Detailed information for compound 648078

Basic information

Technical information
  • TDR Targets ID: 648078
  • Name: (E)-3-furan-2-yl-N-(4-iodophenyl)-2-phenylpro p-2-enamide
  • MW: 415.224 | Formula: C19H14INO2
  • H donors: 1 H acceptors: 1 LogP: 4.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(cc1)NC(=O)C(=Cc1ccco1)c1ccccc1
  • InChi: 1S/C19H14INO2/c20-15-8-10-16(11-9-15)21-19(22)18(13-17-7-4-12-23-17)14-5-2-1-3-6-14/h1-13H,(H,21,22)/b18-13+
  • InChiKey: JCYZPVUTHJLTMW-QGOAFFKASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-furan-2-yl-N-(4-iodophenyl)-2-phenylprop-2-enamide
  • (E)-3-(2-furyl)-N-(4-iodophenyl)-2-phenyl-prop-2-enamide
  • 3-(2-furyl)-N-(4-iodophenyl)-2-phenyl-prop-2-enamide
  • (E)-3-(2-furyl)-N-(4-iodophenyl)-2-phenylprop-2-enamide
  • 3-(2-furyl)-N-(4-iodophenyl)-2-phenylprop-2-enamide
  • (E)-3-(2-furyl)-N-(4-iodophenyl)-2-phenyl-acrylamide
  • 3-(2-furyl)-N-(4-iodophenyl)-2-phenyl-acrylamide
  • 3-furan-2-yl-N-(4-iodophenyl)-2-phenyl-prop-2-enamide
  • (E)-3-furan-2-yl-N-(4-iodophenyl)-2-phenyl-prop-2-enamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum aldo-keto reductase, putative 0.0048 0.1083 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0373 0.0811
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0373 0.0945
Echinococcus granulosus aldo keto reductase 0.0166 0.3945 0.394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1019 0.1013
Onchocerca volvulus 0.0166 0.3945 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0166 0.3945 0.5556
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0231 0.0315
Echinococcus granulosus cpg binding protein 0.003 0.0648 0.0641
Giardia lamblia DINP protein human, muc B family 0.0019 0.0373 0.0928
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.3697 0.937
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0811 0.0805
Leishmania major prostaglandin f synthase, putative 0.0166 0.3945 0.5556
Entamoeba histolytica alcohol dehydrogenase, putative 0.0048 0.1083 0.1076
Schistosoma mansoni hypothetical protein 0.0092 0.2141 0.2136
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0369 0.3367
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.3945 0.394
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0369 0.0362
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0373 0.0366
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0058 0.0071
Brugia malayi follicle stimulating hormone receptor 0.0231 0.5512 0.5509
Entamoeba histolytica aldose reductase, putative 0.0166 0.3945 0.394
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1019 0.1838
Brugia malayi CXXC zinc finger family protein 0.0029 0.0609 0.0602
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0417 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0058 0.0071
Onchocerca volvulus 0.0166 0.3945 1
Echinococcus multilocularis cpg binding protein 0.003 0.0648 0.0641
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0073 0.0184
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0004 0.0007 0.0019
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Giardia lamblia Aldose reductase 0.0166 0.3945 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0811 0.2057
Trypanosoma brucei unspecified product 0.0013 0.0231 0.0315
Trypanosoma cruzi aldo-keto reductase 0.0166 0.3945 0.5556
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0811 0.0805
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0373 0.0928
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0373 0.0366
Loa Loa (eye worm) oxidoreductase 0.0166 0.3945 0.7153
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0373 0.0516
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0073 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Trichomonas vaginalis aldo/keto reductase, putative 0.0166 0.3945 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0811 0.0805
Echinococcus granulosus dna polymerase kappa 0.0019 0.0373 0.0366
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0231 0.0315
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0073 0.0184
Echinococcus granulosus aldo keto reductase 0.0166 0.3945 0.394
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0811 0.0805
Trypanosoma brucei aldo-keto reductase, putative 0.0166 0.3945 0.5556
Echinococcus multilocularis geminin 0.0171 0.4052 0.4048
Schistosoma mansoni rab6-interacting 0.002 0.0392 0.0385
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0058 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Trypanosoma cruzi aldo/keto reductase, putative 0.0166 0.3945 0.5556
Schistosoma mansoni transcription factor LCR-F1 0.0417 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.3313 0.4665
Entamoeba histolytica hypothetical protein 0.0417 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0392 0.3578
Trichomonas vaginalis Phospholipase C precursor, putative 0.0004 0.0007 0.0019
Onchocerca volvulus 0.0048 0.1083 0.2731
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0373 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Leishmania major DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0127 0.012
Schistosoma mansoni ap endonuclease 0.0019 0.0369 0.0362
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1019 0.1013
Loa Loa (eye worm) oxidoreductase 0.0166 0.3945 0.7153
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.013 0.0123
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0166 0.3945 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0048 0.1083 0.1954
Loa Loa (eye worm) hypothetical protein 0.0166 0.3945 0.7153
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1146 0.1607
Brugia malayi hypothetical protein 0.002 0.0392 0.0385
Giardia lamblia DNA damage repair protein 0.0006 0.0058 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0004 0.0007 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Loa Loa (eye worm) hypothetical protein 0.0019 0.0373 0.0664
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.5512 1
Loa Loa (eye worm) oxidoreductase 0.0166 0.3945 0.7153
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0007 0.0019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1228 0.3101
Trypanosoma brucei unspecified product 0.0019 0.0373 0.0516
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1385 0.1379
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Trypanosoma cruzi aldo/keto reductase, putative 0.0048 0.1083 0.1518
Onchocerca volvulus 0.0166 0.3945 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0811 0.1135
Echinococcus multilocularis aldo keto reductase 0.0166 0.3945 0.394
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0088 0.0081
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0811 0.1135
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0088 0.0081
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0373 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0015 0.0008
