Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3273 | 0.3273 |
Brugia malayi | hypothetical protein | 0.0102 | 0.6901 | 0.6901 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0742 | 0.0742 |
Echinococcus granulosus | tar DNA binding protein | 0.014 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0035 | 0.1345 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.2878 | 0.2878 |
Schistosoma mansoni | eyes absent homolog | 0.0102 | 0.6901 | 0.6901 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.2878 | 0.2878 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0035 | 0.1345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6901 | 0.6901 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0104 | 0.7021 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0104 | 0.7021 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.1345 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0024 | 0.048 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.0035 | 0.1345 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.014 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Leishmania major | pyruvate kinase | 0.0035 | 0.1345 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3273 | 0.3273 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.014 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.1345 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0104 | 0.7021 | 0.7021 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2878 | 0.2878 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0035 | 0.1345 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6901 | 0.6901 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.048 | 0.048 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.1345 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1758 | 0.1758 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3273 | 0.3273 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0104 | 0.7021 | 0.7021 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.2878 | 0.2878 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0104 | 0.7021 | 0.7021 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.1345 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.1345 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2878 | 0.2878 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0091 | 0.5982 | 0.5982 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3273 | 0.3273 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0035 | 0.1345 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.2878 | 0.2878 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.1345 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0104 | 0.7021 | 0.7021 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0091 | 0.5982 | 0.5982 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1345 | 0.1345 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0091 | 0.5982 | 0.5982 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1758 | 0.1758 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1758 | 0.1758 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0035 | 0.1345 | 0.1345 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.2878 | 0.2878 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0035 | 0.1345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.7021 | 0.7021 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.048 | 0.048 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0104 | 0.7021 | 0.7021 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0091 | 0.5982 | 0.5982 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2878 | 0.2878 |
Leishmania major | pyruvate kinase | 0.0035 | 0.1345 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.1345 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.1345 | 0.1345 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.1345 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.1345 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.1345 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.2878 | 0.2878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.