TDR Targets

Basic information

Technical information

TDR Targets ID: 648740
Name: (5Z)-5-[(3-bromo-5-ethoxy-4-hydroxyphenyl)met hylidene]-1-(2-fluorophenyl)-1,3-diazinane-2, 4,6-trione
MW: 449.227 | Formula: C19H14BrFN2O5
H donors: 2 H acceptors: 4 LogP: 3.48 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc(c1O)Br
InChi: 1S/C19H14BrFN2O5/c1-2-28-15-9-10(8-12(20)16(15)24)7-11-17(25)22-19(27)23(18(11)26)14-6-4-3-5-13(14)21/h3-9,24H,2H2,1H3,(H,22,25,27)/b11-7-
InChiKey: XGJWAFPDEDAWEU-XFFZJAGNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-5-[(3-bromo-5-ethoxy-4-hydroxy-phenyl)methylene]-1-(2-fluorophenyl)hexahydropyrimidine-2,4,6-trione
(5Z)-5-[(3-bromo-5-ethoxy-4-hydroxyphenyl)methylene]-1-(2-fluorophenyl)hexahydropyrimidine-2,4,6-trione
(5Z)-5-(3-bromo-5-ethoxy-4-hydroxy-benzylidene)-1-(2-fluorophenyl)barbituric acid
(5Z)-5-[(3-bromo-5-ethoxy-4-hydroxy-phenyl)methylidene]-1-(2-fluorophenyl)-1,3-diazinane-2,4,6-trione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	lamin dm0	0.0028	0.1056	0.1023
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.1772	0.1743
Entamoeba histolytica	hypothetical protein	0.0038	0.1772	1
Echinococcus multilocularis	tar DNA binding protein	0.0131	0.8445	0.844
Brugia malayi	intermediate filament protein	0.0028	0.1056	0.0928
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.8445	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0024	0.0794	1
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0085	0.516	0.5886
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0024	0.0794	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0459	0.5
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0085	0.516	0.5091
Entamoeba histolytica	hypothetical protein	0.0038	0.1772	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.516	0.516
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0024	0.0794	1
Schistosoma mansoni	lamin	0.0028	0.1056	0.0747
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0131	0.8445	0.8445
Entamoeba histolytica	hypothetical protein	0.0024	0.0794	0.2547
Echinococcus multilocularis	muscleblind protein 1	0.0153	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0459	0.0323
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.1772	0.1743
Brugia malayi	hypothetical protein	0.0038	0.1772	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0153	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.0794	1
Echinococcus multilocularis	muscleblind protein	0.0153	1	1
Loa Loa (eye worm)	RNA binding protein	0.0131	0.8445	0.8445
Echinococcus granulosus	L aminoadipate semialdehyde	0.0085	0.516	0.5143
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.1056	0.1056
Echinococcus granulosus	lamin	0.0028	0.1056	0.1023
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0024	0.0794	1
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0024	0.0794	0.5
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.1056	0.1056
Schistosoma mansoni	intermediate filament proteins	0.0028	0.1056	0.0747
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.8445	1
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.8445	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0459	0.0425
Echinococcus granulosus	lamin dm0	0.0028	0.1056	0.1023
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0024	0.0794	1
Onchocerca volvulus		0.0085	0.516	1
Brugia malayi	RNA recognition motif domain containing protein	0.0131	0.8445	0.8423
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0794	1
Entamoeba histolytica	hypothetical protein	0.0038	0.1772	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0459	0.5
Echinococcus granulosus	muscleblind protein	0.0153	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.102	0.102
Schistosoma mansoni	lamin	0.0028	0.1056	0.0747
Schistosoma mansoni	hypothetical protein	0.0038	0.1772	0.1644
Brugia malayi	RNA binding protein	0.0131	0.8445	0.8423
Echinococcus multilocularis	lamin	0.0028	0.1056	0.1023
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0794	1
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0024	0.0794	1
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0085	0.516	0.5143
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0036	0.0036
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.1772	0.1644
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0028	0.1056	0.1056
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.8445	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0024	0.0794	1
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.8445	1
Loa Loa (eye worm)	hypothetical protein	0.0153	1	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.1056	0.0928
Echinococcus granulosus	tar DNA binding protein	0.0131	0.8445	0.844
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0459	0.0459
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0459	0.5
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0024	0.0794	1
Loa Loa (eye worm)	TAR-binding protein	0.0131	0.8445	0.8445
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0459	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0024	0.0794	0.5
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0459	0.5
Echinococcus granulosus	intermediate filament protein	0.0028	0.1056	0.1023
Echinococcus multilocularis	musashi	0.0028	0.1056	0.1023
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0459	0.0425
Brugia malayi	TAR-binding protein	0.0131	0.8445	0.8423
Entamoeba histolytica	hypothetical protein	0.0038	0.1772	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 648740