Echinococcus granulosus voltage gated potassium channel subunit 0.0048 0.1083 0.1076
Onchocerca volvulus 0.0166 0.3945 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0811 0.0805
Schistosoma mansoni hypothetical protein 0.0171 0.4052 0.4048
Loa Loa (eye worm) hypothetical protein 0.002 0.0392 0.0699
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0088 0.0081
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0369 1
Onchocerca volvulus 0.0166 0.3945 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Leishmania major aldo-keto reductase-like protein 0.0166 0.3945 0.5556
Echinococcus multilocularis aldo keto reductase 0.0166 0.3945 0.394
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Echinococcus granulosus aldo keto reductase 0.0166 0.3945 0.394
Schistosoma mansoni aldo-keto reductase 0.0166 0.3945 0.394
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0058 0.0467
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0373 0.0945
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0058 0.0071
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0369 0.3367
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0166 0.3945 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0373 0.0366
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0811 0.0805
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0058 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1019 0.1013
Loa Loa (eye worm) oxidoreductase 0.0166 0.3945 0.7153
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0609 0.1092
Brugia malayi hypothetical protein 0.002 0.0392 0.0385
Mycobacterium leprae Conserved hypothetical protein 0.0118 0.2778 0.5922
Leishmania major DNA polymerase kappa, putative 0.0006 0.0058 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0058 0.0071
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0088 0.0081
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Onchocerca volvulus 0.002 0.0392 0.0977
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0373 0.0928
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0048 0.1083 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0373 0.0366
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.3945 0.394
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0058 0.0128
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3313 0.4665
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0811 0.1135
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0925 0.1295
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0373 0.0516
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0073 0.0184
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0373 0.0516
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.125 0.1243
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0369 0.0511
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0369 0.0937
Entamoeba histolytica hypothetical protein 0.0417 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0369 0.0511
Trichomonas vaginalis aldo-keto reductase, putative 0.0048 0.1083 0.2745
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0073 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0073 0.0184
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.3945 0.394
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0007 0.0019
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0058 0.0071
Loa Loa (eye worm) oxidoreductase 0.0166 0.3945 0.7153
Trypanosoma brucei unspecified product 0.0013 0.0231 0.0315
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.013 0.0123
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0369 0.0362
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0392 0.0385
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0925 0.1295
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Trichomonas vaginalis aldo-keto reductase, putative 0.0048 0.1083 0.2745
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0392 0.0699
Schistosoma mansoni lipoxygenase 0.002 0.0392 0.0385
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0373 0.0516
Leishmania major DNA damage repair protein, putative 0.0006 0.0058 0.0071
Plasmodium vivax aldehyde reductase, putative 0.0048 0.1083 1
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0058 0.0071
Echinococcus granulosus hypothetical protein 0.0166 0.3945 0.394
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0004 0.0007 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0073 0.0184
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0048 0.1083 0.2731
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0166 0.3945 0.5556
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0166 0.3945 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0166 0.3945 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0048 0.1083 0.2731
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3313 0.4665
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0058 0.0128
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0088 0.0081
Trichomonas vaginalis aldo-keto reductase, putative 0.0048 0.1083 0.2745
Onchocerca volvulus 0.002 0.0392 0.0977
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0369 0.0362
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0369 0.0362
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0369 0.092
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0369 0.0937
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0007 0.0019
Giardia lamblia Aldose reductase 0.0166 0.3945 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1019 0.1013
Entamoeba histolytica hypothetical protein 0.0417 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0369 0.0362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1019 0.1013
Loa Loa (eye worm) doublecortin family protein 0.002 0.0392 0.0699
Schistosoma mansoni cpg binding protein 0.003 0.0648 0.0641
Trichomonas vaginalis helicase, putative 0.0006 0.0073 0.0184
Mycobacterium ulcerans oxidoreductase 0.0166 0.3945 1
Leishmania major DNA polymerase eta, putative 0.0006 0.0058 0.0071
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.1083 0.2745
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0048 0.1083 0.1076
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.7094 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0392 0.0385
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0048 0.1083 0.1076
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Toxoplasma gondii hypothetical protein 0.0048 0.1074 0.2708
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0058 0.0071
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Echinococcus multilocularis RUN 0.002 0.0392 0.0385
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0811 0.2042
Echinococcus granulosus dna polymerase eta 0.0019 0.0373 0.0366
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Mycobacterium ulcerans hypothetical protein 0.0156 0.3697 0.9362
