Detailed information for compound 647156

Basic information

Technical information
  • TDR Targets ID: 647156
  • Name: N-(4-ethylphenyl)-2-(phenoxy)benzamide
  • MW: 317.381 | Formula: C21H19NO2
  • H donors: 1 H acceptors: 1 LogP: 5.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)c1ccccc1Oc1ccccc1
  • InChi: 1S/C21H19NO2/c1-2-16-12-14-17(15-13-16)22-21(23)19-10-6-7-11-20(19)24-18-8-4-3-5-9-18/h3-15H,2H2,1H3,(H,22,23)
  • InChiKey: VJOWUDOSXRTFMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00445347
  • Oprea1_717375
  • STK013302

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0114 0.0707
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0248 0.0248
Echinococcus granulosus lamin 0.0029 0.0059 0.0059
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0248 0.0247
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0025
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.07 0.4385
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0026 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0514 0.0489
Onchocerca volvulus 0.011 0.0514 0.3722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0077 0.0076
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0514 0.1281
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0135 0.0839
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0075 0.0319 0.1992
Echinococcus multilocularis lamin dm0 0.0029 0.0059 0.0059
Echinococcus granulosus dnaJ subfamily B 0.0422 0.2277 0.2277
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0495 0.0495
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0235 0.021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0589 0.0587
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0248 0.0247
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0248 0.0248
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1793 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0514 0.0513
Brugia malayi beta-lactamase family protein 0.011 0.0514 0.0513
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.0878 0.0877
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0058 0.0057
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.0319 0.0294
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0514 0.1281
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0495 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Brugia malayi hypothetical protein 0.0034 0.0087 0.0085
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0495 0.0471
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0623 0.3404 0.3388
Mycobacterium tuberculosis Conserved protein 0.011 0.0514 0.1281
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0903 0.2649
Onchocerca volvulus 0.0096 0.0435 0.308
Brugia malayi hypothetical protein 0.0469 0.254 0.2539
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0514 0.1506
Echinococcus multilocularis snurportin 1 0.0334 0.1778 0.1778
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.3843 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.0235 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0072 0.0446
Entamoeba histolytica hypothetical protein 0.1793 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0495 0.3097
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0179 0.0903 0.5656
Brugia malayi exodeoxyribonuclease III family protein 0.0075 0.0319 0.0318
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0075 0.0319 0.1992
Schistosoma mansoni cpg binding protein 0.0061 0.0238 0.0237
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0495 0.0494
Brugia malayi MH1 domain containing protein 0.0025 0.0037 0.0035
Echinococcus granulosus neuropeptide s receptor 0.0552 0.3006 0.3006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0203 0.0203
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0058 0.0057
Schistosoma mansoni smad 0.0025 0.0037 0.0035
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0037 0.0037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.011 0.0514 0.0513
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0055 0.0206 0.0204
Mycobacterium ulcerans lipase LipD 0.011 0.0514 0.1506
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1793 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0495 0.047
Toxoplasma gondii exonuclease III APE 0.0075 0.0319 0.0318
Echinococcus multilocularis neuropeptide s receptor 0.0552 0.3006 0.3006
Echinococcus granulosus intermediate filament protein 0.0029 0.0059 0.0059
Trypanosoma brucei unspecified product 0.0041 0.013 0.0806
Brugia malayi phosphofructokinase 0.0106 0.0495 0.0494
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.1009 0.1007
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0114 0.0707
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0191 0.019
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.1958 0.1957
Plasmodium vivax importin-beta 2, putative 0.0031 0.0072 0.0071
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0495 0.0471
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0903 0.2649
Echinococcus granulosus dna polymerase eta 0.006 0.0235 0.0235
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0075 0.0319 0.0295
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0514 0.1281
Loa Loa (eye worm) hypothetical protein 0.0469 0.254 0.2539
Brugia malayi MH2 domain containing protein 0.0366 0.1958 0.1957
Mycobacterium ulcerans hypothetical protein 0.0159 0.0791 0.2321
Brugia malayi hypothetical protein 0.0052 0.0191 0.019
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0058 0.0033
Loa Loa (eye worm) hypothetical protein 0.011 0.0514 0.0513
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0514 0.0513
Schistosoma mansoni hypothetical protein 0.1059 0.5863 0.5862
Schistosoma mansoni hypothetical protein 0.0334 0.1778 0.1777
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0191 0.1193
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0025 0.0024
