Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2075 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0351 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | carboxylesterase | 0.2075 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0351 | 0.1476 | 0.1476 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0351 | 0.1476 | 0.1476 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0351 | 0.1476 | 0.1476 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0351 | 0.1476 | 0.1476 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2075 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0351 | 0.1476 | 0.1476 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Brugia malayi | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | carboxylesterase | 0.0351 | 0.1476 | 0.1476 |
Echinococcus granulosus | acetylcholinesterase | 0.2075 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Brugia malayi | Carboxylesterase family protein | 0.0351 | 0.1476 | 0.1476 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0351 | 0.1476 | 0.1476 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0351 | 0.1476 | 0.1476 |
Brugia malayi | Carboxylesterase family protein | 0.0351 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2075 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0351 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.2075 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0351 | 0.1476 | 0.1476 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | 0.0351 | 0.1476 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0351 | 0.1476 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | 0.0351 | 0.1476 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.2075 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0351 | 0.1476 | 0.1476 |
Echinococcus granulosus | carboxylesterase 5A | 0.2075 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0351 | 0.1476 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0351 | 0.1476 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0351 | 0.1476 | 0.1476 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0351 | 0.1476 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0351 | 0.1476 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | hypothetical protein | 0.2075 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0351 | 0.1476 | 0.1476 |
Onchocerca volvulus | 0.0351 | 0.1476 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2075 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0351 | 0.1476 | 0.1476 |
Echinococcus multilocularis | neuroligin | 0.0351 | 0.1476 | 0.1476 |
Onchocerca volvulus | 0.0351 | 0.1476 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0351 | 0.1476 | 0.1476 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2075 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2075 | 1 | 1 |
Onchocerca volvulus | 0.0351 | 0.1476 | 0.5 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0351 | 0.1476 | 0.1476 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0351 | 0.1476 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0351 | 0.1476 | 0.1476 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Anti-proliferative activity against human tumor cell lines A549, HT-29 and SaOS-2 (Values are average of these cell lines) | ChEMBL. | 15027857 |
IC50 (functional) | > 10 uM | Anti-proliferative activity against human tumor cell lines A549, HT-29 and SaOS-2 (Values are average of these cell lines) | ChEMBL. | 15027857 |
Ki (binding) | = 2.5 uM | Inhibitory activity against human CDK2 (Cyclin dependent kinase 2) | ChEMBL. | 15027857 |
Ki (binding) | = 2.5 uM | Inhibitory activity against human CDK2 (Cyclin dependent kinase 2) | ChEMBL. | 15027857 |
Ki (binding) | > 20 uM | Inhibitory activity against human CDK4 (Cyclin dependent kinase 4) | ChEMBL. | 15027857 |
Ki (binding) | > 20 uM | Inhibitory activity against human CDK4 (Cyclin dependent kinase 4) | ChEMBL. | 15027857 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15027857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.