Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0366 | 0.1339 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0087 | 0.0087 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0951 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0087 | 0.0087 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.0951 | 0.0951 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2737 | 0.2737 |
Echinococcus multilocularis | tar DNA binding protein | 0.0192 | 0.2737 | 0.2737 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0087 | 0.0087 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.0951 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0951 | 0.3473 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0951 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0608 | 0.222 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0676 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0192 | 0.2737 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0065 | 0.0236 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.047 | 0.6907 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0087 | 0.0087 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0074 | 0.0951 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0087 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0087 | 0.0087 |
Plasmodium vivax | hypothetical protein, conserved | 0.0074 | 0.0951 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.0951 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.0951 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0087 | 0.0087 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2737 | 0.2737 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0608 | 0.222 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0676 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.0255 | 0.2679 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0951 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0087 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0951 | 0.3473 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0366 | 0.1339 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0043 | 0.0043 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.0951 | 0.0951 |
Onchocerca volvulus | 0.0074 | 0.0951 | 1 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.0951 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0255 | 0.0931 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.1671 | 0.6103 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.0951 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.0951 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.0951 | 0.3473 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.0951 | 0.5 |
Brugia malayi | RNA binding protein | 0.0192 | 0.2737 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0951 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0192 | 0.2737 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0255 | 0.0931 |
Toxoplasma gondii | ABC1 family protein | 0.0074 | 0.0951 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0255 | 0.0931 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.0951 | 0.3473 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0951 | 0.3473 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2737 | 0.2737 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.0951 | 0.3473 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0043 | 0.0157 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0951 | 0.0951 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.1671 | 0.6103 |
Echinococcus granulosus | lamin | 0.0027 | 0.0255 | 0.0255 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0255 | 0.0255 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.0951 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2737 | 0.2737 |
Loa Loa (eye worm) | TAR-binding protein | 0.0192 | 0.2737 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0255 | 0.0255 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0255 | 0.0255 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0608 | 0.222 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.1671 | 0.6103 |
Schistosoma mansoni | tar DNA-binding protein | 0.0192 | 0.2737 | 0.2737 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0951 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0255 | 0.0931 |
Schistosoma mansoni | lamin | 0.0027 | 0.0255 | 0.0255 |
Onchocerca volvulus | 0.0074 | 0.0951 | 1 | |
Onchocerca volvulus | 0.0027 | 0.0255 | 0.2679 | |
Echinococcus multilocularis | musashi | 0.0027 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0951 | 0.3473 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0247 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0951 | 0.3473 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0608 | 0.222 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0951 | 0.3473 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0065 | 0.0236 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.0951 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0192 | 0.2737 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0951 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0255 | 0.0931 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0255 | 0.0255 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0087 | 0.0316 |
Brugia malayi | TAR-binding protein | 0.0192 | 0.2737 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0951 | 0.3473 |
Brugia malayi | beta-lactamase | 0.0074 | 0.0951 | 0.3473 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0087 | 0.0087 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0366 | 0.0366 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0951 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0951 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0036 | 0.013 |
Echinococcus granulosus | tar DNA binding protein | 0.0192 | 0.2737 | 0.2737 |
Onchocerca volvulus | 0.0074 | 0.0951 | 1 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0087 | 0.0316 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0951 | 0.3473 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0036 | 0.013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.