Onchocerca volvulus 0.0032 0.0077 0.0149
Trichomonas vaginalis flap endonuclease-1, putative 0.0055 0.0206 0.018
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0235 0.0235
Brugia malayi Smad1 0.0025 0.0037 0.0035
Treponema pallidum exodeoxyribonuclease (exoA) 0.0075 0.0319 0.0295
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0514 0.0514
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0058 0.0032
Schistosoma mansoni hypothetical protein 0.0035 0.0094 0.0093
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0058 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Brugia malayi Importin beta-1 subunit 0.0031 0.0072 0.0071
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0058 0.0033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0114 0.0088
Leishmania major DNA polymerase kappa, putative 0.006 0.0235 0.1466
Giardia lamblia DINP protein human, muc B family 0.006 0.0235 0.736
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0003 0.0003
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0514 0.1281
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0354 0.0354
Brugia malayi Pre-SET motif family protein 0.0032 0.0077 0.0076
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0025 0.0148
Loa Loa (eye worm) hypothetical protein 0.0031 0.0072 0.0071
Mycobacterium ulcerans hypothetical protein 0.011 0.0514 0.1506
Loa Loa (eye worm) beta-lactamase 0.011 0.0514 0.0513
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0075 0.0319 0.1992
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1793 1 1
Plasmodium vivax hypothetical protein, conserved 0.011 0.0514 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.013 0.0806
Schistosoma mansoni lamin 0.0029 0.0059 0.0057
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1793 1 1
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1793 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0039 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.07 0.4385
Brugia malayi Pre-SET motif family protein 0.0216 0.1114 0.1113
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0514 0.3216
Brugia malayi MH1 domain containing protein 0.0025 0.0037 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0246 0.1282 0.1259
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0055 0.0206 0.1283
Echinococcus multilocularis lamin 0.0029 0.0059 0.0059
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0114 0.0088
Trichomonas vaginalis esterase, putative 0.011 0.0514 0.0489
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0077 0.0077
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0495 0.3097
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0284 0.0284
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0284 0.0282
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0248 0.0248
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.1793 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.007
Echinococcus granulosus tar DNA binding protein 0.0069 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0054
Schistosoma mansoni hypothetical protein 0.1059 0.5863 0.5862
Trypanosoma brucei glucosidase, putative 0.0039 0.0114 0.0707
Schistosoma mansoni Smad4 0.0025 0.0037 0.0035
Schistosoma mansoni ran 0.0023 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0135 0.0657 0.0655
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0514 0.1281
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1793 1 1
Brugia malayi MH2 domain containing protein 0.0025 0.0037 0.0035
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0354 0.0354
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0026 0.0154
Echinococcus granulosus geminin 0.1059 0.5863 0.5863
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0235 0.055
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0025 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0514 0.0513
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0284 0.0282
Schistosoma mansoni hypothetical protein 0.0062 0.0248 0.0247
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0514 0.1506
Brugia malayi RNA binding protein 0.0069 0.0284 0.0282
Loa Loa (eye worm) hypothetical protein 0.011 0.0514 0.0513
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0495 0.0495
Onchocerca volvulus 0.0246 0.1282 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0216 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0203 0.0203
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0495 0.1231
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0064 0.0064
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.0839
Schistosoma mansoni importin beta-1 0.0031 0.0072 0.0071
Echinococcus granulosus lamin dm0 0.0029 0.0059 0.0059
Trypanosoma brucei unspecified product 0.006 0.0235 0.1466
Brugia malayi MH2 domain containing protein 0.0025 0.0037 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0514 0.0513
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0032
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.007
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0514 0.0514
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0025 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0514 0.0489
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0495 0.1391
Schistosoma mansoni ap endonuclease 0.0075 0.0319 0.0318
Onchocerca volvulus 0.011 0.0514 0.3722
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0077 0.0076
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1793 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0191 0.019
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0247
Leishmania major importin beta-1 subunit, putative 0.0025 0.0039 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0248 0.0247
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0057
Loa Loa (eye worm) RNA binding protein 0.0069 0.0284 0.0282
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0075 0.0319 1
