Detailed information for compound 648508

Basic information

Technical information
  • TDR Targets ID: 648508
  • Name: 2-iodo-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfam oyl]phenyl]benzamide
  • MW: 483.28 | Formula: C17H14IN3O4S
  • H donors: 2 H acceptors: 4 LogP: 3.11 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1onc(c1)NS(=O)(=O)c1ccc(cc1)NC(=O)c1ccccc1I
  • InChi: 1S/C17H14IN3O4S/c1-11-10-16(20-25-11)21-26(23,24)13-8-6-12(7-9-13)19-17(22)14-4-2-3-5-15(14)18/h2-10H,1H3,(H,19,22)(H,20,21)
  • InChiKey: WCQAWJKVRWWJQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-iodo-N-[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]benzamide
  • 2-iodo-N-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]benzamide
  • 2-Iodo-N-[4-(5-methyl-isoxazol-3-ylsulfamoyl)-phenyl]-benzamide
  • BAS 00850783
  • ARONIS018864
  • AG-690/12242306
  • STK068394
  • ZINC00840962

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.077 0.077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.006 0.1279 0.2241
Loa Loa (eye worm) hypothetical protein 0.0023 0.0351 0.0604
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.006 0.1279 0.2237
Echinococcus granulosus FTZ F1 alpha 0.001 0.0038 0.0038
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0199 0.0338
Loa Loa (eye worm) hypothetical protein 0.0023 0.0351 0.0604
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.077 0.077
Echinococcus multilocularis RUN 0.004 0.077 0.077
Onchocerca volvulus 0.0023 0.0351 0.1089
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0797 0.1395
Echinococcus granulosus transmembrane protease serine 3 0.0023 0.0351 0.0351
Onchocerca volvulus 0.0048 0.099 0.3314
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0351 0.0351
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0038 0.0038
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0351 0.0351
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0038 0.0038
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0 0.5
Schistosoma mansoni lamin 0.0055 0.1142 0.1142
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1307 0.1307
Brugia malayi CXXC zinc finger family protein 0.0029 0.0502 0.0876
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.0038
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0038 0.0038
Brugia malayi hypothetical protein 0.004 0.077 0.1347
Schistosoma mansoni survival motor neuron protein 0.0048 0.099 0.099
Onchocerca volvulus 0.006 0.1279 0.432
Schistosoma mansoni rab6-interacting 0.004 0.077 0.077
Schistosoma mansoni coup transcription factor 0.001 0.0038 0.0038
Brugia malayi hypothetical protein 0.0237 0.5691 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0038 0.0038
Onchocerca volvulus 0.004 0.077 0.2549
Brugia malayi ecdysteroid receptor 0.001 0.0038 0.0059
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0041 0.0797 0.1391
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0038 0.0038
Onchocerca volvulus 0.0017 0.0199 0.0562
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.2972 0.5216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0907 0.0907
Onchocerca volvulus 0.0055 0.1142 0.3843
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0111 0.2543 0.2543
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Echinococcus multilocularis lamin dm0 0.0055 0.1142 0.1142
Echinococcus granulosus cpg binding protein 0.003 0.0543 0.0543
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0038 0.0054
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Onchocerca volvulus 0.0055 0.1142 0.3843
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0059
Schistosoma mansoni rab6-interacting 0.004 0.077 0.077
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2972 0.2972
Loa Loa (eye worm) hypothetical protein 0.0017 0.0199 0.0338
Onchocerca volvulus 0.0023 0.0351 0.1089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0351 0.0604
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0054
Onchocerca volvulus 0.004 0.077 0.2549
Brugia malayi Trypsin family protein 0.0023 0.0351 0.0609
Onchocerca volvulus 0.0017 0.0199 0.0562
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2972 0.2972
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.2911 0.2911
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.0038
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.1142 0.1996
Loa Loa (eye worm) hypothetical protein 0.0023 0.0351 0.0604
Schistosoma mansoni intermediate filament proteins 0.0055 0.1142 0.1142
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0 0.5
Schistosoma mansoni hypothetical protein 0.0023 0.0351 0.0351
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0199 0.0338
Brugia malayi hypothetical protein 0.0037 0.0699 0.1222
Trichomonas vaginalis ferritin, putative 0.0009 0 0.5
Echinococcus multilocularis glycoprotein Antigen 5 0.0023 0.0351 0.0351
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.2972 0.5219
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0038 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.0038
Onchocerca volvulus 0.0017 0.0199 0.0562
Echinococcus multilocularis dnaJ subfamily B 0.041 1 1
Brugia malayi hypothetical protein 0.0036 0.0684 0.1195
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0038 0.0054
Onchocerca volvulus 0.0126 0.2911 1
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0684 0.0684
