0.0426 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0057 0.0072
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0354 0.035
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0438 0.0609
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0529 0.0738
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0075 0.0219
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0203
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0015 0.0013
Mycobacterium tuberculosis Probable reductase 0.0084 0.0529 0.0738
Loa Loa (eye worm) hypothetical protein 0.0095 0.0612 0.0862
Loa Loa (eye worm) hypothetical protein 0.005 0.0276 0.0388
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0253 0.1183
Plasmodium vivax SET domain protein, putative 0.0061 0.0354 0.1315
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0057 0.008
Schistosoma mansoni hypothetical protein 0.0303 0.216 0.2155
Brugia malayi Ets-domain containing protein 0.007 0.0426 0.0592
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0253 0.0348
Echinococcus granulosus GPCR family 2 0.0047 0.0253 0.0249
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0253 0.0356
Echinococcus multilocularis musashi 0.0028 0.0112 0.0108
Brugia malayi nuclear receptor NHR-88 0.0021 0.0057 0.0072
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0785 0.1105
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0057 0.0051
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0182 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0057 0.0072
Schistosoma mansoni cpg binding protein 0.006 0.0353 0.0347
Leishmania major hypothetical protein, conserved 0.0072 0.0438 0.163
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0079 0.0232
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0075 0.0219
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0182 0.0662
Echinococcus granulosus intermediate filament protein 0.0028 0.0112 0.0108
Loa Loa (eye worm) glutathione reductase 0.0037 0.0178 0.025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0253 0.0249
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0057 0.0072
Schistosoma mansoni patched 1 0.0041 0.0208 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0057 0.0072
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0075 0.026
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0057 0.0149
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0599 0.0836
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0438 0.163
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0916 0.0912
Loa Loa (eye worm) hypothetical protein 0.0072 0.0438 0.0616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Echinococcus multilocularis snurportin 1 0.0303 0.216 0.2157
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0165 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0231
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.2091 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0006 0.0018
Onchocerca volvulus 0.0453 0.3275 0.9585
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0057 0.0072
Loa Loa (eye worm) hypothetical protein 0.0028 0.0115 0.0161
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0438 0.0609
Loa Loa (eye worm) fli-1 protein 0.0213 0.149 0.2099
Echinococcus granulosus lamin 0.0028 0.0112 0.0108
Brugia malayi glutathione reductase 0.0037 0.0178 0.0242
Loa Loa (eye worm) beta-lactamase 0.0072 0.0438 0.0616
Echinococcus multilocularis dihydrofolate reductase 0.0966 0.7099 0.7098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0354 0.0349
Brugia malayi beta-lactamase 0.0072 0.0438 0.0609
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0369 0.2655 1
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0438 0.1282
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0182 0.0531
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.1286 0.1283
Echinococcus multilocularis cpg binding protein 0.006 0.0353 0.0349
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.2091 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0057 0.0072
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0363 0.0503
Loa Loa (eye worm) hypothetical protein 0.0061 0.0354 0.0499
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0253 0.0348
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0438 0.1282
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0057 0.0051
Brugia malayi Dihydrofolate reductase 0.0966 0.7099 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0073 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0438 0.1282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.1286 0.1283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0057 0.0053
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0026 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0438 0.163
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0182 0.0247
Echinococcus granulosus geminin 0.0328 0.2346 0.2343
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0183 0.0178
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0057 0.0072
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0057 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0363 0.0357
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.3317 0.4669
Schistosoma mansoni ap endonuclease 0.0037 0.0182 0.0176
Loa Loa (eye worm) oxidoreductase 0.0014 0.0006 0.0008
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0112 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0101 0.0659 0.0928
Echinococcus granulosus expressed conserved protein 0.0089 0.0569 0.0565
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0057 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.1356 1 1
Schistosoma mansoni hypothetical protein 0.0094 0.0602 0.0596
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0253 0.0249
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0282 0.104
Mycobacterium leprae Probable lipase LipE 0.0072 0.0438 0.0609
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0282 0.104
Mycobacterium tuberculosis Conserved protein 0.0072 0.0438 0.0609
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0282 0.104
