Detailed information for compound 649135

Basic information

Technical information
  • TDR Targets ID: 649135
  • Name: N-(4-iodophenyl)-3-piperidin-1-ylsulfonylbenz amide
  • MW: 470.325 | Formula: C18H19IN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(cc1)NC(=O)c1cccc(c1)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C18H19IN2O3S/c19-15-7-9-16(10-8-15)20-18(22)14-5-4-6-17(13-14)25(23,24)21-11-2-1-3-12-21/h4-10,13H,1-3,11-12H2,(H,20,22)
  • InChiKey: WHBJMYCTJZXDLO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-iodophenyl)-3-(1-piperidylsulfonyl)benzamide
  • N-(4-iodophenyl)-3-piperidinosulfonyl-benzamide
  • N-(4-iodophenyl)-3-piperidin-1-ylsulfonyl-benzamide
  • BAS 00604081
  • N-(4-Iodo-phenyl)-3-(piperidine-1-sulfonyl)-benzamide
  • Oprea1_816466
  • Oprea1_059342
  • ZINC00866130

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0294 0.0602
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0443 0.0307
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.3652 1
Onchocerca volvulus 0.0029 0.1164 0.2023
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0443 0.1018
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0443 0.1808
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2495 0.2495
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.5467 0.5402
Schistosoma mansoni hypothetical protein 0.0033 0.1448 0.1327
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.1585 0.1465
Echinococcus granulosus pyruvate kinase 0.0036 0.1633 0.1514
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.6484 0.8837
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0419 0.0179
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.1633 0.7718
Loa Loa (eye worm) RNA binding protein 0.0062 0.339 0.3337
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.1633 0.4348
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7481
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7481
Trypanosoma brucei trypanothione reductase 0.0047 0.2385 0.6453
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.2092 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.7299 1
Schistosoma mansoni ap endonuclease 0.0019 0.0443 0.023
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.339 0.339
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.2092 0.8599
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0233 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0837 0.0764
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0419 0.0935
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.1585 0.4215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0082
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0079 0.0079
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.2385 0.2985
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.3652 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1585 0.4215
Onchocerca volvulus 0.0092 0.544 1
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0442 0.0705
Plasmodium vivax pyruvate kinase, putative 0.0036 0.1633 0.6402
Echinococcus granulosus lamin dm0 0.0029 0.1164 0.1038
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.1585 0.7481
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0233 0.0093
Onchocerca volvulus 0.0029 0.1164 0.2023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0245 0.0167
Plasmodium falciparum pyruvate kinase 0.0036 0.1633 0.6402
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0837 0.212
Echinococcus granulosus pyruvate kinase 0.0018 0.0442 0.0306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0443 0.1112
Giardia lamblia Pyruvate kinase 0.0018 0.0442 0.0947
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0837 0.4053
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.185 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.5467 0.5716
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0443 0.0957
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.907 0.9651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.5467 0.5716
Schistosoma mansoni pyruvate kinase 0.0036 0.1633 0.1529
Loa Loa (eye worm) hypothetical protein 0.0018 0.0419 0.0343
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0294 0.0602
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0294 0.1068
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.6484 0.8837
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0892 0.082
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.6484 0.8837
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.339 0.3337
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7481
Plasmodium falciparum thioredoxin reductase 0.0047 0.2385 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.339 0.3296
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.3652 0.3652
Schistosoma mansoni tar DNA-binding protein 0.0062 0.339 0.3449
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.7299 1
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.1633 0.6402
Mycobacterium ulcerans hypothetical protein 0.0024 0.0837 0.4053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0233 0.0154
Schistosoma mansoni alpha glucosidase 0.0035 0.1585 0.1477
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.6484 0.874
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.1633 0.1232
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.1585 0.7481
Brugia malayi glutathione reductase 0.0047 0.2385 0.2385
Chlamydia trachomatis pyruvate kinase 0.0036 0.1633 1
Plasmodium falciparum glutathione reductase 0.0047 0.2385 1
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.907 0.907
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.7299 1
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0442 0.0705
