Detailed information for compound 646766

Basic information

Technical information
  • TDR Targets ID: 646766
  • Name: 4-(azepan-1-yl)-5-nitrophthalonitrile
  • MW: 270.287 | Formula: C14H14N4O2
  • H donors: 0 H acceptors: 4 LogP: 2.51 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc(N2CCCCCC2)c(cc1C#N)[N+](=O)[O-]
  • InChi: 1S/C14H14N4O2/c15-9-11-7-13(17-5-3-1-2-4-6-17)14(18(19)20)8-12(11)10-16/h7-8H,1-6H2
  • InChiKey: KEIGMHXWPAWQCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(azepan-1-yl)-5-nitro-phthalonitrile
  • 4-(1-azepanyl)-5-nitrophthalonitrile
  • STOCK2S-43689
  • ZINC04133156
  • Oprea1_497249

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0045 0.0135
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0491 0.1353
Echinococcus multilocularis purine nucleoside phosphorylase 0.0218 0.2621 0.2587
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0153 0.0136
Toxoplasma gondii phosphorylase family protein 0.0057 0.0582 0.1531
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0153 0.0308
Schistosoma mansoni glucose transport protein 0.0103 0.1168 0.3407
Brugia malayi MTAP 0.0057 0.0582 0.1629
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0061 0.0016
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0262 0.0656
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.1973 0.3595
Brugia malayi Cam kinase protein 1 0.0032 0.0262 0.0656
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0153 0.0201
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0099 0.0163
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0318 0.5089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0292 0.0828
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1168 0.3407
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0254 0.0446
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0153 0.0327
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0262 0.0734
Toxoplasma gondii phosphorylase family protein 0.0057 0.0582 0.1531
Trypanosoma brucei glucose transporter 1E 0.0032 0.0267 0.4126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0057 0.0582 1
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0061 0.0016
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0109 0.0194
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0057 0.0582 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1168 0.3407
Echinococcus multilocularis uridine phosphorylase 1 0.0057 0.0582 0.0539
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1629
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Toxoplasma gondii exonuclease III APE 0.0019 0.0099 0.0153
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0262 0.0404
Loa Loa (eye worm) hypothetical protein 0.0122 0.1409 0.4257
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0047
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0262 0.0404
Schistosoma mansoni purine nucleoside phosphorylase 0.0274 0.3342 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0061 0.0045
Echinococcus granulosus GPCR family 2 0.0016 0.0061 0.0047
Loa Loa (eye worm) sugar transporter 0.0103 0.1168 0.3518
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0318 0.5089
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0267 0.0672
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0254 0.0632
Brugia malayi hypothetical protein 0.0122 0.1409 0.4137
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Leishmania major glucose transporter, lmgt3 0.0032 0.0267 0.4126
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0274 0.3342 1
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0274 0.3342 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0274 0.3342 0.3311
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0153 0.0327
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0262 0.0404
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0262 0.0404
Loa Loa (eye worm) glutaminase 2 0.0269 0.3279 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0099 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0061 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0016
Leishmania major glucose transporter, lmgt1 0.0032 0.0267 0.4126
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0045 0.0135
Entamoeba histolytica protein kinase, putative 0.0032 0.0262 0.3365
Schistosoma mansoni glucose transport protein 0.0103 0.1168 0.3407
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0153 0.0458
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0057 0.0582 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0099 0.0163
Echinococcus multilocularis purine nucleoside phosphorylase 0.0274 0.3342 0.3311
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0267 0.4126
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0109 0.0194
Plasmodium falciparum purine nucleoside phosphorylase 0.0057 0.0582 0.1001
Trypanosoma cruzi hexose transporter 0.0032 0.0267 0.4126
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1168 0.3407
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.1168 0.3201
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0061 0.0048
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0057 0.0582 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0318 0.0779
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0099 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0582 0.1629
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0057 0.0582 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0061 0.0295
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0582 0.1629
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0237 0.0581
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0491 0.1439
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0057 0.0582 0.1742
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0153 0.201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0262 0.0217
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0061 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0262 0.0656
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0061 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0267 0.0672
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0267 0.0672
Entamoeba histolytica protein kinase, putative 0.0032 0.0262 0.3365
Echinococcus multilocularis purine nucleoside phosphorylase 0.0274 0.3342 0.3311
