Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.863 | 0.863 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2231 | 0.2231 |
Brugia malayi | hypothetical protein | 0.0039 | 0.2791 | 0.2791 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0959 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.2231 | 0.2231 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0959 | 0.1692 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.5668 | 0.5668 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.5668 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.863 | 0.863 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.5668 | 0.5668 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.2231 | 0.2231 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.863 | 0.863 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0959 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0959 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0959 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0959 | 0.2914 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3292 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.2231 | 0.6776 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2791 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3292 | 0.5808 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3292 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.2231 | 0.6776 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.863 | 0.863 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3292 | 0.5808 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0959 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0959 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.2231 | 0.6776 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0959 | 0.1692 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3292 | 0.5808 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0959 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0959 | 0.2914 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.3292 | 0.3292 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.2791 | 0.4924 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0959 | 0.0959 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.2791 | 0.8477 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0959 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2231 | 0.3936 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0959 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.2231 | 0.6776 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2791 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3292 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0959 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.3292 | 0.3292 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0959 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2791 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2231 | 0.3936 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2231 | 0.3936 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2231 | 0.3936 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2791 | 0.4924 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0959 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0959 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0959 | 0.0959 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3292 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.2791 | 0.8477 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.2231 | 0.6776 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.2231 | 0.2231 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.2231 | 0.6776 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0959 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2791 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.