Detailed information for compound 648925

Basic information

Technical information
  • TDR Targets ID: 648925
  • Name: N-cyclopropyl-N'-[3-(trifluoromethyl)phenyl]o xamide
  • MW: 272.223 | Formula: C12H11F3N2O2
  • H donors: 2 H acceptors: 2 LogP: 2.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)Nc1cccc(c1)C(F)(F)F)NC1CC1
  • InChi: 1S/C12H11F3N2O2/c13-12(14,15)7-2-1-3-9(6-7)17-11(19)10(18)16-8-4-5-8/h1-3,6,8H,4-5H2,(H,16,18)(H,17,19)
  • InChiKey: LVOVTMAFCLOIDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclopropyl-N'-[3-(trifluoromethyl)phenyl]ethanediamide
  • ZINC02814023
  • STK168182

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0294 0.0602
Schistosoma mansoni pyruvate kinase 0.0036 0.1633 0.1529
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0294 0.1068
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0025
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 1 1
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0442 0.0705
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1585 0.4215
Schistosoma mansoni tar DNA-binding protein 0.0061 0.339 0.3449
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.3652 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0442 0.0228
Schistosoma mansoni ap endonuclease 0.0019 0.0471 0.026
Loa Loa (eye worm) hypothetical protein 0.0028 0.1128 0.1057
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.185 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7483
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0471 0.1134
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0471 0.0335
Loa Loa (eye worm) hypothetical protein 0.0033 0.1448 0.1379
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.6484 0.8732
Giardia lamblia Pyruvate kinase 0.0018 0.0442 0.0948
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0875 0.4336
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.339 0.339
Loa Loa (eye worm) hypothetical protein 0.0018 0.0448 0.0371
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.1164 0.1093
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.3652 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0875 0.0829
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0471 1
Trypanosoma brucei pyruvate kinase 1 0.0036 0.1633 0.4348
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.554 0.5476
Loa Loa (eye worm) hypothetical protein 0.0048 0.2495 0.2435
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0471 0.0394
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0294 0.0602
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.185 0.4955
Echinococcus multilocularis musashi 0.0029 0.1164 0.1038
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.6484 0.8837
Echinococcus granulosus pyruvate kinase 0.0036 0.1633 0.1514
Loa Loa (eye worm) hypothetical protein 0.0025 0.0875 0.0802
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0875 0.4336
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0294 0.0294
Schistosoma mansoni alpha glucosidase 0.0035 0.1585 0.1477
Trypanosoma brucei trypanothione reductase 0.0047 0.2385 0.6453
Brugia malayi MH2 domain containing protein 0.0118 0.7264 0.7264
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0875 0.0875
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0471 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0233 0.0233
Toxoplasma gondii thioredoxin reductase 0.0047 0.2385 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.2092 0.8597
Giardia lamblia Pyruvate kinase 0.0036 0.1633 0.8606
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.2385 0.2277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.554 0.5476
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.2385 0.6453
Schistosoma mansoni tar DNA-binding protein 0.0061 0.339 0.3449
Echinococcus granulosus GPCR family 2 0.0015 0.0233 0.0094
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0156
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0379 0.0121
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.7264 0.7242
Echinococcus granulosus tar DNA binding protein 0.0061 0.339 0.3296
Loa Loa (eye worm) hypothetical protein 0.0018 0.0448 0.0371
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.1585 0.7483
Leishmania major pyruvate kinase 0.0036 0.1633 0.4348
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1585 0.4215
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.2092 0.8597
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0875 0.2226
Onchocerca volvulus 0.0091 0.544 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.2495 0.2495
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0875 0.4336
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0379 0.0121
Loa Loa (eye worm) acetyltransferase 0.0144 0.9068 0.9061
Schistosoma mansoni hypothetical protein 0.0033 0.1448 0.1327
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0442 0.0705
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0233 0.0094
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Echinococcus multilocularis GPCR, family 2 0.0015 0.0233 0.0094
Echinococcus granulosus lamin dm0 0.0029 0.1164 0.1038
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.3652 0.3562
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.1585 0.6174
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.1633 0.772
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.3652 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.1585 0.7483
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0471 0.0843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Brugia malayi RNA binding protein 0.0061 0.339 0.339
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0875 0.2226
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0294 0.1068