Schistosoma mansoni cpg binding protein 0.003 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0025 0.0415 0.0718
Loa Loa (eye worm) TK/ROR protein kinase 0.006 0.1279 0.2237
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0 0.5
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0038 0.0038
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.0036 0.0684 0.0684
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0038 0.0038
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.099 0.1733
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0907 0.0907
Echinococcus granulosus enteropeptidase 0.0023 0.0351 0.0351
Echinococcus granulosus Mastin 0.0023 0.0351 0.0351
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0111 0.2543 0.2543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0199 0.0338
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.0038
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0059
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0023 0.0351 0.0351
Leishmania major hypothetical protein, conserved 0.006 0.1279 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0684 0.0684
Brugia malayi Trypsin family protein 0.0023 0.0351 0.0609
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0007
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0023 0.0351 0.0351
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0199 0.0338
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0351 0.0351
Brugia malayi hypothetical protein 0.0023 0.0351 0.0609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.0025 0.0415 0.0718
Loa Loa (eye worm) hypothetical protein 0.0237 0.5691 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.077 0.077
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0797 0.0797
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0038
Plasmodium vivax cysteine repeat modular protein 1, putative 0.006 0.1279 1
Schistosoma mansoni cpg binding protein 0.0029 0.0502 0.0502
Echinococcus multilocularis tissue type plasminogen activator 0.006 0.1279 0.1279
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0684 0.0684
Onchocerca volvulus 0.0103 0.2346 0.8032
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0512 0.0893
Loa Loa (eye worm) hypothetical protein 0.0026 0.044 0.0761
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.044 0.044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0038 0.0038
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0797 0.1395
Schistosoma mansoni hypothetical protein 0.0048 0.099 0.099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0059
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.0797 0.5542
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0036 0.0684 0.5
Echinococcus granulosus RUN 0.004 0.077 0.077
Brugia malayi hypothetical protein 0.004 0.077 0.1347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0023 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.0041 0.0797 0.0797
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Schistosoma mansoni hypothetical protein 0.0023 0.0351 0.0351
Loa Loa (eye worm) TAR-binding protein 0.0128 0.2972 0.5216
Schistosoma mansoni lipoxygenase 0.0111 0.2543 0.2543
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0059
Brugia malayi Trypsin family protein 0.0126 0.2911 0.5112
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Echinococcus multilocularis enteropeptidase 0.0023 0.0351 0.0351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0907 0.0907
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0038 0.0059
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.5691 0.5691
Onchocerca volvulus 0.0017 0.0199 0.0562
Loa Loa (eye worm) intermediate filament protein 0.0055 0.1142 0.1996
Brugia malayi RNA binding protein 0.0128 0.2972 0.5219
Onchocerca volvulus 0.0017 0.0199 0.0562
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0512 0.0888
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0797 0.054
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Schistosoma mansoni lamin 0.0055 0.1142 0.1142
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0023 0.0351 0.0609
Echinococcus multilocularis lamin 0.0055 0.1142 0.1142
Echinococcus granulosus glycoprotein Antigen 5 0.0023 0.0351 0.0351
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.077 0.077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0502 0.0871
Loa Loa (eye worm) hypothetical protein 0.004 0.077 0.1342
Loa Loa (eye worm) hypothetical protein 0.0017 0.0199 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0054
Brugia malayi Doublecortin family protein 0.004 0.077 0.1347
Entamoeba histolytica hypothetical protein 0.0036 0.0684 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0038 0.0038
Onchocerca volvulus 0.0017 0.0199 0.0562
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2972 0.2972
Schistosoma mansoni lipoxygenase 0.004 0.077 0.077
Brugia malayi Trypsin-like protease protein 5 0.0023 0.0351 0.0609
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Onchocerca volvulus 0.0017 0.0199 0.0562
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0023 0.0351 0.0604
Onchocerca volvulus 0.0017 0.0199 0.0562
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0038 0.0038
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0797 0.1395
Schistosoma mansoni hypothetical protein 0.004 0.077 0.077
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.1142 0.2
