Detailed information for compound 649042

Basic information

Technical information
  • TDR Targets ID: 649042
  • Name: (3,5-dimethoxyphenyl)-[4-(4-fluorophenyl)sulf onylpiperazin-1-yl]methanone
  • MW: 408.444 | Formula: C19H21FN2O5S
  • H donors: 0 H acceptors: 3 LogP: 2.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C19H21FN2O5S/c1-26-16-11-14(12-17(13-16)27-2)19(23)21-7-9-22(10-8-21)28(24,25)18-5-3-15(20)4-6-18/h3-6,11-13H,7-10H2,1-2H3
  • InChiKey: WGZHWRDJHDYUTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3,5-dimethoxyphenyl)-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]methanone
  • Oprea1_567293
  • STK195023
  • Oprea1_628662
  • ZINC00899977

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0011 0.0001 0.000000055349
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0001 0.000000027168
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0614 0.1249
Onchocerca volvulus 0.0071 0.1341 0.273
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0151 0.0306
Schistosoma mansoni hypothetical protein 0.0334 0.7264 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0713 0.5313
Brugia malayi Cytochrome P450 family protein 0.0026 0.0323 0.0752
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0151 0.0306
Loa Loa (eye worm) hypothetical protein 0.0029 0.0411 0.0958
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1867 0.1866
Brugia malayi CHD4 protein 0.0013 0.0039 0.0088
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0569 0.0782
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1122 0.8192
Mycobacterium ulcerans hypothetical protein 0.0071 0.1341 1
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.1293 0.3016
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0361 0.0734
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0186 0.0433
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0323 0.1575
Echinococcus granulosus chromobox protein 1 0.0069 0.1293 0.1292
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0798 0.0797
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1122 0.1544
Mycobacterium ulcerans beta-lactamase 0.0071 0.1341 1
Schistosoma mansoni hypothetical protein 0.0047 0.0798 0.1097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.118 0.1623
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0395 0.0543
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1122 0.1121
Loa Loa (eye worm) TAR-binding protein 0.0191 0.4055 0.9464
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0578 0.0577
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.2936 0.2936
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0713 0.145
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.1182 0.8688
Schistosoma mansoni tar DNA-binding protein 0.0191 0.4055 0.5581
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0082 0.0164
Brugia malayi Bromodomain containing protein 0.0032 0.0475 0.1108
Loa Loa (eye worm) hypothetical protein 0.0047 0.0798 0.186
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1341 0.1234
Onchocerca volvulus 0.003 0.0427 0.0868
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1341 0.273
Mycobacterium tuberculosis Conserved protein 0.0071 0.1341 0.1234
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0001 0.0014
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0001 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0001 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.3066 0.7155
Loa Loa (eye worm) hypothetical protein 0.0071 0.1341 0.3128
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1182 0.8688
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.3028 0.3028
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0323 0.0752
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0531 0.053
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1084 0.2529
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1341 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.3066 0.7155
Mycobacterium ulcerans lipase LipD 0.0071 0.1341 1
Brugia malayi jmjC domain containing protein 0.0094 0.1867 0.4357
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0798 0.186
Echinococcus multilocularis geminin 0.0334 0.7264 0.7264
Onchocerca volvulus 0.0071 0.1341 0.273
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0039 0.0088
Schistosoma mansoni hypothetical protein 0.0101 0.2016 0.2774
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1341 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0411 0.3066
Mycobacterium tuberculosis Conserved protein 0.0071 0.1341 0.1234
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.3028 0.7068
Echinococcus granulosus cpg binding protein 0.0031 0.045 0.0449
Schistosoma mansoni tar DNA-binding protein 0.0191 0.4055 0.5581
Loa Loa (eye worm) hypothetical protein 0.0049 0.0857 0.2
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.9923 1
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1341 0.1234
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1341 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0614 0.1249
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0395 0.0394
Echinococcus granulosus geminin 0.0334 0.7264 0.7264
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0395 0.2942
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0648 0.0648
Echinococcus multilocularis 0.0017 0.0132 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0411 0.0565
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0632 0.5345