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0057 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0254 0.3197
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0061 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0061 0.0016
Onchocerca volvulus Huntingtin homolog 0.0122 0.1409 0.4137
Echinococcus multilocularis purine nucleoside phosphorylase 0.0274 0.3342 0.3311
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0057 0.0582 1
Entamoeba histolytica hypothetical protein 0.0023 0.0153 0.112
Loa Loa (eye worm) hypothetical protein 0.0122 0.1409 0.4257
Giardia lamblia UPL-1 0.0057 0.0582 0.1629
Brugia malayi uridine phosphorylase family protein 0.0057 0.0582 0.1629
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0153 0.0327
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0099 0.01
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1629
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.1973 0.3595
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Mycobacterium ulcerans sugar transporter 0.0014 0.0045 0.0135
Trypanosoma brucei uridine phosphorylase 0.0057 0.0582 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1629
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0047
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0749
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.071
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0153 0.0327
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0061 0.0048
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0267 0.0672
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0099 0.0163
Loa Loa (eye worm) sugar transporter 0.0014 0.0045 0.007
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0237 0.0193
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0274 0.3342 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0153 0.2631
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0274 0.3342 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0099 0.1003
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0057 0.0582 0.1629
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0262 0.0217
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0254 0.0632
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1629
Plasmodium falciparum hexose transporter 0.0103 0.1168 0.2094
Plasmodium vivax CDK-related protein kinase 6, putative 0.0437 0.5407 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1168 0.1128
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0153 0.201
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0254 0.0632
Treponema pallidum pfs protein (pfs) 0.0057 0.0582 1
Plasmodium falciparum protein kinase 6 0.0437 0.5407 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0254 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0582 0.1629
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0099 0.0163
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0099 0.0054
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0099 0.0163
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0274 0.3342 1
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0318 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0118
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0057 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0099 0.1003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0267 0.0672
Loa Loa (eye worm) hypothetical protein 0.0025 0.018 0.0484
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0099 0.1702
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0061 0.0118
Mycobacterium ulcerans glutaminase 0.0269 0.3279 0.9814
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0318 0.5089
Leishmania major methylthioadenosine phosphorylase, putative 0.0057 0.0582 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1629
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0292 0.0749
Entamoeba histolytica hypothetical protein 0.0057 0.0582 1
Echinococcus granulosus General substrate transporter 0.0089 0.0984 0.2849
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0045 0.007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0099 0.0235
Leishmania major nucleoside phosphorylase-like protein 0.0057 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0262 0.0656
Toxoplasma gondii Purine nucleoside phosphorylase 0.0057 0.0582 0.1531
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0267 0.4126
Echinococcus multilocularis purine nucleoside phosphorylase 0.0218 0.2621 0.2587
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0061 0.0295
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0153 0.0201
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0045 0.0135
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0274 0.3342 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0262 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0083 0.0704
Schistosoma mansoni protein kinase 0.0032 0.0262 0.0656
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0057 0.0582 1
Plasmodium falciparum protein kinase 7 0.0291 0.3553 0.6542
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0262 0.0617
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0318 0.051
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0262 0.0404
Echinococcus granulosus methylthioadenosine phosphorylase 0.0057 0.0582 0.1629
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0267 0.4126
Trypanosoma brucei glucose transporter 2A 0.0032 0.0267 0.4126
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0262 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0267 0.4126
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0061 0.0295
Leishmania major protein kinase, putative 0.0032 0.0262 0.403
Schistosoma mansoni uridine phosphorylase 0.0057 0.0582 0.1629
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.1168 0.1128
Schistosoma mansoni methylthioadenosine phosphorylase 0.0057 0.0582 0.1629
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0061 0.0295
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0061 0.0016
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0318 0.5089
Chlamydia trachomatis AMP nucleosidase 0.0057 0.0582 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0318 0.5089
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Schistosoma mansoni glutaminase 0.0269 0.3279 0.9811
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0099 0.1003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0153 0.0401