Toxoplasma gondii aldehyde dehydrogenase 0.0179 0.0903 0.0902
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1793 1 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0114 0.0114
Leishmania major GTP-binding protein, putative 0.0023 0.0026 0.0154
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0354 0.0353
Entamoeba histolytica hypothetical protein 0.1793 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0435 0.0434
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0514 0.3216
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0284 0.0282
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0135 0.0839
Schistosoma mansoni flap endonuclease-1 0.005 0.0176 0.0175
Schistosoma mansoni cpg binding protein 0.0061 0.0238 0.0237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0203 0.0203
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0791 0.2006
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0235 0.0687
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.2277 0.2277
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0037 0.0035
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.0235 0.1466
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0039 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0203 0.0202
Brugia malayi 6-phosphofructokinase 0.0106 0.0495 0.0494
Brugia malayi intermediate filament protein 0.0029 0.0059 0.0057
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.0235 0.1466
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.0319 0.0318
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0072 0.0071
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0114 0.0114
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0235 0.021
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.0623 0.3404 0.3388
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0514 0.0489
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0059 0.0057
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0495 0.0494
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0072 0.0446
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0216 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0284 0.0282
Schistosoma mansoni DNA polymerase eta 0.006 0.0235 0.0234
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0037 0.0037
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1793 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0114 0.0707
Loa Loa (eye worm) hypothetical protein 0.011 0.0514 0.0513
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0235 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0284 0.0282
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0216 0.0216
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0235 0.1466
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0114 0.0113
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0495 0.0494
Onchocerca volvulus 0.011 0.0514 0.3722
Schistosoma mansoni hypothetical protein 0.0135 0.0657 0.0655
Echinococcus granulosus survival motor neuron protein 1 0.0469 0.254 0.254
Schistosoma mansoni cpg binding protein 0.0057 0.022 0.0218
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0059 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0514 0.0489
Echinococcus multilocularis neuropeptide receptor A26 0.0552 0.3006 0.3006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0203 0.0202
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0284 0.0282
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0235 0.0687
Loa Loa (eye worm) hypothetical protein 0.0032 0.0077 0.0076
Schistosoma mansoni survival motor neuron protein 0.0096 0.0435 0.0434
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.0878 0.0877
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.0839
Echinococcus granulosus dna polymerase kappa 0.006 0.0235 0.0235
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0235 0.1466
Echinococcus granulosus flap endonuclease 1 0.0055 0.0206 0.0206
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0235 0.1466
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0354 0.0353
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.1595 1
Echinococcus granulosus dUTP pyrophosphatase 0.1793 1 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0029 0.0029
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0623 0.3404 0.3388
Leishmania major hypothetical protein, conserved 0.0052 0.0191 0.1193
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0623 0.3404 1
Echinococcus multilocularis musashi 0.0029 0.0059 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0284 0.0282
Echinococcus multilocularis dUTP pyrophosphatase 0.1793 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.07 0.4385
Entamoeba histolytica hypothetical protein 0.0025 0.0039 0.0014
Echinococcus multilocularis dna polymerase eta 0.006 0.0235 0.0235
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0029 0.0029
Mycobacterium leprae conserved hypothetical protein 0.011 0.0514 0.1447
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.1009 0.1007
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0037 0.0037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0179 0.0903 0.0903
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1793 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0077 0.0077
Toxoplasma gondii hypothetical protein 0.0049 0.017 0.0169
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0075 0.0319 0.0318
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0495 0.0471
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0025
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0025 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0191 0.019
Schistosoma mansoni ap endonuclease 0.0075 0.0319 0.0318
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0179 0.0903 0.0903
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.0089
Brugia malayi RNA, U transporter 1 0.0089 0.0398 0.0396