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1341 0.3128
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0411 0.041
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0569 0.1327
Leishmania major hypothetical protein, conserved 0.0071 0.1341 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1341 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0039 0.0038
Echinococcus multilocularis GPCR, family 2 0.0047 0.0798 0.0797
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1182 0.8688
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0569 0.0782
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.2016 0.4704
Trichomonas vaginalis chromobox protein, putative 0.0041 0.068 0.1383
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0411 0.0565
Brugia malayi Pre-SET motif family protein 0.0202 0.4284 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.068 0.1383
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1341 0.273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0151 0.0306
Loa Loa (eye worm) beta-lactamase 0.0071 0.1341 0.3128
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.1182 0.1181
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0395 0.2942
Brugia malayi TAR-binding protein 0.0191 0.4055 0.9464
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1341 0.273
Onchocerca volvulus 0.003 0.0412 0.0837
Schistosoma mansoni chromobox protein 0.0069 0.1293 0.1778
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1341 0.1845
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1341 0.1234
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1432 0.197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0151 0.0306
Brugia malayi beta-lactamase family protein 0.0071 0.1341 0.3128
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0962 0.2243
Schistosoma mansoni hypothetical protein 0.0047 0.0798 0.1097
Schistosoma mansoni chromobox protein 0.0069 0.1293 0.1778
Brugia malayi Cytochrome P450 family protein 0.0054 0.0962 0.2243
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.1182 0.1181
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.3066 0.7155
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0632 1
Onchocerca volvulus 0.0071 0.1341 0.273
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1341 0.1234
Echinococcus granulosus tar DNA binding protein 0.0191 0.4055 0.4054
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0001 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1122 0.1544
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1341 1
Onchocerca volvulus 0.0041 0.0664 0.1351
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0395 0.0394
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0151 0.0306
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0713 0.5316
Schistosoma mansoni hypothetical protein 0.0047 0.0798 0.1097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0798 0.0797
Loa Loa (eye worm) cytochrome P450 0.0017 0.0132 0.0307
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0395 0.092
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1293 0.2632
Echinococcus multilocularis neuropeptide s receptor 0.0456 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1122 0.8192
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1341 0.273
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1122 0.1121
Schistosoma mansoni hypothetical protein 0.0017 0.0132 0.0181
Echinococcus multilocularis chromobox protein 1 0.0069 0.1293 0.1292
Schistosoma mansoni cpg binding protein 0.0031 0.045 0.0618
Echinococcus granulosus neuropeptide receptor A26 0.0456 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1341 0.3128
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0039 0.0052
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0713 0.145
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0798 0.0797
Plasmodium falciparum phd finger protein, putative 0.0029 0.0395 0.6248
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0373 0.0372
Echinococcus multilocularis tar DNA binding protein 0.0191 0.4055 0.4054
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1182 0.8688
Onchocerca volvulus 0.0229 0.4909 1
Schistosoma mansoni tar DNA-binding protein 0.0191 0.4055 0.5581
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1867 0.1866
Mycobacterium leprae Probable lipase LipE 0.0071 0.1341 1
Brugia malayi jmjC domain containing protein 0.0037 0.0569 0.1327
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1341 0.273
Brugia malayi beta-lactamase family protein 0.0071 0.1341 0.3128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0798 0.0797
Brugia malayi PHD-finger family protein 0.0029 0.0395 0.092
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0148 0.0203
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0411 0.041
Brugia malayi Pre-SET motif family protein 0.0029 0.0411 0.0958
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.4284 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.1182 0.2758
Toxoplasma gondii ABC1 family protein 0.0071 0.1341 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0664 0.0913
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0411 0.3062
Schistosoma mansoni tar DNA-binding protein 0.0191 0.4055 0.5581
Loa Loa (eye worm) hypothetical protein 0.0148 0.3066 0.7155
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0323 0.0752
Trichomonas vaginalis esterase, putative 0.0071 0.1341 0.273
Echinococcus granulosus peregrin 0.0032 0.0475 0.0475
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0132 0.0132