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0038 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0907 0.0907
Echinococcus granulosus lamin dm0 0.0055 0.1142 0.1142
Loa Loa (eye worm) RNA binding protein 0.0128 0.2972 0.5216
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0038 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0059
Onchocerca volvulus 0.0023 0.0351 0.1089
Onchocerca volvulus 0.0017 0.0199 0.0562
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2972 0.2972
Schistosoma mansoni cpg binding protein 0.003 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0126 0.2911 0.5109
Brugia malayi hypothetical protein 0.0037 0.0699 0.1222
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.1279 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0907 0.1587
Brugia malayi nuclear receptor NHR-88 0.001 0.0038 0.0059
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.2911 0.2911
Onchocerca volvulus 0.0017 0.0199 0.0562
Brugia malayi nuclear hormone receptor 0.001 0.0038 0.0059
Schistosoma mansoni nuclear hormone receptor 0.001 0.0038 0.0038
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.0038
Brugia malayi Trypsin family protein 0.0023 0.0351 0.0609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0907 0.0907
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1144 0.8752
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Echinococcus multilocularis transmembrane protease serine 3 0.0023 0.0351 0.0351
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0199 0.0338
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0797 0.054
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0038 0.0059
Echinococcus multilocularis tar DNA binding protein 0.0128 0.2972 0.2972
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0199 0.0338
Schistosoma mansoni polycystin 1-related 0.004 0.077 0.077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.0038
Brugia malayi intermediate filament protein 0.0055 0.1142 0.2
Schistosoma mansoni hypothetical protein 0.041 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0684 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0059
Loa Loa (eye worm) hypothetical protein 0.0055 0.1142 0.1996
Echinococcus multilocularis cpg binding protein 0.003 0.0543 0.0543
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.0038
Echinococcus granulosus tissue type plasminogen activator 0.006 0.1279 0.1279
Onchocerca volvulus 0.0029 0.0502 0.1618
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.0038
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0023 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.006 0.1279 0.1279
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0059
Loa Loa (eye worm) hypothetical protein 0.0017 0.0199 0.0338
Mycobacterium ulcerans hypothetical protein 0.0023 0.0351 1
Entamoeba histolytica hypothetical protein 0.0036 0.0684 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0059
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Loa Loa (eye worm) hypothetical protein 0.0054 0.1117 0.1953
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Onchocerca volvulus 0.0023 0.0351 0.1089
Onchocerca volvulus 0.0023 0.0351 0.1089
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0059
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.077 0.077
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Loa Loa (eye worm) doublecortin family protein 0.004 0.077 0.1342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0038 0.0038
Echinococcus granulosus tar DNA binding protein 0.0128 0.2972 0.2972
Plasmodium falciparum cysteine repeat modular protein 1 0.006 0.1279 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0054
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0351 0.0351
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0907 0.1583
Echinococcus multilocularis musashi 0.0055 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.004 0.077 0.1342
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0059
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0351 0.0351
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2972 0.2972
Loa Loa (eye worm) hypothetical protein 0.0017 0.0199 0.0338
Brugia malayi Kringle domain containing protein 0.006 0.1279 0.2241
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.5691 0.5691
Brugia malayi TAR-binding protein 0.0128 0.2972 0.5219
Brugia malayi PAN domain containing protein 0.0017 0.0199 0.0343
Loa Loa (eye worm) trypsin family protein 0.0023 0.0351 0.0604
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.044 0.044
Echinococcus granulosus intermediate filament protein 0.0055 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0351 0.0351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.0038
Toxoplasma gondii kringle domain-containing protein 0.006 0.1279 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0199 0.0338
Onchocerca volvulus 0.0017 0.0199 0.0562
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0038 0.0038
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0126 0.2911 0.5109
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0199 0.0338
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0038
Schistosoma mansoni loxhd1 0.004 0.077 0.077
Echinococcus granulosus lamin 0.0055 0.1142 0.1142
Brugia malayi steroid hormone receptor 0.001 0.0038 0.0059
Echinococcus multilocularis Mastin 0.0023 0.0351 0.0351

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.