Entamoeba histolytica hypothetical protein 0.0623 0.3404 0.3388
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0903 0.0902
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0114 0.0113
Echinococcus multilocularis geminin 0.1059 0.5863 0.5863
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0032
Brugia malayi 6-phosphofructokinase 0.0106 0.0495 0.0494
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0514 0.1281
Brugia malayi jmjC domain containing protein 0.0057 0.0216 0.0215
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.1595 1
Schistosoma mansoni hypothetical protein 0.0062 0.0248 0.0247
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0059 0.0057
Entamoeba histolytica Ran family GTPase 0.0023 0.0026 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0077 0.0077
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0055 0.0206 0.1283
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.0235 0.0211
Schistosoma mansoni intermediate filament proteins 0.0029 0.0059 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0235 0.1466
Schistosoma mansoni hypothetical protein 0.0422 0.2277 0.2276
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.007
Schistosoma mansoni hypothetical protein 0.0062 0.0248 0.0247
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0094 0.0094
Mycobacterium ulcerans beta-lactamase 0.011 0.0514 0.1506
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0025 0.0069
Brugia malayi CXXC zinc finger family protein 0.0057 0.022 0.0218
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.0657 0.0655
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.0878 0.0878
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0495 0.0471
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.1009 0.1007
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.0235 0.0234
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0623 0.3404 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0058 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0235 0.0233
Loa Loa (eye worm) hypothetical protein 0.011 0.0514 0.0513
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0235 0.1466
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0075 0.0319 0.0319
Toxoplasma gondii ABC1 family protein 0.011 0.0514 0.0513
Onchocerca volvulus 0.0081 0.0354 0.2416
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0058 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1114 0.1113
Echinococcus granulosus snurportin 1 0.0334 0.1778 0.1778
Mycobacterium tuberculosis Conserved protein 0.011 0.0514 0.1281
Schistosoma mansoni smad1 5 8 and 0.0025 0.0037 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Plasmodium falciparum importin beta, putative 0.0031 0.0072 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0495 0.047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0203 0.0202
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0235 0.0233
Echinococcus granulosus GPCR family 2 0.0062 0.0248 0.0248
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1793 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0094 0.007
Schistosoma mansoni smad1 5 8 and 0.0025 0.0037 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0025 0.0148
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.0235 0.0235
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0037 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0514 0.0489
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0235 0.0234
Loa Loa (eye worm) Smad1 0.0025 0.0037 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0203 0.0202
Wolbachia endosymbiont of Brugia malayi dUTPase 0.1793 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0235 0.1466
Loa Loa (eye worm) flap endonuclease-1 0.0055 0.0206 0.0204
Brugia malayi beta-lactamase 0.011 0.0514 0.0513
Trypanosoma brucei unspecified product 0.0041 0.013 0.0806
Echinococcus granulosus Smad4 0.0025 0.0037 0.0037
Echinococcus multilocularis cpg binding protein 0.0061 0.0238 0.0238
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0026 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0203 0.0202
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.1595 1
Echinococcus multilocularis Smad4 0.0025 0.0037 0.0037
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0114 0.0088
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0216 0.0216
Onchocerca volvulus 0.0057 0.022 0.1316
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0774
Echinococcus granulosus neuropeptide receptor A26 0.0552 0.3006 0.3006
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0001 0.0000016845
Schistosoma mansoni alpha-glucosidase 0.015 0.0741 0.074
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0495 0.3097
Echinococcus multilocularis GPCR, family 2 0.0062 0.0248 0.0248
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0075 0.0319 0.0295
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0077 0.0076
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0495 0.1451
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.0235 0.0234
Entamoeba histolytica Flap nuclease, putative 0.0055 0.0206 0.0181
Echinococcus granulosus smad 0.0025 0.0037 0.0037
Brugia malayi TAR-binding protein 0.0069 0.0284 0.0282
Loa Loa (eye worm) hypothetical protein 0.011 0.0514 0.0513
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0075 0.0319 0.0319
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0191 0.1193
Schistosoma mansoni alpha glucosidase 0.0039 0.0114 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0032
Echinococcus multilocularis smad 0.0025 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.1171 0.6492 0.6483
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.013 0.0806
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0026 0.0025
Schistosoma mansoni hypothetical protein 0.0096 0.0435 0.0434
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0248 0.0248