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.2092 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0875 0.4336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.554 0.5796
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.7299 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0442 0.0306
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.554 0.554
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0294 0.0602
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.9068 0.9649
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.1633 0.2898
Loa Loa (eye worm) glutathione reductase 0.0047 0.2385 0.2324
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.1633 0.772
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.2385 0.2985
Echinococcus granulosus intermediate filament protein 0.0029 0.1164 0.1038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0471 0.1095
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.9068 0.9068
Leishmania major trypanothione reductase 0.0047 0.2385 0.6453
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0875 0.2226
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.6484 0.8837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.2385 0.2277
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0875 0.2226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.554 0.5476
Mycobacterium ulcerans pyruvate kinase 0.0036 0.1633 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0892 0.082
Echinococcus granulosus pyruvate kinase 0.0018 0.0442 0.0306
Brugia malayi TAR-binding protein 0.0061 0.339 0.339
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.3652 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0156
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.1585 0.1465
Echinococcus granulosus pyruvate kinase 0.0018 0.0442 0.0306
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.554 0.5504
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.2092 0.1979
Brugia malayi Thioredoxin reductase 0.0047 0.2385 0.2385
Echinococcus granulosus lamin 0.0029 0.1164 0.1038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0233 0.0094
Echinococcus multilocularis pyruvate kinase 0.0036 0.1633 0.1514
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0875 0.0875
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.1633 0.2898
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0245 0.0245
Plasmodium falciparum thioredoxin reductase 0.0047 0.2385 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0875 0.2226
Loa Loa (eye worm) pyruvate kinase 0.0036 0.1633 0.1566
Echinococcus multilocularis lamin 0.0029 0.1164 0.1038
Plasmodium falciparum pyruvate kinase 0.0036 0.1633 0.6402
Loa Loa (eye worm) hypothetical protein 0.0015 0.0233 0.0154
Echinococcus multilocularis tar DNA binding protein 0.0061 0.339 0.3296
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0448 0.0371
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.7299 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.1633 0.1911
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0875 0.4336
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.1585 0.7483
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 1 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.1633 0.1633
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.1633 0.4348
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0471 0.1944
Echinococcus granulosus transcription factor Dp 1 0.0038 0.1771 0.1654
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.7299 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.8791 0.8774
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0245 0.0167
Trypanosoma brucei glucosidase, putative 0.0035 0.1585 0.4215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.2495 0.2435
Loa Loa (eye worm) RNA binding protein 0.0061 0.339 0.3337
Chlamydia trachomatis pyruvate kinase 0.0036 0.1633 1
Onchocerca volvulus 0.0029 0.1164 0.2023
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0448 0.0734
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0471 0.0335
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0471 0.1095
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0471 0.0471
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.7299 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.6484 0.8837
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 1 1
Schistosoma mansoni pyruvate kinase 0.0036 0.1633 0.1529
Echinococcus granulosus pyruvate kinase 0.0036 0.1633 0.1514
Loa Loa (eye worm) hypothetical protein 0.0014 0.014 0.0062
Mycobacterium tuberculosis Probable reductase 0.0106 0.6484 0.8837
Mycobacterium ulcerans hypothetical protein 0.0025 0.0875 0.4336
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.1585 0.1518
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0448 0.0219
Echinococcus multilocularis pyruvate kinase 0.0018 0.0442 0.0306
Loa Loa (eye worm) hypothetical protein 0.0018 0.0448 0.0371
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1448 0.1448
Echinococcus multilocularis pyruvate kinase 0.0036 0.1633 0.1514
Brugia malayi intermediate filament protein 0.0029 0.1164 0.1164
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.2495 0.2495
Echinococcus multilocularis pyruvate kinase 0.0028 0.1117 0.0991
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Loa Loa (eye worm) pyruvate kinase 0.0036 0.1633 0.1566
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.1633 0.6402
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.1633 0.1633
Schistosoma mansoni ap endonuclease 0.0019 0.0471 0.026
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7483
Onchocerca volvulus 0.0029 0.1164 0.2023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0448 0.1146