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0057 0.0582 0.0539
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.1439
Loa Loa (eye worm) glutaminase 0.0269 0.3279 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.2621 0.7979
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0061 0.0295
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0057 0.0582 0.1629
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0047
Schistosoma mansoni protein kinase 0.0032 0.0262 0.0656
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0267 0.0672
Mycobacterium tuberculosis Hypothetical protein 0.0057 0.0582 0.1629
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0057 0.0582 0.1719
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0057 0.0582 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0061 0.0048
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0045 0.007
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0262 0.0404
Schistosoma mansoni purine nucleoside phosphorylase 0.0274 0.3342 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0254 0.0632
Brugia malayi Sugar transporter family protein 0.0103 0.1168 0.3407
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0262 0.0217
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0153 0.0327
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1629
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0262 0.0404
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0153 0.0327
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1
Brugia malayi glutaminase DH11.1 0.0269 0.3279 0.9811
Treponema pallidum uridine phosphorylase (udp) 0.0057 0.0582 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0267 0.4126
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0262 0.0656
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0057 0.0582 0.1742
Echinococcus granulosus uridine phosphorylase 1 0.0057 0.0582 0.1629
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0262 0.0734
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0099 0.0163
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0267 0.0672
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0099 0.0297
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.1973 0.5495
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0153 0.0458
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0218 0.2621 0.7814
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0057 0.0582 0.1629
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0099 0.01
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0061 0.0119
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0267 0.4126
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0262 0.0617
Schistosoma mansoni hypothetical protein 0.0103 0.1168 0.3407
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0262 0.0617
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0057 0.0582 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0262 0.0217
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0047
Trichomonas vaginalis glutaminase, putative 0.0269 0.3279 0.9811
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0491 0.1353
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1168 0.3407
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0061 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.007
Schistosoma mansoni uridine phosphorylase 0.0057 0.0582 0.1629
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0117 0.0218
Toxoplasma gondii protein kinase, putative 0.0291 0.3553 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0153 0.0108
Schistosoma mansoni methylthioadenosine phosphorylase 0.0057 0.0582 0.1629
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0061 0.003
Echinococcus multilocularis General substrate transporter 0.0089 0.0984 0.0943
Onchocerca volvulus Huntingtin homolog 0.0122 0.1409 0.4137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0016
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0057 0.0582 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0254 0.0632
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1168 0.1128
Echinococcus multilocularis purine nucleoside phosphorylase 0.0274 0.3342 0.3311
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0057 0.0582 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0262 0.403
Schistosoma mansoni ap endonuclease 0.0019 0.0099 0.0163
Schistosoma mansoni methylthioadenosine phosphorylase 0.0057 0.0582 0.1629
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0262 0.0656
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0153 0.201
Plasmodium vivax hexose transporter 0.0103 0.1168 0.2094
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0254 0.0632
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1168 0.3407
Mycobacterium leprae probable uridine phosphorylase 0.0057 0.0582 0.1463
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0047
Schistosoma mansoni protein kinase 0.0032 0.0262 0.0656
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0061 0.0016
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0267 0.4126
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0254 0.0209
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0047
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0057 0.0582 0.1629
Schistosoma mansoni ap endonuclease 0.0019 0.0099 0.0163
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0262 0.0656
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0262 0.0656
Loa Loa (eye worm) uridine phosphorylase 0.0057 0.0582 0.1719
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0274 0.3342 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0267 0.4126
Loa Loa (eye worm) hypothetical protein 0.0031 0.0254 0.071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0061 0.0047
Leishmania major glucose transporter, lmgt2 0.0032 0.0267 0.4126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0262 0.0734
Schistosoma mansoni glucose transport protein 0.0103 0.1168 0.3407
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1168 0.1128
Echinococcus multilocularis GPCR, family 2 0.0016 0.0061 0.0016
Echinococcus multilocularis purine nucleoside phosphorylase 0.0274 0.3342 0.3311
Echinococcus granulosus purine nucleoside phosphorylase 0.0274 0.3342 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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