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0837 0.4053
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1448 0.1448
Schistosoma mansoni lamin 0.0029 0.1164 0.1017
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0837 0.212
Brugia malayi Thioredoxin reductase 0.0047 0.2385 0.2385
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.1633 0.1633
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0443 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0837 0.0764
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.7264 0.7242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0443 0.0213
Echinococcus granulosus tar DNA binding protein 0.0062 0.339 0.3296
Schistosoma mansoni pyruvate kinase 0.0018 0.0442 0.0228
Loa Loa (eye worm) glutathione reductase 0.0047 0.2385 0.2324
Echinococcus multilocularis pyruvate kinase 0.0036 0.1633 0.1514
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0602
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0837 0.4053
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0419 0.0599
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Loa Loa (eye worm) intermediate filament protein 0.0029 0.1164 0.1093
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.1633 0.2898
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.3652 0.3735
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0837 0.212
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0837 0.4053
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0837 0.4053
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.2385 0.2277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.5467 0.5402
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0294 0.0602
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.1633 0.7718
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.2092 0.198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.5467 0.5467
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0837 0.212
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0837 0.0775
Onchocerca volvulus 0.0024 0.0837 0.1413
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0837 0.0837
Echinococcus granulosus pyruvate kinase 0.0036 0.1633 0.1514
Brugia malayi TAR-binding protein 0.0062 0.339 0.339
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0156
Loa Loa (eye worm) hypothetical protein 0.0049 0.2495 0.2435
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0837 0.212
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0233 0.0093
Echinococcus granulosus GPCR family 2 0.0015 0.0233 0.0093
Echinococcus granulosus intermediate filament protein 0.0029 0.1164 0.1038
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1585 0.4215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Schistosoma mansoni ap endonuclease 0.0019 0.0443 0.023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0443 0.1018
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.2385 0.2324
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0443 0.1018
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.2385 0.6453
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.1633 0.2898
Loa Loa (eye worm) hypothetical protein 0.0018 0.0419 0.0343
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.1164 0.1164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0082
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.8792 0.8775
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0029 0.1128 0.1057
Trypanosoma brucei glucosidase, putative 0.0035 0.1585 0.4215
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.2385 0.2277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0837 0.0764
Loa Loa (eye worm) hypothetical protein 0.0033 0.1448 0.1379
Loa Loa (eye worm) pyruvate kinase 0.0036 0.1633 0.1566
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.3652 0.3562
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.1585 0.1585
Loa Loa (eye worm) hypothetical protein 0.0018 0.0419 0.0343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2495 0.2435
Loa Loa (eye worm) hypothetical protein 0.0018 0.0419 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0062 0.339 0.3449
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.1633 0.1911
Plasmodium vivax glutathione reductase, putative 0.0047 0.2385 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.2092 0.8599
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0443 0.0712
Loa Loa (eye worm) hypothetical protein 0.0036 0.1633 0.1566
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.1633 0.4348
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0245 0.0245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.5467 0.5402
Loa Loa (eye worm) hypothetical protein 0.0025 0.0892 0.082
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.3652 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.2385 1
Brugia malayi intermediate filament protein 0.0029 0.1164 0.1164
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.1585 0.4215
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.1633 0.4348
Echinococcus multilocularis GPCR, family 2 0.0015 0.0233 0.0093
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.3652 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0443 0.1018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.7299 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.5467 0.543
Loa Loa (eye worm) hypothetical protein 0.0014 0.014 0.0062
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0419 0.0599
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.1771 0.1654
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0294 0.0602
Giardia lamblia Pyruvate kinase 0.0036 0.1633 0.8604
Leishmania major pyruvate kinase 0.0036 0.1633 0.4348
