Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0043 | 0.0169 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0043 | 0.0169 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.2574 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0043 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.2529 | 1 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0312 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.2529 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0043 | 0.0169 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0043 | 0.0169 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.6874 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.2529 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0043 | 0.0169 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0043 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0043 | 0.0169 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0043 | 0.0169 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.1063 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.2529 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | glutathione reductase | 0.0037 | 0.2529 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.1063 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0043 | 0.0169 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.7738 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0043 | 0.0169 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.2529 | 0.2985 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0043 | 0.0169 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0043 | 0.0169 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0043 | 0.0169 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0094 | 0.7738 | 1 |
Leishmania major | trypanothione reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0043 | 0.0169 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0043 | 0.0169 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.2529 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0094 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.7738 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.6874 | 0.8837 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0013 | 0.0312 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0043 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0043 | 0.0169 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0043 | 0.0169 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0043 | 0.0169 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0312 | 0.1234 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.027 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.2574 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0043 | 0.0169 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0043 | 0.0169 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0043 | 0.0169 |
Onchocerca volvulus | 0.001 | 0.0043 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.