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.068 0.1383
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0323 0.1575
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0323 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0411 0.0565
Brugia malayi Cytochrome P450 family protein 0.0026 0.0323 0.0752
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0713 0.5313
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.1182 0.2758
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0151 0.0306
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.4055 0.9464
Schistosoma mansoni hypothetical protein 0.0047 0.0798 0.1097
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0323 0.1575
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0578 0.0577
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0082 0.0164
Brugia malayi Heterochromatin protein 1 0.0069 0.1293 0.3016
Loa Loa (eye worm) hypothetical protein 0.003 0.0427 0.0994
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.1341 0.3128
Echinococcus multilocularis neuropeptide receptor A26 0.0456 1 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1293 0.2632
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.1182 1
Schistosoma mansoni hypothetical protein 0.0029 0.0395 0.0543
Brugia malayi RNA binding protein 0.0191 0.4055 0.9464
Schistosoma mansoni cpg binding protein 0.0031 0.045 0.0618
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0713 0.0712
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1341 0.1234
Brugia malayi beta-lactamase 0.0071 0.1341 0.3128
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.1182 0.1626
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1122 0.1011
Mycobacterium leprae conserved hypothetical protein 0.0071 0.1341 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1341 0.134
Loa Loa (eye worm) hypothetical protein 0.0071 0.1341 0.3128
Schistosoma mansoni tar DNA-binding protein 0.0191 0.4055 0.5581
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0614 0.1249
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0412 0.0959
Echinococcus granulosus jumonji domain containing protein 0.004 0.0648 0.0648
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0798 0.186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0071 0.0142
Onchocerca volvulus Alhambra homolog 0.0029 0.0395 0.0803
Trichomonas vaginalis set domain proteins, putative 0.0229 0.4909 1
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0323 0.1575
Echinococcus granulosus Chromobox protein 3 0.0011 0.0001 0.000000027168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0151 0.0306
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1341 0.134
Leishmania major cytochrome p450-like protein 0.0026 0.0323 0.1575
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0395 0.2947
Loa Loa (eye worm) RNA binding protein 0.0191 0.4055 0.9464
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.3028 0.4168
Echinococcus granulosus chromobox protein 1 0.0069 0.1293 0.1292
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.111 0.8277
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1341 0.1234
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1341 0.3128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1341 0.1845
Echinococcus granulosus GPCR family 2 0.0047 0.0798 0.0797
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0411 0.041
Brugia malayi chromobox protein homolog 3 0.0038 0.0614 0.1431
Brugia malayi cytochrome P450 0.0017 0.0132 0.0307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.4055 0.9464
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0132 0.0982
Loa Loa (eye worm) hypothetical protein 0.0071 0.1341 0.3128
Mycobacterium tuberculosis Conserved protein 0.0071 0.1341 0.1234
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1341 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0151 0.0306
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1122 0.8192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1122 0.8192
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0039 0.0038
Schistosoma mansoni hypothetical protein 0.0334 0.7264 1
Echinococcus multilocularis cpg binding protein 0.0031 0.045 0.0449
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1122 0.8369
Echinococcus multilocularis peregrin 0.0032 0.0475 0.0475
Schistosoma mansoni cytochrome P450 0.0017 0.0132 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0361 0.0734
Echinococcus multilocularis chromobox protein 1 0.0069 0.1293 0.1292
Loa Loa (eye worm) acetyltransferase 0.0146 0.3028 0.7068
Loa Loa (eye worm) hypothetical protein 0.0038 0.0614 0.1431
Schistosoma mansoni cpg binding protein 0.003 0.0412 0.0566
Loa Loa (eye worm) hypothetical protein 0.0029 0.0395 0.092
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0001 0.0006
Brugia malayi Cytochrome P450 family protein 0.0017 0.0132 0.0307
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0632 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0412 0.0959
Loa Loa (eye worm) hypothetical protein 0.0101 0.2016 0.4704
Loa Loa (eye worm) hypothetical protein 0.0071 0.1341 0.3128
Brugia malayi SET domain containing protein 0.0013 0.0039 0.009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0798 0.186
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0569 0.0568
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1341 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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