Detailed information for compound 648181

Basic information

Technical information
  • TDR Targets ID: 648181
  • Name: N-(4-bromo-2-fluorophenyl)-2-(2-chloro-4,6-di methylphenoxy)acetamide
  • MW: 386.643 | Formula: C16H14BrClFNO2
  • H donors: 1 H acceptors: 1 LogP: 4.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1F)Br)COc1c(C)cc(cc1Cl)C
  • InChi: 1S/C16H14BrClFNO2/c1-9-5-10(2)16(12(18)6-9)22-8-15(21)20-14-4-3-11(17)7-13(14)19/h3-7H,8H2,1-2H3,(H,20,21)
  • InChiKey: SCDMHKSWGJYTEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-2-fluoro-phenyl)-2-(2-chloro-4,6-dimethyl-phenoxy)acetamide
  • N-(4-bromo-2-fluoro-phenyl)-2-(2-chloro-4,6-dimethyl-phenoxy)ethanamide
  • ZINC01185692
  • STK259614

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tissue type plasminogen activator 0.0071 1 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.8392 0.8392
Echinococcus multilocularis fibrillin 1 0.0067 0.8287 0.8287
Loa Loa (eye worm) RNA binding protein 0.0067 0.8392 0.8392
Schistosoma mansoni egf-like domain protein 0.0067 0.8287 0.8287
Loa Loa (eye worm) hypothetical protein 0.0067 0.8287 0.8287
Brugia malayi Kringle domain containing protein 0.0071 1 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0071 1 0.5
Brugia malayi Calcium binding EGF domain containing protein 0.0067 0.8287 0.8287
Schistosoma mansoni tar DNA-binding protein 0.0067 0.8392 0.8392
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0067 0.8287 0.8287
Schistosoma mansoni tar DNA-binding protein 0.0067 0.8392 0.8392
Brugia malayi TAR-binding protein 0.0067 0.8392 0.8392
Schistosoma mansoni hypothetical protein 0.0071 1 1
Echinococcus multilocularis laminin 0.0067 0.8287 0.8287
Loa Loa (eye worm) hypothetical protein 0.0067 0.8287 0.8287
Loa Loa (eye worm) hypothetical protein 0.0071 1 1
Toxoplasma gondii kringle domain-containing protein 0.0071 1 1
Echinococcus granulosus tissue type plasminogen activator 0.0071 1 1
Leishmania major hypothetical protein, conserved 0.0071 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.8287 0.8287
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0067 0.8287 0.8287
Brugia malayi Fibulin-1 precursor 0.0067 0.8287 0.8287
Echinococcus multilocularis Tolloid protein 1 0.0067 0.8287 0.8287
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.8392 0.8392
Loa Loa (eye worm) TAR-binding protein 0.0067 0.8392 0.8392
Loa Loa (eye worm) TK/ROR protein kinase 0.0071 1 1
Onchocerca volvulus 0.0071 1 1
Echinococcus granulosus Tolloid protein 1 0.0067 0.8287 0.8287
Echinococcus multilocularis tar DNA binding protein 0.0067 0.8392 0.8392
Schistosoma mansoni tar DNA-binding protein 0.0067 0.8392 0.8392
Trypanosoma cruzi hypothetical protein, conserved 0.0071 1 0.5
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0067 0.8287 0.8287
Loa Loa (eye worm) hypothetical protein 0.0067 0.8287 0.8287
Echinococcus granulosus tar DNA binding protein 0.0067 0.8392 0.8392
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.8392 0.8392
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0067 0.8287 0.8287
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0067 0.8287 0.8287
Schistosoma mansoni tar DNA-binding protein 0.0067 0.8392 0.8392
Loa Loa (eye worm) hypothetical protein 0.0067 0.8287 0.8287
Echinococcus granulosus laminin 0.0067 0.8287 0.8287
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0071 1 0.5
Brugia malayi RNA binding protein 0.0067 0.8392 0.8392

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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