Loa Loa (eye worm) pyruvate kinase 0.0036 0.1633 0.1566
Echinococcus granulosus transcription factor Dp 1 0.0038 0.1771 0.1654
Echinococcus granulosus pyruvate kinase 0.0018 0.0442 0.0306
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0443 0.0712
Schistosoma mansoni tar DNA-binding protein 0.0062 0.339 0.3449
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0294 0.0602
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0837 0.4053
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0419 0.0935
Trypanosoma brucei pyruvate kinase 1 0.0036 0.1633 0.4348
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0294 0.0602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0837 0.0775
Echinococcus multilocularis lamin dm0 0.0029 0.1164 0.1038
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.1585 0.6174
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.2092 0.8599
Echinococcus multilocularis musashi 0.0029 0.1164 0.1038
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7481
Toxoplasma gondii thioredoxin reductase 0.0047 0.2385 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0443 0.0307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0837 0.0837
Schistosoma mansoni alpha-glucosidase 0.0137 0.8494 0.9022
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.1585 0.7481
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.6484 0.8837
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0443 0.0443
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.1585 0.7481
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0233 0.0154
Echinococcus multilocularis pyruvate kinase 0.0036 0.1633 0.1514
Schistosoma mansoni pyruvate kinase 0.0036 0.1633 0.1529
Mycobacterium ulcerans pyruvate kinase 0.0036 0.1633 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.185 0.4956
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.6484 0.8837
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.185 0.7441
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0443 0.1018
Schistosoma mansoni lamin 0.0029 0.1164 0.1017
Leishmania major trypanothione reductase 0.0047 0.2385 0.6453
Echinococcus granulosus lamin 0.0029 0.1164 0.1038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0419 0.0343
Toxoplasma gondii exonuclease III APE 0.0019 0.0443 0.0712
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0294 0.1068
Echinococcus multilocularis pyruvate kinase 0.0028 0.1117 0.0991
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0443 0.0367
Loa Loa (eye worm) pyruvate kinase 0.0036 0.1633 0.1566
Loa Loa (eye worm) acetyltransferase 0.0146 0.907 0.9062
Brugia malayi RNA binding protein 0.0062 0.339 0.339
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0029 0.1164 0.1093
Leishmania major pyruvate kinase 0.0036 0.1633 0.4348
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 1 1
Mycobacterium tuberculosis Probable reductase 0.0107 0.6484 0.8837
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.3652 1
Echinococcus multilocularis lamin 0.0029 0.1164 0.1038
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.1585 0.1465
Schistosoma mansoni tar DNA-binding protein 0.0062 0.339 0.3449
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0837 0.212
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.2092 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0602
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0233 0.0093
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0294 0.0294
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.1585 0.1518
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0233 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.5467 0.5716
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.1164 0.1093
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0443 0.1808
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0442 0.0705
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.5467 0.5402
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.907 0.9056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2495 0.2495
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.1633 0.1633
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0443 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.339 0.3337
Echinococcus multilocularis pyruvate kinase 0.0018 0.0442 0.0306
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.1585 0.7481
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0892 0.2276
Loa Loa (eye worm) hypothetical protein 0.0014 0.0104 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.7264 0.7242
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.1633 0.2898
Schistosoma mansoni tar DNA-binding protein 0.0062 0.339 0.3449
Echinococcus granulosus pyruvate kinase 0.0018 0.0442 0.0306
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0294 0.0602
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.3652 0.3602
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0294 0.0602
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0294 0.0156
Echinococcus multilocularis pyruvate kinase 0.0018 0.0442 0.0306
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.1585 0.4215
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0837 0.4053
Schistosoma mansoni intermediate filament proteins 0.0029 0.1164 0.1017
Brugia malayi MH2 domain containing protein 0.0119 0.7264 0.7264
Schistosoma mansoni alpha-glucosidase 0.0137 0.8494 0.9022
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.3652 0.3562
Loa Loa (eye worm) hypothetical protein 0.0014 0.0104 0.0025
Echinococcus multilocularis pyruvate kinase 0.0018 0.0442 0.0306

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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