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.1595 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0114 0.0088
Echinococcus granulosus cpg binding protein 0.0061 0.0238 0.0238
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0191 0.019
Schistosoma mansoni lamin 0.0029 0.0059 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0203 0.0203
Mycobacterium leprae Probable lipase LipE 0.011 0.0514 0.1447
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.0027
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0284 0.0282
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0075 0.0319 0.077
Echinococcus multilocularis survival motor neuron protein 1 0.0469 0.254 0.254
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0495 0.0494
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0058 0.0032
Plasmodium vivax flap endonuclease 1, putative 0.0055 0.0206 0.0204
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0623 0.3404 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.013 0.0806
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0235 0.055
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.0319 0.0294
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0058 0.0057
Brugia malayi follicle stimulating hormone receptor 0.0231 0.1198 0.1197
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0058 0.0033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0235 0.1466
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0037 0.0037
Schistosoma mansoni alpha-glucosidase 0.015 0.0741 0.074
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0495 0.047
Brugia malayi beta-lactamase family protein 0.011 0.0514 0.0513
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0039 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0191 0.1193
Entamoeba histolytica hypothetical protein 0.1171 0.6492 0.6483
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0495 0.0494
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0235 0.0233
Loa Loa (eye worm) hypothetical protein 0.0081 0.0354 0.0353
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0026 0.0154
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0075 0.0319 0.1992
Loa Loa (eye worm) dUTP diphosphatase 0.1793 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0903 0.2649
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0514 0.3216
Schistosoma mansoni ran 0.0023 0.0026 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0088
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0072 0.0072
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.022 0.0218
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.0319 0.0318
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0179 0.0903 0.2299
Brugia malayi jmjC domain containing protein 0.006 0.0235 0.0233
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0088
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0058 0.0057
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0025 0.0069
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0878 0.0878
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0094 0.0093
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0623 0.3404 0.3388
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0903 0.0902
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0515 0.0514
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0094 0.0094
Schistosoma mansoni smad1 5 8 and 0.0025 0.0037 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.1958 0.1957
Loa Loa (eye worm) hypothetical protein 0.0197 0.1009 0.1007
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0026 0.0025
Leishmania major DNA polymerase eta, putative 0.006 0.0235 0.1466
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0191 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0235 0.1466
Echinococcus multilocularis flap endonuclease 1 0.0055 0.0206 0.0206
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.0113
Echinococcus multilocularis dna polymerase kappa 0.006 0.0235 0.0235
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0037 0.0035
Plasmodium falciparum flap endonuclease 1 0.0055 0.0206 0.0204
Loa Loa (eye worm) hypothetical protein 0.006 0.0235 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0235 0.1466
Plasmodium vivax SET domain protein, putative 0.0032 0.0077 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.1778 0.1777
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1793 1 1
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0003 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0077 0.0076
Mycobacterium tuberculosis Conserved protein 0.011 0.0514 0.1281
Schistosoma mansoni hypothetical protein 0.0062 0.0248 0.0247
Leishmania major hypothetical protein, conserved 0.011 0.0514 0.3216
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.0089
Brugia malayi Flap endonuclease-1 0.0055 0.0206 0.0204
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.1198 0.1197
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0623 0.3404 0.885
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0055 0.0206 0.1283
Onchocerca volvulus 0.0101 0.0464 0.3315
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0878 0.0878
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0514 0.1281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0077 0.0076
Brugia malayi hypothetical protein 0.0035 0.0094 0.0093
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0039 0.0013
Giardia lamblia Flap structure-specific endonuclease 0.0055 0.0206 0.6439
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0058 0.1782
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0075 0.0319 0.0933
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0187 0.1167
Echinococcus granulosus importin subunit beta 1 0.0031 0.0072 0.0072
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.0235 0.0235

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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