Onchocerca volvulus 0.0057 0.0329 0.0947
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0282 0.104
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0079 0.0073
Brugia malayi beta-lactamase family protein 0.0072 0.0438 0.0609
Brugia malayi hypothetical protein 0.0453 0.3275 0.4609
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0329 0.0325
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0966 0.7099 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0057 0.0053
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0079 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0112 0.0157
Schistosoma mansoni glutaminase 0.0269 0.1908 0.1903
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0438 0.0609
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0057 0.0051
Echinococcus multilocularis lamin dm0 0.0028 0.0112 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0208 0.0607
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0966 0.7099 1
Onchocerca volvulus 0.0021 0.0057 0.0149
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0689 0.5038 0.7096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0726 0.2717
Echinococcus multilocularis lamin 0.0028 0.0112 0.0108
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0529 0.0738
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0057 0.0053
Entamoeba histolytica hypothetical protein 0.0037 0.0183 0.0846
Loa Loa (eye worm) glutaminase 2 0.0269 0.1908 0.2687
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0363 0.0357
Entamoeba histolytica hypothetical protein 0.0023 0.0075 0.033
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0026 0.0021
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0612 0.0608
Loa Loa (eye worm) hypothetical protein 0.006 0.035 0.0493
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0612 0.0854
Loa Loa (eye worm) dihydrofolate reductase 0.0966 0.7099 1
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0438 0.163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.0072 0.0438 0.0616
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0057 0.0053
Echinococcus multilocularis GPCR, family 2 0.0047 0.0253 0.0249
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0115 0.0111
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0438 0.0434
Toxoplasma gondii exonuclease III APE 0.0037 0.0182 0.0662
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0057 0.0072
Loa Loa (eye worm) hypothetical protein 0.0041 0.0208 0.0292
Echinococcus granulosus tar DNA binding protein 0.0062 0.0363 0.0359
Schistosoma mansoni hypothetical protein 0.0023 0.0073 0.0067
Plasmodium falciparum glutathione reductase 0.0037 0.0178 0.0649
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0329 0.0463
Mycobacterium ulcerans hypothetical protein 0.0047 0.0253 0.0348
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0057 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0612 0.0608
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0438 0.1282
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0057 0.0053
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0369 0.2655 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0363 0.0357
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0529 0.0738
Brugia malayi hypothetical protein 0.0051 0.0282 0.0389
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0006 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0363 0.0357
Echinococcus granulosus dihydrofolate reductase 0.0966 0.7099 0.7098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2091 0.6119
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0057 0.0051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0057 0.0051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0182 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0253 0.0348
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0203
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0182 0.0531
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0822 0.0817
Onchocerca volvulus 0.0047 0.0253 0.0723
Onchocerca volvulus 0.0072 0.0438 0.1266
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0438 0.0609
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0354 0.0349
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0006 0.0008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0529 0.0738
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0057 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.1286 0.1812
Leishmania major hypothetical protein, conserved 0.0051 0.0282 0.104
Brugia malayi Pre-SET motif family protein 0.0061 0.0354 0.0491
Trichomonas vaginalis set domain proteins, putative 0.0472 0.3417 1
Schistosoma mansoni importin beta-1 0.0028 0.0115 0.0109
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0079 0.0111
Brugia malayi dihydrofolate reductase family protein 0.0966 0.7099 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0231
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0253 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0253 0.0348
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0282 0.104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0112 0.0157
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0057 0.0051
Brugia malayi nuclear hormone receptor 0.0021 0.0057 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0253 0.0348
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0438 0.0609
Trichomonas vaginalis glutaminase, putative 0.0269 0.1908 0.5584
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0182 0.0247
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0438 0.1282
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0182 0.0662
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0079 0.0276
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0057 0.0149
Brugia malayi RNA, U transporter 1 0.0081 0.0505 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0057 0.008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0529 0.0738

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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