Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.3706 | 0.6421 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.5772 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5772 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.5772 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.5772 | 0.5772 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3706 | 0.6421 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.3373 | 0.5844 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.5772 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.3373 | 0.5844 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.5772 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.5772 | 0.5772 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.5772 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.5772 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3706 | 0.6421 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.3706 | 0.6421 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.3706 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.5772 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.3373 | 0.5844 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.5772 | 0.5772 |
Onchocerca volvulus | 0.0024 | 0.5772 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5772 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3706 | 0.6421 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.5772 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.3373 | 0.5844 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.3706 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.5772 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.5772 | 0.5772 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.5772 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.3706 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.5772 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.5772 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5772 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.5772 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.5772 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.5772 | 0.5772 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.5772 | 0.5772 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.5772 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3706 | 0.6421 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3706 | 0.6421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.