Entamoeba histolytica aldose reductase, putative 0.0166 0.3945 0.394
Schistosoma mansoni potassium channel beta 0.0048 0.1083 0.1076
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0392 0.0385
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0811 0.0805
Mycobacterium tuberculosis Conserved protein 0.0048 0.1083 0.2731
Leishmania major DNA polymerase eta, putative 0.0019 0.0373 0.0516
Schistosoma mansoni lipoxygenase 0.0055 0.125 0.1243
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0811 0.1135
Mycobacterium tuberculosis Probable oxidoreductase 0.0166 0.3945 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0048 0.1083 0.1518
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Onchocerca volvulus 0.0166 0.3945 1
Mycobacterium ulcerans hypothetical protein 0.0048 0.1083 0.2637
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0369 0.0511
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Trypanosoma cruzi DNA polymerase eta, putative 0.0006 0.0058 0.0071
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0369 0.5
Echinococcus multilocularis dna polymerase eta 0.0019 0.0373 0.0366
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.2135 0.2129
Brugia malayi polk-prov protein 0.0006 0.0058 0.005
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.2135 0.2129
Trypanosoma brucei aldo/keto reductase, putative 0.0048 0.1083 0.1518
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0811 0.2057
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0369 0.0511
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Schistosoma mansoni cpg binding protein 0.003 0.0648 0.0641
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0373 0.0366
Toxoplasma gondii exonuclease III APE 0.0019 0.0369 0.092
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0166 0.3945 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0417 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0811 0.1461
Schistosoma mansoni hypothetical protein 0.002 0.0392 0.0385
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.2135 0.2129
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0811 0.0805
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0369 0.0658
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0058 0.0467
Echinococcus multilocularis aldo keto reductase 0.0166 0.3945 0.394
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0058 0.005
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0373 0.0366
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0058 0.0071
Schistosoma mansoni DNA polymerase eta 0.0019 0.0373 0.0366
Schistosoma mansoni pol-related 0.0166 0.3945 0.394
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0811 0.2057
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0373 0.0366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1019 0.1013
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0058 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0166 0.3945 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1019 0.1013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Schistosoma mansoni loxhd1 0.002 0.0392 0.0385
Loa Loa (eye worm) histone methyltransferase 0.0009 0.013 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0231 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1019 0.1013
Trypanosoma brucei prostaglandin f synthase 0.0166 0.3945 0.5556
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0925 0.1295
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.2135 0.2129
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.2135 0.2129
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.2141 0.2136
Brugia malayi NADH-dependent xylose reductase 0.0048 0.1083 0.1076
Onchocerca volvulus 0.0029 0.0609 0.1527
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0925 0.1295
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0373 0.0811
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0373 0.0516
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0373 0.0366
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0073 0.0184
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.7094 1
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0004 0.0007 0.0019
Echinococcus granulosus geminin 0.0171 0.4052 0.4048
Entamoeba histolytica aldose reductase, putative 0.0166 0.3945 0.394
Brugia malayi Doublecortin family protein 0.002 0.0392 0.0385
Schistosoma mansoni cpg binding protein 0.0029 0.0609 0.0602
Toxoplasma gondii aldo-keto reductase 0.0048 0.1083 0.2731
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0392 0.3578
Schistosoma mansoni rab6-interacting 0.002 0.0392 0.0385
Echinococcus granulosus RUN 0.002 0.0392 0.0385
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0392 0.0385
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.7094 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0166 0.3945 0.394
Schistosoma mansoni hypothetical protein 0.0417 1 1
Echinococcus multilocularis aldehyde reductase 0.0118 0.2778 0.2772
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0369 0.092
Toxoplasma gondii aldose reductase, putative 0.0166 0.3945 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0811 0.0805
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0392 0.0385
Plasmodium falciparum aldehyde reductase, putative 0.0048 0.1083 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.1083 0.2745
Schistosoma mansoni polycystin 1-related 0.002 0.0392 0.0385
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0369 0.0802
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Echinococcus multilocularis aldo keto reductase 0.0166 0.3945 0.394
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0811 0.0805
Echinococcus multilocularis voltage gated potassium channel subunit 0.0048 0.1083 0.1076
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.125 0.1243
Entamoeba histolytica hypothetical protein 0.0417 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0166 0.3945 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0392 0.0385
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0166 0.3945 0.394
Schistosoma mansoni hypothetical protein 0.0171 0.4052 0.4048
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.7094 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0373 0.0516
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0058 0.0071
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0048 0.1083 0.1076
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0166 0.3945 0.394
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0004 0.0007 0.0019
Schistosoma mansoni aldo-keto reductase 0.0166 0.3945 0.394
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0058 0.0071
Echinococcus granulosus aldehyde reductase 0.0118 0.2778 0.2772
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0073 0.0184

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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