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0294 0.0602
Loa Loa (eye worm) hypothetical protein 0.0018 0.0448 0.0371
Schistosoma mansoni alpha-glucosidase 0.0135 0.8494 0.9022
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.7264 0.7242
Plasmodium vivax glutathione reductase, putative 0.0047 0.2385 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0875 0.2226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0471 0.1095
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.9068 0.9055
Loa Loa (eye worm) hypothetical protein 0.0025 0.0892 0.082
Toxoplasma gondii exonuclease III APE 0.0019 0.0471 0.0843
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.1633 0.4348
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0875 0.4336
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0379 0.0121
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.185 0.7439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0379 0.0121
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0025
Loa Loa (eye worm) TAR-binding protein 0.0061 0.339 0.3337
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0233 0.0154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0875 0.0802
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.1164 0.1164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Schistosoma mansoni lamin 0.0029 0.1164 0.1017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.554 0.5796
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.1633 0.2898
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0294 0.0602
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0471 0.1944
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0442 0.0705
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0448 0.1146
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.1771 0.1654
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.1633 0.4348
Plasmodium vivax pyruvate kinase, putative 0.0036 0.1633 0.6402
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7483
Loa Loa (eye worm) hypothetical protein 0.0025 0.0875 0.0802
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0294 0.0602
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.3652 0.3735
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0875 0.0829
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0448 0.0734
Echinococcus multilocularis pyruvate kinase 0.0018 0.0442 0.0306
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.1633 0.118
Loa Loa (eye worm) hypothetical protein 0.0036 0.1633 0.1566
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.6484 0.8837
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.2092 0.8597
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.1585 0.1465
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0471 0.0843
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0892 0.2275
Loa Loa (eye worm) hypothetical protein 0.0029 0.1164 0.1093
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0233 0.0094
Leishmania major pyruvate kinase 0.0036 0.1633 0.4348
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7483
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.2385 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0875 0.4336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.554 0.5796
Schistosoma mansoni tar DNA-binding protein 0.0061 0.339 0.3449
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.1585 0.4215
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.3652 0.3562
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0294 0.0602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.554 0.5476
Brugia malayi glutathione reductase 0.0047 0.2385 0.2385
Schistosoma mansoni lamin 0.0029 0.1164 0.1017
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 1 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.1164 0.1017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0471 0.1095
Echinococcus granulosus pyruvate kinase 0.0018 0.0442 0.0306
Onchocerca volvulus 0.0025 0.0875 0.1484
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.3652 0.3602
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7483
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.3652 1
Schistosoma mansoni alpha-glucosidase 0.0135 0.8494 0.9022
Echinococcus multilocularis lamin dm0 0.0029 0.1164 0.1038
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0471 0.1317
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.1585 0.7483
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.2385 0.2324
Loa Loa (eye worm) intermediate filament protein 0.0029 0.1164 0.1093
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.339 0.3337
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0471 0.0252
Plasmodium falciparum glutathione reductase 0.0047 0.2385 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0875 0.0875
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.2092 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.339 0.3449
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.1585 0.1585
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.3652 0.3652
Loa Loa (eye worm) pyruvate kinase 0.0036 0.1633 0.1566
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.1585 0.4215
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.6484 0.8837
Schistosoma mansoni tar DNA-binding protein 0.0061 0.339 0.3449
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.1585 0.4215
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0471 0.1095
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0233 0.0094
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0602
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0079 0.0079

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.