Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0077 | 0.1588 | 0.2731 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0174 | 0.5817 | 0.5 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0174 | 0.5817 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, putative | 0.006 | 0.0841 | 0.1446 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0269 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.456 | 0.456 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0185 | 0.6329 | 0.6329 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0174 | 0.5817 | 1 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0174 | 0.5817 | 0.5817 |
Brugia malayi | Inositol-1 | 0.0077 | 0.1588 | 0.1588 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0185 | 0.6329 | 0.6329 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0174 | 0.5817 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0077 | 0.1588 | 0.2731 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0185 | 0.6329 | 0.6329 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0077 | 0.1588 | 0.2731 |
Entamoeba histolytica | hypothetical protein | 0.006 | 0.0841 | 0.1446 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0603 | 0.0603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0205 | 0.7177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.456 | 0.456 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0077 | 0.1588 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0077 | 0.1588 | 1 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0174 | 0.5817 | 0.5817 |
Brugia malayi | RNA binding protein | 0.0205 | 0.7177 | 0.7177 |
Schistosoma mansoni | tar DNA-binding protein | 0.0205 | 0.7177 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0205 | 0.7177 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0205 | 0.7177 | 0.7177 |
Schistosoma mansoni | tar DNA-binding protein | 0.0205 | 0.7177 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0077 | 0.1588 | 0.1502 |
Entamoeba histolytica | deoxycytidine triphosphate deaminase, putative | 0.006 | 0.0841 | 0.1446 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0185 | 0.6329 | 0.6329 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0174 | 0.5817 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.456 | 0.456 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0174 | 0.5817 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0603 | 0.084 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.3171 | 0.5451 |
Schistosoma mansoni | alpha-glucosidase | 0.0159 | 0.5196 | 0.724 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0174 | 0.5817 | 1 |
Brugia malayi | TAR-binding protein | 0.0205 | 0.7177 | 0.7177 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0174 | 0.5817 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0205 | 0.7177 | 0.7177 |
Schistosoma mansoni | inositol monophosphatase | 0.0077 | 0.1588 | 0.2213 |
Schistosoma mansoni | inositol monophosphatase | 0.0077 | 0.1588 | 0.2213 |
Entamoeba histolytica | hypothetical protein | 0.0174 | 0.5817 | 1 |
Brugia malayi | dUTP diphosphatase | 0.0174 | 0.5817 | 0.5817 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0174 | 0.5817 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0077 | 0.1588 | 0.1588 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0185 | 0.6329 | 0.6329 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0077 | 0.1588 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.3171 | 0.5451 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0174 | 0.5817 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.456 | 0.456 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0069 | 0.1233 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0069 | 0.1233 | 1 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0174 | 0.5817 | 0.5817 |
Schistosoma mansoni | tar DNA-binding protein | 0.0205 | 0.7177 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0174 | 0.5817 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0159 | 0.5196 | 0.724 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0077 | 0.1588 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.456 | 0.456 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0174 | 0.5817 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0077 | 0.1588 | 0.2731 |
Echinococcus multilocularis | tar DNA binding protein | 0.0205 | 0.7177 | 0.7177 |
Echinococcus granulosus | tar DNA binding protein | 0.0205 | 0.7177 | 0.7177 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0603 | 0.084 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0205 | 0.7177 | 0.7177 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0174 | 0.5817 | 1 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0174 | 0.5817 | 0.8105 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0077 | 0.1588 | 0.1588 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0269 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0077 | 0.1588 | 0.2731 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.456 | 0.456 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0077 | 0.1588 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0205 | 0.7177 | 0.7177 |
Loa Loa (eye worm) | inositol-1 | 0.0077 | 0.1588 | 0.1588 |
Onchocerca volvulus | 0.0107 | 0.2899 | 1 | |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0174 | 0.5817 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.