Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0181 | 0.0181 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0181 | 0.0181 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0818 | 0.3793 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0127 | 1 |
Schistosoma mansoni | transcription factor btf3 | 0.0038 | 0.0127 | 0.0127 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2139 | 1 | 0.5 |
Brugia malayi | beta-NAC-like protein | 0.0038 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0181 | 0.0181 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0181 | 0.0181 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2139 | 1 | 1 |
Echinococcus multilocularis | transcription factor btf3 | 0.0038 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | ICD-1 protein | 0.0038 | 0.0127 | 0.0127 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0181 | 0.0181 |
Toxoplasma gondii | NAC domain-containing protein | 0.0038 | 0.0127 | 0.0335 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0498 | 0.2288 | 0.2288 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0038 | 0.0127 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0818 | 0.3793 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0181 | 0.0181 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0818 | 0.3793 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2139 | 1 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0038 | 0.0127 | 0.0335 |
Echinococcus granulosus | neuropeptide s receptor | 0.0498 | 0.2288 | 0.2288 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus multilocularis | neuropeptide s receptor | 0.0498 | 0.2288 | 0.2288 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0181 | 0.0181 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0038 | 0.0127 | 0.0335 |
Echinococcus granulosus | transcription factor btf3 | 0.0038 | 0.0127 | 0.0127 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0818 | 0.3793 | 1 |
Treponema pallidum | DNA ligase (lig) | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0127 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0818 | 0.3793 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0038 | 0.0127 | 0.0335 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0038 | 0.0127 | 0.0335 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0127 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0818 | 0.3793 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2139 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0181 | 0.0181 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2139 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0127 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0038 | 0.0127 | 0.0335 |
Brugia malayi | Dihydrofolate reductase | 0.2139 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2139 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2139 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0498 | 0.2288 | 0.2288 |
Schistosoma mansoni | dihydrofolate reductase | 0.2139 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.